GREMLIN Database
YBDR - Uncharacterized zinc-type alcohol dehydrogenase-like protein YbdR
UniProt: P77316 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13537
Length: 412 (336)
Sequences: 30925 (20196)
Seq/√Len: 1101.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T65_E3.1221.00
366_E369_R3.0931.00
33_T162_D3.0631.00
31_R67_V2.9871.00
189_S213_Q2.8021.00
7_H15_E2.6651.00
29_I67_V2.6131.00
80_D155_K2.5021.00
7_H13_Q2.4851.00
247_S250_E2.4531.00
163_D361_Y2.4521.00
207_R234_I2.4391.00
62_F139_G2.4321.00
161_S164_K2.3731.00
361_Y387_V2.3621.00
25_A71_K2.3401.00
362_M373_I2.2931.00
26_D72_D2.2851.00
46_R375_E2.2771.00
363_P366_E2.2581.00
224_L228_A2.2521.00
372_E376_K2.2301.00
31_R65_E2.2061.00
25_A72_D2.2011.00
360_H373_I2.1911.00
31_R143_Y2.1901.00
159_L348_E2.1431.00
213_Q235_P2.1301.00
77_Q80_D2.1221.00
19_D143_Y2.1111.00
75_N148_K2.1071.00
303_I328_S2.0891.00
190_V206_A2.0601.00
345_P349_K2.0491.00
185_Q188_S2.0361.00
5_T15_E2.0201.00
23_E27_D2.0131.00
191_A258_V2.0091.00
81_R162_D1.9721.00
21_G68_E1.9621.00
225_H230_R1.9601.00
195_A216_V1.8971.00
298_V304_V1.8661.00
221_P225_H1.8651.00
303_I330_K1.8581.00
67_V143_Y1.8301.00
225_H228_A1.8291.00
29_I145_R1.8271.00
226_F230_R1.7621.00
156_V165_A1.7571.00
224_L236_I1.7511.00
62_F84_I1.7391.00
191_A217_V1.7381.00
81_R156_V1.7261.00
235_P251_Q1.7031.00
4_L367_A1.6961.00
259_D299_R1.6801.00
69_T78_K1.6791.00
298_V327_L1.6511.00
203_I233_A1.6481.00
369_R372_E1.6461.00
261_V298_V1.6461.00
373_I378_E1.6371.00
362_M370_G1.6351.00
369_R373_I1.6241.00
213_Q234_I1.6221.00
68_E78_K1.6121.00
368_A372_E1.5961.00
63_M162_D1.5961.00
180_K342_E1.5701.00
215_F258_V1.5591.00
221_P238_F1.5581.00
218_D224_L1.5571.00
29_I143_Y1.5431.00
22_V29_I1.5281.00
242_S247_S1.5211.00
2_K365_E1.5151.00
76_L155_K1.4991.00
66_V76_L1.4961.00
93_C96_C1.4941.00
2_K16_N1.4901.00
345_P348_E1.4891.00
32_I62_F1.4811.00
163_D387_V1.4781.00
172_L201_L1.4701.00
26_D147_P1.4661.00
65_E162_D1.4651.00
243_D246_Q1.4601.00
70_G73_V1.4531.00
65_E81_R1.4421.00
261_V294_C1.4381.00
81_R158_P1.4241.00
219_H239_D1.4241.00
27_D145_R1.4211.00
29_I68_E1.4141.00
27_D147_P1.4091.00
247_S251_Q1.4051.00
228_A236_I1.3931.00
34_A163_D1.3871.00
22_V145_R1.3691.00
76_L80_D1.3641.00
19_D29_I1.3591.00
3_A17_V1.3571.00
28_I151_V1.3561.00
246_Q250_E1.3501.00
34_A387_V1.3501.00
189_S215_F1.3371.00
202_T262_I1.3291.00
203_I216_V1.3291.00
296_A321_D1.3281.00
26_D148_K1.3101.00
298_V302_G1.3081.00
193_Y294_C1.2991.00
221_P224_L1.2941.00
181_N328_S1.2931.00
8_G11_H1.2901.00
90_C93_C1.2731.00
241_D247_S1.2711.00
265_V290_A1.2671.00
188_S303_I1.2671.00
4_L14_V1.2571.00
208_L351_L1.2521.00
94_F299_R1.2491.00
156_V162_D1.2291.00
90_C96_C1.2291.00
180_K339_W1.2271.00
93_C104_C1.2231.00
182_A260_A1.2211.00
32_I144_V1.2071.00
2_K142_E1.2031.00
28_I76_L1.1881.00
292_R296_A1.1841.00
22_V27_D1.1621.00
7_H11_H1.1551.00
164_K353_K1.1521.00
96_C104_C1.1511.00
363_P387_V1.1401.00
364_F388_P1.1361.00
175_A202_T1.1331.00
30_L82_V1.1281.00
92_D106_N1.1271.00
5_T17_V1.1261.00
140_Q371_Y1.1251.00
195_A218_D1.1241.00
105_E300_R1.1231.00
208_L346_L1.1131.00
193_Y217_V1.1121.00
219_H240_E1.1091.00
188_S260_A1.1051.00
34_A162_D1.1021.00
189_S259_D1.0911.00
184_I211_A1.0901.00
216_V227_A1.0871.00
182_A305_S1.0811.00
160_L165_A1.0791.00
221_P241_D1.0771.00
224_L238_F1.0761.00
359_T373_I1.0761.00
67_V78_K1.0731.00
191_A297_A1.0721.00
37_I370_G1.0711.00
204_A353_K1.0661.00
35_T139_G1.0631.00
372_E375_E1.0631.00
188_S259_D1.0631.00
217_V239_D1.0621.00
30_L64_G1.0541.00
17_V57_I1.0461.00
92_D97_R1.0441.00
313_F316_G1.0421.00
184_I188_S1.0421.00
367_A386_L1.0391.00
238_F241_D1.0361.00
222_Y225_H1.0291.00
168_L347_I1.0281.00
100_Q301_G1.0281.00
4_L364_F1.0221.00
90_C104_C1.0151.00
228_A235_P1.0151.00
341_G345_P1.0121.00
177_Q339_W1.0111.00
322_A329_F1.0111.00
140_Q367_A1.0071.00
35_T140_Q1.0031.00
23_E145_R0.9991.00
33_T63_M0.9981.00
178_A307_P0.9971.00
294_C304_V0.9971.00
245_A249_I0.9961.00
94_F98_L0.9911.00
17_V137_P0.9911.00
215_F251_Q0.9911.00
74_K148_K0.9891.00
245_A296_A0.9881.00
14_V365_E0.9871.00
215_F235_P0.9851.00
56_D137_P0.9791.00
33_T81_R0.9781.00
243_D247_S0.9721.00
301_G326_G0.9701.00
215_F237_N0.9621.00
342_E345_P0.9571.00
362_M366_E0.9561.00
45_Y371_Y0.9521.00
19_D68_E0.9461.00
31_R142_E0.9451.00
157_P348_E0.9431.00
94_F105_E0.9371.00
193_Y290_A0.9361.00
321_D325_K0.9321.00
181_N330_K0.9251.00
245_A293_Q0.9241.00
203_I214_I0.9221.00
205_C343_L0.9211.00
175_A205_C0.9201.00
337_H341_G0.9161.00
216_V233_A0.9151.00
34_A385_I0.9121.00
206_A211_A0.9111.00
69_T77_Q0.9101.00
84_I146_V0.9091.00
192_V206_A0.9011.00
5_T57_I0.8981.00
293_Q296_A0.8941.00
346_L351_L0.8931.00
306_V329_F0.8931.00
69_T73_V0.8931.00
95_F105_E0.8791.00
248_I258_V0.8781.00
267_F290_A0.8721.00
140_Q386_L0.8701.00
252_T257_G0.8631.00
220_H223_R0.8631.00
218_D236_I0.8601.00
62_F144_V0.8601.00
219_H224_L0.8591.00
146_V151_V0.8581.00
32_I388_P0.8471.00
193_Y261_V0.8471.00
362_M384_V0.8441.00
362_M386_L0.8421.00
172_L343_L0.8361.00
38_C60_H0.8331.00
261_V304_V0.8301.00
358_V361_Y0.8291.00
19_D67_V0.8291.00
268_E292_R0.8231.00
94_F256_R0.8211.00
318_L321_D0.8041.00
322_A331_M0.8021.00
245_A297_A0.8021.00
175_A201_L0.8011.00
28_I148_K0.8001.00
4_L12_V0.7991.00
258_V261_V0.7981.00
183_Q328_S0.7961.00
195_A203_I0.7961.00
184_I260_A0.7941.00
263_D266_G0.7941.00
338_A342_E0.7921.00
103_A326_G0.7911.00
342_E346_L0.7881.00
177_Q326_G0.7881.00
38_C61_E0.7871.00
26_D71_K0.7851.00
360_H381_C0.7851.00
189_S258_V0.7851.00
176_W342_E0.7841.00
176_W343_L0.7831.00
183_Q330_K0.7821.00
45_Y375_E0.7791.00
183_Q303_I0.7781.00
215_F248_I0.7781.00
373_I384_V0.7751.00
3_A57_I0.7741.00
154_F341_G0.7651.00
95_F100_Q0.7651.00
214_I234_I0.7621.00
175_A198_V0.7611.00
338_A341_G0.7541.00
77_Q155_K0.7531.00
190_V211_A0.7511.00
206_A214_I0.7511.00
226_F381_C0.7441.00
91_G149_G0.7411.00
207_R214_I0.7401.00
4_L368_A0.7371.00
23_E26_D0.7371.00
34_A388_P0.7361.00
22_V70_G0.7341.00
322_A327_L0.7301.00
180_K209_L0.7281.00
94_F259_D0.7271.00
346_L350_G0.7261.00
309_V323_F0.7251.00
76_L151_V0.7221.00
192_V216_V0.7221.00
246_Q249_I0.7211.00
85_P154_F0.7201.00
154_F340_L0.7201.00
373_I376_K0.7171.00
248_I297_A0.7151.00
21_G29_I0.7151.00
34_A361_Y0.7141.00
81_R159_L0.7111.00
95_F300_R0.7111.00
192_V202_T0.7061.00
2_K14_V0.7011.00
80_D158_P0.7001.00
292_R316_G0.6991.00
22_V68_E0.6981.00
30_L84_I0.6971.00
108_N136_V0.6941.00
235_P247_S0.6921.00
36_A61_E0.6911.00
37_I140_Q0.6891.00
154_F344_L0.6891.00
313_F318_L0.6881.00
158_P348_E0.6861.00
42_L375_E0.6851.00
243_D293_Q0.6841.00
63_M166_L0.6841.00
260_A305_S0.6841.00
26_D70_G0.6831.00
14_V364_F0.6821.00
195_A227_A0.6811.00
211_A214_I0.6781.00
26_D149_G0.6781.00
73_V148_K0.6761.00
168_L344_L0.6741.00
300_R325_K0.6731.00
40_S60_H0.6731.00
11_H368_A0.6721.00
168_L343_L0.6711.00
244_P293_Q0.6711.00
360_H369_R0.6701.00
52_V56_D0.6671.00
359_T382_R0.6661.00
179_A206_A0.6641.00
139_G144_V0.6641.00
28_I66_V0.6631.00
42_L374_F0.6611.00
261_V297_A0.6541.00
105_E256_R0.6541.00
347_I354_P0.6501.00
268_E316_G0.6491.00
227_A233_A0.6481.00
175_A179_A0.6481.00
20_P143_Y0.6421.00
35_T388_P0.6401.00
63_M81_R0.6371.00
207_R233_A0.6301.00
204_A231_Y0.6301.00
346_L349_K0.6281.00
186_Q209_L0.6271.00
127_F130_S0.6261.00
305_S330_K0.6251.00
10_H372_E0.6251.00
292_R321_D0.6251.00
374_F384_V0.6251.00
88_I150_N0.6231.00
179_A205_C0.6221.00
263_D304_V0.6221.00
95_F98_L0.6211.00
218_D227_A0.6171.00
173_P335_H0.6161.00
53_K56_D0.6141.00
176_W346_L0.6131.00
260_A303_I0.6131.00
190_V260_A0.6131.00
265_V308_G0.6121.00
218_D239_D0.6091.00
126_L130_S0.6081.00
191_A248_I0.6061.00
321_D324_D0.6061.00
37_I374_F0.6051.00
321_D327_L0.6051.00
192_V203_I0.6051.00
20_P145_R0.6051.00
244_P248_I0.6021.00
60_H170_D0.5931.00
237_N247_S0.5931.00
269_A293_Q0.5921.00
186_Q210_G0.5911.00
202_T264_A0.5911.00
202_T307_P0.5901.00
371_Y375_E0.5891.00
83_V156_V0.5861.00
305_S332_G0.5851.00
59_G140_Q0.5851.00
223_R381_C0.5841.00
75_N155_K0.5831.00
34_A63_M0.5801.00
237_N244_P0.5791.00
358_V385_I0.5781.00
204_A352_L0.5771.00
230_R353_K0.5761.00
370_G386_L0.5761.00
38_C41_D0.5741.00
69_T80_D0.5721.00
160_L347_I0.5711.00
384_V387_V0.5711.00
28_I69_T0.5701.00
380_E384_V0.5701.00
209_L342_E0.5691.00
237_N251_Q0.5671.00
217_V237_N0.5671.00
269_A290_A0.5671.00
36_A166_L0.5661.00
203_I227_A0.5661.00
174_T198_V0.5641.00
160_L348_E0.5621.00
171_I201_L0.5621.00
178_A262_I0.5611.00
69_T76_L0.5601.00
350_G353_K0.5601.00
258_V297_A0.5601.00
91_G96_C0.5591.00
200_L382_R0.5581.00
38_C170_D0.5581.00
269_A292_R0.5571.00
12_V371_Y0.5531.00
205_C346_L0.5521.00
292_R318_L0.5511.00
213_Q251_Q0.5511.00
37_I386_L0.5501.00
44_L56_D0.5501.00
293_Q297_A0.5501.00
176_W205_C0.5491.00
222_Y378_E0.5491.00
291_L306_V0.5471.00
381_C384_V0.5461.00
189_S252_T0.5461.00
20_P29_I0.5461.00
354_P357_I0.5451.00
75_N337_H0.5451.00
33_T387_V0.5451.00
344_L348_E0.5451.00
176_W339_W0.5431.00
193_Y297_A0.5411.00
39_G43_H0.5401.00
249_I257_G0.5381.00
155_K158_P0.5341.00
264_A307_P0.5331.00
42_L46_R0.5321.00
193_Y293_Q0.5321.00
40_S43_H0.5321.00
256_R299_R0.5311.00
94_F97_R0.5301.00
10_H45_Y0.5301.00
182_A303_I0.5291.00
86_F334_T0.5281.00
43_H48_K0.5281.00
170_D174_T0.5271.00
221_P228_A0.5271.00
157_P165_A0.5261.00
228_A234_I0.5241.00
12_V367_A0.5241.00
252_T258_V0.5231.00
172_L205_C0.5231.00
98_L299_R0.5231.00
201_L357_I0.5231.00
95_F103_A0.5231.00
203_I207_R0.5221.00
84_I139_G0.5221.00
201_L204_A0.5211.00
34_A166_L0.5211.00
178_A332_G0.5211.00
197_P383_K0.5201.00
32_I35_T0.5201.00
189_S256_R0.5201.00
178_A202_T0.5181.00
290_A293_Q0.5171.00
263_D308_G0.5151.00
291_L319_F0.5151.00
83_V344_L0.5151.00
100_Q103_A0.5141.00
362_M369_R0.5131.00
14_V367_A0.5121.00
81_R161_S0.5121.00
74_K77_Q0.5121.00
190_V262_I0.5101.00
3_A141_A0.5091.00
63_M165_A0.5091.00
173_P339_W0.5091.00
219_H238_F0.5091.00
208_L352_L0.5091.00
200_L226_F0.5091.00
218_D223_R0.5081.00
201_L205_C0.5081.00
28_I73_V0.5071.00
242_S246_Q0.5071.00
81_R165_A0.5071.00
295_I304_V0.5051.00
256_R259_D0.5051.00
253_A256_R0.5051.00
75_N341_G0.5041.00
19_D22_V0.5031.00
320_G324_D0.5031.00
66_V80_D0.5031.00
339_W342_E0.5021.00
177_Q332_G0.5021.00
183_Q188_S0.5011.00
75_N78_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cpdA 2 0.8374 100 0.256 Contact Map
3ukoA 4 0.8762 100 0.259 Contact Map
4ilkA 2 0.8107 100 0.26 Contact Map
4ej6A 1 0.8155 100 0.261 Contact Map
1cdoA 2 0.8689 100 0.265 Contact Map
1h2bA 4 0.8107 100 0.266 Contact Map
1f8fA 4 0.8544 100 0.269 Contact Map
1e3iA 2 0.8665 100 0.271 Contact Map
1rjwA 4 0.8155 100 0.271 Contact Map
2dq4A 4 0.8155 100 0.271 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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