GREMLIN Database
YAHE - Uncharacterized protein YahE
UniProt: P77297 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13589
Length: 287 (262)
Sequences: 281 (256)
Seq/√Len: 15.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A39_T5.4361.00
21_Q28_N4.4621.00
20_E28_N4.1061.00
26_A41_L3.4400.99
51_S221_T3.1530.99
166_S170_L3.0430.98
28_N37_L2.9990.98
49_P225_A2.9100.98
17_G69_V2.8800.98
188_I271_M2.7760.97
181_Y273_D2.4180.94
41_L53_R2.3800.93
27_V40_L2.3270.92
164_V182_L2.2630.91
26_A40_L2.2590.91
167_M178_A2.1570.89
257_K265_C2.1070.88
183_T225_A2.0920.87
183_T221_T2.0510.86
185_L274_G2.0510.86
47_N92_W2.0090.85
187_L230_C1.9960.84
51_S170_L1.9910.84
260_G270_G1.9580.83
263_S270_G1.9580.83
260_G263_S1.9580.83
17_G22_V1.9400.83
221_T231_R1.9030.81
175_T180_D1.8550.80
49_P186_A1.8450.79
170_L221_T1.8330.79
28_N221_T1.7950.77
41_L51_S1.7850.77
221_T230_C1.7720.76
187_L234_I1.7060.74
62_L253_I1.6820.72
49_P184_G1.6780.72
264_G270_G1.6620.72
260_G264_G1.6620.72
184_G222_L1.6230.70
234_I271_M1.6210.70
46_D231_R1.6150.69
39_T170_L1.6070.69
51_S215_T1.5980.68
222_L225_A1.5780.67
215_T221_T1.5730.67
263_S266_D1.5670.67
266_D270_G1.5670.67
260_G266_D1.5670.67
221_T262_S1.5580.66
27_V124_E1.5490.66
231_R267_M1.5030.64
175_T264_G1.4990.63
180_D264_G1.4990.63
17_G230_C1.4730.62
39_T45_Y1.4620.61
174_L214_T1.4590.61
49_P222_L1.4530.61
26_A189_L1.4380.60
174_L177_S1.4370.60
20_E216_L1.4280.59
30_A216_L1.4210.59
29_I40_L1.4150.59
21_Q37_L1.4050.58
28_N39_T1.4020.58
41_L267_M1.3870.57
256_I259_I1.3740.56
39_T50_N1.3710.56
171_G176_P1.3630.56
173_G176_P1.3630.56
17_G31_L1.3420.55
26_A45_Y1.3360.54
170_L215_T1.3020.52
25_R44_E1.3000.52
185_L225_A1.2770.51
50_N170_L1.2660.50
76_I183_T1.2610.50
21_Q217_L1.2590.50
225_A262_S1.2530.49
177_S266_D1.2480.49
169_G218_S1.2430.49
48_A51_S1.2330.48
171_G179_D1.2160.47
173_G179_D1.2160.47
176_P179_D1.2160.47
169_G214_T1.2030.47
171_G180_D1.2020.46
173_G180_D1.2020.46
171_G175_T1.2020.46
176_P180_D1.2020.46
36_Q207_L1.1970.46
27_V39_T1.1960.46
170_L178_A1.1900.46
17_G29_I1.1880.46
224_A230_C1.1730.45
45_Y48_A1.1500.44
182_L222_L1.1450.43
115_I151_I1.1450.43
23_F256_I1.1440.43
169_G176_P1.1410.43
169_G173_G1.1410.43
48_A231_R1.1340.43
183_T267_M1.1260.42
220_I224_A1.1200.42
26_A50_N1.1170.42
23_F28_N1.1080.41
164_V207_L1.1070.41
40_L170_L1.1040.41
171_G270_G1.0990.41
173_G260_G1.0990.41
176_P263_S1.0990.41
173_G263_S1.0990.41
171_G263_S1.0990.41
171_G260_G1.0990.41
176_P270_G1.0990.41
173_G270_G1.0990.41
176_P260_G1.0990.41
274_G277_L1.0960.40
117_H244_D1.0930.40
39_T183_T1.0920.40
177_S234_I1.0880.40
173_G184_G1.0860.40
171_G184_G1.0860.40
176_P184_G1.0860.40
262_S273_D1.0740.39
19_V22_V1.0730.39
191_I201_E1.0710.39
41_L46_D1.0630.39
86_M257_K1.0520.38
174_L180_D1.0480.38
26_A221_T1.0440.38
175_T179_D1.0430.38
164_V203_F1.0340.37
21_Q170_L1.0220.36
50_N232_E1.0060.36
177_S261_S0.9890.35
47_N261_S0.9790.34
169_G179_D0.9780.34
256_I267_M0.9750.34
169_G180_D0.9650.33
169_G175_T0.9650.33
37_L221_T0.9550.33
183_T222_L0.9530.33
256_I273_D0.9520.33
179_D260_G0.9460.32
179_D263_S0.9460.32
179_D270_G0.9460.32
50_N220_I0.9400.32
175_T270_G0.9340.32
175_T263_S0.9340.32
180_D263_S0.9340.32
175_T260_G0.9340.32
180_D270_G0.9340.32
180_D260_G0.9340.32
168_M182_L0.9330.32
228_Q256_I0.9330.32
164_V186_A0.9230.31
84_I188_I0.9220.31
66_G218_S0.9110.31
41_L170_L0.9100.31
116_I250_T0.9080.31
63_F220_I0.8990.30
179_D184_G0.8860.30
19_V42_C0.8860.30
27_V166_S0.8840.29
28_N230_C0.8730.29
180_D184_G0.8720.29
175_T184_G0.8720.29
169_G263_S0.8710.29
169_G270_G0.8710.29
169_G260_G0.8710.29
205_L251_Q0.8670.29
267_M273_D0.8670.29
39_T221_T0.8660.29
26_A181_Y0.8620.28
84_I93_L0.8600.28
216_L219_A0.8580.28
71_F115_I0.8570.28
48_A92_W0.8560.28
26_A215_T0.8550.28
20_E37_L0.8520.28
183_T234_I0.8500.28
46_D273_D0.8460.28
62_L197_E0.8430.28
164_V210_G0.8430.28
48_A261_S0.8400.27
171_G264_G0.8380.27
173_G264_G0.8380.27
176_P264_G0.8380.27
172_I268_L0.8340.27
72_D118_Q0.8250.27
135_F231_R0.8200.26
188_I241_I0.8190.26
52_C126_L0.8190.26
25_R205_L0.8110.26
222_L231_R0.8100.26
38_L166_S0.8050.26
25_R39_T0.8010.26
184_G268_L0.8000.26
184_G270_G0.7970.25
184_G260_G0.7970.25
184_G263_S0.7970.25
54_L114_D0.7970.25
169_G184_G0.7950.25
39_T49_P0.7940.25
215_T267_M0.7920.25
268_L271_M0.7910.25
235_H262_S0.7880.25
77_T154_V0.7860.25
176_P214_T0.7830.25
171_G214_T0.7830.25
173_G214_T0.7830.25
253_I256_I0.7790.25
41_L178_A0.7780.25
171_G218_S0.7730.24
173_G218_S0.7730.24
176_P218_S0.7730.24
170_L259_I0.7670.24
169_G174_L0.7620.24
125_T129_Y0.7620.24
39_T51_S0.7580.24
39_T261_S0.7570.24
26_A78_V0.7550.24
44_E267_M0.7540.24
171_G266_D0.7530.24
173_G266_D0.7530.24
176_P266_D0.7530.24
20_E23_F0.7520.24
46_D267_M0.7520.24
57_T168_M0.7510.23
49_P185_L0.7510.23
20_E223_E0.7480.23
165_A213_N0.7460.23
68_K141_K0.7370.23
73_D177_S0.7340.23
187_L224_A0.7340.23
89_C256_I0.7310.23
163_A269_Y0.7250.22
67_D224_A0.7230.22
186_A230_C0.7190.22
35_Q275_C0.7190.22
64_R90_R0.7170.22
54_L199_Y0.7160.22
39_T189_L0.7140.22
170_L189_L0.7130.22
188_I261_S0.7120.22
74_Q100_T0.7110.22
38_L50_N0.7090.22
21_Q52_C0.7080.22
119_H241_I0.7080.22
19_V29_I0.7040.22
38_L98_Q0.7040.22
112_W118_Q0.7010.21
186_A203_F0.7000.21
160_I188_I0.6980.21
28_N217_L0.6920.21
66_G274_G0.6920.21
174_L218_S0.6890.21
75_G153_A0.6880.21
39_T269_Y0.6880.21
178_A203_F0.6840.21
215_T256_I0.6820.21
50_N267_M0.6800.21
152_Q262_S0.6800.21
58_H234_I0.6750.20
108_A238_I0.6710.20
25_R69_V0.6710.20
112_W115_I0.6690.20
99_M191_I0.6680.20
181_Y189_L0.6670.20
179_D264_G0.6660.20
164_V226_L0.6650.20
85_E107_I0.6650.20
21_Q221_T0.6650.20
58_H189_L0.6630.20
160_I185_L0.6620.20
49_P229_R0.6580.20
54_L73_D0.6560.20
120_L124_E0.6510.20
167_M195_P0.6510.20
23_F266_D0.6480.19
174_L264_G0.6480.19
150_V156_D0.6480.19
232_E269_Y0.6460.19
46_D237_F0.6420.19
37_L237_F0.6410.19
40_L193_G0.6370.19
48_A134_P0.6370.19
105_H108_A0.6360.19
92_W261_S0.6350.19
54_L157_K0.6330.19
203_F274_G0.6310.19
164_V230_C0.6300.19
214_T218_S0.6280.19
129_Y133_N0.6260.19
26_A170_L0.6220.19
22_V65_H0.6160.18
217_L257_K0.6150.18
49_P234_I0.6140.18
52_C185_L0.6120.18
225_A230_C0.6100.18
132_D258_H0.6090.18
119_H157_K0.6060.18
92_W170_L0.6050.18
94_S164_V0.6020.18
29_I125_T0.6010.18
178_A275_C0.6010.18
237_F256_I0.6000.18
179_D214_T0.5990.18
61_D276_A0.5990.18
35_Q90_R0.5980.18
40_L97_L0.5960.18
57_T275_C0.5960.18
41_L50_N0.5960.18
25_R71_F0.5940.18
203_F224_A0.5930.18
213_N228_Q0.5890.17
27_V189_L0.5890.17
26_A185_L0.5890.17
180_D214_T0.5880.17
175_T214_T0.5880.17
47_N232_E0.5870.17
106_L245_I0.5870.17
169_G264_G0.5860.17
254_E259_I0.5860.17
65_H132_D0.5850.17
71_F271_M0.5850.17
190_F271_M0.5840.17
230_C267_M0.5840.17
178_A270_G0.5830.17
178_A260_G0.5830.17
178_A263_S0.5830.17
42_C59_F0.5830.17
17_G48_A0.5790.17
50_N269_Y0.5770.17
262_S271_M0.5730.17
50_N224_A0.5720.17
50_N221_T0.5710.17
35_Q155_N0.5710.17
26_A53_R0.5680.17
46_D181_Y0.5660.17
92_W189_L0.5660.17
14_R18_Q0.5630.17
50_N185_L0.5600.16
179_D266_D0.5570.16
35_Q234_I0.5550.16
207_L217_L0.5520.16
93_L133_N0.5520.16
215_T219_A0.5500.16
175_T266_D0.5480.16
180_D266_D0.5480.16
29_I113_H0.5470.16
27_V170_L0.5460.16
179_D218_S0.5420.16
168_M255_K0.5420.16
66_G207_L0.5410.16
170_L181_Y0.5400.16
106_L238_I0.5400.16
115_I140_N0.5390.16
147_R193_G0.5380.16
109_W248_N0.5380.16
152_Q243_Y0.5370.16
101_A187_L0.5340.16
180_D218_S0.5330.16
175_T218_S0.5330.16
221_T267_M0.5330.16
48_A221_T0.5300.16
170_L217_L0.5300.16
27_V64_R0.5300.16
112_W220_I0.5290.16
133_N136_Y0.5280.15
197_E227_Q0.5260.15
217_L266_D0.5260.15
208_Q271_M0.5250.15
225_A241_I0.5250.15
146_K247_G0.5240.15
52_C206_G0.5240.15
114_D191_I0.5220.15
28_N174_L0.5160.15
16_Q67_D0.5130.15
36_Q206_G0.5110.15
170_L183_T0.5080.15
185_L275_C0.5080.15
52_C215_T0.5040.15
46_D172_I0.5030.15
214_T270_G0.5020.15
214_T263_S0.5020.15
214_T260_G0.5020.15
27_V70_Q0.5020.15
187_L238_I0.5020.15
96_T235_H0.5010.15
19_V49_P0.5010.15
186_A231_R0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ifdJ 1 0.3066 13.6 0.96 Contact Map
2vnuD 1 0.2753 13.5 0.96 Contact Map
5a1uG 1 0.2091 13.3 0.96 Contact Map
1jalA 1 0.2544 11.7 0.961 Contact Map
1eoqA 1 0.2509 9.9 0.962 Contact Map
2r7dA 1 0.2474 8.4 0.963 Contact Map
4p6zG 1 0.2857 8.1 0.964 Contact Map
2od5A 4 0.2997 7.7 0.964 Contact Map
4q9vA 2 0.223 6.1 0.966 Contact Map
3nbxX 1 0.5226 5.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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