GREMLIN Database
YNIC - 2-deoxyglucose-6-phosphate phosphatase
UniProt: P77247 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13988
Length: 222 (205)
Sequences: 29434 (23287)
Seq/√Len: 1626.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_L167_T4.1201.00
127_T132_R2.9371.00
156_D160_K2.8131.00
146_Y150_H2.7941.00
181_S188_S2.6011.00
172_E177_G2.5911.00
119_L123_E2.5161.00
9_A163_V2.4421.00
102_A134_S2.4201.00
98_R102_A2.3741.00
7_I187_R2.3091.00
112_G137_A2.2751.00
156_D159_A2.2601.00
110_L136_D2.2491.00
119_L143_K2.2281.00
12_F111_V2.1621.00
35_S78_R2.1231.00
115_S122_L2.1211.00
114_A153_V2.1111.00
158_A168_C2.1061.00
146_Y152_Q2.0711.00
182_K206_D2.0261.00
137_A160_K2.0101.00
178_M188_S1.9861.00
210_S214_E1.9761.00
179_I183_A1.8851.00
31_D82_R1.8711.00
187_R206_D1.8551.00
164_D167_T1.8131.00
10_A109_L1.7601.00
105_K134_S1.7271.00
158_A186_M1.7071.00
105_K136_D1.7031.00
170_A181_S1.6681.00
169_V189_I1.6651.00
11_I170_A1.6611.00
103_L107_Q1.6151.00
123_E132_R1.5641.00
111_V135_F1.5641.00
97_V212_L1.5571.00
11_I157_C1.5501.00
158_A165_P1.5361.00
7_I169_V1.5291.00
9_A161_L1.5251.00
163_V168_C1.5201.00
11_I114_A1.4931.00
36_L78_R1.4461.00
10_A104_C1.4341.00
192_P210_S1.4251.00
189_I209_L1.4161.00
112_G161_L1.4161.00
94_L193_A1.4121.00
10_A171_L1.3951.00
82_R85_S1.3221.00
175_V179_I1.3111.00
56_M59_D1.3111.00
17_L171_L1.3061.00
35_S82_R1.2991.00
31_D35_S1.2881.00
78_R81_A1.2871.00
14_M113_L1.2801.00
14_M19_I1.2671.00
103_L106_E1.2671.00
100_A212_L1.2641.00
151_P155_L1.2611.00
71_S74_E1.2611.00
14_M122_L1.2571.00
18_L97_V1.2511.00
123_E127_T1.2351.00
192_P208_K1.2241.00
154_Y170_A1.2161.00
96_G99_E1.2131.00
27_R86_L1.2121.00
74_E78_R1.2061.00
139_A160_K1.1991.00
31_D86_L1.1921.00
122_L140_S1.1821.00
211_S214_E1.1661.00
11_I168_C1.1581.00
93_L131_L1.1561.00
189_I207_V1.1271.00
139_A157_C1.1221.00
154_Y180_A1.1201.00
9_A110_L1.1161.00
15_D21_S1.1141.00
99_E213_T1.1061.00
82_R86_L1.1021.00
9_A168_C1.0921.00
78_R82_R1.0911.00
32_V36_L1.0851.00
154_Y186_M1.0821.00
168_C186_M1.0811.00
105_K111_V1.0701.00
152_Q156_D1.0671.00
155_L159_A1.0641.00
14_M117_S1.0471.00
27_R31_D1.0431.00
113_L135_F1.0361.00
34_A40_I1.0341.00
102_A106_E1.0311.00
101_V135_F1.0271.00
114_A157_C1.0261.00
88_E124_K1.0111.00
77_E81_A1.0111.00
31_D34_A1.0071.00
182_K188_S1.0001.00
155_L184_A0.9921.00
9_A112_G0.9881.00
81_A85_S0.9831.00
119_L140_S0.9821.00
15_D117_S0.9811.00
170_A186_M0.9781.00
137_A161_L0.9731.00
130_D133_D0.9721.00
157_C161_L0.9651.00
152_Q155_L0.9591.00
124_K128_M0.9531.00
180_A184_A0.9471.00
124_K127_T0.9411.00
30_L34_A0.9371.00
59_D63_A0.9311.00
99_E102_A0.9301.00
59_D72_R0.9171.00
122_L125_V0.9161.00
27_R30_L0.9131.00
98_R134_S0.9121.00
15_D115_S0.9091.00
178_M205_A0.9061.00
119_L142_E0.9021.00
144_L156_D0.8991.00
176_N179_I0.8971.00
115_S140_S0.8961.00
56_M60_L0.8941.00
11_I186_M0.8931.00
154_Y172_E0.8921.00
198_N201_R0.8871.00
93_L98_R0.8861.00
11_I161_L0.8791.00
187_R207_V0.8741.00
155_L165_P0.8621.00
7_I109_L0.8581.00
117_S122_L0.8541.00
139_A156_D0.8541.00
171_L189_I0.8481.00
145_P152_Q0.8461.00
104_C109_L0.8461.00
73_Q77_E0.8431.00
102_A133_D0.8401.00
27_R90_T0.8371.00
111_V134_S0.8361.00
200_P204_L0.8351.00
165_P186_M0.8321.00
94_L191_V0.8271.00
52_L60_L0.8261.00
169_V187_R0.8221.00
86_L89_E0.8121.00
94_L97_V0.8111.00
112_G157_C0.8061.00
14_M125_V0.8051.00
96_G211_S0.8051.00
41_S45_E0.8041.00
10_A169_V0.8021.00
58_V62_Y0.7961.00
8_L109_L0.7891.00
60_L63_A0.7851.00
101_V134_S0.7851.00
182_K204_L0.7841.00
76_V80_I0.7801.00
55_D59_D0.7761.00
26_D30_L0.7721.00
140_S143_K0.7711.00
42_R45_E0.7671.00
33_M38_V0.7651.00
19_I125_V0.7641.00
19_I129_F0.7621.00
104_C111_V0.7521.00
154_Y177_G0.7471.00
163_V167_T0.7451.00
15_D173_D0.7441.00
17_L177_G0.7431.00
188_S206_D0.7431.00
79_V83_A0.7391.00
98_R133_D0.7291.00
200_P203_V0.7221.00
143_K160_K0.7201.00
30_L41_S0.7161.00
50_L53_R0.7141.00
98_R130_D0.7081.00
8_L110_L0.7071.00
52_L56_M0.7071.00
153_V157_C0.7061.00
7_I167_T0.7061.00
151_P183_A0.7061.00
63_A66_P0.7021.00
23_P92_P0.7021.00
179_I182_K0.6991.00
170_A177_G0.6991.00
28_A32_V0.6931.00
178_M190_V0.6921.00
11_I112_G0.6821.00
116_A149_P0.6801.00
96_G213_T0.6751.00
77_E80_I0.6671.00
20_D92_P0.6661.00
99_E103_L0.6641.00
70_P74_E0.6641.00
126_L132_R0.6631.00
198_N210_S0.6611.00
49_T53_R0.6601.00
15_D125_V0.6591.00
190_V208_K0.6591.00
111_V136_D0.6581.00
55_D73_Q0.6581.00
86_L90_T0.6571.00
93_L129_F0.6561.00
28_A82_R0.6561.00
116_A147_S0.6551.00
116_A176_N0.6541.00
30_L40_I0.6521.00
193_A212_L0.6501.00
24_L91_R0.6491.00
25_W117_S0.6481.00
16_G22_E0.6471.00
60_L64_R0.6451.00
62_Y65_Q0.6451.00
122_L138_L0.6441.00
165_P168_C0.6431.00
96_G100_A0.6431.00
25_W29_E0.6411.00
110_L163_V0.6401.00
8_L163_V0.6381.00
53_R56_M0.6381.00
137_A157_C0.6371.00
153_V180_A0.6361.00
123_E138_L0.6321.00
88_E128_M0.6311.00
75_V78_R0.6281.00
209_L212_L0.6271.00
144_L153_V0.6271.00
45_E48_D0.6251.00
135_F138_L0.6241.00
139_A153_V0.6231.00
141_A153_V0.6231.00
100_A171_L0.6221.00
21_S117_S0.6221.00
20_D23_P0.6171.00
74_E77_E0.6161.00
83_A87_V0.6161.00
36_L74_E0.6131.00
49_T52_L0.6091.00
158_A163_V0.6091.00
25_W79_V0.6071.00
40_I43_R0.6071.00
114_A170_A0.6051.00
30_L42_R0.6011.00
75_V79_V0.6001.00
43_R47_P0.6001.00
34_A39_D0.6001.00
19_I91_R0.5981.00
105_K108_G0.5981.00
190_V200_P0.5961.00
158_A184_A0.5931.00
12_F100_A0.5931.00
47_P50_L0.5891.00
122_L126_L0.5871.00
23_P27_R0.5861.00
20_D94_L0.5851.00
170_A180_A0.5851.00
17_L191_V0.5831.00
102_A105_K0.5811.00
85_S89_E0.5791.00
114_A139_A0.5771.00
80_I84_I0.5751.00
126_L131_L0.5741.00
48_D60_L0.5731.00
97_V100_A0.5691.00
97_V101_V0.5681.00
155_L158_A0.5651.00
105_K133_D0.5641.00
93_L97_V0.5611.00
95_P213_T0.5561.00
100_A104_C0.5561.00
69_G73_Q0.5531.00
84_I124_K0.5511.00
120_H124_K0.5511.00
57_V62_Y0.5501.00
100_A103_L0.5451.00
50_L54_I0.5451.00
176_N180_A0.5411.00
107_Q110_L0.5391.00
62_Y67_W0.5381.00
11_I154_Y0.5361.00
46_L49_T0.5341.00
84_I120_H0.5331.00
96_G193_A0.5311.00
55_D76_V0.5261.00
175_V190_V0.5241.00
154_Y181_S0.5221.00
36_L75_V0.5181.00
7_I10_A0.5171.00
117_S121_M0.5131.00
10_A111_V0.5061.00
81_A84_I0.5031.00
180_A183_A0.5021.00
49_T54_I0.5021.00
158_A164_D0.5021.00
116_A141_A0.5021.00
57_V60_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1te2A 2 0.982 100 0.257 Contact Map
4uw9A 1 0.9144 100 0.261 Contact Map
3nasA 2 0.8964 100 0.283 Contact Map
3l5kA 1 0.9775 100 0.293 Contact Map
4eekA 2 0.964 100 0.295 Contact Map
1swvA 2 0.964 100 0.297 Contact Map
3iruA 4 0.9865 100 0.298 Contact Map
3sd7A 1 0.9595 100 0.3 Contact Map
3s6jA 2 0.9595 100 0.304 Contact Map
2hszA 1 0.982 100 0.31 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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