GREMLIN Database
YDFI - Uncharacterized oxidoreductase YdfI
UniProt: P77260 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13821
Length: 486 (460)
Sequences: 2272 (1595)
Seq/√Len: 74.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_D89_R4.2391.00
317_D477_K3.9021.00
57_V108_V3.3901.00
231_E234_L3.1891.00
41_A270_W3.1581.00
22_P55_Y3.0571.00
470_S479_T2.9841.00
238_E244_R2.9451.00
308_Y317_D2.8761.00
325_Y348_N2.8721.00
55_Y111_A2.8041.00
106_E168_R2.7821.00
43_I89_R2.7791.00
96_K111_A2.7411.00
114_E117_I2.7121.00
201_Q212_E2.6201.00
110_A172_A2.4901.00
24_I41_A2.4891.00
259_I275_A2.4241.00
193_R197_T2.3861.00
20_L53_G2.3531.00
118_A267_R2.3261.00
301_Y370_G2.3131.00
235_A239_Q2.2891.00
326_G330_Q2.2821.00
79_A88_A2.2601.00
190_H219_S2.2121.00
314_C320_Y2.2121.00
25_V117_I2.1921.00
216_T264_V2.1601.00
319_H481_A2.1461.00
385_H390_S2.1211.00
329_L347_A2.0971.00
399_V460_F2.0641.00
177_F215_V2.0591.00
157_T160_G2.0571.00
70_Q74_N2.0511.00
478_A481_A2.0511.00
200_A211_I2.0281.00
96_K107_T2.0221.00
40_Y255_R2.0081.00
112_M165_A1.9621.00
196_V217_F1.9531.00
144_M156_K1.9511.00
269_E272_K1.9481.00
167_A171_A1.9411.00
33_H37_Q1.9341.00
361_H365_Q1.9281.00
164_E168_R1.9271.00
80_E251_C1.9051.00
304_Y416_I1.9021.00
59_L161_V1.8981.00
270_W275_A1.8961.00
302_L401_G1.8901.00
321_R355_S1.8711.00
106_E110_A1.8711.00
104_G107_T1.8691.00
179_V192_M1.8681.00
295_S324_A1.8671.00
291_M328_M1.8521.00
298_F327_L1.8441.00
291_M347_A1.8391.00
131_H195_V1.8371.00
75_L90_V1.8341.00
39_V78_V1.8261.00
55_Y96_K1.8251.00
209_Q213_D1.8251.00
53_G95_K1.8151.00
22_P117_I1.8121.00
170_K206_K1.8111.00
471_L479_T1.8081.00
42_D46_T1.7871.00
22_P96_K1.7821.00
216_T262_N1.7541.00
178_T264_V1.7471.00
302_L397_L1.7441.00
25_V57_V1.7381.00
333_A347_A1.7111.00
463_R467_T1.7081.00
303_G314_C1.6941.00
187_E190_H1.6911.00
164_E167_A1.6821.00
180_M259_I1.6801.00
295_S328_M1.6681.00
311_I366_I1.6671.00
16_D19_N1.6641.00
21_A116_Q1.6471.00
168_R172_A1.6461.00
65_Q68_D1.6371.00
56_E94_V1.6341.00
382_V399_V1.6331.00
201_Q208_A1.6251.00
78_V91_V1.6201.00
15_Y42_D1.6181.00
298_F398_G1.6161.00
382_V460_F1.6040.99
321_R325_Y1.5990.99
403_M443_L1.5680.99
20_L95_K1.5630.99
24_I54_Y1.5630.99
22_P95_K1.5490.99
147_A151_N1.5450.99
187_E282_L1.5440.99
98_L108_V1.5410.99
23_R118_A1.5410.99
176_A215_V1.5400.99
458_S462_A1.5370.99
312_N316_E1.5220.99
386_L457_N1.4970.99
112_M177_F1.4920.99
441_Q461_T1.4860.99
384_W387_A1.4790.99
342_D345_D1.4780.99
55_Y117_I1.4750.99
322_Y326_G1.4730.99
132_S135_T1.4510.99
113_C164_E1.4400.99
113_C168_R1.4260.99
120_V177_F1.4240.99
167_A203_V1.4190.99
124_I158_A1.4140.99
231_E235_A1.4110.99
302_L471_L1.4050.99
397_L479_T1.4040.99
162_I196_V1.3990.99
38_G54_Y1.3990.99
41_A54_Y1.3900.98
410_D414_N1.3880.98
319_H477_K1.3820.98
445_A455_P1.3790.98
163_V211_I1.3740.98
392_F396_A1.3730.98
81_M233_T1.3670.98
455_P461_T1.3620.98
404_R468_Y1.3540.98
137_Q198_S1.3490.98
206_K209_Q1.3460.98
107_T110_A1.3220.98
77_T90_V1.3210.98
311_I314_C1.3210.98
137_Q194_D1.3200.98
396_A464_V1.3200.98
383_R452_D1.3180.98
309_Q362_R1.3150.98
229_V248_G1.3120.98
404_R472_L1.3090.98
309_Q313_D1.3090.98
351_I355_S1.3070.98
208_A211_I1.3010.98
329_L348_N1.3010.98
45_A50_S1.2990.98
447_K456_D1.2920.98
43_I47_E1.2880.97
77_T88_A1.2800.97
197_T212_E1.2780.97
291_M350_L1.2700.97
325_Y329_L1.2690.97
300_A367_A1.2690.97
201_Q209_Q1.2650.97
229_V234_L1.2620.97
109_L164_E1.2590.97
427_Q431_Q1.2460.97
345_D349_R1.2430.97
298_F323_A1.2370.97
144_M147_A1.2320.97
122_L158_A1.2310.97
67_A71_Q1.2230.97
306_A320_Y1.2230.97
278_V283_P1.2200.97
14_V46_T1.2160.96
383_R451_G1.2150.96
291_M333_A1.2120.96
164_E203_V1.2040.96
290_R384_W1.1940.96
407_G430_V1.1850.96
177_F264_V1.1830.96
311_I363_T1.1780.96
109_L168_R1.1670.95
166_L169_R1.1650.95
280_D283_P1.1600.95
127_K372_Q1.1550.95
297_S373_K1.1540.95
149_V199_Y1.1500.95
29_F94_V1.1450.95
74_N97_A1.1360.95
151_N154_Q1.1360.95
175_P265_A1.1350.95
469_L473_A1.1340.95
315_M321_R1.1330.95
470_S474_H1.1320.95
29_F56_E1.1310.95
110_A113_C1.1300.95
74_N96_K1.1270.95
147_A156_K1.1260.95
211_I217_F1.1210.94
326_G394_L1.1180.94
27_L158_A1.1150.94
304_Y405_Y1.1060.94
393_D463_R1.1040.94
311_I324_A1.1020.94
299_L320_Y1.0980.94
27_L112_M1.0960.94
201_Q205_V1.0950.94
163_V200_A1.0940.94
75_L92_G1.0930.94
13_P92_G1.0880.93
474_H478_A1.0820.93
397_L471_L1.0820.93
69_L74_N1.0760.93
315_M351_I1.0750.93
179_V217_F1.0740.93
190_H193_R1.0690.93
194_D198_S1.0690.93
118_A266_G1.0640.93
205_V209_Q1.0630.93
209_Q212_E1.0620.93
267_R271_E1.0610.93
39_V91_V1.0610.93
304_Y364_W1.0580.92
224_R251_C1.0560.92
167_A204_D1.0540.92
60_I144_M1.0520.92
80_E87_T1.0490.92
286_E337_K1.0490.92
364_W405_Y1.0460.92
381_S395_L1.0410.92
441_Q445_A1.0370.92
32_F182_C1.0360.92
422_L425_V1.0360.92
180_M220_T1.0230.91
165_A169_R1.0220.91
374_L398_G1.0210.91
138_L198_S1.0210.91
71_Q246_P1.0190.91
364_W419_S1.0120.91
39_V89_R1.0120.91
384_W388_H1.0110.91
25_V165_A1.0110.91
82_S253_P1.0040.90
312_N360_R1.0010.90
328_M351_I0.9970.90
396_A460_F0.9970.90
362_R365_Q0.9920.90
47_E272_K0.9920.90
425_V448_A0.9900.90
119_I267_R0.9890.90
37_Q121_S0.9880.90
461_T465_T0.9880.90
39_V43_I0.9840.89
428_K431_Q0.9810.89
361_H377_R0.9780.89
83_A357_P0.9780.89
441_Q465_T0.9770.89
157_T169_R0.9770.89
343_L347_A0.9700.89
371_S449_I0.9700.89
332_Q395_L0.9680.89
46_T89_R0.9670.89
77_T243_V0.9650.89
72_Q245_D0.9650.89
163_V196_V0.9650.89
237_I241_T0.9650.89
404_R408_G0.9640.88
425_V446_I0.9610.88
25_V120_V0.9560.88
40_Y273_A0.9530.88
41_A275_A0.9520.88
446_I449_I0.9490.88
372_Q422_L0.9490.88
333_A343_L0.9460.88
43_I255_R0.9410.87
66_I97_A0.9390.87
475_G479_T0.9380.87
229_V249_V0.9360.87
191_V194_D0.9310.87
364_W416_I0.9280.87
66_I70_Q0.9260.86
17_L92_G0.9230.86
371_S402_W0.9220.86
163_V166_L0.9170.86
121_S220_T0.9150.86
127_K377_R0.9150.86
345_D348_N0.9140.86
368_M419_S0.9120.86
327_L395_L0.9120.86
315_M324_A0.9120.86
291_M332_Q0.9120.86
144_M157_T0.9110.85
24_I119_I0.9050.85
88_A241_T0.9050.85
379_L382_V0.9040.85
270_W277_L0.9020.85
310_H313_D0.9020.85
22_P111_A0.9010.85
70_Q96_K0.9010.85
304_Y363_T0.9000.85
111_A114_E0.9000.85
170_K204_D0.8980.85
405_Y418_I0.8960.85
378_M398_G0.8940.84
323_A394_L0.8900.84
439_R445_A0.8870.84
197_T211_I0.8860.84
105_L161_V0.8810.84
411_E476_A0.8780.83
463_R466_E0.8770.83
159_T165_A0.8740.83
299_L363_T0.8720.83
404_R411_E0.8690.83
425_V428_K0.8690.83
340_G344_Q0.8690.83
42_D93_V0.8660.82
146_A150_Q0.8650.82
121_S180_M0.8640.82
310_H360_R0.8550.82
361_H366_I0.8500.81
131_H191_V0.8490.81
329_L333_A0.8420.81
233_T250_A0.8400.81
327_L332_Q0.8390.80
424_P428_K0.8380.80
178_T218_P0.8380.80
437_K465_T0.8380.80
37_Q182_C0.8350.80
382_V396_A0.8330.80
158_A166_L0.8320.80
399_V464_V0.8280.80
58_N99_H0.8270.79
325_Y351_I0.8260.79
429_A446_I0.8250.79
197_T208_A0.8240.79
54_Y93_V0.8240.79
179_V215_V0.8230.79
236_K240_L0.8220.79
23_R52_W0.8220.79
235_A238_E0.8190.79
424_P427_Q0.8180.79
403_M464_V0.8180.79
158_A161_V0.8160.79
328_M347_A0.8150.78
162_I192_M0.8140.78
297_S370_G0.8090.78
392_F459_L0.8050.78
371_S420_D0.8030.77
33_H38_G0.8030.77
475_G478_A0.7990.77
349_R352_A0.7990.77
271_E277_L0.7990.77
21_A51_D0.7980.77
178_T267_R0.7970.77
157_T166_L0.7920.76
41_A44_L0.7880.76
163_V169_R0.7880.76
43_I273_A0.7880.76
110_A168_R0.7860.76
157_T165_A0.7860.76
471_L476_A0.7850.76
23_R45_A0.7850.76
55_Y95_K0.7840.76
122_L181_S0.7790.75
143_P146_A0.7790.75
22_P53_G0.7780.75
159_T169_R0.7770.75
177_F200_A0.7760.75
325_Y347_A0.7740.75
165_A177_F0.7730.75
438_A441_Q0.7680.74
466_E470_S0.7660.74
115_P174_L0.7650.74
306_A317_D0.7650.74
204_D208_A0.7650.74
302_L320_Y0.7630.74
313_D316_E0.7620.74
331_E394_L0.7610.74
158_A163_V0.7600.73
295_S354_Y0.7600.73
304_Y309_Q0.7600.73
369_D421_P0.7540.73
234_L248_G0.7540.73
396_A463_R0.7530.73
219_S260_E0.7510.73
348_N351_I0.7480.72
58_N97_A0.7470.72
47_E273_A0.7450.72
32_F37_Q0.7450.72
15_Y92_G0.7440.72
27_L165_A0.7440.72
200_A208_A0.7430.72
22_P116_Q0.7430.72
58_N66_I0.7430.72
290_R335_T0.7420.72
445_A461_T0.7410.72
210_W214_N0.7380.71
49_F272_K0.7340.71
49_F269_E0.7330.71
332_Q381_S0.7330.71
307_G317_D0.7320.71
29_F59_L0.7320.71
98_L107_T0.7320.71
43_I46_T0.7290.70
198_S202_A0.7280.70
330_Q394_L0.7270.70
330_Q391_K0.7260.70
154_Q169_R0.7240.70
382_V395_L0.7230.70
263_F267_R0.7220.70
130_F157_T0.7200.69
286_E384_W0.7200.69
101_Q105_L0.7190.69
297_S301_Y0.7190.69
379_L399_V0.7190.69
303_G363_T0.7190.69
78_V359_L0.7190.69
112_M120_V0.7190.69
159_T196_V0.7180.69
39_V255_R0.7170.69
166_L210_W0.7120.69
148_D160_G0.7100.68
163_V167_A0.7100.68
121_S182_C0.7090.68
331_E385_H0.7080.68
157_T161_V0.7080.68
96_K110_A0.7080.68
100_V161_V0.7060.68
121_S257_W0.7050.68
76_Y224_R0.7050.68
58_N65_Q0.7020.67
232_D236_K0.7020.67
301_Y405_Y0.6990.67
418_I423_L0.6970.67
160_G199_Y0.6970.67
320_Y480_V0.6950.67
16_D20_L0.6900.66
170_K207_L0.6900.66
127_K369_D0.6870.66
319_H480_V0.6860.66
335_T385_H0.6850.66
281_V285_E0.6770.65
444_L460_F0.6770.65
81_M224_R0.6760.65
311_I373_K0.6760.65
365_Q419_S0.6750.64
29_F58_N0.6750.64
13_P90_V0.6750.64
406_V416_I0.6740.64
338_V341_V0.6740.64
233_T236_K0.6710.64
166_L170_K0.6700.64
392_F457_N0.6700.64
447_K452_D0.6700.64
90_V243_V0.6690.64
425_V429_A0.6690.64
283_P336_L0.6690.64
309_Q414_N0.6690.64
313_D363_T0.6670.63
344_Q348_N0.6670.63
271_E275_A0.6650.63
166_L179_V0.6640.63
476_A479_T0.6620.63
253_P352_A0.6600.63
328_M350_L0.6600.63
82_S358_A0.6590.63
386_L459_L0.6590.63
66_I103_D0.6570.62
57_V98_L0.6570.62
459_L463_R0.6570.62
182_C254_F0.6560.62
32_F36_H0.6540.62
200_A207_L0.6530.62
308_Y313_D0.6520.62
291_M295_S0.6510.62
430_V439_R0.6510.62
153_H164_E0.6500.61
186_P294_G0.6490.61
221_M281_V0.6490.61
397_L476_A0.6480.61
335_T381_S0.6470.61
25_V112_M0.6430.61
397_L467_T0.6430.61
126_E369_D0.6430.61
299_L314_C0.6420.61
72_Q75_L0.6420.61
174_L177_F0.6410.60
393_D466_E0.6400.60
165_A170_K0.6380.60
287_M343_L0.6350.60
20_L45_A0.6350.60
380_D384_W0.6340.60
416_I476_A0.6330.59
232_D235_A0.6320.59
408_G411_E0.6320.59
88_A240_L0.6290.59
44_L273_A0.6270.59
163_V199_Y0.6260.59
115_P175_P0.6230.58
29_F97_A0.6220.58
44_L50_S0.6220.58
122_L162_I0.6210.58
37_Q257_W0.6210.58
216_T265_A0.6200.58
372_Q377_R0.6190.58
451_G455_P0.6180.58
33_H36_H0.6180.58
386_L460_F0.6180.58
303_G308_Y0.6170.58
27_L108_V0.6170.58
352_A357_P0.6170.58
331_E335_T0.6160.57
60_I63_E0.6160.57
399_V450_F0.6150.57
133_P137_Q0.6110.57
159_T199_Y0.6110.57
392_F463_R0.6110.57
109_L113_C0.6110.57
386_L392_F0.6100.57
302_L476_A0.6090.57
310_H359_L0.6090.57
120_V179_V0.6090.57
372_Q376_Q0.6080.56
381_S384_W0.6070.56
318_E322_Y0.6060.56
375_P451_G0.6050.56
18_N473_A0.6040.56
319_H322_Y0.6040.56
50_S53_G0.6040.56
60_I124_I0.6030.56
289_L377_R0.5990.55
290_R381_S0.5970.55
177_F265_A0.5960.55
160_G169_R0.5950.55
145_V148_D0.5940.55
423_L427_Q0.5930.55
151_N156_K0.5930.55
82_S357_P0.5930.55
79_A237_I0.5920.54
409_V413_G0.5920.54
226_V241_T0.5920.54
113_C165_A0.5910.54
327_L394_L0.5900.54
88_A237_I0.5900.54
33_H54_Y0.5900.54
120_V162_I0.5890.54
78_V226_V0.5890.54
178_T263_F0.5880.54
256_Q346_Y0.5850.54
114_E174_L0.5840.53
287_M338_V0.5840.53
458_S461_T0.5830.53
307_G410_D0.5820.53
29_F60_I0.5810.53
99_H103_D0.5810.53
109_L161_V0.5800.53
180_M270_W0.5780.53
172_A175_P0.5780.53
443_L449_I0.5780.53
297_S368_M0.5780.53
263_F271_E0.5770.53
254_F275_A0.5730.52
138_L195_V0.5730.52
119_I270_W0.5720.52
209_Q456_D0.5720.52
197_T359_L0.5710.52
186_P285_E0.5700.52
179_V363_T0.5680.51
226_V359_L0.5680.51
80_E255_R0.5670.51
407_G472_L0.5670.51
127_K365_Q0.5660.51
328_M333_A0.5660.51
127_K421_P0.5650.51
105_L108_V0.5650.51
406_V418_I0.5650.51
236_K239_Q0.5650.51
437_K469_L0.5650.51
126_E368_M0.5640.51
385_H392_F0.5640.51
193_R212_E0.5640.51
297_S366_I0.5620.51
226_V361_H0.5610.51
379_L383_R0.5610.51
190_H445_A0.5610.51
230_T233_T0.5610.51
383_R387_A0.5600.50
308_Y320_Y0.5590.50
82_S352_A0.5590.50
224_R255_R0.5590.50
227_P250_A0.5590.50
168_R171_A0.5580.50
403_M450_F0.5580.50
229_V233_T0.5580.50
58_N61_G0.5570.50
166_L215_V0.5550.50
195_V198_S0.5550.50
191_V195_V0.5540.50
117_I161_V0.5540.50
287_M341_V0.5540.50
331_E395_L0.5530.50
301_Y314_C0.5530.50
262_N279_S0.5520.49
229_V247_A0.5510.49
98_L111_A0.5510.49
432_S442_S0.5510.49
338_V342_D0.5500.49
205_V408_G0.5490.49
380_D383_R0.5490.49
306_A477_K0.5480.49
443_L450_F0.5460.49
31_A250_A0.5460.49
159_T166_L0.5450.49
155_P164_E0.5450.49
163_V170_K0.5440.48
45_A93_V0.5430.48
225_I367_A0.5430.48
44_L49_F0.5420.48
74_N78_V0.5420.48
220_T282_L0.5410.48
371_S426_I0.5410.48
41_A277_L0.5380.48
72_Q247_A0.5380.48
59_L65_Q0.5380.48
404_R471_L0.5380.48
233_T248_G0.5370.48
462_A466_E0.5370.48
306_A319_H0.5360.47
156_K169_R0.5360.47
159_T163_V0.5340.47
404_R409_V0.5340.47
131_H199_Y0.5340.47
180_M275_A0.5330.47
401_G476_A0.5330.47
365_Q377_R0.5320.47
165_A171_A0.5320.47
306_A314_C0.5300.47
161_V165_A0.5300.47
100_V105_L0.5300.47
42_D92_G0.5290.47
69_L182_C0.5280.46
153_H156_K0.5270.46
378_M381_S0.5260.46
366_I373_K0.5250.46
175_P214_N0.5250.46
311_I354_Y0.5240.46
139_M143_P0.5240.46
174_L215_V0.5230.46
106_E388_H0.5220.46
27_L42_D0.5220.46
436_G472_L0.5200.45
154_Q166_L0.5200.45
410_D413_G0.5200.45
154_Q157_T0.5200.45
374_L378_M0.5190.45
159_T361_H0.5180.45
237_I248_G0.5180.45
263_F266_G0.5180.45
175_P216_T0.5180.45
310_H366_I0.5170.45
78_V251_C0.5170.45
377_R464_V0.5170.45
378_M395_L0.5160.45
409_V414_N0.5160.45
196_V211_I0.5150.45
158_A165_A0.5150.45
366_I377_R0.5150.45
258_V284_Y0.5150.45
268_P277_L0.5140.45
147_A154_Q0.5140.45
70_Q97_A0.5140.45
476_A480_V0.5130.45
441_Q458_S0.5130.45
63_E100_V0.5120.44
68_D246_P0.5110.44
174_L214_N0.5110.44
202_A212_E0.5100.44
119_I180_M0.5100.44
235_A244_R0.5100.44
251_C255_R0.5090.44
439_R442_S0.5090.44
336_L342_D0.5080.44
206_K424_P0.5080.44
418_I427_Q0.5070.44
256_Q276_E0.5060.44
81_M250_A0.5050.44
23_R50_S0.5040.43
31_A365_Q0.5030.43
39_V382_V0.5010.43
167_A170_K0.5010.43
131_H202_A0.5010.43
123_T183_D0.5010.43
55_Y98_L0.5000.43
331_E379_L0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4im7A 1 0.9918 100 0.107 Contact Map
1lj8A 1 0.9918 100 0.119 Contact Map
3h2zA 2 0.7613 100 0.401 Contact Map
3hn2A 2 0.6132 31.4 0.98 Contact Map
3wfiA 2 0.6193 25.2 0.981 Contact Map
3hwrA 2 0.6049 24.1 0.981 Contact Map
3k7dA 2 0.3107 22.7 0.981 Contact Map
1z9bA 1 0.1728 20.2 0.982 Contact Map
3i83A 2 0.6296 16.8 0.983 Contact Map
1y8xB 1 0.1811 14.2 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0131 seconds.