GREMLIN Database
CITG - 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
UniProt: P77231 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13539
Length: 292 (263)
Sequences: 1100 (816)
Seq/√Len: 50.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_C191_I3.5301.00
194_A286_T3.3681.00
233_G236_G3.3001.00
228_V240_L3.2691.00
185_A188_P3.1281.00
51_K273_N3.0081.00
46_N266_D2.9741.00
68_W98_C2.9661.00
36_S45_I2.9631.00
255_T258_D2.7371.00
91_L124_A2.7011.00
75_F94_I2.6311.00
251_G258_D2.6231.00
240_L269_C2.5951.00
36_S43_D2.5421.00
265_F269_C2.4401.00
228_V274_L2.4251.00
232_G236_G2.3891.00
21_Y123_C2.3811.00
166_A230_S2.3211.00
36_S44_R2.3071.00
243_E268_E2.3051.00
232_G274_L2.3001.00
220_M240_L2.2951.00
123_C127_G2.2901.00
151_G184_E2.2241.00
29_M115_S2.2011.00
252_G258_D2.1471.00
34_N59_H2.0791.00
176_L229_A2.0061.00
142_C145_A1.9991.00
34_N55_L1.9630.99
219_L223_N1.9580.99
182_E189_L1.9470.99
214_D252_G1.9350.99
189_L223_N1.9280.99
76_G127_G1.9250.99
212_L287_W1.9220.99
216_L220_M1.9120.99
214_D251_G1.8850.99
166_A170_L1.8820.99
277_G281_D1.8720.99
49_A270_I1.8330.99
207_D210_L1.8240.99
195_L286_T1.8230.99
141_V144_T1.8060.99
177_T181_G1.7760.99
23_L66_Q1.7730.99
197_H201_L1.7350.99
61_S102_M1.7250.99
34_N44_R1.7140.99
247_L258_D1.7050.99
149_C152_L1.6940.98
25_G119_L1.6560.98
22_A26_W1.6360.98
103_F113_K1.6010.98
79_S87_V1.5970.98
53_M109_V1.5930.98
141_V289_L1.5840.98
71_R97_A1.5720.97
266_D270_I1.5560.97
126_I141_V1.5490.97
21_Y127_G1.4840.96
30_L62_A1.4810.96
110_N281_D1.4800.96
36_S46_N1.4590.96
153_T157_L1.4550.96
197_H218_L1.4530.96
25_G288_F1.4490.96
118_S179_A1.4360.96
214_D258_D1.4280.96
151_G155_R1.4190.95
193_H222_I1.3810.95
43_D46_N1.3580.94
153_T156_E1.3530.94
53_M58_F1.3310.93
65_I69_L1.3250.93
224_G241_Q1.3170.93
65_I98_C1.3150.93
31_T60_R1.3080.93
238_R241_Q1.3000.93
183_A187_Y1.2960.93
266_D269_C1.2940.92
229_A237_L1.2670.92
61_S112_H1.2640.92
223_N279_S1.2590.91
170_L230_S1.2420.91
119_L284_I1.2260.90
26_W66_Q1.2100.90
121_L183_A1.2060.90
215_T286_T1.1990.89
76_G124_A1.1960.89
50_H227_N1.1940.89
236_G274_L1.1900.89
115_S179_A1.1850.89
102_M106_T1.1840.89
53_M111_T1.1830.89
25_G65_I1.1740.88
243_E265_F1.1710.88
217_L262_L1.1500.87
67_G101_D1.1470.87
251_G255_T1.1290.86
106_T109_V1.1280.86
43_D266_D1.1130.85
73_I123_C1.1080.85
118_S285_L1.1060.85
239_W243_E1.0970.85
144_T148_F1.0930.84
270_I273_N1.0770.83
37_P43_D1.0750.83
110_N277_G1.0550.82
194_A218_L1.0540.82
252_G255_T1.0490.82
277_G280_A1.0420.81
26_W62_A1.0350.81
237_L241_Q1.0350.81
262_L266_D1.0340.81
153_T184_E1.0270.80
140_T144_T1.0230.80
61_S111_T1.0110.79
88_L92_R1.0090.79
92_R117_F1.0070.79
194_A219_L1.0050.79
145_A149_C1.0020.79
220_M244_A0.9810.77
102_M111_T0.9810.77
181_G185_A0.9800.77
44_R55_L0.9780.77
74_E78_C0.9680.76
247_L250_K0.9660.76
122_L285_L0.9660.76
250_K261_Y0.9650.76
30_L34_N0.9630.76
88_L117_F0.9590.76
117_F227_N0.9590.76
102_M231_R0.9570.75
71_R94_I0.9500.75
21_Y73_I0.9470.75
236_G239_W0.9460.75
91_L228_V0.9390.74
178_G231_R0.9250.73
50_H53_M0.9190.72
247_L252_G0.9180.72
112_H115_S0.9160.72
285_L289_L0.9160.72
43_D113_K0.9140.72
219_L279_S0.9140.72
79_S128_R0.9110.72
229_A234_E0.9010.71
190_V289_L0.9000.71
19_D70_P0.8980.71
221_A244_A0.8830.69
217_L244_A0.8830.69
190_V196_P0.8810.69
122_L145_A0.8790.69
33_V55_L0.8780.69
148_F157_L0.8770.69
147_S150_R0.8690.68
242_R246_T0.8650.68
37_P213_L0.8610.67
64_A101_D0.8590.67
122_L289_L0.8580.67
38_K187_Y0.8570.67
30_L63_L0.8490.66
216_L283_L0.8470.66
99_E116_I0.8360.65
112_H116_I0.8340.65
149_C156_E0.8340.65
33_V62_A0.8300.65
200_T204_Q0.8290.64
46_N270_I0.8280.64
62_A67_G0.8280.64
189_L219_L0.8260.64
73_I126_I0.8250.64
49_A274_L0.8230.64
115_S288_F0.8230.64
128_R144_T0.8210.64
123_C288_F0.8190.64
152_L157_L0.8150.63
206_L210_L0.8130.63
220_M228_V0.8130.63
40_G111_T0.8100.63
149_C183_A0.8080.62
52_D110_N0.8060.62
138_P141_V0.7950.61
58_F110_N0.7910.61
56_E209_E0.7870.60
42_V52_D0.7830.60
33_V58_F0.7820.60
167_G171_Y0.7790.60
147_S157_L0.7790.60
87_V128_R0.7780.60
49_A266_D0.7780.60
189_L279_S0.7690.59
243_E246_T0.7650.58
55_L59_H0.7630.58
178_G181_G0.7630.58
95_G178_G0.7630.58
205_G211_A0.7540.57
131_Q267_R0.7530.57
268_E272_R0.7510.57
52_D231_R0.7500.57
102_M110_N0.7490.57
88_L96_M0.7440.56
42_V53_M0.7420.56
91_L123_C0.7410.56
169_R230_S0.7410.56
170_L220_M0.7380.55
92_R227_N0.7360.55
95_G117_F0.7350.55
234_E238_R0.7330.55
145_A150_R0.7330.55
112_H278_G0.7330.55
170_L226_T0.7320.55
278_G283_L0.7310.55
92_R180_R0.7290.55
68_W101_D0.7280.54
197_H214_D0.7170.53
145_A148_F0.7160.53
55_L262_L0.7150.53
118_S191_I0.7120.53
198_Y286_T0.7090.53
129_L144_T0.7090.53
109_V118_S0.7040.52
263_R267_R0.7040.52
214_D253_I0.7030.52
230_S284_I0.7000.52
43_D112_H0.6970.51
42_V110_N0.6940.51
182_E224_G0.6910.51
179_A226_T0.6900.51
233_G262_L0.6880.50
242_R245_Q0.6870.50
88_L149_C0.6860.50
154_D157_L0.6830.50
208_P290_A0.6830.50
32_E110_N0.6820.50
63_L66_Q0.6820.50
95_G283_L0.6800.50
95_G278_G0.6790.49
219_L282_L0.6750.49
50_H231_R0.6750.49
38_K43_D0.6730.49
32_E281_D0.6730.49
93_P97_A0.6680.48
258_D261_Y0.6660.48
92_R156_E0.6660.48
65_I106_T0.6650.48
112_H183_A0.6640.48
198_Y290_A0.6640.48
190_V285_L0.6630.48
220_M269_C0.6620.48
32_E277_G0.6590.47
218_L221_A0.6590.47
40_G276_P0.6580.47
191_I289_L0.6540.47
246_T264_Q0.6530.47
47_C54_A0.6530.47
137_T147_S0.6530.47
50_H106_T0.6520.47
152_L156_E0.6510.47
176_L226_T0.6510.47
52_D281_D0.6490.46
35_L38_K0.6480.46
164_L172_Q0.6440.46
95_G120_G0.6410.46
92_R152_L0.6410.46
126_I288_F0.6410.46
40_G274_L0.6400.45
216_L279_S0.6400.45
143_S147_S0.6390.45
26_W63_L0.6380.45
95_G102_M0.6310.45
29_M183_A0.6280.44
112_H227_N0.6280.44
213_L258_D0.6250.44
50_H178_G0.6220.44
62_A191_I0.6220.44
244_A269_C0.6200.43
117_F278_G0.6190.43
136_V140_T0.6160.43
178_G278_G0.6160.43
113_K278_G0.6160.43
102_M112_H0.6120.43
115_S230_S0.6120.43
28_A69_L0.6110.43
176_L230_S0.6110.43
35_L212_L0.6110.43
49_A276_P0.6100.42
198_Y208_P0.6070.42
171_Y180_R0.6050.42
227_N275_S0.6030.42
136_V161_N0.6030.42
194_A215_T0.6020.42
247_L265_F0.6020.42
57_D109_V0.6010.42
57_D111_T0.5990.41
206_L214_D0.5940.41
204_Q245_Q0.5940.41
217_L247_L0.5910.41
239_W272_R0.5890.40
228_V276_P0.5880.40
198_Y287_W0.5870.40
228_V269_C0.5860.40
41_L275_S0.5860.40
72_F116_I0.5850.40
68_W72_F0.5850.40
99_E278_G0.5840.40
100_G256_P0.5840.40
265_F274_L0.5830.40
247_L262_L0.5830.40
195_L199_L0.5810.40
32_E42_V0.5810.40
100_G199_L0.5810.40
102_M167_G0.5810.40
27_R31_T0.5800.39
111_T281_D0.5740.39
214_D254_R0.5740.39
32_E52_D0.5740.39
144_T149_C0.5730.39
88_L148_F0.5720.39
101_D104_R0.5710.39
112_H230_S0.5710.39
141_V145_A0.5700.38
35_L213_L0.5690.38
92_R168_Q0.5680.38
185_A260_D0.5660.38
118_S227_N0.5660.38
149_C170_L0.5660.38
155_R184_E0.5660.38
97_A100_G0.5630.38
189_L229_A0.5620.38
72_F76_G0.5620.38
92_R157_L0.5620.38
41_L99_E0.5610.38
35_L232_G0.5590.37
42_V58_F0.5580.37
220_M279_S0.5570.37
145_A157_L0.5560.37
29_M119_L0.5550.37
95_G231_R0.5540.37
267_R271_E0.5520.37
106_T275_S0.5510.37
149_C153_T0.5500.37
102_M281_D0.5500.37
29_M69_L0.5490.36
245_Q249_Q0.5470.36
78_C90_G0.5460.36
44_R209_E0.5460.36
221_A245_Q0.5450.36
35_L209_E0.5440.36
53_M117_F0.5440.36
31_T212_L0.5440.36
91_L199_L0.5440.36
132_L250_K0.5430.36
25_G112_H0.5430.36
122_L288_F0.5390.35
95_G99_E0.5390.35
25_G102_M0.5380.35
41_L50_H0.5370.35
71_R260_D0.5360.35
113_K171_Y0.5340.35
190_V282_L0.5320.35
276_P284_I0.5320.35
75_F90_G0.5320.35
102_M116_I0.5320.35
177_T185_A0.5320.35
117_F180_R0.5320.35
128_R217_L0.5270.34
53_M110_N0.5260.34
141_V155_R0.5200.34
19_D67_G0.5200.34
38_K227_N0.5200.34
122_L187_Y0.5180.34
170_L228_V0.5180.34
213_L262_L0.5160.33
204_Q267_R0.5150.33
99_E102_M0.5100.33
286_T290_A0.5100.33
142_C149_C0.5080.33
101_D126_I0.5080.33
141_V152_L0.5070.33
21_Y47_C0.5070.33
218_L248_L0.5060.32
121_L244_A0.5060.32
107_A150_R0.5060.32
145_A152_L0.5050.32
174_L234_E0.5050.32
50_H109_V0.5040.32
35_L283_L0.5030.32
232_G286_T0.5030.32
108_G145_A0.5010.32
118_S187_Y0.5000.32
262_L269_C0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h9pA 2 0.7158 100 0.355 Contact Map
2w4sA 2 0.2158 13.7 0.968 Contact Map
2xc7A 1 0.2397 11.3 0.969 Contact Map
4a4zA 1 0.3836 9.3 0.97 Contact Map
4qu4A 1 0.3459 7.1 0.972 Contact Map
1e91A 1 0.2808 6.5 0.972 Contact Map
4u4cA 1 0.3801 6.3 0.972 Contact Map
2cr7A 1 0.2705 6.1 0.972 Contact Map
1g1eB 1 0.2842 5.2 0.973 Contact Map
2czyA 1 0.2568 5.1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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