GREMLIN Database
YDEN - Uncharacterized sulfatase YdeN
UniProt: P77318 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13796
Length: 560 (435)
Sequences: 2374 (1818)
Seq/√Len: 87.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
404_D420_S7.1931.00
330_K335_Y4.9501.00
458_Y505_K4.3741.00
327_E331_K4.2291.00
267_D328_Q4.0481.00
111_T323_K3.9671.00
259_T282_Y3.7801.00
118_E379_W3.5771.00
263_I328_Q3.4801.00
326_L340_I3.4041.00
65_M68_L3.3631.00
74_P113_L3.2821.00
522_V525_E3.2281.00
262_A278_L3.0111.00
460_K511_Q2.9241.00
60_I171_F2.8911.00
280_L325_I2.8371.00
282_Y321_G2.8331.00
63_L322_V2.7181.00
260_D324_R2.7171.00
339_I378_M2.7161.00
328_Q332_N2.6631.00
174_H408_I2.6481.00
65_M342_F2.5371.00
400_P418_G2.5341.00
147_R417_D2.5041.00
348_A357_N2.5001.00
61_I340_I2.4971.00
243_K261_E2.4601.00
60_I406_A2.4421.00
180_A279_Y2.4011.00
295_D299_K2.3891.00
115_L377_F2.3881.00
259_T321_G2.3741.00
341_L402_A2.3291.00
456_D525_E2.3231.00
125_G393_I2.3211.00
179_A265_V2.2861.00
135_S395_A2.2831.00
114_S118_E2.2521.00
436_N529_V2.2101.00
181_V278_L2.2101.00
263_I324_R2.2001.00
114_S330_K2.1861.00
335_Y379_W2.1791.00
266_V325_I2.1601.00
68_L342_F2.1041.00
393_I421_L2.0931.00
124_N455_W2.0771.00
405_A422_L2.0611.00
403_L408_I1.9831.00
261_E264_G1.9781.00
398_F402_A1.9671.00
65_M318_V1.9541.00
120_V388_N1.9451.00
167_L277_M1.9361.00
502_G514_N1.9311.00
516_A523_V1.9271.00
297_Y320_Q1.9051.00
264_G268_R1.9021.00
330_K379_W1.8591.00
112_L342_F1.8521.00
335_Y340_I1.8491.00
143_R164_E1.8161.00
339_I405_A1.8001.00
75_F121_R1.7871.00
404_D422_L1.7631.00
267_D331_K1.7621.00
299_K302_N1.7341.00
267_D332_N1.7321.00
328_Q331_K1.7181.00
301_F316_Y1.7131.00
64_T139_I1.7051.00
62_V341_L1.6741.00
456_D529_V1.6731.00
64_T343_T1.6311.00
170_L403_L1.6291.00
259_T263_I1.5901.00
60_I405_A1.5611.00
295_D298_Q1.5591.00
177_Y269_A1.5391.00
128_A145_P1.5191.00
255_S284_A1.4991.00
461_F523_V1.4951.00
59_N338_T1.4941.00
177_Y274_Q1.4941.00
256_D317_S1.4870.99
115_L379_W1.4860.99
259_T325_I1.4840.99
344_S374_T1.4800.99
133_G150_V1.4760.99
111_T114_S1.4740.99
68_L315_V1.4670.99
61_I329_L1.4560.99
326_L335_Y1.4510.99
329_L335_Y1.4480.99
120_V384_L1.4330.99
68_L285_P1.4300.99
180_A281_A1.4160.99
119_G377_F1.4150.99
160_I166_F1.4130.99
515_L519_N1.4100.99
341_L378_M1.4080.99
172_Q201_R1.4000.99
126_Y372_T1.3990.99
519_N522_V1.3790.99
368_Y502_G1.3630.99
114_S327_E1.3500.99
121_R389_Y1.3410.99
170_L399_Y1.3240.99
64_T281_A1.3210.99
123_T390_D1.3180.99
291_N313_A1.3140.99
454_F526_M1.3130.99
455_W458_Y1.3100.99
282_Y318_V1.3070.99
383_K426_Q1.2940.99
57_K174_H1.2910.99
63_L340_I1.2900.99
256_D321_G1.2750.98
340_I379_W1.2650.98
285_P315_V1.2590.98
62_V343_T1.2490.98
254_I258_L1.2480.98
339_I380_W1.2410.98
138_A145_P1.2380.98
125_G376_M1.2360.98
146_A440_I1.2320.98
255_S282_Y1.2310.98
454_F461_F1.2300.98
258_L280_L1.2290.98
76_D377_F1.2260.98
108_S301_F1.2260.98
459_H515_L1.2230.98
59_N276_F1.2200.98
515_L522_V1.2160.98
270_K332_N1.2160.98
372_T439_W1.2150.98
171_F402_A1.2120.98
194_V197_D1.2060.98
67_D364_K1.2050.98
122_F376_M1.2030.98
253_Y317_S1.2010.98
241_L244_N1.2010.98
324_R327_E1.2000.98
76_D121_R1.1970.98
300_Q316_Y1.1950.98
458_Y522_V1.1850.97
116_M121_R1.1800.97
350_I363_Y1.1780.97
422_L426_Q1.1700.97
68_L73_L1.1690.97
179_A278_L1.1670.97
165_T173_N1.1640.97
378_M384_L1.1630.97
327_E330_K1.1600.97
118_E335_Y1.1580.97
114_S326_L1.1520.97
263_I267_D1.1470.97
380_W383_K1.1410.97
262_A280_L1.1390.97
127_V374_T1.1360.97
195_P199_Q1.1310.97
124_N373_H1.1240.96
404_D423_P1.1170.96
61_I278_L1.1030.96
378_M421_L1.1010.96
132_S136_R1.1000.96
109_T113_L1.0980.96
359_A509_L1.0930.96
513_D518_A1.0920.96
265_V269_A1.0880.96
108_S316_Y1.0860.96
58_P176_Y1.0850.96
296_Q300_Q1.0720.95
304_G309_D1.0720.95
213_E216_Q1.0700.95
130_G367_T1.0680.95
253_Y314_S1.0580.95
339_I402_A1.0550.95
112_L115_L1.0520.95
515_L518_A1.0500.95
179_A202_D1.0460.95
61_I338_T1.0410.95
60_I402_A1.0390.95
140_M279_Y1.0360.94
262_A266_V1.0350.94
320_Q324_R1.0340.94
438_T454_F1.0330.94
243_K246_E1.0330.94
140_M186_L1.0190.94
364_K371_G1.0170.94
115_L326_L1.0150.94
67_D371_G1.0150.94
244_N247_R1.0140.94
56_G337_N1.0140.94
305_S309_D1.0140.94
133_G185_H1.0110.94
165_T170_L1.0110.94
109_T112_L1.0100.94
361_K368_Y1.0080.94
440_I443_Y1.0030.93
376_M398_F1.0000.93
118_E330_K0.9970.93
487_N490_Y0.9890.93
167_L171_F0.9710.92
61_I276_F0.9690.92
317_S321_G0.9650.92
67_D346_N0.9620.92
62_V277_M0.9600.92
459_H519_N0.9580.92
127_V135_S0.9560.92
195_P200_T0.9550.92
184_W187_S0.9530.92
73_L76_D0.9500.91
309_D312_Y0.9470.91
399_Y403_L0.9460.91
313_A317_S0.9450.91
284_A318_V0.9420.91
122_F424_W0.9400.91
411_P414_L0.9390.91
70_Y346_N0.9390.91
298_Q313_A0.9330.91
427_D430_Q0.9330.91
167_L399_Y0.9330.91
529_V532_E0.9330.91
267_D327_E0.9320.91
61_I326_L0.9310.91
460_K506_L0.9300.91
69_G371_G0.9290.91
266_V269_A0.9270.90
221_G226_M0.9240.90
276_F338_T0.9230.90
459_H503_L0.9230.90
75_F113_L0.9220.90
143_R148_F0.9220.90
329_L332_N0.9170.90
296_Q320_Q0.9130.90
69_G346_N0.9120.90
64_T395_A0.9050.89
524_K527_Q0.9040.89
500_Q514_N0.9030.89
115_L119_G0.9030.89
326_L379_W0.9030.89
529_V533_F0.8990.89
167_L402_A0.8990.89
120_V386_P0.8980.89
67_D348_A0.8950.89
171_F339_I0.8920.89
505_K522_V0.8890.89
321_G324_R0.8870.88
69_G72_Q0.8860.88
420_S423_P0.8850.88
459_H522_V0.8840.88
138_A396_M0.8840.88
70_Y123_T0.8810.88
300_Q313_A0.8800.88
65_M285_P0.8800.88
69_G348_A0.8780.88
436_N456_D0.8770.88
276_F334_Q0.8750.88
61_I325_I0.8730.88
270_K334_Q0.8720.88
523_V527_Q0.8700.87
128_A138_A0.8700.87
348_A356_L0.8670.87
241_L245_R0.8660.87
291_N314_S0.8580.87
238_S242_F0.8560.87
255_S321_G0.8510.86
239_P244_N0.8500.86
299_K303_T0.8490.86
115_L322_V0.8480.86
258_L283_N0.8470.86
484_T487_N0.8460.86
171_F408_I0.8450.86
269_A274_Q0.8450.86
122_F378_M0.8440.86
122_F425_L0.8430.86
461_F526_M0.8420.86
309_D313_A0.8380.85
329_L340_I0.8350.85
392_L434_H0.8350.85
114_S335_Y0.8320.85
74_P109_T0.8300.85
141_T164_E0.8300.85
112_L377_F0.8290.85
344_S375_P0.8280.85
208_T211_S0.8220.84
69_G370_G0.8190.84
528_G532_E0.8190.84
221_G224_Y0.8170.84
203_Y206_N0.8160.84
369_P460_K0.8140.84
369_P455_W0.8140.84
76_D376_M0.8130.84
200_T205_D0.8120.84
291_N298_Q0.8100.83
306_Q309_D0.8100.83
243_K247_R0.8080.83
237_N243_K0.8080.83
62_V402_A0.8070.83
325_I328_Q0.8050.83
285_P311_Y0.8040.83
501_L516_A0.8030.83
137_A150_V0.8020.83
144_A396_M0.8020.83
503_L526_M0.8010.83
169_E172_Q0.7970.82
270_K273_D0.7940.82
70_Y76_D0.7940.82
191_N197_D0.7930.82
263_I325_I0.7930.82
59_N334_Q0.7910.82
259_T324_R0.7900.82
290_D314_S0.7900.82
108_S300_Q0.7820.81
485_V489_D0.7810.81
181_V202_D0.7790.81
269_A272_L0.7790.81
439_W453_P0.7780.81
240_S243_K0.7770.81
172_Q178_T0.7760.81
333_G336_D0.7760.81
403_L410_I0.7730.80
169_E198_K0.7720.80
219_N222_F0.7710.80
296_Q299_K0.7710.80
391_K424_W0.7700.80
62_V139_I0.7670.80
228_F231_A0.7670.80
483_Y486_R0.7650.80
260_D263_I0.7610.79
419_V434_H0.7590.79
221_G225_F0.7580.79
524_K528_G0.7580.79
369_P373_H0.7570.79
243_K248_V0.7570.79
63_L280_L0.7530.79
486_R489_D0.7530.79
177_Y265_V0.7530.79
195_P205_D0.7530.79
300_Q320_Q0.7520.79
457_N505_K0.7490.78
126_Y369_P0.7490.78
456_D522_V0.7480.78
438_T444_S0.7480.78
132_S183_K0.7470.78
73_L121_R0.7450.78
200_T222_F0.7450.78
252_G260_D0.7450.78
400_P416_L0.7410.78
127_V395_A0.7400.78
317_S320_Q0.7400.78
136_R183_K0.7400.78
181_V280_L0.7390.77
61_I266_V0.7380.77
507_T521_Q0.7380.77
337_N526_M0.7370.77
103_E113_L0.7370.77
291_N310_N0.7340.77
402_A406_A0.7320.77
125_G395_A0.7300.77
128_A395_A0.7270.76
343_T395_A0.7250.76
483_Y488_N0.7250.76
106_Q308_A0.7250.76
419_V424_W0.7240.76
346_N371_G0.7240.76
396_M416_L0.7230.76
165_T414_L0.7230.76
195_P198_K0.7220.76
253_Y256_D0.7150.75
257_Q261_E0.7110.75
533_F536_S0.7100.75
369_P506_L0.7090.74
72_Q356_L0.7090.74
266_V332_N0.7080.74
378_M425_L0.7060.74
76_D122_F0.7060.74
57_K175_G0.7060.74
419_V433_P0.7040.74
501_L523_V0.7040.74
530_V534_I0.7010.74
147_R536_S0.7010.74
454_F529_V0.7010.74
255_S280_L0.6970.73
435_K456_D0.6960.73
503_L520_P0.6960.73
362_G366_Q0.6950.73
441_T444_S0.6950.73
514_N517_A0.6930.73
61_I334_Q0.6920.73
183_K364_K0.6910.73
385_Q388_N0.6910.73
139_I398_F0.6880.72
520_P523_V0.6870.72
285_P344_S0.6870.72
264_G267_D0.6860.72
265_V511_Q0.6850.72
68_L318_V0.6840.72
238_S244_N0.6830.72
297_Y300_Q0.6830.72
206_N211_S0.6820.72
392_L437_L0.6820.72
136_R182_G0.6790.71
168_P172_Q0.6790.71
133_G305_S0.6780.71
187_S195_P0.6780.71
461_F501_L0.6760.71
241_L249_P0.6750.71
72_Q371_G0.6750.71
209_T212_A0.6740.71
503_L514_N0.6720.70
501_L527_Q0.6710.70
518_A521_Q0.6710.70
202_D268_R0.6690.70
181_V266_V0.6660.70
394_S437_L0.6650.70
226_M231_A0.6650.70
203_Y207_F0.6640.70
67_D183_K0.6640.70
174_H406_A0.6630.69
150_V154_T0.6620.69
490_Y494_Y0.6560.69
484_T488_N0.6520.68
180_A203_Y0.6520.68
318_V342_F0.6510.68
182_G185_H0.6490.68
195_P204_H0.6490.68
237_N240_S0.6490.68
520_P524_K0.6480.68
141_T166_F0.6460.67
120_V387_G0.6460.67
115_L340_I0.6450.67
333_G454_F0.6420.67
240_S247_R0.6410.67
133_G153_N0.6400.67
62_V398_F0.6390.67
238_S247_R0.6390.67
380_W405_A0.6370.66
301_F405_A0.6370.66
463_R527_Q0.6340.66
68_L112_L0.6320.66
217_P222_F0.6320.66
113_L311_Y0.6300.66
255_S317_S0.6300.66
220_R223_D0.6270.65
120_V385_Q0.6260.65
107_K312_Y0.6260.65
522_V526_M0.6260.65
114_S379_W0.6250.65
348_A370_G0.6240.65
364_K417_D0.6230.65
196_E205_D0.6220.65
138_A148_F0.6220.65
383_K386_P0.6220.65
528_G531_R0.6210.64
434_H438_T0.6210.64
72_Q184_W0.6200.64
168_P178_T0.6200.64
298_Q310_N0.6190.64
456_D459_H0.6190.64
164_E416_L0.6190.64
200_T204_H0.6190.64
461_F527_Q0.6170.64
326_L330_K0.6170.64
199_Q222_F0.6170.64
74_P116_M0.6160.64
532_E535_D0.6150.64
187_S199_Q0.6150.64
259_T280_L0.6150.64
121_R388_N0.6130.63
360_Q509_L0.6130.63
72_Q348_A0.6120.63
391_K430_Q0.6100.63
241_L248_V0.6090.63
483_Y487_N0.6080.63
340_I377_F0.6080.63
239_P243_K0.6060.63
58_P339_I0.6060.63
327_E524_K0.6050.62
139_I395_A0.6050.62
484_T489_D0.6040.62
503_L523_V0.6040.62
322_V342_F0.6030.62
125_G343_T0.6030.62
255_S259_T0.6010.62
177_Y332_N0.6000.62
225_F245_R0.6000.62
222_F226_M0.5980.61
485_V490_Y0.5970.61
227_G231_A0.5960.61
107_K285_P0.5960.61
110_P319_D0.5930.61
224_Y232_G0.5910.61
364_K370_G0.5910.61
211_S216_Q0.5910.61
68_L311_Y0.5890.60
384_L388_N0.5890.60
413_D505_K0.5860.60
67_D136_R0.5850.60
378_M402_A0.5820.59
245_R248_V0.5810.59
439_W506_L0.5790.59
239_P247_R0.5780.59
259_T318_V0.5780.59
438_T533_F0.5770.59
135_S151_Y0.5760.59
346_N370_G0.5760.59
171_F406_A0.5740.58
311_Y315_V0.5740.58
376_M393_I0.5740.58
265_V276_F0.5720.58
318_V322_V0.5710.58
426_Q524_K0.5700.58
217_P225_F0.5690.58
69_G361_K0.5670.57
323_K327_E0.5660.57
113_L117_D0.5650.57
63_L282_Y0.5640.57
391_K432_E0.5640.57
527_Q531_R0.5630.57
424_W433_P0.5630.57
147_R164_E0.5630.57
242_F247_R0.5620.57
423_P428_K0.5610.57
440_I530_V0.5610.57
322_V325_I0.5600.57
399_Y416_L0.5590.56
329_L337_N0.5590.56
137_A148_F0.5590.56
206_N258_L0.5590.56
133_G184_W0.5570.56
260_D264_G0.5570.56
423_P427_D0.5550.56
309_D317_S0.5550.56
132_S182_G0.5540.56
199_Q205_D0.5540.56
148_F151_Y0.5530.56
411_P415_K0.5530.56
341_L398_F0.5520.55
146_A438_T0.5520.55
253_Y290_D0.5520.55
284_A346_N0.5520.55
531_R535_D0.5500.55
114_S260_D0.5480.55
370_G417_D0.5480.55
292_P317_S0.5470.55
517_A520_P0.5460.55
204_H207_F0.5460.55
438_T441_T0.5450.55
181_V258_L0.5430.54
458_Y461_F0.5430.54
222_F227_G0.5420.54
164_E414_L0.5420.54
133_G146_A0.5410.54
266_V329_L0.5400.54
120_V425_L0.5400.54
253_Y257_Q0.5390.54
128_A135_S0.5390.54
305_S316_Y0.5390.54
125_G288_P0.5390.54
330_K340_I0.5380.54
56_G60_I0.5370.53
226_M229_H0.5370.53
196_E202_D0.5360.53
56_G117_D0.5360.53
178_T201_R0.5350.53
519_N523_V0.5340.53
238_S241_L0.5340.53
165_T413_D0.5340.53
181_V262_A0.5330.53
296_Q303_T0.5330.53
259_T262_A0.5330.53
139_I402_A0.5330.53
297_Y302_N0.5310.53
60_I531_R0.5310.53
73_L113_L0.5300.52
390_D507_T0.5300.52
65_M112_L0.5290.52
131_V365_S0.5290.52
135_S355_P0.5280.52
502_G516_A0.5280.52
217_P226_M0.5280.52
387_G407_D0.5280.52
75_F116_M0.5280.52
56_G273_D0.5280.52
184_W279_Y0.5270.52
68_L344_S0.5260.52
316_Y320_Q0.5260.52
224_Y243_K0.5260.52
181_V265_V0.5260.52
64_T154_T0.5250.52
107_K315_V0.5250.52
314_S348_A0.5240.52
385_Q426_Q0.5230.52
128_A394_S0.5230.52
242_F245_R0.5220.51
331_K334_Q0.5220.51
151_Y440_I0.5220.51
439_W445_H0.5220.51
297_Y313_A0.5220.51
368_Y464_H0.5210.51
267_D330_K0.5200.51
171_F403_L0.5200.51
236_Y239_P0.5190.51
298_Q302_N0.5180.51
126_Y145_P0.5180.51
140_M166_F0.5180.51
453_P460_K0.5160.51
263_I340_I0.5160.51
521_Q524_K0.5150.50
182_G364_K0.5120.50
56_G271_T0.5120.50
185_H209_T0.5120.50
433_P436_N0.5120.50
276_F329_L0.5120.50
380_W417_D0.5110.50
297_Y317_S0.5110.50
384_L426_Q0.5100.50
75_F112_L0.5100.50
143_R161_P0.5090.50
439_W443_Y0.5090.50
137_A160_I0.5090.50
137_A149_G0.5090.50
396_M434_H0.5090.50
330_K384_L0.5090.50
341_L376_M0.5090.50
252_G257_Q0.5090.50
159_G164_E0.5080.50
331_K532_E0.5080.50
376_M424_W0.5080.50
295_D429_K0.5070.49
322_V421_L0.5070.49
225_F230_A0.5060.49
74_P390_D0.5060.49
526_M530_V0.5050.49
125_G344_S0.5050.49
489_D494_Y0.5050.49
273_D532_E0.5050.49
65_M322_V0.5040.49
140_M200_T0.5020.49
458_Y507_T0.5020.49
120_V382_G0.5020.49
143_R413_D0.5020.49
258_L284_A0.5010.49
113_L116_M0.5010.49
129_H145_P0.5010.49
310_N314_S0.5010.49
434_H437_L0.5010.49
256_D292_P0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4upiA 2 0.7679 100 0.358 Contact Map
1hdhA 1 0.7375 100 0.358 Contact Map
1p49A 3 0.8071 100 0.359 Contact Map
4uplA 2 0.7696 100 0.362 Contact Map
2vqrA 3 0.7536 100 0.362 Contact Map
4uphA 2 0.7607 100 0.369 Contact Map
1fsuA 1 0.8054 100 0.369 Contact Map
3ed4A 3 0.7804 100 0.373 Contact Map
4upkA 3 0.7607 100 0.376 Contact Map
1aukA 3 0.8036 100 0.378 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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