FETB - ECOLI - GREMLIN Contacts

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FETB - Probable iron export permease protein FetB

UniProt:	P77307	Sequences: MNSHNITNESLALALMLVVVAILISHKEKLALEKDILWSVGRAIIQLIIVGYVLKYIFSVDDASLTLLMVLFICFNAAWNAQKRSKYIAKAFISSFIAITVGAGITLAVLILSGSIEFIPMQVIPIAGMIAGNAMVAVGLCYNNLGQRVISEQQQIQEKLSLGATPKQASAILIRDSIRAALIPTVDSAKTVGLVSLPGMMSGLIFAGIDPVKAIKYQIMVTFMLLSTASLSTIIACYLTYRKFYNSRHQLVVTQLKKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13260
Length:	259 (245)
Sequences:	1262 (926)
Seq/√Len:	59.2

ECOLI - FETB
BACSU - YJKA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
152_E	155_Q	6.029	1.00
246_N	250_Q	5.060	1.00
50_V	197_L	4.988	1.00
165_T	168_Q	3.285	1.00
70_V	127_A	3.242	1.00
129_M	200_M	3.216	1.00
25_S	30_L	3.034	1.00
18_V	40_V	3.008	1.00
144_N	180_A	2.846	1.00
159_K	164_A	2.819	1.00
68_L	72_F	2.757	1.00
141_C	237_C	2.687	1.00
43_A	222_T	2.629	1.00
138_V	232_S	2.412	1.00
129_M	196_S	2.321	1.00
98_A	235_I	2.315	1.00
143_N	180_A	2.309	1.00
192_V	222_T	2.301	1.00
34_K	38_W	2.130	1.00
55_K	210_D	2.090	1.00
99_I	102_G	2.037	1.00
76_N	194_L	1.997	1.00
96_F	99_I	1.982	1.00
25_S	33_E	1.963	1.00
134_A	232_S	1.906	1.00
193_G	199_G	1.893	1.00
196_S	200_M	1.893	1.00
122_Q	204_L	1.890	1.00
23_L	27_K	1.760	0.99
133_N	225_L	1.731	0.99
166_P	249_H	1.726	0.99
153_Q	157_Q	1.710	0.99
204_L	217_Y	1.706	0.99
144_N	148_R	1.704	0.99
204_L	209_I	1.697	0.99
78_A	96_F	1.657	0.99
51_G	215_I	1.632	0.99
149_V	170_S	1.608	0.99
66_T	120_P	1.593	0.99
58_F	202_S	1.533	0.98
73_I	131_A	1.522	0.98
197_L	202_S	1.507	0.98
116_I	204_L	1.503	0.98
39_S	226_L	1.501	0.98
197_L	215_I	1.493	0.98
129_M	225_L	1.485	0.98
39_S	190_K	1.457	0.98
8_N	216_K	1.452	0.98
11_L	220_M	1.447	0.97
48_I	215_I	1.432	0.97
221_V	224_M	1.409	0.97
39_S	189_A	1.407	0.97
12_A	72_F	1.404	0.97
46_Q	203_G	1.399	0.97
191_T	197_L	1.395	0.97
50_V	194_L	1.391	0.97
171_A	175_R	1.389	0.97
129_M	202_S	1.389	0.97
40_V	223_F	1.381	0.97
44_I	219_I	1.369	0.96
147_Q	152_E	1.364	0.96
185_T	229_A	1.350	0.96
85_S	88_I	1.331	0.96
195_V	200_M	1.325	0.96
75_F	79_W	1.317	0.96
25_S	36_I	1.313	0.96
49_I	53_V	1.303	0.95
98_A	101_V	1.290	0.95
191_T	196_S	1.289	0.95
9_E	12_A	1.263	0.94
141_C	233_T	1.263	0.94
81_A	139_G	1.254	0.94
76_N	191_T	1.240	0.94
108_A	123_V	1.222	0.93
128_G	199_G	1.218	0.93
194_L	221_V	1.203	0.93
12_A	16_M	1.198	0.93
49_I	57_I	1.198	0.93
23_L	31_A	1.188	0.92
15_L	19_V	1.183	0.92
202_S	205_I	1.182	0.92
187_D	190_K	1.178	0.92
97_I	101_V	1.165	0.92
135_M	139_G	1.165	0.92
17_L	102_G	1.164	0.92
167_K	241_Y	1.158	0.91
60_V	65_L	1.155	0.91
7_T	10_S	1.152	0.91
156_I	183_I	1.138	0.91
56_Y	135_M	1.136	0.91
199_G	203_G	1.132	0.90
195_V	199_G	1.129	0.90
46_Q	193_G	1.123	0.90
18_V	226_L	1.123	0.90
158_E	161_S	1.121	0.90
24_I	57_I	1.120	0.90
167_K	238_Y	1.112	0.90
133_N	195_V	1.106	0.89
85_S	142_Y	1.103	0.89
154_Q	158_E	1.102	0.89
166_P	246_N	1.100	0.89
49_I	52_Y	1.092	0.89
189_A	226_L	1.090	0.89
43_A	219_I	1.089	0.89
45_I	49_I	1.080	0.88
98_A	219_I	1.077	0.88
152_E	181_A	1.075	0.88
64_S	67_L	1.074	0.88
107_L	127_A	1.061	0.87
193_G	203_G	1.055	0.87
202_S	206_F	1.047	0.87
125_P	206_F	1.046	0.87
43_A	192_V	1.043	0.86
201_M	222_T	1.041	0.86
186_V	234_I	1.038	0.86
205_I	215_I	1.031	0.86
35_D	38_W	1.028	0.86
81_A	177_S	1.028	0.86
130_I	228_T	1.026	0.86
101_V	231_L	1.023	0.85
129_M	221_V	1.017	0.85
110_L	221_V	1.015	0.85
200_M	205_I	1.015	0.85
76_N	195_V	1.013	0.85
73_I	211_P	1.012	0.85
27_K	97_I	1.012	0.85
54_L	202_S	1.006	0.84
159_K	162_L	1.004	0.84
140_L	180_A	1.002	0.84
58_F	120_P	0.999	0.84
141_C	181_A	0.998	0.84
74_C	145_L	0.995	0.84
67_L	71_L	0.992	0.84
46_Q	199_G	0.990	0.83
144_N	176_D	0.989	0.83
99_I	103_A	0.988	0.83
86_K	234_I	0.981	0.83
136_V	187_D	0.978	0.83
122_Q	126_I	0.973	0.82
152_E	173_L	0.965	0.82
70_V	123_V	0.961	0.82
201_M	205_I	0.957	0.81
71_L	150_I	0.953	0.81
17_L	227_S	0.952	0.81
137_A	229_A	0.947	0.81
149_V	244_F	0.946	0.81
199_G	202_S	0.940	0.80
100_T	126_I	0.934	0.80
126_I	235_I	0.933	0.80
74_C	215_I	0.932	0.80
205_I	216_K	0.928	0.79
22_I	29_K	0.928	0.79
53_V	119_I	0.924	0.79
201_M	215_I	0.923	0.79
128_G	132_G	0.919	0.79
22_I	37_L	0.918	0.78
139_G	187_D	0.912	0.78
131_A	196_S	0.909	0.78
220_M	223_F	0.907	0.78
16_M	67_L	0.906	0.78
57_I	69_M	0.900	0.77
202_S	225_L	0.897	0.77
38_W	242_R	0.896	0.77
52_Y	56_Y	0.889	0.76
141_C	236_A	0.876	0.75
65_L	68_L	0.857	0.74
77_A	191_T	0.853	0.73
38_W	229_A	0.846	0.73
45_I	108_A	0.835	0.72
47_L	128_G	0.832	0.71
97_I	231_L	0.828	0.71
35_D	186_V	0.826	0.71
37_L	41_G	0.821	0.70
148_R	151_S	0.820	0.70
58_F	124_I	0.819	0.70
117_E	204_L	0.818	0.70
133_N	188_S	0.817	0.70
73_I	77_A	0.815	0.70
38_W	41_G	0.811	0.69
95_S	99_I	0.810	0.69
99_I	134_A	0.804	0.69
129_M	201_M	0.798	0.68
122_Q	189_A	0.798	0.68
37_L	112_L	0.798	0.68
51_G	126_I	0.797	0.68
155_Q	195_V	0.787	0.67
99_I	106_T	0.785	0.67
231_L	234_I	0.785	0.67
53_V	135_M	0.783	0.67
31_A	232_S	0.777	0.66
145_L	149_V	0.775	0.66
127_A	131_A	0.773	0.66
55_K	212_V	0.764	0.65
182_L	240_T	0.762	0.65
73_I	202_S	0.761	0.64
17_L	175_R	0.759	0.64
15_L	220_M	0.757	0.64
66_T	135_M	0.747	0.63
244_F	250_Q	0.742	0.62
100_T	123_V	0.739	0.62
16_M	52_Y	0.738	0.62
17_L	223_F	0.736	0.62
25_S	32_L	0.735	0.62
35_D	222_T	0.733	0.61
80_N	191_T	0.731	0.61
134_A	228_T	0.728	0.61
93_I	126_I	0.728	0.61
148_R	176_D	0.725	0.61
27_K	104_G	0.722	0.60
68_L	247_S	0.719	0.60
199_G	218_Q	0.719	0.60
147_Q	180_A	0.718	0.60
189_A	202_S	0.716	0.60
101_V	235_I	0.716	0.60
51_G	197_L	0.714	0.59
145_L	177_S	0.709	0.59
163_G	169_A	0.709	0.59
15_L	41_G	0.707	0.59
35_D	188_S	0.705	0.58
131_A	135_M	0.704	0.58
200_M	221_V	0.704	0.58
178_I	238_Y	0.700	0.58
126_I	192_V	0.697	0.58
28_E	238_Y	0.697	0.58
9_E	179_R	0.694	0.57
124_I	140_L	0.692	0.57
41_G	174_I	0.691	0.57
167_K	171_A	0.688	0.57
12_A	221_V	0.687	0.57
53_V	76_N	0.687	0.57
9_E	48_I	0.686	0.56
113_S	204_L	0.682	0.56
185_T	226_L	0.681	0.56
55_K	59_S	0.677	0.55
20_V	91_A	0.676	0.55
114_G	117_E	0.674	0.55
205_I	229_A	0.673	0.55
180_A	232_S	0.671	0.55
22_I	41_G	0.670	0.55
66_T	226_L	0.666	0.54
24_I	27_K	0.666	0.54
80_N	135_M	0.663	0.54
85_S	146_G	0.661	0.54
187_D	204_L	0.660	0.54
149_V	156_I	0.655	0.53
24_I	98_A	0.655	0.53
81_A	142_Y	0.654	0.53
143_N	147_Q	0.654	0.53
116_I	187_D	0.651	0.53
182_L	230_S	0.651	0.53
192_V	221_V	0.650	0.52
26_H	29_K	0.648	0.52
132_G	196_S	0.646	0.52
42_R	46_Q	0.646	0.52
81_A	171_A	0.645	0.52
96_F	119_I	0.641	0.51
170_S	245_Y	0.640	0.51
8_N	12_A	0.640	0.51
74_C	99_I	0.639	0.51
159_K	250_Q	0.636	0.51
50_V	216_K	0.634	0.51
172_I	176_D	0.634	0.51
73_I	199_G	0.634	0.51
102_G	105_I	0.633	0.51
35_D	57_I	0.631	0.50
58_F	211_P	0.627	0.50
42_R	217_Y	0.627	0.50
114_G	190_K	0.627	0.50
117_E	187_D	0.624	0.50
178_I	182_L	0.624	0.50
155_Q	231_L	0.624	0.50
77_A	245_Y	0.623	0.49
124_I	219_I	0.623	0.49
71_L	86_K	0.621	0.49
42_R	193_G	0.620	0.49
23_L	49_I	0.620	0.49
30_L	169_A	0.614	0.48
84_R	156_I	0.614	0.48
137_A	232_S	0.614	0.48
130_I	197_L	0.613	0.48
30_L	58_F	0.610	0.48
140_L	199_G	0.610	0.48
32_L	35_D	0.609	0.48
61_D	119_I	0.606	0.48
160_L	251_L	0.603	0.47
86_K	98_A	0.601	0.47
18_V	52_Y	0.601	0.47
114_G	118_F	0.601	0.47
25_S	169_A	0.600	0.47
11_L	18_V	0.598	0.47
59_S	78_A	0.594	0.46
225_L	228_T	0.594	0.46
102_G	134_A	0.594	0.46
91_A	94_S	0.594	0.46
34_K	153_Q	0.591	0.46
80_N	197_L	0.590	0.46
41_G	67_L	0.590	0.46
73_I	76_N	0.588	0.46
128_G	202_S	0.583	0.45
23_L	172_I	0.582	0.45
137_A	221_V	0.580	0.45
69_M	219_I	0.575	0.44
193_G	197_L	0.574	0.44
145_L	173_L	0.574	0.44
141_C	223_F	0.573	0.44
10_S	112_L	0.570	0.44
47_L	193_G	0.570	0.44
217_Y	221_V	0.569	0.43
204_L	211_P	0.567	0.43
58_F	121_M	0.567	0.43
114_G	123_V	0.567	0.43
58_F	206_F	0.566	0.43
80_N	85_S	0.566	0.43
146_G	157_Q	0.565	0.43
195_V	217_Y	0.564	0.43
75_F	104_G	0.562	0.43
98_A	239_L	0.560	0.42
23_L	176_D	0.559	0.42
130_I	176_D	0.559	0.42
132_G	169_A	0.559	0.42
18_V	82_Q	0.556	0.42
125_P	217_Y	0.556	0.42
118_F	126_I	0.553	0.42
128_G	195_V	0.552	0.42
104_G	228_T	0.551	0.41
98_A	107_L	0.551	0.41
31_A	183_I	0.549	0.41
69_M	124_I	0.548	0.41
140_L	229_A	0.547	0.41
133_N	185_T	0.544	0.41
38_W	177_S	0.542	0.41
140_L	183_I	0.540	0.40
78_A	90_K	0.539	0.40
114_G	126_I	0.538	0.40
62_D	92_F	0.532	0.39
161_S	240_T	0.529	0.39
211_P	217_Y	0.529	0.39
192_V	196_S	0.528	0.39
232_S	237_C	0.528	0.39
183_I	210_D	0.527	0.39
78_A	210_D	0.527	0.39
21_A	28_E	0.526	0.39
54_L	219_I	0.523	0.38
23_L	90_K	0.522	0.38
145_L	181_A	0.519	0.38
26_H	70_V	0.519	0.38
66_T	124_I	0.517	0.38
41_G	151_S	0.516	0.38
200_M	204_L	0.516	0.38
201_M	216_K	0.515	0.38
57_I	137_A	0.513	0.37
195_V	203_G	0.512	0.37
120_P	240_T	0.512	0.37
72_F	75_F	0.512	0.37
197_L	204_L	0.512	0.37
110_L	115_S	0.509	0.37
60_V	96_F	0.508	0.37
111_I	213_K	0.506	0.37
57_I	138_V	0.506	0.37
46_Q	195_V	0.505	0.37
221_V	227_S	0.504	0.37
110_L	136_V	0.504	0.37
114_G	204_L	0.504	0.37
96_F	101_V	0.501	0.36
98_A	124_I	0.501	0.36
122_Q	197_L	0.500	0.36
76_N	122_Q	0.500	0.36
40_V	53_V	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ymuD	2	0.7915	91.2	0.934	Contact Map
3tuiA	2	0.7954	82.7	0.942	Contact Map
3aqpA	1	0.7954	80.3	0.944	Contact Map
3d31C	2	0.8533	76.3	0.946	Contact Map
2onkC	2	0.8571	74	0.947	Contact Map
3ne5A	3	0.7761	67	0.949	Contact Map
4tquN	1	0.9035	59.6	0.952	Contact Map
3rlfF	1	0.8456	52.5	0.954	Contact Map
3w9iA	3	0.7529	42.1	0.956	Contact Map
4k0jA	3	0.7606	40.5	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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