GREMLIN Database
YBET - Uncharacterized protein YbeT
UniProt: P77296 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13650
Length: 184 (145)
Sequences: 3103 (2576)
Seq/√Len: 213.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_R163_L2.7821.00
74_L91_Y2.5871.00
139_Q162_W2.5371.00
139_Q169_Q2.5111.00
66_Q97_Q2.4311.00
158_E161_K2.3851.00
103_Q126_W2.3041.00
103_Q133_Q2.2411.00
167_A175_E2.2121.00
111_L127_Y2.1371.00
122_K125_L2.1321.00
70_G91_Y2.1271.00
46_S49_F2.0191.00
95_A103_Q2.0121.00
66_Q90_W2.0041.00
86_Q89_Y1.9851.00
58_A66_Q1.9211.00
69_L73_Y1.8921.00
88_R106_L1.8601.00
107_G127_Y1.8081.00
67_Y99_N1.7391.00
155_N158_E1.7041.00
128_K158_E1.7041.00
53_A57_S1.6971.00
128_K132_E1.6591.00
159_S163_L1.6161.00
35_N38_F1.5731.00
162_W165_L1.5201.00
123_A127_Y1.5111.00
119_D122_K1.5051.00
131_A139_Q1.4961.00
143_G163_L1.4941.00
124_I152_I1.4931.00
54_T68_R1.4861.00
164_K168_K1.4841.00
104_S138_A1.4411.00
67_Y102_A1.4411.00
158_E162_W1.4331.00
104_S135_Y1.4201.00
88_R92_E1.3931.00
94_S102_A1.3851.00
87_A91_Y1.3691.00
144_L163_L1.3461.00
140_Y177_L1.3371.00
47_L50_T1.3101.00
55_E59_I1.3081.00
90_W93_Q1.2781.00
142_L146_Y1.2751.00
130_A138_A1.2131.00
92_E96_E1.2041.00
50_T54_T1.2021.00
95_A126_W1.1891.00
140_Y171_Y1.1861.00
106_L110_Y1.1751.00
92_E122_K1.1741.00
113_G119_D1.1701.00
57_S62_H1.1581.00
126_W129_E1.1561.00
88_R116_V1.1511.00
58_A90_W1.1431.00
42_S47_L1.1291.00
103_Q129_E1.1241.00
122_K126_W1.1181.00
51_T55_E1.1171.00
58_A61_G1.1131.00
160_Q164_K1.0881.00
113_G116_V1.0861.00
91_Y105_K1.0661.00
139_Q165_L1.0511.00
67_Y105_K1.0361.00
95_A131_A1.0351.00
93_Q97_Q1.0271.00
166_T174_A1.0221.00
104_S108_W1.0191.00
113_G118_P1.0111.00
85_T121_R1.0001.00
64_T99_N0.9931.00
145_I151_G0.9851.00
143_G162_W0.9781.00
88_R110_Y0.9721.00
127_Y141_T0.9561.00
131_A134_G0.9511.00
124_I128_K0.9501.00
110_Y116_V0.9491.00
76_G79_G0.9471.00
111_L123_A0.9461.00
67_Y71_E0.9400.99
104_S141_T0.9370.99
58_A65_S0.9320.99
38_F42_S0.9280.99
124_I142_L0.9270.99
55_E86_Q0.9250.99
76_G83_D0.9230.99
89_Y93_Q0.9100.99
125_L129_E0.9040.99
101_R135_Y0.8990.99
83_D86_Q0.8970.99
147_R177_L0.8870.99
68_R71_E0.8840.99
136_A171_Y0.8790.99
107_G126_W0.8720.99
66_Q93_Q0.8660.99
131_A162_W0.8650.99
62_H65_S0.8610.99
108_W127_Y0.8590.99
74_L105_K0.8550.99
109_I115_G0.8500.99
51_T69_L0.8450.99
74_L87_A0.8450.99
129_E133_Q0.8440.99
163_L177_L0.8350.99
53_A56_L0.8330.99
88_R109_I0.8240.99
172_K176_R0.8230.99
90_W126_W0.8200.99
72_F145_I0.8130.99
105_K108_W0.8130.99
108_W111_L0.8110.98
41_L46_S0.8100.98
129_E165_L0.8070.98
130_A135_Y0.8010.98
94_S99_N0.7910.98
36_Y39_D0.7910.98
171_Y174_A0.7880.98
38_F41_L0.7880.98
107_G123_A0.7710.98
124_I145_I0.7700.98
92_E106_L0.7650.98
49_F53_A0.7570.98
61_G65_S0.7560.98
111_L141_T0.7520.98
146_Y149_G0.7470.97
95_A98_E0.7450.97
91_Y109_I0.7440.97
51_T80_K0.7390.97
84_Y114_L0.7370.97
172_K175_E0.7340.97
76_G82_L0.7330.97
63_S94_S0.7290.97
141_T144_L0.7270.97
86_Q90_W0.7270.97
109_I116_V0.7230.97
165_L169_Q0.7230.97
76_G80_K0.7220.97
38_F45_G0.7170.97
71_E75_H0.7110.97
120_T150_S0.7100.97
100_P130_A0.7080.96
170_H174_A0.7040.96
32_A36_Y0.7010.96
55_E69_L0.6950.96
146_Y158_E0.6930.96
149_G152_I0.6870.96
106_L126_W0.6870.96
99_N102_A0.6860.96
49_F52_A0.6830.96
41_L49_F0.6790.96
146_Y152_I0.6740.95
161_K165_L0.6720.95
147_R159_S0.6680.95
73_Y86_Q0.6610.95
58_A95_A0.6570.95
70_G94_S0.6540.95
110_Y122_K0.6520.94
56_L59_I0.6520.94
166_T171_Y0.6460.94
103_Q139_Q0.6410.94
167_A174_A0.6350.94
89_Y125_L0.6340.94
47_L77_S0.6340.94
149_G155_N0.6340.94
58_A131_A0.6260.93
34_V37_A0.6260.93
151_G155_N0.6240.93
85_T157_Y0.6190.93
42_S54_T0.6150.93
38_F54_T0.6150.93
73_Y80_K0.6150.93
108_W141_T0.6060.92
37_A40_Y0.6050.92
50_T53_A0.6050.92
57_S65_S0.6010.92
134_G169_Q0.5880.91
63_S99_N0.5850.91
33_M37_A0.5780.90
54_T65_S0.5780.90
129_E132_E0.5760.90
121_R124_I0.5760.90
142_L162_W0.5750.90
72_F79_G0.5740.90
149_G154_V0.5710.90
71_E105_K0.5680.89
110_Y113_G0.5640.89
115_G118_P0.5590.89
35_N62_H0.5560.88
32_A35_N0.5540.88
42_S50_T0.5440.87
57_S60_H0.5410.87
171_Y175_E0.5350.86
71_E74_L0.5340.86
140_Y174_A0.5330.86
88_R113_G0.5310.86
98_E134_G0.5260.85
98_E103_Q0.5220.85
32_A39_D0.5190.85
72_F80_K0.5160.84
162_W166_T0.5160.84
38_F50_T0.5160.84
71_E91_Y0.5120.84
145_I150_S0.5120.84
48_P52_A0.5090.84
140_Y144_L0.5070.83
45_G56_L0.5060.83
136_A143_G0.5040.83
100_P133_Q0.5040.83
32_A38_F0.5030.83
144_L147_R0.5020.83
136_A166_T0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwrA 1 0.913 99.9 0.349 Contact Map
1ouvA 1 0.837 99.9 0.374 Contact Map
1klxA 1 0.7228 99.8 0.416 Contact Map
3e4bA 1 0.9728 99.7 0.499 Contact Map
3rjvA 1 0.9022 99.5 0.566 Contact Map
1hh8A 1 0.7826 99.1 0.642 Contact Map
4gywA 2 0.7826 99.1 0.647 Contact Map
3qkyA 1 0.788 99.1 0.65 Contact Map
2pziA 1 0.8913 99.1 0.653 Contact Map
2vsyA 1 0.6033 99 0.665 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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