GREMLIN Database
GTRB - Bactoprenol glucosyl transferase homolog from prophage CPS-53
UniProt: P77293 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14132
Length: 306 (265)
Sequences: 20639 (17003)
Seq/√Len: 1044.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_E46_A4.3161.00
161_R165_E4.1551.00
40_N65_S3.9791.00
46_A49_S2.9691.00
4_S35_E2.7591.00
9_V47_T2.7481.00
12_E93_V2.7411.00
39_I79_G2.7151.00
87_A109_W2.7071.00
113_A189_D2.7041.00
48_E65_S2.6761.00
4_S85_G2.6561.00
35_E62_V2.6431.00
48_E52_N2.5711.00
40_N43_S2.4841.00
176_F180_I2.4821.00
104_H193_Y2.4101.00
66_F78_A2.3811.00
163_V186_G2.2801.00
51_I63_P2.2591.00
17_P21_K2.2251.00
108_K111_A2.2061.00
108_K189_D2.2021.00
17_P50_I2.1801.00
89_I158_L2.1751.00
30_K103_P2.1731.00
48_E63_P2.1641.00
21_K54_L2.1451.00
38_F51_I2.1131.00
17_P53_A2.1051.00
6_V79_G2.0681.00
109_W158_L2.0561.00
108_K191_V2.0271.00
72_K76_L2.0261.00
52_N65_S1.9521.00
78_A82_H1.9081.00
87_A158_L1.9021.00
20_Y54_L1.8751.00
114_D160_S1.8261.00
114_D186_G1.7961.00
166_N186_G1.7931.00
76_L90_P1.7631.00
104_H107_E1.7581.00
11_N44_K1.7541.00
3_I106_I1.7541.00
64_L82_H1.7521.00
105_L158_L1.7001.00
50_I53_A1.6821.00
4_S37_V1.6681.00
4_S83_A1.6561.00
162_D166_N1.6321.00
166_N184_V1.6311.00
35_E85_G1.6251.00
80_L164_V1.6241.00
13_E50_I1.6161.00
46_A50_I1.6111.00
11_N43_S1.6031.00
24_R58_D1.5821.00
7_V19_F1.5741.00
89_I102_I1.5701.00
21_K25_E1.5511.00
97_D101_V1.5431.00
49_S53_A1.5411.00
10_F69_N1.5341.00
39_I75_A1.5251.00
87_A106_I1.4931.00
17_P54_L1.4671.00
62_V82_H1.4571.00
78_A81_D1.4531.00
100_E104_H1.4481.00
109_W160_S1.4421.00
3_I102_I1.4371.00
80_L88_I1.4351.00
41_D69_N1.4261.00
115_M188_T1.4151.00
9_V93_V1.3891.00
22_T97_D1.3891.00
18_I96_Q1.3891.00
35_E84_T1.3771.00
76_L92_D1.3531.00
40_N48_E1.3491.00
107_E110_Q1.3161.00
20_Y38_F1.3111.00
121_S194_V1.3081.00
20_Y58_D1.3021.00
91_I97_D1.2971.00
22_T100_E1.2871.00
115_M181_L1.2771.00
70_F74_P1.2641.00
9_V12_E1.2501.00
12_E15_A1.2451.00
83_A161_R1.2441.00
18_I21_K1.2431.00
7_V36_I1.2421.00
9_V38_F1.2351.00
103_P107_E1.2131.00
89_I101_V1.2131.00
209_K212_N1.2061.00
64_L78_A1.2061.00
31_S106_I1.1991.00
88_I161_R1.1911.00
29_L32_Y1.1701.00
119_K192_E1.1701.00
50_I54_L1.1661.00
163_V181_L1.1521.00
120_R155_D1.1451.00
49_S52_N1.1341.00
72_K92_D1.1291.00
37_V62_V1.1171.00
107_E111_A1.1131.00
162_D165_E1.1091.00
22_T96_Q1.1041.00
29_L33_E1.1001.00
5_L23_V1.0961.00
8_P75_A1.0931.00
24_R60_L1.0921.00
160_S163_V1.0711.00
25_E99_I1.0581.00
55_A61_V1.0451.00
108_K116_V1.0351.00
18_I199_I1.0301.00
72_K154_G1.0151.00
73_E173_R1.0131.00
6_V39_I0.9991.00
118_A156_F0.9981.00
67_T70_F0.9971.00
18_I22_T0.9861.00
52_N55_A0.9831.00
41_D71_G0.9721.00
109_W116_V0.9721.00
86_D162_D0.9711.00
81_D168_K0.9631.00
80_L90_P0.9621.00
105_L118_A0.9551.00
88_I164_V0.9481.00
20_Y24_R0.9461.00
5_L89_I0.9361.00
127_G130_K0.9341.00
16_I50_I0.9291.00
30_K33_E0.9291.00
101_V156_F0.9231.00
86_D160_S0.9191.00
97_D195_R0.9151.00
31_S34_V0.9141.00
7_V93_V0.9081.00
62_V84_T0.8961.00
34_V60_L0.8961.00
191_V194_V0.8961.00
66_F75_A0.8951.00
108_K112_G0.8941.00
128_R131_R0.8811.00
215_L219_T0.8791.00
19_F23_V0.8731.00
5_L102_I0.8721.00
77_F81_D0.8681.00
87_A160_S0.8651.00
8_P41_D0.8641.00
139_K143_K0.8641.00
128_R132_K0.8511.00
38_F61_V0.8501.00
67_T78_A0.8491.00
80_L83_A0.8401.00
34_V102_I0.8361.00
176_F179_G0.8351.00
119_K190_I0.8321.00
72_K173_R0.8311.00
19_F22_T0.8301.00
246_W250_D0.8301.00
101_V105_L0.8281.00
37_V83_A0.8271.00
8_P93_V0.8261.00
114_D187_K0.8221.00
105_L109_W0.8221.00
139_K142_N0.8201.00
233_G237_A0.8201.00
258_V261_Y0.8101.00
171_P176_F0.8081.00
133_T136_W0.8051.00
172_E175_L0.8031.00
66_F70_F0.8001.00
259_R262_P0.7981.00
240_A270_F0.7971.00
36_I61_V0.7971.00
159_M164_V0.7951.00
48_E51_I0.7951.00
152_N157_R0.7941.00
220_S224_F0.7931.00
20_Y61_V0.7841.00
106_I110_Q0.7751.00
100_E103_P0.7741.00
22_T196_A0.7741.00
95_L198_R0.7741.00
104_H108_K0.7721.00
104_H191_V0.7701.00
79_G83_A0.7671.00
29_L34_V0.7611.00
73_E77_F0.7591.00
203_T206_N0.7591.00
130_K133_T0.7581.00
16_I51_I0.7571.00
224_F227_R0.7571.00
214_A217_G0.7541.00
20_Y36_I0.7521.00
83_A88_I0.7501.00
23_V36_I0.7491.00
105_L194_V0.7491.00
214_A218_I0.7461.00
167_I181_L0.7451.00
15_A199_I0.7401.00
101_V118_A0.7401.00
11_N47_T0.7371.00
43_S47_T0.7321.00
24_R61_V0.7311.00
209_K213_L0.7291.00
9_V16_I0.7261.00
51_I55_A0.7251.00
114_D162_D0.7241.00
22_T25_E0.7221.00
54_L58_D0.7201.00
138_Y142_N0.7191.00
16_I47_T0.7171.00
55_A59_P0.7171.00
213_L217_G0.7161.00
29_L103_P0.7151.00
210_L213_L0.7151.00
207_G210_L0.7131.00
181_L186_G0.7131.00
132_K136_W0.7101.00
37_V82_H0.7091.00
260_G263_S0.7071.00
132_K135_E0.7061.00
7_V23_V0.7031.00
81_D169_L0.7021.00
237_A240_A0.7021.00
8_P76_L0.6991.00
105_L156_F0.6981.00
222_S225_P0.6971.00
159_M181_L0.6971.00
166_N169_L0.6961.00
55_A58_D0.6931.00
211_W215_L0.6931.00
42_G66_F0.6931.00
106_I158_L0.6921.00
101_V104_H0.6911.00
4_S161_R0.6911.00
30_K34_V0.6901.00
6_V83_A0.6881.00
24_R54_L0.6851.00
189_D192_E0.6841.00
7_V38_F0.6831.00
15_A19_F0.6831.00
136_W139_K0.6831.00
216_E219_T0.6791.00
76_L173_R0.6771.00
37_V79_G0.6751.00
72_K90_P0.6741.00
13_E49_S0.6741.00
7_V91_I0.6711.00
109_W113_A0.6711.00
108_K113_A0.6631.00
256_N259_R0.6621.00
12_E72_K0.6611.00
52_N63_P0.6611.00
231_Y235_V0.6601.00
269_L272_G0.6591.00
10_F41_D0.6591.00
41_D70_F0.6571.00
19_F91_I0.6541.00
9_V51_I0.6481.00
12_E16_I0.6421.00
114_D163_V0.6411.00
23_V91_I0.6401.00
66_F69_N0.6371.00
97_D156_F0.6371.00
13_E45_D0.6341.00
3_I158_L0.6341.00
225_P228_I0.6331.00
201_G204_K0.6331.00
10_F44_K0.6281.00
262_P266_V0.6281.00
171_P180_I0.6241.00
159_M177_M0.6211.00
227_R231_Y0.6191.00
257_A262_P0.6171.00
213_L216_E0.6161.00
238_S242_I0.6141.00
157_R178_K0.6131.00
58_D61_V0.6121.00
160_S186_G0.6111.00
10_F42_G0.6101.00
195_R198_R0.6081.00
240_A244_G0.6071.00
19_F93_V0.6061.00
80_L169_L0.6041.00
233_G240_A0.6041.00
13_E17_P0.6031.00
257_A260_G0.6031.00
41_D92_D0.6011.00
154_G157_R0.6001.00
72_K75_A0.5991.00
41_D66_F0.5981.00
89_I105_L0.5971.00
210_L214_A0.5961.00
229_W233_G0.5951.00
41_D75_A0.5941.00
255_G258_V0.5911.00
137_F141_H0.5881.00
96_Q123_R0.5861.00
98_P197_E0.5851.00
177_M181_L0.5851.00
11_N40_N0.5831.00
44_K47_T0.5831.00
67_T74_P0.5831.00
35_E83_A0.5811.00
131_R135_E0.5781.00
148_K187_K0.5781.00
133_T137_F0.5771.00
55_A63_P0.5771.00
23_V97_D0.5771.00
245_A249_L0.5771.00
138_Y141_H0.5751.00
225_P233_G0.5751.00
21_K24_R0.5751.00
105_L116_V0.5711.00
11_N45_D0.5701.00
8_P72_K0.5701.00
98_P101_V0.5691.00
12_E47_T0.5681.00
230_T233_G0.5671.00
86_D161_R0.5661.00
260_G264_L0.5661.00
163_V167_I0.5651.00
164_V177_M0.5641.00
95_L196_A0.5621.00
255_G260_G0.5611.00
163_V166_N0.5611.00
112_G187_K0.5601.00
130_K134_A0.5601.00
89_I97_D0.5581.00
237_A241_F0.5571.00
267_S272_G0.5561.00
12_E92_D0.5551.00
254_F257_A0.5541.00
254_F258_V0.5541.00
62_V65_S0.5531.00
85_G161_R0.5521.00
172_E178_K0.5511.00
113_A187_K0.5501.00
141_H145_S0.5471.00
16_I93_V0.5451.00
22_T95_L0.5451.00
175_L179_G0.5441.00
257_A261_Y0.5431.00
178_K188_T0.5381.00
117_L120_R0.5371.00
152_N178_K0.5371.00
16_I38_F0.5361.00
30_K100_E0.5361.00
167_I184_V0.5351.00
33_E60_L0.5351.00
142_N146_N0.5341.00
164_V169_L0.5311.00
98_P195_R0.5311.00
182_S188_T0.5281.00
75_A78_A0.5271.00
18_I198_R0.5271.00
198_R201_G0.5261.00
19_F95_L0.5231.00
140_L144_I0.5221.00
149_I152_N0.5211.00
262_P265_L0.5201.00
39_I78_A0.5201.00
13_E47_T0.5201.00
267_S271_L0.5201.00
172_E176_F0.5201.00
75_A79_G0.5191.00
233_G239_V0.5191.00
16_I54_L0.5191.00
264_L267_S0.5171.00
76_L154_G0.5161.00
244_G266_V0.5151.00
117_L152_N0.5151.00
234_L237_A0.5131.00
261_Y264_L0.5131.00
223_T227_R0.5131.00
102_I158_L0.5111.00
71_G94_D0.5101.00
14_E50_I0.5091.00
212_N215_L0.5081.00
95_L155_D0.5061.00
74_P78_A0.5061.00
116_V191_V0.5061.00
15_A18_I0.5041.00
208_W212_N0.5041.00
51_I61_V0.5011.00
208_W211_W0.5011.00
241_F248_I0.5001.00
207_G211_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.5621 100 0.41 Contact Map
2z86A 2 0.7843 100 0.411 Contact Map
4p02A 1 0.9673 100 0.417 Contact Map
3l7iA 4 0.1013 100 0.43 Contact Map
2d7iA 1 0.9314 100 0.436 Contact Map
1qg8A 1 0.7059 100 0.437 Contact Map
4fixA 3 0.9641 100 0.441 Contact Map
1xhbA 1 0.9052 100 0.447 Contact Map
2bo4A 4 0.9346 100 0.452 Contact Map
3ckjA 2 0.8072 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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