GREMLIN Database
ECPE - Probable fimbrial chaperone EcpE
UniProt: P77263 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13561
Length: 236 (209)
Sequences: 302 (223)
Seq/√Len: 15.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V146_T6.9301.00
65_I116_V3.3380.99
14_L18_C2.8590.97
28_I31_G2.8240.97
111_E198_P2.7100.96
15_T18_C2.6830.96
170_N184_C2.6340.96
151_R174_T2.4100.93
57_I121_V2.3860.93
50_N144_M2.3740.92
45_S195_Y2.2170.89
52_N143_V2.2160.89
46_K146_T2.1120.87
215_L218_N2.0730.86
21_A27_A2.0470.85
81_E140_P2.0030.84
50_N56_R1.9760.83
31_G34_T1.7980.76
114_Y196_L1.7790.76
58_Y138_T1.7750.75
105_G112_R1.7640.75
87_R93_A1.7550.75
120_E174_T1.7430.74
136_V168_V1.7300.74
49_V178_L1.7210.73
152_P173_N1.6770.71
114_Y193_A1.6680.71
28_I33_L1.6640.70
85_A93_A1.6390.69
24_L82_L1.6290.69
116_V148_L1.6270.69
113_Y146_T1.6220.68
86_P172_G1.6150.68
103_Y197_R1.6030.68
84_F101_F1.5860.67
14_L23_P1.5740.66
24_L27_A1.5690.66
117_S145_D1.5690.66
49_V114_Y1.5670.66
177_K195_Y1.5580.65
15_T19_M1.5540.65
16_A22_A1.5450.65
133_G171_T1.5450.65
13_L219_D1.5430.64
105_G113_Y1.5400.64
62_I116_V1.5260.64
46_K113_Y1.5240.63
46_K197_R1.5180.63
14_L19_M1.5140.63
31_G50_N1.5080.63
178_L215_L1.4490.59
147_I197_R1.4360.59
47_R64_A1.4250.58
17_V156_Q1.4190.58
51_N94_G1.4050.57
68_P91_L1.3890.56
16_A201_V1.3750.55
18_C21_A1.3660.55
34_T149_V1.3570.54
107_R117_S1.3480.54
21_A70_S1.3450.54
68_P152_P1.3450.54
145_D177_K1.3420.53
65_I147_I1.3400.53
20_L39_S1.3210.52
15_T25_T1.3090.52
176_F221_F1.2910.51
88_Q117_S1.2890.50
93_A125_N1.2490.48
113_Y118_F1.2410.48
196_L209_Q1.2350.47
185_D196_L1.2340.47
28_I196_L1.2330.47
50_N143_V1.2240.47
14_L17_V1.2220.47
90_A217_Y1.2190.46
57_I138_T1.1970.45
84_F90_A1.1870.45
47_R118_F1.1790.44
13_L216_V1.1590.43
160_S167_T1.1520.43
128_R165_T1.1470.42
168_V178_L1.1460.42
28_I34_T1.1370.42
112_R149_V1.1300.41
119_R143_V1.1060.40
69_G142_V1.0970.40
28_I88_Q1.0820.39
50_N119_R1.0810.39
129_R133_G1.0770.39
14_L187_T1.0770.39
30_V198_P1.0740.38
113_Y157_F1.0730.38
52_N95_E1.0570.37
145_D181_K1.0560.37
208_R220_K1.0560.37
87_R204_Q1.0540.37
33_L148_L1.0490.37
115_R147_I1.0380.36
13_L110_R1.0370.36
58_Y120_E1.0350.36
46_K157_F1.0330.36
154_Q171_T1.0250.36
31_G113_Y1.0200.36
122_P215_L1.0190.35
168_V220_K1.0040.35
61_A198_P1.0030.35
130_S164_V0.9970.34
90_A144_M0.9890.34
65_I165_T0.9870.34
88_Q143_V0.9690.33
31_G55_A0.9630.33
38_P168_V0.9610.33
50_N83_L0.9580.32
14_L207_L0.9540.32
118_F146_T0.9530.32
170_N176_F0.9500.32
17_V20_L0.9430.32
51_N80_G0.9380.31
64_A112_R0.9320.31
198_P211_G0.9320.31
187_T201_V0.9300.31
56_R97_E0.9270.31
15_T78_V0.9130.30
48_V118_F0.9030.30
192_D214_Y0.9030.30
112_R151_R0.8990.30
14_L22_A0.8990.30
55_A90_A0.8970.29
31_G119_R0.8940.29
18_C59_R0.8910.29
205_P209_Q0.8900.29
56_R143_V0.8890.29
48_V92_Q0.8860.29
82_L199_G0.8840.29
47_R178_L0.8790.29
50_N114_Y0.8760.28
140_P151_R0.8730.28
76_R130_S0.8720.28
132_T164_V0.8700.28
66_D153_R0.8630.28
79_D133_G0.8610.28
31_G118_F0.8540.27
34_T114_Y0.8530.27
97_E117_S0.8490.27
111_E152_P0.8480.27
86_P152_P0.8480.27
152_P172_G0.8480.27
168_V201_V0.8470.27
84_F204_Q0.8440.27
86_P170_N0.8400.27
13_L22_A0.8400.27
50_N195_Y0.8380.27
21_A25_T0.8370.27
62_I76_R0.8370.27
55_A85_A0.8330.26
100_K215_L0.8280.26
32_N175_W0.8200.26
140_P182_P0.8190.26
22_A79_D0.8190.26
100_K138_T0.8180.26
188_E191_G0.8180.26
48_V101_F0.8110.26
22_A26_Q0.8100.25
216_V220_K0.8080.25
103_Y113_Y0.8080.25
91_L180_I0.8060.25
52_N144_M0.8050.25
52_N56_R0.8040.25
191_G200_D0.8030.25
141_V144_M0.8030.25
168_V188_E0.8010.25
106_P153_R0.7870.24
126_H213_H0.7860.24
25_T40_E0.7860.24
52_N88_Q0.7790.24
52_N119_R0.7780.24
20_L153_R0.7760.24
27_A68_P0.7750.24
16_A208_R0.7690.24
16_A76_R0.7670.24
33_L63_S0.7640.24
65_I94_G0.7610.23
20_L185_D0.7550.23
34_T193_A0.7540.23
21_A26_Q0.7530.23
83_L139_E0.7510.23
16_A21_A0.7480.23
212_N217_Y0.7470.23
112_R174_T0.7450.23
94_G188_E0.7430.23
30_V160_S0.7410.23
100_K145_D0.7360.22
26_Q131_P0.7360.22
13_L16_A0.7320.22
140_P176_F0.7320.22
105_G157_F0.7320.22
32_N198_P0.7300.22
89_L218_N0.7270.22
32_N147_I0.7260.22
167_T201_V0.7250.22
132_T174_T0.7200.22
17_V101_F0.7190.22
56_R144_M0.7130.22
100_K184_C0.7130.22
45_S139_E0.7110.21
27_A198_P0.7110.21
34_T195_Y0.7070.21
59_R143_V0.7060.21
46_K105_G0.7030.21
85_A102_Y0.7010.21
65_I174_T0.7010.21
13_L57_I0.7010.21
61_A215_L0.7000.21
100_K170_N0.6990.21
34_T60_I0.6960.21
46_K148_L0.6950.21
37_L168_V0.6880.21
113_Y197_R0.6830.20
88_Q99_F0.6790.20
120_E144_M0.6790.20
114_Y177_K0.6760.20
50_N90_A0.6730.20
108_D112_R0.6710.20
83_L130_S0.6700.20
164_V187_T0.6660.20
91_L95_E0.6660.20
171_T187_T0.6630.20
30_V145_D0.6610.20
48_V159_W0.6550.19
69_G185_D0.6540.19
115_R172_G0.6540.19
86_P115_R0.6540.19
62_I73_L0.6520.19
52_N159_W0.6490.19
48_V81_E0.6490.19
59_R121_V0.6460.19
93_A118_F0.6460.19
70_S169_S0.6390.19
36_S137_S0.6380.19
33_L49_V0.6370.19
17_V132_T0.6310.19
33_L180_I0.6200.18
52_N178_L0.6140.18
161_F181_K0.6130.18
103_Y195_Y0.6070.18
36_S157_F0.6060.18
113_Y149_V0.6060.18
101_F181_K0.6040.18
55_A92_Q0.6040.18
118_F139_E0.5990.17
33_L72_E0.5990.17
25_T61_A0.5980.17
80_G150_V0.5980.17
19_M114_Y0.5980.17
16_A167_T0.5980.17
110_R154_Q0.5970.17
48_V123_T0.5960.17
127_T131_P0.5880.17
93_A122_P0.5870.17
31_G56_R0.5840.17
36_S91_L0.5800.17
58_Y184_C0.5770.17
155_V217_Y0.5760.17
37_L150_V0.5750.17
188_E209_Q0.5750.17
116_V134_G0.5740.17
16_A154_Q0.5730.17
15_T186_S0.5710.17
62_I90_A0.5700.17
46_K102_Y0.5690.16
101_F110_R0.5690.16
214_Y217_Y0.5680.16
91_L147_I0.5670.16
20_L126_H0.5660.16
99_F146_T0.5640.16
111_E145_D0.5610.16
61_A66_D0.5580.16
13_L130_S0.5570.16
91_L152_P0.5540.16
142_V174_T0.5510.16
35_F214_Y0.5500.16
49_V103_Y0.5480.16
136_V192_D0.5450.16
88_Q179_L0.5440.16
140_P175_W0.5440.16
32_N148_L0.5430.16
14_L30_V0.5420.16
85_A122_P0.5420.16
28_I99_F0.5400.16
43_F58_Y0.5400.16
62_I171_T0.5350.15
29_S93_A0.5320.15
133_G169_S0.5280.15
76_R166_G0.5270.15
97_E149_V0.5260.15
150_V169_S0.5250.15
133_G202_V0.5250.15
88_Q197_R0.5230.15
18_C187_T0.5230.15
112_R173_N0.5230.15
43_F145_D0.5200.15
39_S203_H0.5200.15
42_D71_S0.5200.15
140_P146_T0.5190.15
62_I145_D0.5190.15
58_Y65_I0.5170.15
105_G195_Y0.5120.15
110_R178_L0.5100.15
16_A24_L0.5070.15
186_S207_L0.5040.15
108_D138_T0.5040.15
57_I96_S0.5020.14
62_I181_K0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ncdA 2 0.8305 100 0.586 Contact Map
3q48A 1 0.7585 99.9 0.626 Contact Map
4djmA 1 0.8051 99.9 0.689 Contact Map
4ay0A 2 0.7415 99.8 0.701 Contact Map
2co7B 1 0.7754 99.7 0.736 Contact Map
1l4iA 2 0.7415 99.6 0.763 Contact Map
2xg5A 1 0.8305 99.6 0.769 Contact Map
1klfA 1 0.8008 99.5 0.78 Contact Map
3gfuC 1 0.8178 99.3 0.797 Contact Map
3o0lA 2 0.4407 64.2 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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