GREMLIN Database
PTYBC - PTS system N-acetylmuramic acid-specific EIIBC component
UniProt: P77272 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14163
Length: 474 (438)
Sequences: 3711 (2188)
Seq/√Len: 104.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
407_F454_V4.1041.00
400_G458_C3.8831.00
305_G402_A3.7741.00
8_E12_T3.6891.00
352_A460_F3.4511.00
45_P48_K3.4261.00
235_A271_A3.4111.00
37_V43_V3.2811.00
262_I266_I3.1781.00
14_L79_M3.0931.00
40_S58_L3.0901.00
16_R44_D2.9391.00
9_L50_L2.9321.00
178_G192_G2.8721.00
407_F447_V2.8711.00
51_E362_A2.8471.00
239_C263_T2.7261.00
403_A458_C2.6961.00
39_D42_L2.6421.00
55_G66_V2.5451.00
7_S11_N2.5181.00
346_Q387_T2.5151.00
107_T112_Q2.5081.00
250_M258_L2.4911.00
396_T466_F2.4261.00
179_Y193_A2.4141.00
20_P84_G2.4081.00
78_A81_E2.3801.00
24_A38_H2.3771.00
35_L65_V2.3691.00
245_M249_F2.3211.00
326_L333_N2.3191.00
246_V262_I2.2871.00
16_R46_N2.2741.00
247_R255_D2.2461.00
407_F411_I2.2331.00
7_S78_A2.2251.00
16_R50_L2.2091.00
411_I447_V2.2081.00
238_A270_L2.2041.00
449_A453_L2.1811.00
35_L79_M2.1561.00
17_V35_L2.1491.00
78_A82_L2.1211.00
179_Y189_G2.0991.00
175_I197_A2.0511.00
26_C79_M2.0451.00
304_A401_G2.0351.00
357_A363_L2.0041.00
12_T50_L1.9531.00
11_N82_L1.9431.00
14_L83_L1.9141.00
26_C35_L1.9081.00
254_L258_L1.9081.00
137_I141_I1.9001.00
116_K185_F1.8951.00
13_I47_I1.8831.00
348_G459_G1.8151.00
408_I451_G1.7731.00
396_T462_F1.7701.00
461_I465_L1.7571.00
25_S36_G1.7521.00
354_Y368_R1.7491.00
12_T15_T1.7441.00
241_R244_G1.7381.00
281_W285_G1.7371.00
447_V450_G1.7361.00
348_G456_W1.7321.00
28_N76_A1.7071.00
462_F466_F1.7021.00
175_I193_A1.6961.00
351_L371_I1.6871.00
347_V374_G1.6821.00
46_N49_T1.6731.00
135_L167_K1.6571.00
241_R245_M1.6431.00
141_I146_H1.6361.00
234_I279_G1.6311.00
47_I50_L1.6301.00
458_C462_F1.6241.00
246_V250_M1.6191.00
395_V399_L1.6161.00
76_A80_S1.6141.00
187_G236_A1.6051.00
301_A406_L1.6011.00
11_N15_T1.5951.00
390_R393_P1.5811.00
350_A382_L1.5801.00
57_I66_V1.5701.00
13_I67_F1.5571.00
300_C405_G1.5561.00
258_L262_I1.5461.00
242_I267_T1.5461.00
383_I394_F1.5421.00
10_L79_M1.5361.00
183_Q189_G1.5331.00
396_T400_G1.5271.00
115_A184_A1.5191.00
332_F414_W1.5141.00
309_I398_C1.5051.00
457_V461_I1.5031.00
109_G112_Q1.4811.00
17_V37_V1.4781.00
237_W240_A1.4641.00
285_G289_L1.4611.00
23_I85_E1.4581.00
308_L343_G1.4551.00
284_E288_W1.4491.00
133_L261_L1.4271.00
181_A237_W1.4161.00
430_V433_P1.4101.00
45_P58_L1.4001.00
305_G309_I1.3951.00
182_A236_A1.3841.00
242_I266_I1.3791.00
406_L410_L1.3681.00
179_Y190_V1.3621.00
217_D220_G1.3570.99
353_L357_A1.3560.99
14_L82_L1.3390.99
237_W241_R1.3290.99
390_R468_C1.3260.99
422_S426_P1.3230.99
161_F223_I1.3200.99
26_C80_S1.3160.99
238_A275_I1.3070.99
301_A402_A1.3030.99
300_C406_L1.2840.99
400_G459_G1.2790.99
352_A464_T1.2750.99
109_G113_F1.2570.99
16_R47_I1.2480.99
340_S448_Y1.2480.99
47_I63_V1.2480.99
255_D259_T1.2270.99
356_R467_G1.2170.99
460_F464_T1.2100.99
403_A454_V1.2090.99
23_I83_L1.2090.99
399_L462_F1.2070.99
192_G196_A1.2050.99
407_F451_G1.2010.99
40_S61_D1.1950.99
289_L292_H1.1930.99
363_L390_R1.1890.99
407_F450_G1.1860.99
9_L52_G1.1610.98
427_S430_V1.1570.98
186_G244_G1.1520.98
292_H295_S1.1490.98
392_K467_G1.1470.98
177_V229_I1.1450.98
195_I264_L1.1430.98
121_F229_I1.1380.98
187_G239_C1.1380.98
300_C409_G1.1360.98
14_L23_I1.1350.98
12_T46_N1.1340.98
124_L173_L1.1330.98
463_T467_G1.1280.98
383_I397_A1.1280.98
182_A189_G1.1250.98
286_M310_A1.1230.98
196_A232_V1.1220.98
245_M248_R1.1180.98
180_N190_V1.1170.98
47_I53_V1.1120.98
267_T271_A1.1090.98
131_A169_L1.1080.98
10_L82_L1.1010.98
20_P83_L1.1010.98
182_A187_G1.0990.98
246_V259_T1.0960.98
167_K171_T1.0930.98
165_F268_A1.0930.98
427_S435_M1.0920.98
215_F220_G1.0920.98
182_A192_G1.0920.98
236_A240_A1.0870.98
134_L166_S1.0870.98
427_S431_A1.0860.98
341_M408_I1.0850.98
185_F237_W1.0830.98
67_F75_A1.0730.97
195_I232_V1.0730.97
400_G404_G1.0720.97
238_A267_T1.0710.97
348_G352_A1.0690.97
79_M83_L1.0690.97
140_L144_V1.0650.97
7_S82_L1.0580.97
8_E11_N1.0520.97
50_L53_V1.0510.97
77_K81_E1.0470.97
230_I234_I1.0460.97
404_G455_A1.0440.97
355_W460_F1.0410.97
290_F334_S1.0390.97
371_I375_L1.0360.97
79_M82_L1.0360.97
181_A233_L1.0300.97
188_T243_E1.0300.97
282_L285_G1.0280.97
454_V458_C1.0230.96
70_G252_D1.0200.96
119_T184_A1.0200.96
138_A159_L1.0160.96
198_L268_A1.0160.96
30_M378_V1.0100.96
353_L363_L1.0040.96
285_G288_W1.0030.96
349_A387_T1.0020.96
310_A319_F1.0020.96
124_L180_N1.0020.96
274_I278_L1.0010.96
45_P63_V0.9980.96
70_G74_R0.9970.96
187_G192_G0.9950.96
348_G375_L0.9950.96
40_S63_V0.9940.96
334_S337_P0.9940.96
356_R468_C0.9940.96
396_T463_T0.9930.96
279_G283_F0.9880.96
240_A244_G0.9850.96
369_G373_P0.9840.96
185_F240_A0.9840.96
13_I50_L0.9840.96
426_P430_V0.9830.96
387_T393_P0.9810.96
7_S81_E0.9800.96
120_I233_L0.9780.95
181_A185_F0.9760.95
294_N297_P0.9740.95
15_T46_N0.9740.95
172_F202_G0.9740.95
178_G232_V0.9690.95
444_A447_V0.9690.95
301_A403_A0.9670.95
80_S85_E0.9650.95
73_H77_K0.9620.95
168_G197_A0.9610.95
446_A450_G0.9600.95
349_A397_A0.9580.95
195_I267_T0.9570.95
230_I279_G0.9510.95
446_A449_A0.9500.95
116_K120_I0.9500.95
345_G397_A0.9460.95
176_L194_I0.9450.95
207_A216_H0.9430.94
281_W284_E0.9400.94
433_P436_T0.9400.94
9_L13_I0.9390.94
106_Q112_Q0.9370.94
177_V232_V0.9340.94
351_L355_W0.9330.94
423_A426_P0.9330.94
56_V63_V0.9320.94
24_A36_G0.9230.94
158_A161_F0.9090.93
456_W459_G0.9070.93
37_V63_V0.9000.93
252_D255_D0.9000.93
411_I454_V0.8980.93
148_P156_P0.8940.93
393_P396_T0.8930.93
325_A329_S0.8910.93
105_K109_G0.8900.93
404_G454_V0.8900.93
346_Q397_A0.8890.93
344_A347_V0.8870.92
10_L78_A0.8860.92
349_A393_P0.8820.92
218_F273_L0.8800.92
425_G434_L0.8770.92
392_K469_R0.8760.92
165_F198_L0.8740.92
200_L226_R0.8690.92
167_K201_L0.8680.92
217_D222_P0.8610.91
342_A346_Q0.8590.91
275_I279_G0.8580.91
175_I196_A0.8580.91
348_G455_A0.8550.91
319_F323_Y0.8540.91
247_R259_T0.8530.91
363_L367_V0.8500.91
58_L63_V0.8500.91
353_L386_V0.8490.91
234_I275_I0.8480.91
300_C338_I0.8470.91
242_I246_V0.8460.91
17_V63_V0.8460.91
250_M254_L0.8450.91
48_K389_P0.8450.91
101_Q104_A0.8440.90
354_Y364_R0.8430.90
131_A168_G0.8420.90
361_S364_R0.8410.90
363_L386_V0.8400.90
278_L282_L0.8400.90
307_F338_I0.8310.90
238_A242_I0.8290.90
178_G236_A0.8280.90
393_P463_T0.8270.90
12_T51_E0.8260.90
149_A155_L0.8260.90
354_Y367_V0.8250.89
186_G192_G0.8250.89
454_V457_V0.8200.89
300_C304_A0.8190.89
270_L275_I0.8180.89
225_P231_G0.8160.89
113_F116_K0.8160.89
41_S44_D0.8150.89
304_A405_G0.8140.89
353_L367_V0.8140.89
387_T397_A0.8110.89
28_N72_A0.8100.89
374_G379_G0.8070.88
408_I413_W0.8060.88
47_I65_V0.8060.88
26_C83_L0.8050.88
178_G193_A0.8050.88
427_S434_L0.8030.88
12_T16_R0.8030.88
309_I394_F0.8030.88
105_K112_Q0.7990.88
43_V56_V0.7980.88
455_A459_G0.7980.88
325_A328_D0.7970.88
223_I273_L0.7920.87
430_V435_M0.7900.87
187_G243_E0.7890.87
74_R252_D0.7850.87
422_S427_S0.7840.87
66_V384_Y0.7840.87
386_V390_R0.7830.87
250_M259_T0.7830.87
427_S433_P0.7810.87
46_N50_L0.7810.87
392_K468_C0.7760.86
8_E51_E0.7700.86
178_G196_A0.7700.86
110_V113_F0.7680.86
43_V63_V0.7680.86
356_R464_T0.7670.86
345_G349_A0.7630.85
306_L398_C0.7620.85
105_K108_S0.7590.85
15_T44_D0.7560.85
169_L176_L0.7550.85
251_P254_L0.7540.85
403_A407_F0.7500.84
379_G382_L0.7500.84
309_I313_F0.7500.84
192_G236_A0.7500.84
242_I263_T0.7480.84
13_I17_V0.7450.84
210_G214_G0.7450.84
176_L197_A0.7440.84
464_T467_G0.7430.84
176_L193_A0.7420.84
13_I16_R0.7420.84
341_M404_G0.7410.84
353_L393_P0.7400.84
116_K237_W0.7400.84
11_N20_P0.7390.84
48_K56_V0.7380.84
430_V434_L0.7330.83
453_L461_I0.7310.83
351_L460_F0.7310.83
395_V398_C0.7300.83
21_G42_L0.7300.83
250_M262_I0.7280.83
232_V236_A0.7280.83
340_S431_A0.7260.83
422_S436_T0.7250.82
191_N239_C0.7250.82
38_H42_L0.7240.82
125_I428_G0.7230.82
20_P85_E0.7210.82
80_S83_L0.7190.82
413_W451_G0.7190.82
426_P434_L0.7190.82
204_N272_Y0.7190.82
374_G382_L0.7170.82
157_D217_D0.7140.81
108_S111_Q0.7140.81
303_L310_A0.7140.81
423_A434_L0.7110.81
346_Q382_L0.7100.81
164_V201_L0.7100.81
99_K102_L0.7080.81
283_F315_V0.7080.81
40_S45_P0.7080.81
14_L17_V0.7070.81
115_A119_T0.7060.81
452_I455_A0.7050.81
77_K80_S0.7050.81
415_G434_L0.7030.80
99_K103_K0.6940.80
305_G398_C0.6940.80
287_S319_F0.6930.79
120_I185_F0.6930.79
308_L394_F0.6900.79
168_G198_L0.6880.79
359_P364_R0.6880.79
179_Y183_Q0.6870.79
7_S74_R0.6870.79
196_A263_T0.6860.79
308_L342_A0.6850.79
48_K55_G0.6830.79
114_L388_L0.6820.78
346_Q374_G0.6820.78
170_F173_L0.6820.78
138_A166_S0.6810.78
29_C32_R0.6810.78
399_L402_A0.6800.78
142_A159_L0.6780.78
413_W447_V0.6760.78
134_L261_L0.6760.78
346_Q379_G0.6760.78
424_F427_S0.6740.78
305_G395_V0.6730.77
187_G240_A0.6720.77
186_G243_E0.6710.77
396_T399_L0.6700.77
308_L383_I0.6690.77
266_I269_T0.6670.77
254_L376_L0.6660.77
140_L143_T0.6660.77
127_G194_I0.6660.77
437_S444_A0.6640.77
80_S84_G0.6630.76
215_F222_P0.6620.76
9_L67_F0.6620.76
426_P433_P0.6620.76
364_R368_R0.6610.76
293_L302_V0.6590.76
308_L346_Q0.6580.76
132_G321_P0.6580.76
133_L136_G0.6570.76
132_G136_G0.6570.76
432_L435_M0.6550.76
215_F219_F0.6530.75
79_M84_G0.6520.75
35_L63_V0.6510.75
280_G284_E0.6510.75
346_Q349_A0.6510.75
136_G300_C0.6500.75
10_L81_E0.6500.75
236_A239_C0.6490.75
158_A218_F0.6480.75
400_G462_F0.6480.75
171_T226_R0.6470.75
104_A112_Q0.6460.75
301_A304_A0.6460.75
27_G61_D0.6450.74
366_Q370_A0.6450.74
230_I312_V0.6450.74
263_T267_T0.6440.74
453_L457_V0.6420.74
205_P209_T0.6420.74
38_H85_E0.6390.74
81_E84_G0.6370.74
21_G38_H0.6370.74
33_L67_F0.6360.73
9_L75_A0.6350.73
356_R392_K0.6330.73
70_G73_H0.6330.73
335_L339_L0.6330.73
355_W463_T0.6330.73
120_I181_A0.6330.73
42_L49_T0.6320.73
464_T468_C0.6310.73
433_P437_S0.6290.73
21_G90_D0.6290.73
121_F321_P0.6280.73
160_N163_K0.6270.72
49_T362_A0.6270.72
29_C34_R0.6260.72
14_L20_P0.6220.72
427_S432_L0.6220.72
168_G201_L0.6210.72
311_V346_Q0.6210.72
243_E259_T0.6210.72
349_A463_T0.6200.72
144_V147_V0.6200.72
55_G313_F0.6200.72
17_V23_I0.6180.71
313_F384_Y0.6170.71
289_L293_L0.6170.71
9_L12_T0.6170.71
344_A456_W0.6160.71
355_W464_T0.6150.71
100_R103_K0.6140.71
342_A401_G0.6140.71
343_G379_G0.6140.71
411_I450_G0.6120.71
128_F317_Q0.6110.70
447_V454_V0.6070.70
135_L201_L0.6060.70
157_D160_N0.6050.70
10_L83_L0.6040.70
225_P276_M0.6020.69
283_F296_N0.6010.69
367_V371_I0.6010.69
40_S43_V0.6000.69
235_A267_T0.5990.69
371_I374_G0.5990.69
158_A219_F0.5990.69
344_A452_I0.5990.69
11_N78_A0.5980.69
187_G263_T0.5980.69
270_L274_I0.5970.69
243_E247_R0.5970.69
342_A397_A0.5970.69
235_A270_L0.5950.68
345_G400_G0.5950.68
341_M455_A0.5940.68
318_G321_P0.5940.68
305_G308_L0.5930.68
16_R43_V0.5910.68
400_G403_A0.5910.68
389_P393_P0.5910.68
343_G397_A0.5900.68
311_V342_A0.5900.68
238_A241_R0.5890.68
11_N23_I0.5880.68
288_W292_H0.5870.67
284_E329_S0.5860.67
80_S87_P0.5860.67
428_G434_L0.5860.67
424_F431_A0.5850.67
256_M259_T0.5820.67
104_A107_T0.5820.67
403_A406_L0.5800.66
407_F410_L0.5790.66
27_G65_V0.5790.66
349_A396_T0.5780.66
101_Q105_K0.5770.66
350_A387_T0.5760.66
306_L309_I0.5750.66
292_H296_N0.5750.66
120_I136_G0.5740.66
422_S431_A0.5740.66
401_G405_G0.5730.66
163_K167_K0.5730.66
165_F267_T0.5720.65
352_A463_T0.5710.65
387_T394_F0.5700.65
156_P160_N0.5700.65
48_K54_K0.5700.65
214_G217_D0.5690.65
216_H223_I0.5690.65
177_V181_A0.5680.65
66_V313_F0.5670.65
209_T212_Y0.5660.65
102_L105_K0.5660.65
12_T53_V0.5650.64
182_A239_C0.5650.64
168_G194_I0.5650.64
30_M427_S0.5630.64
188_T247_R0.5630.64
320_I323_Y0.5630.64
424_F433_P0.5630.64
288_W291_M0.5610.64
303_L319_F0.5600.64
125_I377_G0.5600.64
393_P397_A0.5570.63
9_L16_R0.5570.63
127_G176_L0.5570.63
194_I198_L0.5570.63
42_L65_V0.5560.63
347_V456_W0.5530.63
426_P435_M0.5530.63
413_W445_M0.5520.63
67_F70_G0.5520.63
84_G88_V0.5500.62
405_G409_G0.5500.62
341_M401_G0.5500.62
204_N208_T0.5490.62
342_A379_G0.5480.62
21_G79_M0.5470.62
125_I129_I0.5450.62
169_L194_I0.5450.62
432_L438_A0.5440.62
30_M256_M0.5440.62
303_L321_P0.5430.61
44_D186_G0.5420.61
323_Y333_N0.5410.61
350_A354_Y0.5410.61
160_N164_V0.5410.61
278_L281_W0.5410.61
343_G382_L0.5410.61
135_L171_T0.5400.61
128_F389_P0.5370.61
186_G236_A0.5370.61
315_V322_V0.5370.61
131_A173_L0.5350.60
108_S112_Q0.5350.60
13_I75_A0.5340.60
52_G75_A0.5320.60
41_S46_N0.5310.60
42_L47_I0.5300.60
303_L339_L0.5290.59
77_K87_P0.5280.59
154_T158_A0.5260.59
54_K67_F0.5250.59
36_G61_D0.5240.59
394_F398_C0.5230.59
171_T201_L0.5220.58
10_L75_A0.5220.58
189_G236_A0.5220.58
338_I405_G0.5200.58
23_I80_S0.5200.58
171_T202_G0.5180.58
304_A402_A0.5180.58
359_P362_A0.5170.58
169_L173_L0.5170.58
349_A353_L0.5170.58
133_L204_N0.5140.57
218_F222_P0.5130.57
140_L146_H0.5120.57
43_V65_V0.5100.57
54_K69_P0.5100.57
375_L456_W0.5090.57
130_A261_L0.5090.57
333_N337_P0.5080.56
448_Y452_I0.5070.56
303_L338_I0.5070.56
426_P436_T0.5060.56
145_M148_P0.5060.56
394_F397_A0.5060.56
45_P51_E0.5060.56
231_G276_M0.5050.56
41_S47_I0.5030.56
141_I147_V0.5030.56
396_T465_L0.5030.56
343_G371_I0.5030.56
27_G62_Q0.5030.56
347_V371_I0.5020.56
353_L390_R0.5020.56
308_L398_C0.5020.56
428_G438_A0.5020.56
27_G30_M0.5020.56
353_L387_T0.5020.56
148_P155_L0.5010.55
290_F322_V0.5010.55
367_V370_A0.5010.55
178_G186_G0.5010.55
206_A209_T0.5010.55
181_A239_C0.5010.55
86_A457_V0.5000.55
434_L437_S0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.7785 100 0.667 Contact Map
3ipjA 1 0.1983 100 0.803 Contact Map
1ibaA 1 0.1624 99.9 0.808 Contact Map
3bp3A 1 0.1688 99.9 0.809 Contact Map
2hwvA 1 0.1287 46.8 0.973 Contact Map
4n8nA 1 0.1076 46.2 0.973 Contact Map
3q9vA 1 0.1224 45.2 0.973 Contact Map
1m0sA 2 0.1603 42.5 0.974 Contact Map
4x84A 2 0.1624 42 0.974 Contact Map
2k4jA 1 0.1245 38.5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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