GREMLIN Database
MURR - HTH-type transcriptional regulator MurR
UniProt: P77245 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14161
Length: 285 (257)
Sequences: 9144 (6464)
Seq/√Len: 403.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_P183_G4.8491.00
214_A227_A3.8761.00
203_E226_L3.1251.00
131_V211_T2.9641.00
188_A202_A2.9031.00
194_S222_P2.8441.00
11_G23_D2.7801.00
10_A13_E2.5921.00
137_F163_R2.4911.00
60_A69_A2.4681.00
128_I229_F2.4411.00
136_P181_K2.4171.00
128_I213_I2.4171.00
38_R57_K2.4171.00
111_L115_Q2.3921.00
206_R228_H2.3711.00
202_A212_V2.3241.00
136_P184_D2.2601.00
28_N31_E2.1691.00
244_S247_T2.1571.00
129_I261_G2.0931.00
180_L210_A2.0841.00
204_A207_K2.0681.00
110_E114_E2.0601.00
181_K184_D2.0551.00
186_Q205_A2.0041.00
130_E265_L1.9921.00
23_D27_A1.9251.00
185_V213_I1.8811.00
131_V229_F1.8791.00
211_T228_H1.8721.00
189_I255_T1.8621.00
59_G62_G1.8611.00
24_F28_N1.8601.00
135_A185_V1.8601.00
153_L157_L1.8541.00
121_D124_R1.8161.00
188_A198_I1.8001.00
189_I215_I1.7741.00
133_S265_L1.7451.00
202_A223_L1.7421.00
22_A54_F1.7031.00
140_I187_I1.6841.00
35_V39_Q1.6731.00
205_A210_A1.6331.00
34_S76_A1.6291.00
9_N13_E1.6151.00
211_T229_F1.6081.00
18_E57_K1.5741.00
127_K229_F1.5711.00
140_I153_L1.5561.00
190_S223_L1.5491.00
140_I150_G1.5361.00
186_Q210_A1.5231.00
113_L253_S1.5211.00
68_M71_I1.5211.00
63_F67_R1.5161.00
40_M53_K1.5151.00
214_A223_L1.5141.00
55_A66_L1.5031.00
21_I54_F1.4941.00
35_V43_Q1.4821.00
231_L254_V1.4661.00
266_N269_E1.4661.00
212_V227_A1.4641.00
106_N113_L1.4591.00
214_A230_T1.4521.00
224_R230_T1.4471.00
66_L70_L1.4081.00
65_E68_M1.4031.00
261_G265_L1.4011.00
40_M56_Q1.3991.00
130_E134_K1.3911.00
141_T186_Q1.3871.00
60_A63_F1.3871.00
40_M57_K1.3851.00
188_A212_V1.3621.00
11_G19_Q1.3591.00
187_I215_I1.3381.00
124_R127_K1.3291.00
73_E77_S1.3271.00
61_Q65_E1.3241.00
116_T234_V1.3121.00
131_V185_V1.3111.00
150_G189_I1.2801.00
133_S266_N1.2781.00
206_R226_L1.2771.00
133_S262_L1.2641.00
9_N12_S1.2581.00
128_I131_V1.2561.00
188_A205_A1.2551.00
19_Q23_D1.2501.00
196_K200_L1.2481.00
151_R168_A1.2411.00
233_T251_Q1.2401.00
137_F184_D1.2391.00
36_S39_Q1.2331.00
200_L203_E1.2181.00
17_N50_S1.2171.00
17_N20_K1.2061.00
60_A66_L1.2031.00
132_I185_V1.1911.00
97_S100_V1.1871.00
73_E76_A1.1711.00
149_V255_T1.1661.00
69_A72_G1.1621.00
37_S52_V1.1561.00
67_R71_I1.1001.00
134_K211_T1.0991.00
152_D156_K1.0851.00
180_L186_Q1.0781.00
124_R229_F1.0601.00
11_G22_A1.0571.00
24_F44_L1.0561.00
31_E43_Q1.0481.00
261_G264_Q1.0471.00
139_Q184_D1.0331.00
180_L184_D1.0321.00
145_G244_S1.0281.00
96_D104_K1.0271.00
127_K131_V1.0201.00
112_A250_A1.0161.00
63_F66_L1.0091.00
55_A73_E1.0081.00
129_I265_L1.0071.00
37_S41_A0.9981.00
184_D210_A0.9981.00
139_Q180_L0.9951.00
20_K52_V0.9911.00
132_I262_L0.9881.00
138_I185_V0.9811.00
204_A208_Q0.9801.00
138_I162_Y0.9801.00
116_T233_T0.9721.00
122_Y126_Q0.9721.00
114_E118_A0.9691.00
31_E35_V0.9681.00
140_I154_S0.9661.00
127_K130_E0.9541.00
21_I44_L0.9521.00
62_G65_E0.9421.00
103_R117_C0.9371.00
132_I187_I0.9371.00
199_V222_P0.9331.00
131_V134_K0.9311.00
29_V33_Q0.9301.00
154_S165_A0.9281.00
32_L70_L0.9191.00
130_E133_S0.9161.00
25_L66_L0.9141.00
153_L256_D0.9111.00
24_F43_Q0.9061.00
103_R107_R0.9011.00
216_T224_R0.9001.00
65_E69_A0.8991.00
156_K177_S0.8941.00
203_E207_K0.8891.00
153_L187_I0.8871.00
52_V62_G0.8861.00
116_T250_A0.8851.00
147_A166_C0.8851.00
40_M51_I0.8841.00
15_T18_E0.8811.00
74_Y77_S0.8801.00
129_I133_S0.8791.00
224_R232_D0.8771.00
24_F35_V0.8741.00
10_A14_F0.8711.00
154_S158_M0.8701.00
106_N253_S0.8671.00
137_F165_A0.8621.00
24_F31_E0.8591.00
115_Q118_A0.8581.00
135_A184_D0.8571.00
38_R48_Q0.8561.00
154_S166_C0.8561.00
132_I135_A0.8531.00
66_L76_A0.8521.00
14_F40_M0.8421.00
64_T67_R0.8411.00
99_E122_Y0.8401.00
154_S164_V0.8381.00
205_A212_V0.8371.00
126_Q265_L0.8331.00
140_I164_V0.8311.00
40_M63_F0.8291.00
123_A126_Q0.8291.00
14_F56_Q0.8181.00
153_L255_T0.8121.00
159_K179_A0.8101.00
82_N85_A0.8031.00
55_A70_L0.8001.00
199_V203_E0.7981.00
110_E113_L0.7921.00
111_L114_E0.7891.00
190_S193_G0.7881.00
49_S52_V0.7861.00
102_A122_Y0.7861.00
185_V211_T0.7861.00
215_I255_T0.7861.00
67_R70_L0.7841.00
66_L73_E0.7831.00
152_D248_R0.7771.00
134_K183_G0.7761.00
68_M72_G0.7731.00
165_A173_Q0.7711.00
128_I231_L0.7661.00
245_M248_R0.7631.00
69_A73_E0.7621.00
148_L151_R0.7601.00
229_F232_D0.7561.00
151_R154_S0.7541.00
132_I138_I0.7541.00
154_S259_F0.7531.00
55_A62_G0.7521.00
139_Q186_Q0.7491.00
124_R128_I0.7391.00
188_A201_C0.7371.00
99_E103_R0.7361.00
248_R251_Q0.7361.00
219_T232_D0.7321.00
98_L107_R0.7301.00
50_S53_K0.7241.00
33_Q36_S0.7231.00
171_H200_L0.7191.00
202_A226_L0.7181.00
250_A253_S0.7161.00
153_L156_K0.7161.00
51_I77_S0.7151.00
72_G75_S0.7141.00
138_I187_I0.7141.00
157_L262_L0.7131.00
159_K177_S0.7131.00
241_R244_S0.7111.00
137_F181_K0.7101.00
59_G76_A0.7101.00
21_I50_S0.7041.00
20_K45_G0.7031.00
109_K253_S0.7001.00
147_A168_A0.6981.00
14_F57_K0.6981.00
259_F263_V0.6981.00
15_T57_K0.6951.00
33_Q71_I0.6941.00
17_N56_Q0.6921.00
147_A151_R0.6901.00
120_L125_L0.6891.00
171_H197_E0.6851.00
63_F73_E0.6851.00
100_V103_R0.6851.00
71_I74_Y0.6841.00
149_V189_I0.6810.99
199_V223_L0.6800.99
25_L54_F0.6760.99
143_L195_K0.6740.99
128_I258_L0.6720.99
53_K57_K0.6720.99
139_Q165_A0.6670.99
60_A65_E0.6660.99
32_L35_V0.6660.99
71_I75_S0.6650.99
126_Q261_G0.6630.99
177_S208_Q0.6610.99
187_I213_I0.6560.99
21_I51_I0.6540.99
14_F19_Q0.6510.99
216_T230_T0.6470.99
131_V135_A0.6440.99
48_Q52_V0.6420.99
264_Q271_L0.6410.99
154_S262_L0.6410.99
194_S217_S0.6390.99
136_P163_R0.6360.99
121_D125_L0.6340.99
140_I157_L0.6300.99
178_Q204_A0.6290.99
29_V32_L0.6270.99
183_G211_T0.6250.99
233_T254_V0.6240.99
109_K249_T0.6220.99
53_K56_Q0.6220.99
22_A26_Q0.6220.99
253_S256_D0.6210.99
36_S41_A0.6200.99
106_N116_T0.6190.99
213_I229_F0.6190.99
151_R155_F0.6180.99
123_A127_K0.6150.99
125_L257_L0.6140.99
105_L253_S0.6110.99
163_R167_E0.6090.99
221_S224_R0.6090.99
106_N109_K0.6080.99
227_A230_T0.6070.99
15_T40_M0.6070.99
149_V251_Q0.6050.99
25_L32_L0.6040.99
39_Q42_K0.6000.99
142_G147_A0.6000.99
248_R252_N0.5990.99
89_H92_I0.5960.99
199_V226_L0.5950.99
216_T221_S0.5930.99
129_I262_L0.5930.99
140_I189_I0.5920.99
107_R111_L0.5900.99
54_F58_L0.5900.99
154_S162_Y0.5890.99
177_S210_A0.5880.99
15_T56_Q0.5870.99
222_P226_L0.5810.98
142_G146_S0.5810.98
146_S251_Q0.5780.98
200_L204_A0.5730.98
35_V40_M0.5710.98
214_A221_S0.5690.98
241_R248_R0.5680.98
116_T254_V0.5670.98
59_G63_F0.5660.98
260_V263_V0.5660.98
192_S195_K0.5650.98
66_L71_I0.5630.98
182_K209_G0.5620.98
141_T188_A0.5610.98
109_K256_D0.5600.98
66_L74_Y0.5590.98
125_L261_G0.5590.98
63_F76_A0.5580.98
20_K48_Q0.5570.98
242_S245_M0.5560.98
267_D270_S0.5550.98
21_I46_I0.5530.98
20_K51_I0.5520.98
44_L51_I0.5520.98
105_L109_K0.5490.98
110_E117_C0.5490.98
244_S249_T0.5480.98
241_R247_T0.5470.98
115_Q234_V0.5450.98
88_L91_S0.5440.98
155_F158_M0.5410.97
223_L227_A0.5400.97
70_L73_E0.5360.97
145_G155_F0.5350.97
244_S248_R0.5350.97
260_V264_Q0.5340.97
128_I187_I0.5340.97
188_A214_A0.5340.97
143_L197_E0.5330.97
224_R227_A0.5320.97
39_Q43_Q0.5290.97
136_P182_K0.5290.97
150_G153_L0.5280.97
168_A172_V0.5270.97
141_T180_L0.5250.97
139_Q167_E0.5240.97
157_L259_F0.5240.97
263_V270_S0.5240.97
190_S221_S0.5240.97
85_A89_H0.5200.97
88_L93_T0.5190.97
55_A60_A0.5170.97
116_T119_L0.5170.97
71_I76_A0.5150.97
233_T250_A0.5150.97
206_R212_V0.5120.97
258_L262_L0.5120.97
159_K178_Q0.5110.96
217_S233_T0.5110.96
38_R42_K0.5100.96
141_T201_C0.5100.96
177_S204_A0.5100.96
43_Q53_K0.5100.96
247_T250_A0.5100.96
267_D271_L0.5100.96
18_E66_L0.5100.96
251_Q255_T0.5080.96
62_G66_L0.5060.96
239_E242_S0.5060.96
101_I104_K0.5060.96
234_V237_E0.5040.96
117_C253_S0.5030.96
119_L122_Y0.5020.96
266_N270_S0.5010.96
231_L258_L0.5000.96
237_E240_W0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ivnA 2 0.9228 100 0.183 Contact Map
3shoA 4 0.6491 100 0.525 Contact Map
2xhzA 4 0.6 100 0.549 Contact Map
3fxaA 4 0.6596 100 0.555 Contact Map
3etnA 4 0.6561 100 0.563 Contact Map
2pocA 4 0.6561 100 0.571 Contact Map
3tbfA 2 0.6737 99.9 0.574 Contact Map
1m3sA 4 0.6246 99.9 0.574 Contact Map
1moqA 2 0.6667 99.9 0.577 Contact Map
1jeoA 4 0.6035 99.9 0.582 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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