GREMLIN Database
YDEU - Uncharacterized protein YdeU
UniProt: P77286 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 466 (406)
Sequences: 3257 (2662)
Seq/√Len: 132.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_M263_G4.7491.00
441_W461_G4.5241.00
399_W422_N4.0051.00
401_N422_N3.7871.00
366_N402_N3.7101.00
279_Y315_G3.4921.00
444_V456_T3.3471.00
190_V211_V3.2111.00
335_V373_V3.1311.00
438_L464_Y2.9991.00
236_G261_S2.9861.00
286_Y306_R2.9171.00
8_P28_N2.8731.00
261_S287_N2.7881.00
27_F71_L2.7871.00
427_R445_G2.5591.00
438_L462_V2.4881.00
235_A260_Y2.4461.00
120_P128_N2.4411.00
47_T74_V2.4111.00
194_E207_A2.3021.00
278_A316_Y2.2991.00
343_W365_G2.2731.00
20_G23_G2.2711.00
18_Y43_V2.2681.00
9_G28_N2.2641.00
282_S312_V2.2631.00
369_T399_W2.2601.00
53_V71_L2.2481.00
343_W367_V2.2341.00
162_R166_R2.2231.00
10_N28_N2.1981.00
15_N44_K2.1951.00
217_D265_Y2.1471.00
292_S302_D2.1211.00
291_N305_S2.1171.00
396_E427_R2.1121.00
340_Q370_R2.1101.00
44_K75_G2.1021.00
18_Y25_M2.1001.00
70_E73_E2.0701.00
239_N258_S2.0121.00
295_S353_R2.0101.00
394_Y429_G2.0061.00
338_Q398_N1.9851.00
220_Q231_L1.9841.00
391_F432_A1.9741.00
339_A371_L1.9721.00
338_Q370_R1.9481.00
284_A310_A1.9101.00
267_T281_D1.8791.00
17_N46_D1.8621.00
397_A426_V1.8291.00
229_W268_W1.8161.00
334_Y376_Y1.8151.00
283_W311_S1.7821.00
372_G398_N1.7681.00
259_G289_F1.7641.00
341_I369_T1.7341.00
190_V238_A1.7251.00
305_S348_D1.7151.00
333_W377_L1.6991.00
263_G285_L1.6861.00
192_G209_R1.6791.00
341_I367_V1.6761.00
335_V375_T1.6381.00
259_G287_N1.6291.00
317_T336_Q1.6201.00
186_W217_D1.6141.00
395_I428_T1.6111.00
42_N75_G1.5991.00
30_T37_P1.5991.00
9_G39_D1.5971.00
345_G365_G1.5931.00
193_H208_N1.5911.00
293_V301_D1.5781.00
304_D349_S1.5781.00
400_I425_E1.5701.00
70_E108_N1.5621.00
191_G210_Y1.5591.00
242_S255_G1.5561.00
289_F307_G1.5541.00
74_V78_S1.5501.00
46_D77_N1.5421.00
291_N303_Y1.5381.00
11_V40_K1.5311.00
286_Y308_V1.5291.00
370_R398_N1.5271.00
288_W306_R1.5211.00
279_Y313_E1.5161.00
160_S166_R1.5101.00
183_S218_L1.5021.00
143_P146_G1.4981.00
338_Q396_E1.4941.00
280_V314_G1.4941.00
199_G202_Q1.4861.00
29_A38_T1.4791.00
25_M41_M1.4671.00
89_V92_G1.4661.00
233_V264_L1.4641.00
13_T42_N1.4601.00
445_G457_Q1.4511.00
185_M216_G1.4461.00
333_W375_T1.4301.00
237_Y260_Y1.4231.00
28_N39_D1.4141.00
284_A308_V1.4081.00
446_V456_T1.3981.00
299_S356_G1.3851.00
142_R146_G1.3781.00
410_M413_Q1.3681.00
155_A158_L1.3661.00
141_Y146_G1.3511.00
42_N73_E1.3441.00
403_S406_Y1.3391.00
242_S257_I1.3271.00
19_T48_Q1.3271.00
394_Y443_N1.3221.00
144_E148_Y1.3211.00
166_R170_P1.3201.00
350_D358_R1.3201.00
187_M214_L1.3191.00
24_L54_R1.3051.00
99_A112_T1.3001.00
234_M285_L1.2841.00
232_G265_Y1.2771.00
74_V77_N1.2771.00
116_D128_N1.2751.00
89_V96_Y1.2741.00
332_T377_L1.2731.00
186_W215_G1.2681.00
431_E441_W1.2631.00
229_W266_A1.2631.00
101_G108_N1.2571.00
14_V17_N1.2541.00
13_T44_K1.2531.00
303_Y348_D1.2531.00
186_W265_Y1.2491.00
281_D315_G1.2481.00
207_A240_Q1.2411.00
280_V312_V1.2361.00
51_T83_A1.2351.00
255_G293_V1.2301.00
288_W304_D1.2271.00
278_A314_G1.2241.00
369_T401_N1.2221.00
285_L309_T1.2111.00
117_G120_P1.2101.00
63_A66_V1.2071.00
244_T253_S1.2051.00
138_P144_E1.1840.99
46_D76_G1.1830.99
153_A157_S1.1820.99
391_F430_V1.1790.99
371_L399_W1.1790.99
369_T403_S1.1720.99
166_R171_Q1.1650.99
32_G36_S1.1630.99
143_P148_Y1.1610.99
189_H210_Y1.1560.99
352_T358_R1.1520.99
434_V440_L1.1510.99
317_T334_Y1.1450.99
98_L101_G1.1370.99
369_T422_N1.1330.99
142_R148_Y1.1280.99
14_V43_V1.1220.99
321_G331_N1.1110.99
138_P146_G1.1060.99
184_S217_D1.1030.99
68_G112_T1.0990.99
353_R357_T1.0950.99
160_S342_T1.0770.99
351_H359_I1.0730.99
398_N425_E1.0680.99
370_R425_E1.0630.99
311_S342_T1.0600.99
196_S205_T1.0580.99
187_M212_L1.0570.99
338_Q372_G1.0530.99
213_Q236_G1.0480.99
295_S357_T1.0470.99
11_V42_N1.0460.99
62_G65_T1.0410.99
81_N100_K1.0410.99
336_Q374_K1.0400.99
294_S300_A1.0400.99
25_M51_T1.0400.99
426_V448_L1.0350.98
91_A96_Y1.0280.98
143_P147_S1.0280.98
115_W128_N1.0250.98
84_L89_V1.0240.98
20_G47_T1.0220.98
348_D362_E1.0220.98
159_F166_R1.0210.98
141_Y148_Y1.0160.98
359_I408_V1.0150.98
409_K412_G1.0080.98
403_S407_A1.0060.98
101_G110_Y1.0060.98
24_L52_R1.0050.98
188_R213_Q1.0000.98
217_D232_G0.9990.98
221_W227_D0.9980.98
435_N438_L0.9920.98
82_F109_W0.9860.98
279_Y338_Q0.9850.98
164_H168_G0.9700.98
26_T54_R0.9700.98
17_N45_G0.9690.98
290_D304_D0.9680.98
20_G82_F0.9650.98
138_P143_P0.9590.97
30_T33_G0.9580.97
301_D351_H0.9580.97
41_M72_I0.9500.97
167_L170_P0.9480.97
47_T72_I0.9480.97
368_Q402_N0.9470.97
138_P142_R0.9470.97
47_T78_S0.9450.97
393_P430_V0.9420.97
18_Y51_T0.9410.97
320_A335_V0.9390.97
336_Q376_Y0.9380.97
160_S164_H0.9330.97
243_N254_D0.9280.97
238_A261_S0.9240.97
367_V402_N0.9180.97
321_G332_T0.9160.97
290_D302_D0.9140.97
43_V47_T0.9100.97
163_L167_L0.9080.97
164_H167_L0.9070.96
100_K109_W0.9070.96
408_V411_N0.9070.96
289_F305_S0.9060.96
77_N107_K0.8990.96
92_G96_Y0.8970.96
20_G51_T0.8940.96
431_E439_S0.8920.96
159_F163_L0.8900.96
140_V143_P0.8880.96
46_D74_V0.8850.96
375_T395_I0.8810.96
89_V95_V0.8790.96
441_W463_K0.8780.96
28_N56_D0.8780.96
116_D120_P0.8780.96
8_P11_V0.8710.96
27_F55_V0.8700.96
47_T80_G0.8690.96
231_L266_A0.8680.95
315_G336_Q0.8680.95
152_I158_L0.8640.95
345_G363_G0.8600.95
237_Y258_S0.8600.95
282_S314_G0.8590.95
93_A100_K0.8550.95
142_R147_S0.8540.95
147_S253_S0.8530.95
376_Y392_Q0.8520.95
26_T56_D0.8520.95
374_K396_E0.8520.95
162_R170_P0.8490.95
209_R240_Q0.8490.95
360_E363_G0.8470.95
306_R349_S0.8470.95
163_L269_Y0.8460.95
301_D353_R0.8450.95
389_R432_A0.8430.95
141_Y144_E0.8420.95
27_F41_M0.8410.95
77_N81_N0.8410.95
378_N392_Q0.8400.95
152_I156_N0.8370.95
394_Y431_E0.8360.94
219_A230_H0.8360.94
380_H390_E0.8340.94
26_T30_T0.8340.94
311_S340_Q0.8330.94
439_S465_S0.8330.94
153_A156_N0.8310.94
313_E340_Q0.8310.94
40_K70_E0.8290.94
53_V98_L0.8230.94
367_V404_K0.8210.94
305_S349_S0.8200.94
107_K112_T0.8190.94
135_P138_P0.8180.94
146_G293_V0.8170.94
55_V71_L0.8150.94
241_H254_D0.8150.94
162_R167_L0.8140.94
397_A424_G0.8140.94
27_F31_L0.8140.94
408_V413_Q0.8120.94
68_G110_Y0.8110.94
309_T344_M0.8100.93
350_D361_T0.8100.93
154_A158_L0.8070.93
166_R281_D0.8040.93
408_V412_G0.8010.93
70_E74_V0.7980.93
159_F162_R0.7980.93
102_K107_K0.7970.93
53_V84_L0.7920.93
211_V238_A0.7890.93
118_V128_N0.7870.92
14_V28_N0.7870.92
183_S216_G0.7850.92
370_R400_I0.7840.92
45_G76_G0.7830.92
205_T242_S0.7810.92
262_A288_W0.7800.92
287_N307_G0.7790.92
18_Y41_M0.7780.92
159_F165_D0.7770.92
203_L251_Y0.7720.92
458_G464_Y0.7710.92
100_K107_K0.7680.92
20_G50_N0.7660.91
167_L171_Q0.7660.91
306_R397_A0.7650.91
111_L115_W0.7650.91
33_G36_S0.7610.91
399_W424_G0.7610.91
152_I155_A0.7600.91
141_Y145_A0.7600.91
62_G66_V0.7590.91
16_G45_G0.7590.91
404_K407_A0.7580.91
49_G109_W0.7570.91
270_Q278_A0.7560.91
159_F170_P0.7550.91
396_E443_N0.7540.91
291_N348_D0.7540.91
19_T46_D0.7500.91
206_Q243_N0.7490.91
78_S109_W0.7480.90
377_L393_P0.7480.90
427_R443_N0.7450.90
350_D362_E0.7450.90
52_R85_T0.7440.90
143_P155_A0.7430.90
448_L456_T0.7400.90
163_L166_R0.7400.90
28_N31_L0.7400.90
20_G25_M0.7390.90
390_E393_P0.7390.90
239_N243_N0.7390.90
368_Q400_I0.7380.90
9_G37_P0.7340.90
40_K73_E0.7310.89
171_Q281_D0.7300.89
78_S107_K0.7250.89
254_D296_D0.7220.89
380_H388_Q0.7210.89
449_G452_G0.7210.89
301_D359_I0.7200.89
9_G30_T0.7190.89
420_A452_G0.7170.89
281_D311_S0.7170.89
115_W118_V0.7170.89
91_A100_K0.7160.88
270_Q276_T0.7160.88
64_Q69_I0.7120.88
307_G346_V0.7100.88
309_T342_T0.7100.88
268_W280_V0.7080.88
29_A36_S0.7030.88
280_V315_G0.7030.88
138_P141_Y0.7000.87
14_V18_Y0.6990.87
348_D466_W0.6970.87
148_Y152_I0.6950.87
9_G13_T0.6950.87
301_D355_D0.6940.87
48_Q79_A0.6940.87
140_V147_S0.6910.87
140_V146_G0.6910.87
151_N155_A0.6880.86
145_A149_I0.6840.86
402_N405_V0.6840.86
186_W313_E0.6820.86
279_Y336_Q0.6800.86
295_S355_D0.6760.85
70_E110_Y0.6720.85
211_V236_G0.6710.85
277_G316_Y0.6690.85
161_H340_Q0.6680.85
400_I447_Q0.6660.85
159_F164_H0.6660.85
18_Y47_T0.6660.85
115_W120_P0.6660.85
344_M368_Q0.6650.85
304_D365_G0.6650.85
119_T128_N0.6640.84
170_P463_K0.6640.84
146_G149_I0.6640.84
89_V94_Y0.6640.84
234_M265_Y0.6630.84
46_D50_N0.6630.84
55_V60_G0.6580.84
213_Q261_S0.6570.84
313_E370_R0.6560.84
51_T81_N0.6550.84
317_T376_Y0.6540.84
10_N27_F0.6540.84
92_G100_K0.6530.83
18_Y23_G0.6530.83
194_E455_D0.6530.83
162_R169_E0.6520.83
310_A343_W0.6520.83
30_T61_V0.6490.83
221_W229_W0.6470.83
425_E447_Q0.6460.83
38_T49_G0.6460.83
430_V442_G0.6460.83
143_P154_A0.6460.83
150_S153_A0.6440.83
188_R340_Q0.6430.83
32_G37_P0.6430.83
166_R169_E0.6410.82
139_S142_R0.6400.82
29_A32_G0.6390.82
166_R217_D0.6390.82
96_Y113_S0.6350.82
263_G283_W0.6330.82
185_M237_Y0.6330.82
168_G188_R0.6320.81
110_Y113_S0.6310.81
39_D76_G0.6300.81
52_R83_A0.6300.81
159_F167_L0.6300.81
153_A158_L0.6250.81
51_T71_L0.6240.81
217_D220_Q0.6230.81
257_I291_N0.6230.81
31_L36_S0.6230.81
62_G68_G0.6220.80
340_Q398_N0.6210.80
160_S168_G0.6210.80
186_W336_Q0.6210.80
31_L57_N0.6200.80
73_E78_S0.6180.80
429_G443_N0.6180.80
293_V353_R0.6180.80
147_S150_S0.6180.80
59_G91_A0.6150.80
392_Q433_K0.6110.79
28_N71_L0.6100.79
20_G43_V0.6100.79
379_S393_P0.6100.79
37_P44_K0.6090.79
239_N256_R0.6090.79
67_N91_A0.6070.79
148_Y153_A0.6070.79
55_V111_L0.6070.79
162_R165_D0.6070.79
203_L244_T0.6040.78
136_E140_V0.5990.78
342_T400_I0.5990.78
311_S370_R0.5960.78
423_L447_Q0.5960.78
447_Q455_D0.5950.77
116_D119_T0.5930.77
151_N154_A0.5920.77
392_Q431_E0.5920.77
182_A219_A0.5920.77
26_T29_A0.5910.77
236_G287_N0.5900.77
342_T368_Q0.5900.77
65_T69_I0.5870.76
409_K413_Q0.5870.76
9_G25_M0.5860.76
402_N423_L0.5850.76
146_G151_N0.5830.76
24_L53_V0.5830.76
144_E147_S0.5820.76
107_K115_W0.5810.76
163_L168_G0.5790.75
109_W113_S0.5790.75
256_R294_S0.5750.75
443_N459_M0.5740.75
197_R292_S0.5740.75
120_P129_N0.5740.75
282_S286_Y0.5730.75
221_W228_R0.5720.75
293_V299_S0.5720.75
240_Q257_I0.5710.74
47_T107_K0.5700.74
373_V403_S0.5690.74
338_Q394_Y0.5690.74
438_L442_G0.5690.74
220_Q262_A0.5680.74
185_M235_A0.5680.74
18_Y22_N0.5680.74
164_H336_Q0.5680.74
60_G63_A0.5680.74
138_P147_S0.5660.74
27_F38_T0.5660.74
283_W340_Q0.5650.74
257_I303_Y0.5640.74
401_N420_A0.5630.73
27_F53_V0.5610.73
82_F98_L0.5600.73
93_A98_L0.5600.73
262_A341_I0.5600.73
154_A157_S0.5590.73
423_L449_G0.5580.73
393_P397_A0.5580.73
238_A259_G0.5570.73
77_N80_G0.5560.73
367_V403_S0.5550.72
160_S167_L0.5550.72
135_P139_S0.5540.72
90_E96_Y0.5540.72
388_Q393_P0.5530.72
235_A262_A0.5530.72
446_V454_S0.5530.72
192_G196_S0.5520.72
435_N465_S0.5520.72
213_Q234_M0.5520.72
26_T32_G0.5510.72
442_G460_L0.5500.72
73_E108_N0.5500.72
185_M189_H0.5500.72
442_G458_G0.5490.72
191_G211_V0.5490.72
148_Y353_R0.5470.71
400_I423_L0.5450.71
446_V455_D0.5450.71
49_G78_S0.5450.71
19_T75_G0.5430.71
93_A96_Y0.5420.71
236_G263_G0.5420.71
281_D336_Q0.5400.70
23_G26_T0.5400.70
20_G49_G0.5400.70
156_N344_M0.5370.70
281_D370_R0.5370.70
31_L60_G0.5370.70
342_T370_R0.5350.70
160_S169_E0.5340.70
202_Q417_R0.5340.70
293_V303_Y0.5330.69
137_G140_V0.5330.69
78_S100_K0.5310.69
10_N14_V0.5310.69
399_W426_V0.5300.69
290_D294_S0.5290.69
350_D360_E0.5290.69
206_Q349_S0.5290.69
91_A94_Y0.5280.69
38_T69_I0.5250.68
395_I424_G0.5240.68
17_N37_P0.5240.68
203_L246_S0.5230.68
90_E94_Y0.5230.68
142_R145_A0.5220.68
12_L18_Y0.5210.68
10_N33_G0.5210.68
279_Y370_R0.5200.68
160_S163_L0.5200.68
161_H167_L0.5200.68
58_I67_N0.5190.67
38_T92_G0.5190.67
120_P135_P0.5190.67
8_P39_D0.5190.67
302_D427_R0.5180.67
192_G455_D0.5180.67
14_V20_G0.5170.67
255_G433_K0.5170.67
98_L109_W0.5160.67
60_G68_G0.5150.67
22_N31_L0.5150.67
193_H458_G0.5140.67
185_M464_Y0.5140.67
143_P157_S0.5140.67
320_A333_W0.5140.67
292_S405_V0.5140.67
158_L287_N0.5120.66
23_G31_L0.5120.66
74_V80_G0.5110.66
402_N420_A0.5110.66
143_P151_N0.5100.66
79_A100_K0.5100.66
320_A440_L0.5100.66
439_S442_G0.5090.66
84_L87_G0.5080.66
168_G313_E0.5060.65
160_S309_T0.5060.65
94_Y100_K0.5050.65
11_V39_D0.5040.65
442_G461_G0.5040.65
286_Y399_W0.5040.65
320_A331_N0.5040.65
88_T95_V0.5040.65
147_S153_A0.5040.65
270_Q280_V0.5030.65
313_E342_T0.5030.65
201_G204_N0.5020.65
20_G109_W0.5020.65
63_A92_G0.5010.65
160_S170_P0.5000.65
256_R292_S0.5000.65
252_K264_L0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4meeA 1 0.6502 100 0.253 Contact Map
3sltA 1 0.6352 100 0.474 Contact Map
3qq2A 2 0.5258 100 0.478 Contact Map
3aehA 1 0.5858 100 0.49 Contact Map
1uynX 1 0.5773 100 0.494 Contact Map
3kvnX 1 0.9013 100 0.513 Contact Map
3ml3A 1 0.2468 99.6 0.783 Contact Map
3syjA 2 0.2232 99.4 0.808 Contact Map
3h09A 1 0.2232 99.2 0.827 Contact Map
1wxrA 1 0.2682 99.1 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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