GREMLIN Database
FETB - Probable iron export permease protein FetB
UniProt: P77307 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13260
Length: 259 (245)
Sequences: 1262 (926)
Seq/√Len: 59.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_E155_Q6.0291.00
246_N250_Q5.0601.00
50_V197_L4.9881.00
165_T168_Q3.2851.00
70_V127_A3.2421.00
129_M200_M3.2161.00
25_S30_L3.0341.00
18_V40_V3.0081.00
144_N180_A2.8461.00
159_K164_A2.8191.00
68_L72_F2.7571.00
141_C237_C2.6871.00
43_A222_T2.6291.00
138_V232_S2.4121.00
129_M196_S2.3211.00
98_A235_I2.3151.00
143_N180_A2.3091.00
192_V222_T2.3011.00
34_K38_W2.1301.00
55_K210_D2.0901.00
99_I102_G2.0371.00
76_N194_L1.9971.00
96_F99_I1.9821.00
25_S33_E1.9631.00
134_A232_S1.9061.00
193_G199_G1.8931.00
196_S200_M1.8931.00
122_Q204_L1.8901.00
23_L27_K1.7600.99
133_N225_L1.7310.99
166_P249_H1.7260.99
153_Q157_Q1.7100.99
204_L217_Y1.7060.99
144_N148_R1.7040.99
204_L209_I1.6970.99
78_A96_F1.6570.99
51_G215_I1.6320.99
149_V170_S1.6080.99
66_T120_P1.5930.99
58_F202_S1.5330.98
73_I131_A1.5220.98
197_L202_S1.5070.98
116_I204_L1.5030.98
39_S226_L1.5010.98
197_L215_I1.4930.98
129_M225_L1.4850.98
39_S190_K1.4570.98
8_N216_K1.4520.98
11_L220_M1.4470.97
48_I215_I1.4320.97
221_V224_M1.4090.97
39_S189_A1.4070.97
12_A72_F1.4040.97
46_Q203_G1.3990.97
191_T197_L1.3950.97
50_V194_L1.3910.97
171_A175_R1.3890.97
129_M202_S1.3890.97
40_V223_F1.3810.97
44_I219_I1.3690.96
147_Q152_E1.3640.96
185_T229_A1.3500.96
85_S88_I1.3310.96
195_V200_M1.3250.96
75_F79_W1.3170.96
25_S36_I1.3130.96
49_I53_V1.3030.95
98_A101_V1.2900.95
191_T196_S1.2890.95
9_E12_A1.2630.94
141_C233_T1.2630.94
81_A139_G1.2540.94
76_N191_T1.2400.94
108_A123_V1.2220.93
128_G199_G1.2180.93
194_L221_V1.2030.93
12_A16_M1.1980.93
49_I57_I1.1980.93
23_L31_A1.1880.92
15_L19_V1.1830.92
202_S205_I1.1820.92
187_D190_K1.1780.92
97_I101_V1.1650.92
135_M139_G1.1650.92
17_L102_G1.1640.92
167_K241_Y1.1580.91
60_V65_L1.1550.91
7_T10_S1.1520.91
156_I183_I1.1380.91
56_Y135_M1.1360.91
199_G203_G1.1320.90
195_V199_G1.1290.90
46_Q193_G1.1230.90
18_V226_L1.1230.90
158_E161_S1.1210.90
24_I57_I1.1200.90
167_K238_Y1.1120.90
133_N195_V1.1060.89
85_S142_Y1.1030.89
154_Q158_E1.1020.89
166_P246_N1.1000.89
49_I52_Y1.0920.89
189_A226_L1.0900.89
43_A219_I1.0890.89
45_I49_I1.0800.88
98_A219_I1.0770.88
152_E181_A1.0750.88
64_S67_L1.0740.88
107_L127_A1.0610.87
193_G203_G1.0550.87
202_S206_F1.0470.87
125_P206_F1.0460.87
43_A192_V1.0430.86
201_M222_T1.0410.86
186_V234_I1.0380.86
205_I215_I1.0310.86
35_D38_W1.0280.86
81_A177_S1.0280.86
130_I228_T1.0260.86
101_V231_L1.0230.85
129_M221_V1.0170.85
110_L221_V1.0150.85
200_M205_I1.0150.85
76_N195_V1.0130.85
73_I211_P1.0120.85
27_K97_I1.0120.85
54_L202_S1.0060.84
159_K162_L1.0040.84
140_L180_A1.0020.84
58_F120_P0.9990.84
141_C181_A0.9980.84
74_C145_L0.9950.84
67_L71_L0.9920.84
46_Q199_G0.9900.83
144_N176_D0.9890.83
99_I103_A0.9880.83
86_K234_I0.9810.83
136_V187_D0.9780.83
122_Q126_I0.9730.82
152_E173_L0.9650.82
70_V123_V0.9610.82
201_M205_I0.9570.81
71_L150_I0.9530.81
17_L227_S0.9520.81
137_A229_A0.9470.81
149_V244_F0.9460.81
199_G202_S0.9400.80
100_T126_I0.9340.80
126_I235_I0.9330.80
74_C215_I0.9320.80
205_I216_K0.9280.79
22_I29_K0.9280.79
53_V119_I0.9240.79
201_M215_I0.9230.79
128_G132_G0.9190.79
22_I37_L0.9180.78
139_G187_D0.9120.78
131_A196_S0.9090.78
220_M223_F0.9070.78
16_M67_L0.9060.78
57_I69_M0.9000.77
202_S225_L0.8970.77
38_W242_R0.8960.77
52_Y56_Y0.8890.76
141_C236_A0.8760.75
65_L68_L0.8570.74
77_A191_T0.8530.73
38_W229_A0.8460.73
45_I108_A0.8350.72
47_L128_G0.8320.71
97_I231_L0.8280.71
35_D186_V0.8260.71
37_L41_G0.8210.70
148_R151_S0.8200.70
58_F124_I0.8190.70
117_E204_L0.8180.70
133_N188_S0.8170.70
73_I77_A0.8150.70
38_W41_G0.8110.69
95_S99_I0.8100.69
99_I134_A0.8040.69
129_M201_M0.7980.68
122_Q189_A0.7980.68
37_L112_L0.7980.68
51_G126_I0.7970.68
155_Q195_V0.7870.67
99_I106_T0.7850.67
231_L234_I0.7850.67
53_V135_M0.7830.67
31_A232_S0.7770.66
145_L149_V0.7750.66
127_A131_A0.7730.66
55_K212_V0.7640.65
182_L240_T0.7620.65
73_I202_S0.7610.64
17_L175_R0.7590.64
15_L220_M0.7570.64
66_T135_M0.7470.63
244_F250_Q0.7420.62
100_T123_V0.7390.62
16_M52_Y0.7380.62
17_L223_F0.7360.62
25_S32_L0.7350.62
35_D222_T0.7330.61
80_N191_T0.7310.61
134_A228_T0.7280.61
93_I126_I0.7280.61
148_R176_D0.7250.61
27_K104_G0.7220.60
68_L247_S0.7190.60
199_G218_Q0.7190.60
147_Q180_A0.7180.60
189_A202_S0.7160.60
101_V235_I0.7160.60
51_G197_L0.7140.59
145_L177_S0.7090.59
163_G169_A0.7090.59
15_L41_G0.7070.59
35_D188_S0.7050.58
131_A135_M0.7040.58
200_M221_V0.7040.58
178_I238_Y0.7000.58
126_I192_V0.6970.58
28_E238_Y0.6970.58
9_E179_R0.6940.57
124_I140_L0.6920.57
41_G174_I0.6910.57
167_K171_A0.6880.57
12_A221_V0.6870.57
53_V76_N0.6870.57
9_E48_I0.6860.56
113_S204_L0.6820.56
185_T226_L0.6810.56
55_K59_S0.6770.55
20_V91_A0.6760.55
114_G117_E0.6740.55
205_I229_A0.6730.55
180_A232_S0.6710.55
22_I41_G0.6700.55
66_T226_L0.6660.54
24_I27_K0.6660.54
80_N135_M0.6630.54
85_S146_G0.6610.54
187_D204_L0.6600.54
149_V156_I0.6550.53
24_I98_A0.6550.53
81_A142_Y0.6540.53
143_N147_Q0.6540.53
116_I187_D0.6510.53
182_L230_S0.6510.53
192_V221_V0.6500.52
26_H29_K0.6480.52
132_G196_S0.6460.52
42_R46_Q0.6460.52
81_A171_A0.6450.52
96_F119_I0.6410.51
170_S245_Y0.6400.51
8_N12_A0.6400.51
74_C99_I0.6390.51
159_K250_Q0.6360.51
50_V216_K0.6340.51
172_I176_D0.6340.51
73_I199_G0.6340.51
102_G105_I0.6330.51
35_D57_I0.6310.50
58_F211_P0.6270.50
42_R217_Y0.6270.50
114_G190_K0.6270.50
117_E187_D0.6240.50
178_I182_L0.6240.50
155_Q231_L0.6240.50
77_A245_Y0.6230.49
124_I219_I0.6230.49
71_L86_K0.6210.49
42_R193_G0.6200.49
23_L49_I0.6200.49
30_L169_A0.6140.48
84_R156_I0.6140.48
137_A232_S0.6140.48
130_I197_L0.6130.48
30_L58_F0.6100.48
140_L199_G0.6100.48
32_L35_D0.6090.48
61_D119_I0.6060.48
160_L251_L0.6030.47
86_K98_A0.6010.47
18_V52_Y0.6010.47
114_G118_F0.6010.47
25_S169_A0.6000.47
11_L18_V0.5980.47
59_S78_A0.5940.46
225_L228_T0.5940.46
102_G134_A0.5940.46
91_A94_S0.5940.46
34_K153_Q0.5910.46
80_N197_L0.5900.46
41_G67_L0.5900.46
73_I76_N0.5880.46
128_G202_S0.5830.45
23_L172_I0.5820.45
137_A221_V0.5800.45
69_M219_I0.5750.44
193_G197_L0.5740.44
145_L173_L0.5740.44
141_C223_F0.5730.44
10_S112_L0.5700.44
47_L193_G0.5700.44
217_Y221_V0.5690.43
204_L211_P0.5670.43
58_F121_M0.5670.43
114_G123_V0.5670.43
58_F206_F0.5660.43
80_N85_S0.5660.43
146_G157_Q0.5650.43
195_V217_Y0.5640.43
75_F104_G0.5620.43
98_A239_L0.5600.42
23_L176_D0.5590.42
130_I176_D0.5590.42
132_G169_A0.5590.42
18_V82_Q0.5560.42
125_P217_Y0.5560.42
118_F126_I0.5530.42
128_G195_V0.5520.42
104_G228_T0.5510.41
98_A107_L0.5510.41
31_A183_I0.5490.41
69_M124_I0.5480.41
140_L229_A0.5470.41
133_N185_T0.5440.41
38_W177_S0.5420.41
140_L183_I0.5400.40
78_A90_K0.5390.40
114_G126_I0.5380.40
62_D92_F0.5320.39
161_S240_T0.5290.39
211_P217_Y0.5290.39
192_V196_S0.5280.39
232_S237_C0.5280.39
183_I210_D0.5270.39
78_A210_D0.5270.39
21_A28_E0.5260.39
54_L219_I0.5230.38
23_L90_K0.5220.38
145_L181_A0.5190.38
26_H70_V0.5190.38
66_T124_I0.5170.38
41_G151_S0.5160.38
200_M204_L0.5160.38
201_M216_K0.5150.38
57_I137_A0.5130.37
195_V203_G0.5120.37
120_P240_T0.5120.37
72_F75_F0.5120.37
197_L204_L0.5120.37
110_L115_S0.5090.37
60_V96_F0.5080.37
111_I213_K0.5060.37
57_I138_V0.5060.37
46_Q195_V0.5050.37
221_V227_S0.5040.37
110_L136_V0.5040.37
114_G204_L0.5040.37
96_F101_V0.5010.36
98_A124_I0.5010.36
122_Q197_L0.5000.36
76_N122_Q0.5000.36
40_V53_V0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.7915 91.2 0.934 Contact Map
3tuiA 2 0.7954 82.7 0.942 Contact Map
3aqpA 1 0.7954 80.3 0.944 Contact Map
3d31C 2 0.8533 76.3 0.946 Contact Map
2onkC 2 0.8571 74 0.947 Contact Map
3ne5A 3 0.7761 67 0.949 Contact Map
4tquN 1 0.9035 59.6 0.952 Contact Map
3rlfF 1 0.8456 52.5 0.954 Contact Map
3w9iA 3 0.7529 42.1 0.956 Contact Map
4k0jA 3 0.7606 40.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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