GREMLIN Database
DTPA - Dipeptide and tripeptide permease A
UniProt: P77304 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13939
Length: 500 (460)
Sequences: 4695 (2933)
Seq/√Len: 136.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_L185_L4.1151.00
374_A378_G3.9751.00
288_F395_G3.4341.00
366_I391_L3.3871.00
321_Y382_V3.3591.00
80_L85_L3.2581.00
56_E305_R3.1951.00
85_L90_V3.0711.00
355_I398_M2.9911.00
368_P462_L2.9521.00
298_S303_A2.9251.00
309_H315_A2.9171.00
328_W390_G2.8711.00
466_V470_V2.8431.00
300_N303_A2.8391.00
100_I121_A2.7101.00
403_G423_W2.6051.00
80_L84_V2.5931.00
104_L121_A2.5811.00
104_L118_G2.5441.00
85_L93_L2.5411.00
174_A319_E2.5351.00
99_A191_L2.4711.00
36_G102_Y2.4561.00
310_S315_A2.4021.00
358_V472_A2.3891.00
46_V300_N2.3621.00
94_G128_L2.3581.00
365_L465_G2.3491.00
386_V390_G2.3281.00
303_A385_L2.3061.00
96_I100_I2.2441.00
359_M394_I2.2211.00
374_A377_A2.2131.00
260_F263_E2.1851.00
33_E130_K2.1621.00
30_E34_R2.1481.00
298_S302_F2.1201.00
335_I339_I2.1031.00
348_P351_T2.0751.00
92_M198_A2.0541.00
205_K208_G2.0481.00
105_V118_G2.0351.00
152_F408_A2.0241.00
30_E33_E1.9861.00
361_S469_A1.9831.00
289_F400_S1.9761.00
473_V477_L1.9751.00
366_I387_A1.9711.00
324_L386_V1.9701.00
175_A318_P1.9611.00
340_Y344_G1.9361.00
106_A187_V1.9351.00
37_Y67_S1.8861.00
88_K201_Q1.8641.00
45_A49_V1.8561.00
101_G122_I1.8521.00
469_A473_V1.8431.00
375_S378_G1.8381.00
332_G394_I1.8351.00
208_G211_P1.8101.00
73_L76_I1.7981.00
270_A273_R1.7971.00
241_N249_L1.7821.00
260_F264_A1.7791.00
325_N393_S1.7721.00
372_K378_G1.7541.00
137_L151_A1.7501.00
474_L478_T1.7261.00
98_L129_F1.7091.00
249_L252_V1.7081.00
74_V81_G1.7011.00
373_F376_D1.6651.00
30_E130_K1.6611.00
157_M330_I1.6521.00
373_F378_G1.6521.00
325_N329_I1.6311.00
281_L294_Q1.6261.00
54_M62_L1.6231.00
358_V362_G1.6091.00
259_I263_E1.6021.00
50_K179_W1.6001.00
300_N304_I1.5981.00
113_G117_M1.5921.00
456_V459_R1.5831.00
247_M251_V1.5771.00
46_V318_P1.5761.00
209_S212_D1.5711.00
372_K375_S1.5461.00
287_I471_I1.5451.00
164_F330_I1.5351.00
63_F297_T1.5311.00
480_P483_H1.5201.00
331_I335_I1.5091.00
73_L123_A1.5061.00
56_E301_F1.5021.00
290_V430_A1.5001.00
103_A187_V1.5001.00
472_A476_L1.4921.00
155_Y159_V1.4831.00
249_L253_A1.4791.00
317_E320_Q1.4771.00
262_K265_F1.4741.00
372_K376_D1.4721.00
201_Q206_Q1.4651.00
224_T227_G1.4651.00
354_A472_A1.4521.00
299_L303_A1.4311.00
101_G125_G1.4301.00
380_V384_W1.4291.00
363_A392_Q1.4261.00
248_A251_V1.4181.00
362_G391_L1.4151.00
292_Y295_M1.4001.00
134_S424_F1.3981.00
45_A301_F1.3941.00
245_A248_A1.3891.00
93_L96_I1.3861.00
253_A256_I1.3831.00
339_I343_M1.3811.00
367_L388_S1.3701.00
361_S472_A1.3641.00
181_V184_A1.3591.00
118_G122_I1.3531.00
31_L158_S1.3511.00
55_S58_D1.3471.00
477_L481_K1.3301.00
261_G265_F1.3301.00
48_L63_F1.3251.00
178_G181_V1.3231.00
373_F377_A1.3171.00
463_Q466_V1.3151.00
80_L90_V1.3061.00
171_P319_E1.3061.00
87_T139_T1.3031.00
39_G170_T1.3021.00
156_Y396_E1.3011.00
285_A426_T1.2981.00
217_N220_N1.2971.00
390_G394_I1.2951.00
171_P320_Q1.2901.00
270_A274_K1.2891.00
463_Q467_A1.2861.00
354_A476_L1.2811.00
160_N325_N1.2771.00
139_T408_A1.2721.00
417_G421_G1.2691.00
328_W393_S1.2681.00
204_V211_P1.2661.00
245_A250_G1.2651.00
269_G273_R1.2531.00
347_L355_I1.2521.00
48_L115_V1.2521.00
112_A116_Y1.2501.00
245_A249_L1.2441.00
173_L177_Y1.2311.00
272_R275_M1.2291.00
306_N379_I1.2281.00
184_A188_V1.2211.00
54_M112_A1.2131.00
47_Y108_S1.2121.00
31_L161_I1.2061.00
45_A59_S1.1961.00
350_P479_A1.1891.00
342_K345_D1.1851.00
99_A194_I1.1820.99
242_Q245_A1.1820.99
309_H318_P1.1810.99
170_T173_L1.1720.99
108_S114_I1.1710.99
359_M395_G1.1660.99
246_R252_V1.1650.99
241_N252_V1.1590.99
310_S313_G1.1590.99
157_M333_S1.1570.99
61_T439_G1.1570.99
30_E155_Y1.1560.99
156_Y329_I1.1550.99
246_R249_L1.1540.99
204_V208_G1.1510.99
25_L200_C1.1510.99
272_R278_A1.1470.99
381_S384_W1.1430.99
34_R37_Y1.1430.99
250_G254_F1.1390.99
206_Q209_S1.1380.99
220_N269_G1.1300.99
329_I396_E1.1280.99
99_A103_A1.1260.99
258_V262_K1.1180.99
314_L320_Q1.1180.99
159_V424_F1.1150.99
78_G417_G1.1110.99
309_H317_E1.1080.99
149_D405_A1.1040.99
168_I320_Q1.1020.99
252_V256_I1.0980.99
34_R130_K1.0970.99
243_E249_L1.0950.99
169_A185_L1.0930.99
246_R250_G1.0910.99
400_S404_L1.0890.99
283_L294_Q1.0860.99
126_N129_F1.0850.99
272_R279_F1.0820.99
126_N130_K1.0810.99
130_K424_F1.0800.99
248_A252_V1.0790.99
163_S326_P1.0690.99
188_V192_I1.0680.99
353_F399_I1.0650.99
85_L89_R1.0580.99
362_G366_I1.0570.99
276_I279_F1.0570.99
370_G384_W1.0560.99
141_Y151_A1.0550.99
265_F269_G1.0540.99
356_G399_I1.0530.99
234_I237_W1.0490.99
134_S155_Y1.0480.99
462_L466_V1.0430.99
322_Q326_P1.0410.99
101_G105_V1.0410.99
70_V123_A1.0400.99
307_V385_L1.0400.99
77_G127_G1.0390.99
47_Y115_V1.0370.99
33_E38_Y1.0300.99
32_W189_G1.0190.98
98_L126_N1.0190.98
50_K175_A1.0190.98
351_T479_A1.0180.98
195_V199_F1.0140.98
134_S420_M1.0070.98
240_H244_V1.0060.98
480_P484_R1.0040.98
249_L256_I1.0030.98
49_V301_F1.0030.98
159_V404_L1.0020.98
30_E129_F1.0010.98
237_W241_N0.9970.98
232_I236_T0.9970.98
261_G264_A0.9890.98
297_T303_A0.9870.98
137_L140_C0.9830.98
361_S365_L0.9820.98
234_I238_L0.9800.98
461_F464_I0.9800.98
41_Q63_F0.9780.98
257_V260_F0.9770.98
241_N245_A0.9750.98
247_M253_A0.9740.98
289_F292_Y0.9720.98
292_Y400_S0.9620.98
71_Y130_K0.9590.98
303_A307_V0.9550.98
245_A251_V0.9520.98
268_K272_R0.9500.98
205_K211_P0.9500.98
267_M271_A0.9490.98
298_S304_I0.9490.98
212_D217_N0.9450.98
138_S408_A0.9440.98
250_G253_A0.9400.97
49_V56_E0.9390.97
333_S337_A0.9390.97
267_M272_R0.9360.97
224_T228_V0.9340.97
75_A421_G0.9320.97
150_G337_A0.9290.97
258_V261_G0.9280.97
54_M58_D0.9270.97
34_R38_Y0.9260.97
230_A234_I0.9250.97
73_L127_G0.9180.97
34_R159_V0.9170.97
359_M391_L0.9100.97
283_L286_I0.9080.97
70_V73_L0.9070.97
205_K209_S0.9060.97
46_V50_K0.9050.97
41_Q293_S0.9040.97
172_W177_Y0.9040.97
184_A187_V0.9030.97
282_M286_I0.9020.97
272_R276_I0.8990.97
27_F158_S0.8940.97
241_N250_G0.8930.97
292_Y393_S0.8920.97
78_G421_G0.8890.96
244_V250_G0.8880.96
328_W386_V0.8860.96
199_F202_R0.8860.96
440_M444_P0.8840.96
269_G272_R0.8830.96
58_D61_T0.8810.96
110_H114_I0.8810.96
228_V264_A0.8800.96
134_S404_L0.8790.96
69_L432_L0.8780.96
71_Y424_F0.8770.96
459_R462_L0.8770.96
270_A279_F0.8750.96
32_W133_P0.8730.96
61_T435_G0.8710.96
282_M407_V0.8710.96
171_P174_A0.8660.96
222_L225_I0.8660.96
406_M482_L0.8650.96
222_L226_I0.8650.96
295_M392_Q0.8640.96
368_P371_A0.8640.96
231_L253_A0.8630.96
241_N248_A0.8610.96
241_N246_R0.8590.96
156_Y160_N0.8580.96
64_S434_G0.8570.96
307_V382_V0.8560.96
92_M95_A0.8550.96
333_S401_G0.8540.96
62_L116_Y0.8530.95
299_L388_S0.8440.95
299_L304_I0.8430.95
273_R487_Q0.8420.95
316_V320_Q0.8410.95
396_E400_S0.8380.95
247_M250_G0.8350.95
251_V255_G0.8350.95
336_L340_Y0.8350.95
332_G397_L0.8320.95
155_Y411_V0.8310.95
19_Q23_F0.8300.95
281_L353_F0.8290.95
301_F304_I0.8250.95
285_A423_W0.8220.94
248_A253_A0.8210.94
332_G335_I0.8190.94
367_L370_G0.8190.94
240_H243_E0.8180.94
241_N244_V0.8130.94
478_T481_K0.8110.94
291_L392_Q0.8090.94
366_I388_S0.8070.94
308_E379_I0.8070.94
336_L394_I0.8060.94
400_S423_W0.8060.94
100_I104_L0.8010.94
405_A409_Q0.8010.94
324_L328_W0.7980.94
293_S427_T0.7950.93
272_R280_I0.7950.93
306_N457_Y0.7950.93
325_N396_E0.7940.93
55_S59_S0.7930.93
298_S301_F0.7920.93
400_S403_G0.7920.93
129_F133_P0.7890.93
172_W176_K0.7870.93
336_L339_I0.7870.93
30_E159_V0.7850.93
17_F20_P0.7840.93
20_P23_F0.7840.93
32_W35_F0.7830.93
332_G390_G0.7820.93
329_I334_P0.7810.93
290_V433_I0.7800.93
460_V464_I0.7760.93
242_Q249_L0.7760.93
351_T354_A0.7750.93
70_V132_N0.7720.92
481_K485_M0.7680.92
244_V247_M0.7630.92
99_A187_V0.7630.92
293_S431_N0.7620.92
43_I48_L0.7610.92
106_A194_I0.7600.92
350_P484_R0.7580.92
215_P219_R0.7570.92
221_L225_I0.7560.92
82_D86_G0.7540.92
33_E190_L0.7540.92
235_A238_L0.7520.91
138_S152_F0.7520.91
204_V209_S0.7510.91
165_F168_I0.7500.91
180_S184_A0.7480.91
433_I436_Y0.7460.91
288_F325_N0.7460.91
155_Y396_E0.7430.91
371_A458_G0.7430.91
200_C204_V0.7420.91
132_N417_G0.7420.91
164_F327_F0.7410.91
309_H382_V0.7390.91
281_L286_I0.7390.91
200_C203_W0.7380.91
335_I340_Y0.7370.91
92_M194_I0.7370.91
174_A178_G0.7350.90
297_T301_F0.7330.90
139_T416_M0.7330.90
245_A252_V0.7320.90
244_V251_V0.7320.90
45_A60_I0.7310.90
410_L486_T0.7310.90
370_G388_S0.7300.90
106_A184_A0.7280.90
368_P464_I0.7280.90
243_E247_M0.7270.90
470_V477_L0.7270.90
240_H245_A0.7270.90
160_N396_E0.7270.90
284_E475_M0.7260.90
164_F326_P0.7260.90
299_L389_Y0.7260.90
295_M396_E0.7160.89
241_N251_V0.7160.89
43_I182_A0.7160.89
240_H254_F0.7160.89
282_M285_A0.7160.89
269_G279_F0.7150.89
239_L249_L0.7150.89
25_L203_W0.7130.89
31_L159_V0.7120.89
154_M157_M0.7110.89
282_M294_Q0.7080.89
47_Y337_A0.7070.89
273_R278_A0.7070.89
43_I56_E0.7050.89
89_R93_L0.7040.89
258_V263_E0.7040.89
134_S159_V0.7010.88
19_Q22_A0.7000.88
54_M116_Y0.7000.88
226_I229_V0.6990.88
430_A433_I0.6970.88
160_N326_P0.6960.88
61_T65_S0.6950.88
372_K377_A0.6950.88
247_M252_V0.6950.88
133_P159_V0.6940.88
169_A172_W0.6940.88
353_F403_G0.6930.88
102_Y187_V0.6910.88
181_V186_S0.6900.88
246_R254_F0.6890.87
354_A479_A0.6860.87
268_K271_A0.6840.87
316_V382_V0.6830.87
281_L406_M0.6810.87
153_T340_Y0.6800.87
246_R253_A0.6800.87
79_W84_V0.6790.87
244_V254_F0.6770.87
161_I329_I0.6760.86
276_I280_I0.6760.86
251_V254_F0.6760.86
167_M323_A0.6750.86
257_V263_E0.6740.86
34_R126_N0.6740.86
77_G141_Y0.6730.86
441_M463_Q0.6720.86
91_I417_G0.6720.86
198_A201_Q0.6720.86
45_A300_N0.6710.86
343_M346_T0.6700.86
155_Y404_L0.6700.86
436_Y440_M0.6670.86
233_A253_A0.6660.86
336_L397_L0.6640.85
129_F132_N0.6620.85
244_V278_A0.6620.85
238_L243_E0.6620.85
46_V305_R0.6600.85
474_L477_L0.6600.85
67_S70_V0.6600.85
75_A79_W0.6590.85
259_I262_K0.6580.85
215_P218_Y0.6580.85
286_I294_Q0.6570.85
288_F294_Q0.6560.85
64_S435_G0.6530.85
277_V485_M0.6530.85
295_M325_N0.6510.84
314_L317_E0.6480.84
291_L360_C0.6480.84
413_Q416_M0.6480.84
95_A190_L0.6480.84
33_E37_Y0.6460.84
243_E246_R0.6440.84
233_A236_T0.6440.84
368_P458_G0.6420.84
177_Y317_E0.6410.83
288_F329_I0.6410.83
248_A270_A0.6400.83
354_A358_V0.6380.83
90_V128_L0.6370.83
242_Q250_G0.6370.83
444_P456_V0.6350.83
465_G469_A0.6350.83
104_L114_I0.6340.83
340_Y347_L0.6330.83
459_R466_V0.6330.83
33_E294_Q0.6320.83
221_L227_G0.6310.82
60_I301_F0.6300.82
174_A177_Y0.6260.82
285_A289_F0.6260.82
370_G380_V0.6260.82
220_N262_K0.6240.82
46_V49_V0.6240.82
243_E250_G0.6230.82
292_Y325_N0.6230.82
135_S420_M0.6230.82
221_L224_T0.6230.82
169_A173_L0.6210.81
246_R251_V0.6210.81
60_I441_M0.6210.81
297_T438_A0.6190.81
282_M290_V0.6170.81
469_A472_A0.6160.81
42_G166_S0.6150.81
237_W240_H0.6140.81
14_L21_K0.6120.81
262_K266_A0.6110.80
49_V304_I0.6100.80
257_V264_A0.6090.80
175_A319_E0.6080.80
270_A278_A0.6080.80
102_Y190_L0.6080.80
92_M96_I0.6070.80
266_A272_R0.6070.80
244_V248_A0.6070.80
72_G431_N0.6040.80
215_P220_N0.6030.80
37_Y130_K0.6030.80
354_A475_M0.6020.79
152_F411_V0.6000.79
291_L468_T0.6000.79
97_V124_V0.5990.79
351_T476_L0.5990.79
69_L123_A0.5990.79
457_Y460_V0.5980.79
131_A135_S0.5970.79
134_S400_S0.5970.79
98_L122_I0.5960.79
160_N400_S0.5950.79
160_N163_S0.5950.79
179_W183_F0.5950.79
228_V234_I0.5950.79
48_L52_L0.5940.79
103_A107_W0.5940.79
152_F281_L0.5930.78
93_L198_A0.5920.78
245_A253_A0.5920.78
225_I229_V0.5910.78
407_V419_I0.5850.77
14_L17_F0.5850.77
25_L196_N0.5840.77
133_P136_L0.5840.77
50_K304_I0.5840.77
290_V437_V0.5830.77
302_F385_L0.5830.77
335_I338_A0.5820.77
233_A238_L0.5810.77
267_M270_A0.5810.77
473_V481_K0.5800.77
156_Y325_N0.5790.77
360_C468_T0.5790.77
281_L285_A0.5760.76
21_K24_Y0.5740.76
71_Y160_N0.5740.76
399_I423_W0.5740.76
166_S434_G0.5740.76
61_T64_S0.5730.76
470_V474_L0.5730.76
142_E205_K0.5730.76
15_N21_K0.5720.76
341_N344_G0.5720.76
228_V232_I0.5720.76
475_M479_A0.5720.76
414_R421_G0.5710.76
235_A240_H0.5710.76
287_I290_V0.5700.76
215_P221_L0.5700.76
220_N264_A0.5680.75
172_W319_E0.5670.75
438_A441_M0.5660.75
286_I433_I0.5660.75
241_N256_I0.5650.75
22_A26_I0.5650.75
33_E39_G0.5640.75
22_A25_L0.5630.75
132_N186_S0.5630.75
38_Y166_S0.5630.75
232_I237_W0.5620.75
110_H113_G0.5610.75
238_L241_N0.5600.74
223_L227_G0.5580.74
81_G91_I0.5550.74
425_L429_G0.5550.74
378_G381_S0.5540.74
306_N378_G0.5540.74
165_F169_A0.5520.73
98_L125_G0.5520.73
71_Y325_N0.5520.73
129_F155_Y0.5520.73
63_F431_N0.5500.73
267_M280_I0.5490.73
38_Y130_K0.5490.73
359_M398_M0.5480.73
174_A179_W0.5470.73
157_M334_P0.5470.73
68_A432_L0.5470.73
42_G167_M0.5460.73
229_V237_W0.5450.72
265_F268_K0.5440.72
132_N141_Y0.5440.72
98_L102_Y0.5440.72
192_I196_N0.5440.72
295_M389_Y0.5430.72
113_G331_I0.5420.72
272_R277_V0.5420.72
197_F201_Q0.5420.72
153_T337_A0.5420.72
288_F396_E0.5410.72
72_G76_I0.5400.72
434_G464_I0.5390.72
91_I197_F0.5380.71
168_I323_A0.5370.71
468_T472_A0.5360.71
30_E39_G0.5350.71
236_T239_L0.5340.71
63_F119_M0.5330.71
33_E129_F0.5320.71
400_S420_M0.5310.70
266_A270_A0.5300.70
268_K279_F0.5300.70
436_Y439_G0.5280.70
362_G365_L0.5280.70
139_T207_Y0.5280.70
34_R190_L0.5280.70
27_F31_L0.5260.70
123_A430_A0.5250.70
34_R155_Y0.5250.70
130_K190_L0.5240.69
441_M460_V0.5240.69
30_E37_Y0.5230.69
288_F399_I0.5230.69
291_L367_L0.5230.69
29_I158_S0.5230.69
226_I463_Q0.5220.69
32_W36_G0.5220.69
244_V249_L0.5220.69
266_A269_G0.5210.69
72_G430_A0.5200.69
289_F294_Q0.5200.69
236_T241_N0.5190.69
156_Y322_Q0.5190.69
292_Y329_I0.5190.69
434_G460_V0.5180.69
242_Q252_V0.5170.68
218_Y227_G0.5170.68
228_V231_L0.5160.68
19_Q141_Y0.5160.68
84_V105_V0.5150.68
22_A203_W0.5140.68
156_Y159_V0.5120.68
37_Y41_Q0.5120.68
242_Q246_R0.5120.68
129_F134_S0.5120.68
404_L424_F0.5120.68
240_H247_M0.5110.68
95_A186_S0.5100.67
182_A186_S0.5090.67
36_G180_S0.5090.67
356_G395_G0.5070.67
252_V359_M0.5060.67
35_F189_G0.5050.67
416_M421_G0.5050.67
268_K275_M0.5050.67
229_V234_I0.5050.67
273_R276_I0.5030.66
60_I297_T0.5030.66
481_K484_R0.5020.66
149_D352_K0.5010.66
151_A408_A0.5010.66
202_R205_K0.5010.66
143_K148_L0.5010.66
289_F295_M0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oh3A 2 0.938 100 0.515 Contact Map
4uvmA 1 0.93 100 0.549 Contact Map
4q65A 1 0.854 100 0.594 Contact Map
4tphA 2 0.88 100 0.601 Contact Map
4ikvA 1 0.942 100 0.617 Contact Map
4xnjA 1 0.894 100 0.642 Contact Map
4w6vA 1 0.92 100 0.722 Contact Map
1pw4A 1 0.842 100 0.75 Contact Map
3wdoA 1 0.816 100 0.751 Contact Map
2cfqA 1 0.826 100 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0139 seconds.