GREMLIN Database
SFMC - Probable fimbrial chaperone SfmC
UniProt: P77249 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13882
Length: 230 (211)
Sequences: 2885 (2169)
Seq/√Len: 149.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_I138_L3.2931.00
176_T191_M3.2591.00
37_P40_A2.9931.00
174_Y193_A2.9891.00
168_H197_N2.9771.00
193_A196_V2.9691.00
103_R195_R2.9301.00
29_L136_M2.9191.00
106_L191_M2.9031.00
157_K168_H2.6631.00
99_L107_F2.6471.00
158_F167_V2.6181.00
166_N199_Q2.5941.00
166_N197_N2.5821.00
56_F113_T2.5251.00
34_I43_T2.5221.00
34_I109_M2.4781.00
34_I92_I2.3951.00
139_F191_M2.3821.00
164_Y199_Q2.3741.00
39_D143_I2.3691.00
151_E154_D2.2601.00
167_V200_I2.2591.00
216_N222_T2.2131.00
139_F174_Y2.1371.00
55_R83_E2.0721.00
63_E135_R2.0471.00
159_S166_N2.0401.00
61_W110_N1.9941.00
112_K133_L1.8911.00
100_A105_S1.8601.00
37_P43_T1.8161.00
60_S90_L1.7961.00
55_R81_V1.7781.00
152_A175_V1.7291.00
73_F92_I1.7161.00
145_L173_F1.7091.00
156_L167_V1.6821.00
156_L175_V1.6681.00
75_I90_L1.6641.00
63_E110_N1.6271.00
83_E86_S1.6181.00
29_L111_V1.6041.00
175_V214_T1.6011.00
110_N135_R1.5501.00
155_T171_S1.5331.00
152_A214_T1.5301.00
62_I71_K1.5261.00
45_V109_M1.4991.00
100_A103_R1.4851.00
216_N220_S1.4741.00
156_L177_L1.4691.00
106_L139_F1.4651.00
148_L151_E1.4601.00
161_S166_N1.4381.00
179_N213_Q1.4071.00
58_V80_F1.4021.00
149_P152_A1.3891.00
38_A101_A1.3861.00
73_F138_L1.3701.00
159_S168_H1.3651.00
36_Y43_T1.3581.00
46_W87_E1.3081.00
42_Q91_R1.2991.00
192_A198_S1.2911.00
106_L176_T1.2881.00
164_Y201_P1.2541.00
94_Y97_P1.2511.00
53_N85_K1.2441.00
158_F212_F1.2321.00
51_H113_T1.2181.00
34_I136_M1.2161.00
172_P195_R1.1981.00
38_A143_I1.1901.00
181_Q211_K1.1821.00
75_I92_I1.1711.00
176_T214_T1.1701.00
64_N68_V1.1511.00
29_L45_V1.1491.00
47_I82_S1.1401.00
9_M17_I1.1321.00
160_R163_N1.1260.99
178_V221_V1.1170.99
109_M138_L1.1150.99
92_I138_L1.1150.99
94_Y98_P1.1140.99
61_W135_R1.1000.99
94_Y140_L1.0980.99
161_S164_Y1.0970.99
214_T222_T1.0940.99
153_P175_V1.0840.99
181_Q186_K1.0820.99
118_D129_Q1.0720.99
63_E67_G1.0570.99
177_L192_A1.0500.99
165_I202_L1.0370.99
113_T132_I1.0370.99
80_F88_N1.0290.99
108_W135_R1.0240.99
27_I82_S1.0240.99
90_L109_M1.0240.99
30_G46_W1.0160.99
61_W112_K1.0050.99
28_A31_A1.0050.99
36_Y93_I1.0030.99
147_E173_F0.9900.99
27_I58_V0.9900.99
88_N112_K0.9890.99
66_S69_K0.9890.99
26_G113_T0.9770.99
48_R87_E0.9650.98
38_A140_L0.9590.98
90_L111_V0.9580.98
118_D127_V0.9510.98
75_I109_M0.9390.98
13_F16_I0.9360.98
155_T170_P0.9340.98
51_H56_F0.9240.98
31_A45_V0.9240.98
153_P212_F0.9220.98
181_Q184_S0.9140.98
177_L214_T0.8990.97
213_Q221_V0.8940.97
137_K215_V0.8900.97
29_L47_I0.8830.97
33_R141_R0.8830.97
63_E108_W0.8750.97
30_G87_E0.8710.97
131_A158_F0.8690.97
62_I75_I0.8610.97
104_E141_R0.8610.97
82_S87_E0.8500.96
88_N113_T0.8470.96
34_I45_V0.8410.96
178_V215_V0.8400.96
108_W112_K0.8300.96
51_H54_E0.8270.96
36_Y73_F0.8250.96
165_I180_L0.8250.96
11_I14_Y0.8240.96
153_P214_T0.8180.96
102_D195_R0.8130.95
9_M12_I0.8060.95
82_S88_N0.8060.95
120_N125_R0.8050.95
126_N129_Q0.8000.95
174_Y194_P0.7980.95
157_K170_P0.7950.95
151_E155_T0.7910.95
60_S75_I0.7820.94
80_F90_L0.7810.94
168_H195_R0.7740.94
101_A144_Q0.7710.94
60_S111_V0.7690.94
110_N133_L0.7690.94
161_S199_Q0.7670.94
56_F112_K0.7630.94
149_P175_V0.7620.94
31_A34_I0.7560.93
158_F165_I0.7490.93
177_L220_S0.7470.93
47_I58_V0.7470.93
144_Q147_E0.7460.93
176_T189_N0.7440.93
107_F140_L0.7420.93
185_Q205_G0.7370.92
22_H206_V0.7310.92
35_I141_R0.7310.92
106_L174_Y0.7210.92
183_G208_G0.7160.91
149_P153_P0.7150.91
59_N112_K0.7150.91
158_F180_L0.7130.91
46_W79_L0.7110.91
33_R137_K0.7100.91
110_N137_K0.7090.91
147_E152_A0.7040.91
56_F60_S0.6990.90
26_G56_F0.6980.90
165_I210_L0.6980.90
55_R116_S0.6980.90
179_N186_K0.6950.90
102_D141_R0.6950.90
65_S108_W0.6940.90
64_N70_E0.6920.90
10_L13_F0.6910.90
28_A134_S0.6900.90
62_I114_I0.6900.90
10_L18_S0.6880.90
147_E151_E0.6850.89
82_S86_S0.6820.89
33_R142_P0.6800.89
64_N71_K0.6780.89
153_P171_S0.6770.89
92_I109_M0.6760.89
163_N201_P0.6720.88
189_N200_I0.6690.88
79_L87_E0.6650.88
28_A50_S0.6630.88
50_S116_S0.6610.88
9_M14_Y0.6610.88
182_V210_L0.6600.88
37_P139_F0.6540.87
58_V82_S0.6520.87
113_T131_A0.6490.87
153_P156_L0.6460.86
26_G50_S0.6460.86
137_K176_T0.6460.86
20_S24_A0.6450.86
103_R142_P0.6440.86
13_F24_A0.6400.86
14_Y20_S0.6380.86
27_I56_F0.6350.86
65_S106_L0.6340.85
36_Y94_Y0.6340.85
91_R115_P0.6330.85
36_Y40_A0.6330.85
151_E223_P0.6320.85
12_I15_L0.6250.85
108_W137_K0.6250.85
21_A223_P0.6250.85
111_V136_M0.6250.85
137_K141_R0.6200.84
78_P114_I0.6200.84
132_I189_N0.6200.84
14_Y17_I0.6190.84
29_L57_L0.6180.84
202_L205_G0.6150.84
184_S204_S0.6130.83
60_S88_N0.6120.83
203_P206_V0.6110.83
32_T141_R0.6100.83
105_S140_L0.6090.83
57_L112_K0.5970.82
73_F105_S0.5960.82
14_Y21_A0.5940.82
24_A165_I0.5900.81
153_P170_P0.5890.81
15_L20_S0.5880.81
29_L50_S0.5870.81
47_I111_V0.5830.80
47_I116_S0.5790.80
180_L200_I0.5760.80
62_I107_F0.5740.79
128_L135_R0.5740.79
141_R194_P0.5740.79
73_F140_L0.5740.79
102_D105_S0.5730.79
33_R217_D0.5730.79
159_S185_Q0.5730.79
182_V209_K0.5720.79
117_V129_Q0.5680.79
36_Y41_K0.5680.79
183_G188_G0.5660.78
108_W176_T0.5660.78
63_E130_L0.5640.78
43_T138_L0.5630.78
72_S105_S0.5630.78
192_A196_V0.5620.78
143_I146_Q0.5580.77
9_M21_A0.5570.77
44_A130_L0.5560.77
39_D128_L0.5560.77
19_A23_A0.5550.77
148_L155_T0.5530.77
51_H112_K0.5520.77
119_K157_K0.5520.77
181_Q185_Q0.5510.76
174_Y196_V0.5510.76
65_S135_R0.5500.76
60_S80_F0.5480.76
198_S201_P0.5480.76
9_M13_F0.5450.76
113_T133_L0.5440.76
108_W111_V0.5410.75
163_N204_S0.5380.75
167_V192_A0.5350.74
158_F191_M0.5340.74
115_P131_A0.5340.74
181_Q213_Q0.5330.74
161_S201_P0.5320.74
180_L202_L0.5310.74
177_L212_F0.5300.74
21_A24_A0.5280.73
46_W130_L0.5280.73
114_I132_I0.5260.73
142_P194_P0.5240.73
57_L173_F0.5240.73
10_L206_V0.5230.73
93_I194_P0.5220.73
145_L172_P0.5210.72
14_Y19_A0.5200.72
147_E155_T0.5180.72
11_I15_L0.5180.72
156_L214_T0.5170.72
133_L158_F0.5160.72
190_A200_I0.5140.71
113_T176_T0.5120.71
164_Y202_L0.5110.71
56_F82_S0.5100.71
99_L105_S0.5100.71
205_G209_K0.5090.71
215_V222_T0.5080.71
163_N203_P0.5070.70
63_E133_L0.5060.70
57_L113_T0.5050.70
160_R164_Y0.5040.70
99_L102_D0.5030.70
61_W134_S0.5020.70
19_A24_A0.5020.70
158_F210_L0.5010.70
46_W112_K0.5000.69
141_R145_L0.5000.69
212_F222_T0.5000.69
156_L192_A0.5000.69
132_I135_R0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co7B 1 0.8522 100 0.126 Contact Map
1klfA 1 0.887 100 0.127 Contact Map
1l4iA 2 0.8261 100 0.133 Contact Map
3q48A 1 0.8 100 0.167 Contact Map
2xg5A 1 0.8565 100 0.173 Contact Map
4djmA 1 0.8696 100 0.173 Contact Map
4ay0A 2 0.8174 100 0.175 Contact Map
3gfuC 1 0.8391 100 0.186 Contact Map
4ncdA 2 0.8087 100 0.254 Contact Map
1mspA 3 0.4913 92.9 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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