GREMLIN Database
YKGE - Uncharacterized protein YkgE
UniProt: P77252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13582
Length: 239 (222)
Sequences: 7322 (4606)
Seq/√Len: 309.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_R161_E3.6241.00
24_L237_M3.4791.00
21_D234_E3.4461.00
2_N32_R3.4271.00
131_R163_L3.2741.00
116_V152_T3.2241.00
111_L233_A3.1181.00
51_Y54_E2.9011.00
109_Q117_N2.8241.00
75_S81_T2.6381.00
204_Y230_M2.4281.00
41_C80_C2.3551.00
165_F197_L2.2741.00
22_S76_P2.1731.00
17_R234_E2.1651.00
136_P151_L2.1401.00
22_S111_L2.1351.00
167_E196_H2.1301.00
130_G204_Y2.1211.00
166_A199_E2.0571.00
190_V219_R2.0431.00
2_N34_N1.9931.00
5_F76_P1.9401.00
151_L164_T1.9361.00
2_N71_D1.8911.00
31_C114_F1.8571.00
206_I235_V1.8281.00
4_N70_D1.8051.00
3_V114_F1.8041.00
9_C41_C1.8021.00
151_L155_K1.7991.00
152_T155_K1.7881.00
42_C80_C1.7691.00
47_I83_A1.7221.00
130_G203_E1.6861.00
85_K113_S1.6781.00
11_G19_A1.6731.00
18_M234_E1.6541.00
72_P107_R1.6471.00
133_V165_F1.6331.00
72_P109_Q1.6191.00
56_I60_K1.6131.00
59_M87_Y1.6091.00
195_A199_E1.5721.00
9_C80_C1.5511.00
190_V215_N1.5311.00
117_N149_E1.5151.00
132_A160_L1.4651.00
40_G61_N1.4591.00
131_R203_E1.4571.00
23_V33_V1.4421.00
109_Q114_F1.4401.00
196_H199_E1.4231.00
187_G219_R1.4001.00
60_K64_A1.3951.00
127_S158_R1.3841.00
104_V108_M1.3781.00
132_A206_I1.3751.00
109_Q113_S1.3731.00
154_L206_I1.3401.00
77_A209_D1.3281.00
64_A67_E1.3011.00
28_K237_M1.3011.00
197_L205_L1.2711.00
34_N70_D1.2701.00
132_A235_V1.2681.00
190_V194_V1.2651.00
74_I114_F1.2651.00
113_S149_E1.2611.00
167_E192_E1.2531.00
141_A147_K1.2431.00
61_N65_A1.2321.00
112_T232_I1.2161.00
113_S117_N1.2141.00
167_E170_T1.2141.00
191_K195_A1.2061.00
230_M234_E1.2011.00
133_V200_V1.2001.00
25_L236_L1.1871.00
129_Q161_E1.1871.00
22_S26_L1.1861.00
81_T144_L1.1821.00
183_A187_G1.1791.00
27_E33_V1.1761.00
134_Y150_P1.1711.00
132_A204_Y1.1611.00
81_T108_M1.1501.00
44_Q79_S1.1491.00
146_V149_E1.1471.00
75_S84_V1.1391.00
208_A232_I1.1351.00
155_K162_L1.1251.00
172_C212_C1.1221.00
9_C42_C1.1201.00
73_I104_V1.1191.00
3_V31_C1.1131.00
62_L84_V1.1121.00
4_N71_D1.1091.00
148_D152_T1.1091.00
46_A54_E1.1031.00
8_T77_A1.1001.00
113_S146_V1.0951.00
72_P114_F1.0911.00
20_R24_L1.0881.00
23_V27_E1.0831.00
21_D237_M1.0831.00
7_V35_F1.0621.00
31_C118_K1.0561.00
137_S207_G1.0501.00
59_M91_L1.0381.00
166_A196_H1.0281.00
36_P39_Q1.0281.00
198_M225_Q1.0161.00
205_L216_I1.0061.00
25_L237_M0.9991.00
44_Q48_N0.9931.00
152_T156_N0.9821.00
103_K107_R0.9811.00
114_F118_K0.9771.00
115_I236_L0.9671.00
111_L115_I0.9551.00
197_L227_V0.9531.00
24_L28_K0.9501.00
207_G213_L0.9501.00
120_G152_T0.9481.00
148_D151_L0.9471.00
19_A23_V0.9421.00
103_K106_A0.9411.00
3_V74_I0.9391.00
25_L233_A0.9381.00
133_V202_P0.9381.00
62_L65_A0.9271.00
7_V39_Q0.9271.00
133_V197_L0.9221.00
188_E191_K0.9211.00
55_A83_A0.9141.00
148_D169_D0.9111.00
230_M235_V0.9051.00
183_A218_G0.9021.00
127_S130_G0.9001.00
63_I67_E0.8981.00
195_A198_M0.8941.00
25_L111_L0.8881.00
59_M90_Y0.8841.00
82_Y143_K0.8831.00
168_Q196_H0.8801.00
49_S177_T0.8691.00
5_F19_A0.8641.00
7_V19_A0.8571.00
88_P105_A0.8541.00
154_L160_L0.8531.00
67_E103_K0.8501.00
48_N79_S0.8441.00
133_V205_L0.8341.00
116_V149_E0.8341.00
128_L160_L0.8311.00
131_R201_R0.8241.00
17_R20_R0.8231.00
23_V35_F0.8151.00
129_Q159_G0.8091.00
60_K94_E0.8021.00
47_I55_A0.8011.00
174_F179_S0.8001.00
140_L146_V0.7991.00
65_A68_D0.7981.00
198_M226_K0.7971.00
177_T181_K0.7961.00
53_K56_I0.7961.00
26_L31_C0.7961.00
46_A58_G0.7951.00
109_Q118_K0.7941.00
197_L216_I0.7931.00
86_S143_K0.7780.99
116_V120_G0.7770.99
205_L227_V0.7760.99
54_E58_G0.7760.99
191_K219_R0.7750.99
118_K121_V0.7740.99
57_P61_N0.7740.99
58_G61_N0.7660.99
126_A130_G0.7650.99
75_S108_M0.7610.99
5_F22_S0.7550.99
15_K210_V0.7500.99
165_F168_Q0.7480.99
55_A59_M0.7480.99
58_G62_L0.7470.99
54_E57_P0.7430.99
128_L204_Y0.7400.99
20_R23_V0.7380.99
79_S139_S0.7370.99
187_G191_K0.7360.99
117_N121_V0.7340.99
184_E188_E0.7330.99
127_S159_G0.7270.99
79_S211_S0.7180.99
149_E152_T0.7160.99
18_M21_D0.7090.99
2_N69_N0.7050.99
146_V150_P0.7040.99
57_P60_K0.7030.99
213_L229_V0.7020.99
81_T85_K0.7000.99
194_V216_I0.6960.99
3_V33_V0.6940.99
27_E32_R0.6940.99
16_S20_R0.6910.99
115_I119_L0.6910.99
84_V104_V0.6870.99
206_I232_I0.6870.99
79_S209_D0.6860.99
64_A68_D0.6860.99
91_L94_E0.6840.99
120_G156_N0.6840.99
179_S186_S0.6770.99
140_L208_A0.6750.99
62_L87_Y0.6740.99
66_L73_I0.6740.99
136_P141_A0.6730.99
134_Y162_L0.6720.99
47_I52_I0.6710.98
24_L27_E0.6690.98
122_V125_G0.6680.98
136_P147_K0.6630.98
192_E195_A0.6600.98
22_S74_I0.6590.98
81_T110_D0.6540.98
61_N64_A0.6540.98
26_L74_I0.6520.98
116_V153_L0.6450.98
82_Y86_S0.6430.98
148_D155_K0.6430.98
194_V198_M0.6430.98
174_F211_S0.6400.98
34_N37_E0.6400.98
71_D107_R0.6380.98
4_N66_L0.6380.98
21_D25_L0.6380.98
15_K18_M0.6370.98
77_A80_C0.6360.98
92_A106_A0.6360.98
87_Y90_Y0.6350.98
11_G18_M0.6340.98
15_K214_L0.6340.98
39_Q66_L0.6270.98
8_T209_D0.6250.98
4_N36_P0.6240.98
29_L118_K0.6240.98
26_L111_L0.6200.97
11_G76_P0.6190.97
124_V156_N0.6190.97
89_T92_A0.6160.97
153_L236_L0.6160.97
184_E187_G0.6160.97
134_Y154_L0.6160.97
115_I153_L0.6100.97
130_G160_L0.6100.97
137_S209_D0.6080.97
79_S174_F0.6080.97
162_L165_F0.6060.97
158_R236_L0.6020.97
69_N72_P0.6010.97
205_L229_V0.5960.97
151_L162_L0.5920.97
193_K196_H0.5900.97
21_D24_L0.5900.97
169_D193_K0.5890.97
134_Y151_L0.5880.97
27_E31_C0.5880.97
15_K213_L0.5880.97
112_T150_P0.5870.97
217_S228_K0.5860.96
72_P75_S0.5850.96
107_R117_N0.5830.96
84_V87_Y0.5800.96
85_K144_L0.5800.96
88_P91_L0.5790.96
120_G123_D0.5790.96
151_L168_Q0.5790.96
4_N34_N0.5780.96
45_P80_C0.5750.96
48_N211_S0.5720.96
178_F189_M0.5700.96
22_S233_A0.5650.96
143_K146_V0.5650.96
4_N7_V0.5640.96
25_L153_L0.5640.96
55_A90_Y0.5640.96
78_G137_S0.5630.96
35_F39_Q0.5620.96
112_T208_A0.5570.95
9_C77_A0.5570.95
67_E105_A0.5560.95
78_G139_S0.5490.95
48_N174_F0.5480.95
86_S89_T0.5480.95
4_N73_I0.5470.95
41_C45_P0.5460.95
112_T116_V0.5440.95
142_R145_G0.5420.95
52_I56_I0.5410.95
82_Y144_L0.5410.95
198_M202_P0.5400.94
138_C171_C0.5400.94
178_F181_K0.5350.94
78_G208_A0.5350.94
139_S215_N0.5330.94
139_S210_V0.5310.94
121_V124_V0.5300.94
126_A129_Q0.5300.94
138_C212_C0.5280.94
45_P48_N0.5280.94
63_I87_Y0.5220.93
154_L162_L0.5190.93
6_F84_V0.5180.93
142_R147_K0.5180.93
216_I229_V0.5180.93
118_K122_V0.5170.93
25_L29_L0.5160.93
136_P150_P0.5140.93
118_K123_D0.5140.93
88_P92_A0.5130.93
131_R228_K0.5110.93
44_Q83_A0.5110.93
38_K68_D0.5100.93
119_L122_V0.5100.93
197_L200_V0.5080.93
18_M213_L0.5080.93
163_L200_V0.5070.92
116_V156_N0.5060.92
201_R227_V0.5020.92
178_F186_S0.5000.92
14_L213_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.9331 100 0.304 Contact Map
3cf4A 2 0.7741 100 0.565 Contact Map
3c8yA 1 0.8954 98.7 0.823 Contact Map
1jflA 2 0.8745 79.1 0.928 Contact Map
2jfnA 1 0.8619 78.4 0.928 Contact Map
3s81A 2 0.8703 77.1 0.929 Contact Map
3qvlA 3 0.8577 74.4 0.931 Contact Map
2gzmA 3 0.4226 70.9 0.932 Contact Map
2jfzA 2 0.41 65.5 0.935 Contact Map
2eq5A 2 0.4268 64.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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