GREMLIN Database
EUTJ - Ethanolamine utilization protein EutJ
UniProt: P77277 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14184
Length: 278 (239)
Sequences: 11458 (6483)
Seq/√Len: 419.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_E192_R3.3481.00
95_H119_E3.1061.00
214_A244_Q3.0731.00
142_V209_M3.0051.00
164_D208_K2.9221.00
175_T204_P2.7171.00
255_H258_F2.4571.00
41_V81_H2.4331.00
189_Q193_G2.2761.00
82_L86_E2.2091.00
39_C146_G2.1641.00
203_K207_E2.1281.00
99_S264_I2.0931.00
80_R84_T2.0551.00
98_T113_L2.0451.00
75_V115_S2.0321.00
179_N201_A2.0151.00
239_E243_K2.0091.00
242_R249_Q1.9901.00
38_T147_G1.9641.00
210_A244_Q1.9111.00
233_M257_L1.9061.00
153_I216_H1.9001.00
138_N155_K1.8581.00
231_S234_Q1.8481.00
172_I202_V1.8431.00
172_I205_V1.8211.00
197_E200_P1.8161.00
240_L243_K1.8001.00
210_A240_L1.7931.00
194_H197_E1.7781.00
238_A252_L1.7661.00
44_M265_A1.7651.00
137_D223_T1.7301.00
177_A184_L1.7191.00
203_K240_L1.7091.00
144_I149_T1.7011.00
198_I234_Q1.6761.00
107_R111_N1.6671.00
195_G199_W1.6571.00
206_Y236_G1.6431.00
175_T205_V1.6371.00
202_V234_Q1.6121.00
95_H121_S1.6111.00
111_N114_E1.6031.00
153_I220_Q1.5931.00
44_M261_P1.5921.00
140_G153_I1.5631.00
258_F262_L1.5591.00
79_R83_D1.5391.00
68_V73_G1.5371.00
43_S81_H1.5301.00
76_T79_R1.5271.00
202_V206_Y1.4941.00
215_R219_G1.4771.00
210_A214_A1.4721.00
137_D224_D1.4721.00
125_D128_T1.4691.00
175_T178_G1.4531.00
211_D215_R1.4481.00
159_V162_S1.4261.00
32_L43_S1.4101.00
206_Y240_L1.3951.00
202_V205_V1.3881.00
186_E189_Q1.3851.00
200_P203_K1.3841.00
74_A109_S1.3721.00
255_H262_L1.3601.00
83_D87_Q1.3541.00
51_Q58_D1.3531.00
144_I172_I1.3511.00
176_L187_A1.3501.00
225_L245_F1.3411.00
82_L118_L1.3381.00
151_I216_H1.3271.00
238_A242_R1.3251.00
110_I114_E1.3241.00
54_A57_L1.3131.00
62_V67_I1.3091.00
224_D251_H1.3011.00
124_L267_S1.2991.00
169_G231_S1.2951.00
177_A187_A1.2951.00
86_E92_R1.2801.00
240_L244_Q1.2801.00
71_F111_N1.2791.00
36_L74_A1.2741.00
47_D50_G1.2701.00
180_R187_A1.2641.00
42_V261_P1.2621.00
213_V241_F1.2491.00
174_L178_G1.2441.00
182_I186_E1.2411.00
179_N197_E1.2091.00
236_G239_E1.1931.00
140_G151_I1.1921.00
101_P104_T1.1901.00
199_W239_E1.1891.00
203_K236_G1.1811.00
227_L241_F1.1761.00
149_T209_M1.1681.00
33_G264_I1.1631.00
100_F123_V1.1621.00
31_W268_G1.1481.00
172_I231_S1.1431.00
36_L78_V1.1411.00
144_I237_V1.1361.00
40_D257_L1.1341.00
142_V149_T1.1231.00
172_I198_I1.1131.00
68_V76_T1.1121.00
80_R83_D1.0961.00
124_L129_A1.0951.00
62_V65_D1.0811.00
151_I212_I1.0801.00
72_F115_S1.0701.00
36_L109_S1.0701.00
215_R218_E1.0681.00
174_L177_A1.0551.00
126_E150_G1.0551.00
46_V269_R1.0511.00
214_A218_E1.0401.00
174_L184_L1.0301.00
216_H220_Q1.0281.00
207_E240_L1.0261.00
102_P127_P1.0241.00
130_V228_A1.0221.00
185_E189_Q1.0141.00
106_P125_D1.0141.00
33_G261_P1.0131.00
267_S270_E1.0131.00
207_E211_D1.0121.00
140_G213_V1.0111.00
95_H120_V1.0081.00
172_I234_Q1.0061.00
227_L232_C1.0001.00
52_P55_V0.9961.00
163_A215_R0.9931.00
31_W121_S0.9921.00
239_E242_R0.9811.00
175_T202_V0.9751.00
97_A268_G0.9731.00
241_F250_V0.9731.00
198_I231_S0.9721.00
122_H267_S0.9681.00
198_I202_V0.9621.00
236_G240_L0.9611.00
130_V260_T0.9581.00
161_Y216_H0.9551.00
53_V57_L0.9491.00
110_I123_V0.9431.00
114_E119_E0.9421.00
143_D150_G0.9401.00
147_G150_G0.9401.00
186_E190_Y0.9311.00
207_E210_A0.9311.00
134_L226_W0.9281.00
197_E201_A0.9251.00
228_A259_M0.9191.00
82_L96_A0.9121.00
45_V89_F0.9121.00
75_V79_R0.9061.00
81_H84_T0.9051.00
144_I231_S0.8911.00
173_S188_E0.8881.00
207_E244_Q0.8841.00
83_D86_E0.8761.00
71_F108_I0.8701.00
33_G265_A0.8641.00
199_W203_K0.8601.00
187_A190_Y0.8561.00
202_V236_G0.8551.00
79_R82_L0.8541.00
52_P57_L0.8511.00
195_G235_P0.8381.00
111_N115_S0.8371.00
41_V77_I0.8331.00
51_Q54_A0.8311.00
211_D214_A0.8211.00
196_E199_W0.8201.00
70_D74_A0.8201.00
184_L187_A0.8161.00
173_S184_L0.8141.00
131_A154_V0.8101.00
187_A192_R0.8081.00
33_G37_G0.8061.00
195_G198_I0.8021.00
128_T154_V0.7991.00
191_K231_S0.7941.00
84_T87_Q0.7911.00
196_E200_P0.7881.00
144_I209_M0.7881.00
138_N223_T0.7851.00
71_F75_V0.7831.00
60_A65_D0.7821.00
34_V96_A0.7811.00
201_A204_P0.7791.00
46_V50_G0.7781.00
55_V58_D0.7731.00
208_K211_D0.7701.00
72_F75_V0.7681.00
100_F106_P0.7661.00
107_R110_I0.7661.00
164_D167_T0.7631.00
63_V66_G0.7621.00
106_P110_I0.7581.00
172_I206_Y0.7581.00
109_S112_V0.7461.00
134_L259_M0.7441.00
132_D267_S0.7411.00
166_A171_H0.7381.00
242_R250_V0.7361.00
37_G49_D0.7271.00
217_I220_Q0.7231.00
216_H219_G0.7191.00
86_E93_F0.7171.00
60_A67_I0.7161.00
72_F76_T0.7141.00
133_L262_L0.7141.00
60_A63_V0.7131.00
177_A181_R0.7121.00
135_Q157_G0.7111.00
199_W236_G0.7101.00
167_T171_H0.7081.00
245_F248_L0.7031.00
74_A78_V0.6991.00
73_G76_T0.6981.00
138_N222_I0.6981.00
167_T208_K0.6971.00
98_T109_S0.6901.00
38_T148_T0.6851.00
153_I222_I0.6851.00
189_Q192_R0.6851.00
76_T80_R0.6841.00
143_D147_G0.6801.00
126_E146_G0.6791.00
94_S119_E0.6781.00
100_F125_D0.6781.00
106_P123_V0.6721.00
262_L266_S0.6721.00
77_I81_H0.6711.00
133_L259_M0.6711.00
127_P148_T0.6680.99
212_I216_H0.6640.99
98_T101_P0.6640.99
42_V258_F0.6600.99
176_L179_N0.6590.99
108_I112_V0.6580.99
183_S190_Y0.6560.99
210_A213_V0.6550.99
127_P130_V0.6540.99
99_S102_P0.6530.99
51_Q55_V0.6520.99
155_K160_T0.6460.99
34_V78_V0.6440.99
176_L201_A0.6420.99
205_V208_K0.6400.99
142_V213_V0.6390.99
136_L157_G0.6360.99
108_I111_N0.6340.99
186_E193_G0.6330.99
86_E90_G0.6330.99
183_S187_A0.6320.99
32_L85_L0.6280.99
202_V231_S0.6260.99
46_V265_A0.6250.99
65_D68_V0.6250.99
99_S260_T0.6240.99
191_K234_Q0.6190.99
74_A77_I0.6180.99
214_A245_F0.6180.99
32_L93_F0.6140.99
142_V151_I0.6130.99
85_L89_F0.6100.99
54_A58_D0.6080.99
126_E148_T0.6060.99
71_F115_S0.6050.99
225_L248_L0.6020.99
32_L96_A0.6020.99
183_S191_K0.6020.99
180_R183_S0.5990.99
112_V116_A0.5940.99
126_E260_T0.5930.99
175_T201_A0.5920.99
144_I232_C0.5920.99
187_A191_K0.5920.99
59_W62_V0.5860.99
163_A219_G0.5850.99
213_V244_Q0.5830.99
31_W95_H0.5830.99
227_L237_V0.5820.99
75_V112_V0.5820.99
124_L128_T0.5810.99
204_P207_E0.5800.99
53_V56_C0.5800.99
52_P56_C0.5770.99
102_P109_S0.5760.99
251_H259_M0.5760.99
104_T109_S0.5750.99
247_A250_V0.5740.98
100_F109_S0.5740.98
143_D146_G0.5740.98
170_H173_S0.5710.98
173_S187_A0.5690.98
178_G181_R0.5690.98
32_L89_F0.5680.98
164_D168_G0.5670.98
70_D73_G0.5670.98
232_C252_L0.5660.98
233_M255_H0.5660.98
213_V245_F0.5650.98
168_G171_H0.5650.98
109_S123_V0.5640.98
171_H174_L0.5600.98
130_V146_G0.5550.98
217_I221_G0.5550.98
113_L123_V0.5540.98
69_W72_F0.5540.98
225_L241_F0.5500.98
63_V68_V0.5490.98
182_I190_Y0.5480.98
68_V71_F0.5460.98
36_L77_I0.5440.98
141_V228_A0.5440.98
146_G150_G0.5430.98
61_D64_R0.5430.98
59_W63_V0.5430.98
212_I215_R0.5410.98
90_G93_F0.5410.98
60_A64_R0.5400.98
210_A243_K0.5400.98
96_A118_L0.5380.98
170_H184_L0.5370.98
33_G104_T0.5350.98
242_R251_H0.5320.98
45_V48_R0.5280.97
34_V98_T0.5280.97
165_E212_I0.5270.97
99_S104_T0.5260.97
206_Y234_Q0.5240.97
190_Y193_G0.5220.97
37_G46_V0.5220.97
173_S191_K0.5210.97
143_D148_T0.5210.97
183_S186_E0.5200.97
112_V115_S0.5190.97
114_E120_V0.5120.97
209_M237_V0.5120.97
35_D147_G0.5110.97
40_D192_R0.5100.97
208_K212_I0.5100.97
36_L40_D0.5080.97
206_Y210_A0.5080.97
253_P259_M0.5060.97
42_V257_L0.5040.97
176_L198_I0.5030.97
133_L266_S0.5000.96
210_A237_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jneA 2 0.8957 100 0.324 Contact Map
3d2fA 1 0.8921 100 0.324 Contact Map
4fl9A 1 0.8849 100 0.33 Contact Map
2v7yA 1 0.8993 100 0.331 Contact Map
3i33A 1 0.8777 100 0.361 Contact Map
4kboA 1 0.8705 100 0.365 Contact Map
4rtfD 1 0.8705 100 0.37 Contact Map
4j8fA 2 0.9137 100 0.371 Contact Map
4gniA 2 0.8741 100 0.398 Contact Map
3h1qA 1 0.946 100 0.399 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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