GREMLIN Database
YAHG - Uncharacterized protein YahG
UniProt: P77221 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13591
Length: 472 (409)
Sequences: 285 (180)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_A162_S5.5341.00
171_K178_I5.3571.00
252_L256_L5.1191.00
370_M434_N4.3390.99
109_K317_E4.0440.98
130_D133_E3.6600.97
322_V325_L3.6100.96
198_Q202_D3.4970.96
70_L400_G3.3200.94
303_E469_R3.1740.93
82_G220_K3.1260.92
98_I162_S3.0890.92
170_V290_A3.0190.91
106_T109_K2.9980.90
391_S416_P2.9340.89
421_I463_I2.9190.89
322_V421_I2.8990.89
184_S286_P2.8190.87
82_G169_I2.7950.87
395_R401_E2.6750.84
210_V272_E2.6500.83
172_N177_N2.5970.82
184_S436_A2.5670.81
156_S286_P2.5040.80
226_D229_L2.4980.79
127_L163_A2.4650.79
234_A248_G2.4490.78
68_Q72_R2.3900.76
115_K135_A2.3870.76
84_D88_N2.3780.76
436_A446_M2.3720.76
260_I270_Q2.3560.75
124_F208_R2.3210.74
421_I466_W2.3080.74
292_C363_Y2.2950.73
94_T97_T2.2950.73
295_A405_V2.2470.72
118_V138_A2.2380.71
85_Q88_N2.2020.70
338_I347_P2.1940.70
286_P436_A2.1900.69
401_E413_M2.1770.69
307_V399_L2.1310.67
83_F212_G2.1300.67
216_R220_K2.0890.66
306_T466_W2.0680.65
119_T123_V2.0550.64
296_M310_T2.0430.64
119_T131_L1.9490.60
257_T274_F1.9120.58
87_I164_S1.8680.57
135_A139_A1.8670.57
62_I422_T1.8350.55
77_H226_D1.8310.55
207_M211_Q1.8030.54
269_Q272_E1.7780.53
156_S184_S1.7520.52
395_R413_M1.7490.51
323_S326_P1.7080.50
73_I296_M1.7040.50
353_D435_T1.6980.49
313_R353_D1.6980.49
205_N208_R1.6950.49
341_M347_P1.6780.48
184_S379_L1.6720.48
96_K142_E1.6650.48
73_I307_V1.6380.47
183_M283_F1.6130.46
63_A422_T1.6050.45
79_V229_L1.5960.45
61_K304_Y1.5910.45
339_G437_I1.5900.45
267_V270_Q1.5810.44
95_A127_L1.5600.43
316_V447_I1.5580.43
337_V351_G1.5490.43
430_L454_P1.5330.42
112_G227_L1.5310.42
214_I260_I1.5270.42
96_K127_L1.5170.42
211_Q283_F1.4990.41
315_G356_D1.4840.40
111_C316_V1.4800.40
98_I127_L1.4790.40
243_N376_I1.4770.40
325_L421_I1.4440.38
222_I225_I1.4430.38
170_V277_V1.4320.38
255_A306_T1.4080.37
76_S175_Y1.4050.37
268_E272_E1.4020.37
457_A461_K1.3990.37
332_G454_P1.3980.37
313_R435_T1.3950.37
143_I176_G1.3910.36
162_S323_S1.3850.36
93_M249_T1.3660.35
94_T127_L1.3620.35
252_L299_A1.3610.35
326_P352_L1.3440.34
248_G290_A1.3390.34
212_G287_T1.3340.34
146_S150_E1.3330.34
307_V400_G1.3330.34
80_L252_L1.3270.34
300_H321_R1.3270.34
100_H315_G1.3190.34
146_S151_H1.3060.33
303_E307_V1.3050.33
337_V452_V1.3030.33
332_G335_Q1.2990.33
100_H356_D1.2870.32
73_I302_I1.2870.32
217_D265_Y1.2870.32
72_R217_D1.2800.32
157_M435_T1.2760.32
227_L248_G1.2740.32
67_Q71_E1.2570.31
92_G127_L1.2440.31
119_T255_A1.2420.31
309_T358_A1.2390.31
184_S190_I1.2360.30
193_M354_I1.2350.30
183_M211_Q1.2300.30
156_S188_A1.2290.30
121_A358_A1.2280.30
317_E354_I1.2260.30
122_L127_L1.2260.30
221_I262_Q1.2210.30
354_I447_I1.2110.29
172_N297_D1.2050.29
73_I179_A1.2020.29
184_S446_M1.1980.29
123_V336_Q1.1930.29
157_M353_D1.1910.29
82_G216_R1.1800.28
157_M313_R1.1800.28
286_P446_M1.1770.28
127_L454_P1.1710.28
243_N334_A1.1660.28
369_A415_V1.1600.28
312_A368_F1.1590.28
192_R200_V1.1580.28
316_V354_I1.1530.27
303_E323_S1.1510.27
300_H309_T1.1450.27
206_W276_F1.1290.27
97_T144_T1.1280.27
190_I286_P1.1260.27
143_I396_E1.1180.26
122_L138_A1.1120.26
162_S298_A1.1090.26
256_L373_A1.1030.26
124_F209_D1.0950.25
235_L371_A1.0950.25
190_I436_A1.0910.25
67_Q133_E1.0870.25
160_V454_P1.0870.25
181_T285_G1.0830.25
183_M212_G1.0790.25
282_Y376_I1.0690.25
122_L137_L1.0650.25
243_N282_Y1.0640.24
245_N438_A1.0570.24
218_A297_D1.0540.24
124_F207_M1.0430.24
159_G185_E1.0420.24
84_D169_I1.0400.24
148_C359_I1.0390.24
103_P319_G1.0360.24
99_L148_C1.0330.24
295_A400_G1.0230.23
411_G425_G1.0190.23
76_S294_A1.0170.23
214_I265_Y1.0160.23
109_K316_V1.0140.23
341_M437_I1.0140.23
115_K179_A1.0130.23
74_I417_S1.0120.23
105_I143_I1.0090.23
311_M318_F1.0060.23
148_C245_N1.0010.23
351_G354_I0.9980.22
292_C416_P0.9980.22
186_Q285_G0.9970.22
78_P179_A0.9920.22
85_Q220_K0.9920.22
331_T396_E0.9920.22
69_A371_A0.9830.22
127_L373_A0.9770.22
338_I345_Y0.9710.22
116_G192_R0.9700.22
139_A167_M0.9700.22
183_M372_T0.9680.22
249_T277_V0.9650.21
149_H359_I0.9640.21
236_H375_A0.9600.21
67_Q108_E0.9590.21
123_V130_D0.9580.21
325_L444_V0.9530.21
222_I259_G0.9500.21
339_G458_C0.9480.21
303_E461_K0.9470.21
76_S172_N0.9460.21
181_T290_A0.9440.21
340_P379_L0.9430.21
152_D468_E0.9430.21
77_H310_T0.9420.21
80_L386_E0.9420.21
104_P211_Q0.9400.21
173_K423_R0.9380.21
115_K440_K0.9370.21
131_L196_N0.9360.21
137_L140_S0.9350.21
160_V335_Q0.9320.21
79_V226_D0.9320.21
149_H312_A0.9310.20
439_H444_V0.9310.20
177_N294_A0.9300.20
69_A307_V0.9280.20
75_Q172_N0.9280.20
306_T463_I0.9270.20
163_A287_T0.9270.20
254_Q274_F0.9260.20
322_V352_L0.9260.20
207_M258_P0.9210.20
184_S188_A0.9190.20
249_T372_T0.9180.20
304_Y421_I0.9170.20
69_A72_R0.9160.20
94_T197_D0.9130.20
132_D143_I0.9100.20
280_S376_I0.9080.20
328_Q469_R0.9040.20
391_S415_V0.9030.20
241_C365_I0.8980.20
115_K173_K0.8980.20
385_E411_G0.8950.19
236_H406_T0.8920.19
78_P227_L0.8910.19
214_I307_V0.8900.19
206_W215_L0.8890.19
119_T323_S0.8890.19
300_H327_G0.8880.19
343_A378_A0.8860.19
317_E338_I0.8840.19
284_S287_T0.8830.19
230_M421_I0.8820.19
192_R286_P0.8800.19
236_H341_M0.8800.19
328_Q461_K0.8750.19
111_C439_H0.8690.19
219_M417_S0.8690.19
248_G411_G0.8680.19
136_E269_Q0.8640.19
183_M421_I0.8630.19
192_R206_W0.8620.19
96_K174_T0.8620.19
234_A251_L0.8620.19
111_C407_I0.8600.19
127_L401_E0.8590.19
250_T378_A0.8540.18
73_I123_V0.8520.18
75_Q321_R0.8490.18
230_M299_A0.8490.18
299_A309_T0.8460.18
76_S177_N0.8430.18
163_A375_A0.8420.18
166_F426_S0.8420.18
376_I451_I0.8410.18
228_R368_F0.8410.18
116_G370_M0.8390.18
70_L447_I0.8380.18
76_S182_N0.8330.18
115_K224_E0.8300.18
89_V214_I0.8290.18
256_L389_D0.8290.18
71_E75_Q0.8290.18
199_S235_L0.8280.18
286_P379_L0.8260.18
322_V466_W0.8250.18
73_I295_A0.8220.18
398_T419_I0.8220.18
335_Q458_C0.8210.18
187_M410_L0.8180.17
129_K136_E0.8120.17
223_G400_G0.8110.17
85_Q253_I0.8110.17
123_V131_L0.8100.17
215_L345_Y0.8090.17
190_I446_M0.8050.17
166_F439_H0.8040.17
175_Y298_A0.8040.17
132_D296_M0.8010.17
79_V224_E0.8000.17
353_D387_A0.7990.17
98_I216_R0.7970.17
172_N294_A0.7960.17
110_M439_H0.7930.17
243_N377_V0.7930.17
188_A446_M0.7930.17
240_E282_Y0.7900.17
292_C391_S0.7880.17
318_F367_G0.7860.17
217_D256_L0.7850.17
328_Q468_E0.7840.17
190_I284_S0.7820.17
201_I205_N0.7800.17
148_C360_T0.7800.17
406_T415_V0.7800.17
111_C351_G0.7760.16
82_G85_Q0.7760.16
368_F419_I0.7740.16
83_F208_R0.7730.16
258_P429_I0.7710.16
127_L290_A0.7700.16
70_L126_G0.7700.16
101_A192_R0.7690.16
136_E140_S0.7680.16
187_M190_I0.7680.16
89_V255_A0.7670.16
241_C288_W0.7670.16
136_E307_V0.7660.16
195_A200_V0.7620.16
155_G159_G0.7600.16
96_K401_E0.7580.16
136_E217_D0.7570.16
129_K143_I0.7570.16
252_L461_K0.7560.16
266_S269_Q0.7530.16
73_I266_S0.7510.16
129_K133_E0.7500.16
73_I162_S0.7490.16
216_R249_T0.7480.16
231_L407_I0.7470.16
205_N272_E0.7470.16
223_G429_I0.7460.16
69_A305_S0.7460.16
68_Q71_E0.7460.16
340_P436_A0.7440.16
188_A286_P0.7430.16
260_I441_D0.7430.16
168_H283_F0.7410.16
305_S371_A0.7410.16
212_G292_C0.7410.16
90_V167_M0.7380.16
100_H314_N0.7370.16
287_T292_C0.7370.16
297_D300_H0.7360.16
263_A266_S0.7350.16
121_A299_A0.7310.15
199_S444_V0.7300.15
124_F343_A0.7290.15
304_Y447_I0.7290.15
334_A376_I0.7270.15
83_F138_A0.7260.15
423_R461_K0.7240.15
116_G442_A0.7190.15
401_E454_P0.7180.15
186_Q436_A0.7170.15
166_F288_W0.7160.15
77_H228_R0.7160.15
123_V196_N0.7150.15
192_R370_M0.7140.15
215_L372_T0.7130.15
234_A309_T0.7120.15
196_N434_N0.7100.15
74_I88_N0.7080.15
230_M323_S0.7060.15
111_C375_A0.7050.15
167_M204_L0.7030.15
79_V121_A0.7030.15
158_A241_C0.7020.15
197_D388_I0.7000.15
174_T177_N0.6980.15
283_F371_A0.6980.15
80_L204_L0.6970.15
177_N298_A0.6960.15
260_I310_T0.6950.15
181_T446_M0.6950.15
121_A309_T0.6940.15
156_S190_I0.6940.15
62_I439_H0.6910.15
231_L379_L0.6900.15
70_L138_A0.6900.15
379_L449_A0.6900.15
150_E255_A0.6900.15
314_N356_D0.6890.15
99_L458_C0.6890.15
105_I299_A0.6870.14
313_R387_A0.6870.14
163_A444_V0.6850.14
379_L386_E0.6790.14
280_S288_W0.6780.14
84_D278_A0.6770.14
403_P466_W0.6770.14
167_M180_Y0.6750.14
321_R391_S0.6740.14
120_G191_L0.6740.14
310_T411_G0.6720.14
220_K292_C0.6710.14
234_A290_A0.6680.14
97_T365_I0.6650.14
248_G295_A0.6610.14
81_I126_G0.6590.14
292_C368_F0.6580.14
230_M269_Q0.6560.14
365_I416_P0.6560.14
278_A290_A0.6550.14
156_S192_R0.6550.14
64_A469_R0.6550.14
231_L405_V0.6510.14
292_C360_T0.6500.14
209_D328_Q0.6490.14
64_A267_V0.6490.14
191_L419_I0.6470.14
117_A376_I0.6470.14
303_E386_E0.6450.14
120_G360_T0.6430.14
298_A301_G0.6430.14
200_V206_W0.6430.14
165_M189_K0.6430.14
376_I430_L0.6420.14
339_G370_M0.6420.14
333_P352_L0.6410.14
219_M234_A0.6400.13
277_V290_A0.6390.13
232_A379_L0.6390.13
341_M350_S0.6380.13
343_A410_L0.6380.13
113_A356_D0.6380.13
194_G204_L0.6360.13
161_T208_R0.6350.13
411_G423_R0.6350.13
230_M251_L0.6340.13
73_I292_C0.6330.13
149_H435_T0.6320.13
110_M353_D0.6310.13
377_V451_I0.6310.13
411_G444_V0.6300.13
67_Q137_L0.6300.13
310_T322_V0.6300.13
351_G446_M0.6280.13
271_R275_E0.6280.13
334_A356_D0.6260.13
98_I456_F0.6240.13
181_T281_D0.6240.13
407_I413_M0.6190.13
437_I447_I0.6180.13
98_I332_G0.6180.13
73_I76_S0.6180.13
75_Q456_F0.6170.13
332_G430_L0.6170.13
292_C434_N0.6170.13
184_S276_F0.6170.13
317_E331_T0.6160.13
263_A270_Q0.6150.13
262_Q271_R0.6140.13
192_R315_G0.6110.13
226_D256_L0.6100.13
158_A376_I0.6090.13
162_S299_A0.6060.13
126_G307_V0.6050.13
284_S436_A0.6040.13
212_G363_Y0.6020.13
120_G297_D0.6010.13
149_H157_M0.6010.13
193_M413_M0.6000.13
167_M212_G0.6000.13
422_T439_H0.5990.13
212_G220_K0.5980.13
156_S356_D0.5970.13
301_G305_S0.5970.13
158_A430_L0.5960.13
359_I362_T0.5950.13
61_K68_Q0.5930.13
106_T426_S0.5920.13
72_R177_N0.5920.13
67_Q136_E0.5900.13
350_S433_I0.5890.12
345_Y358_A0.5880.12
117_A185_E0.5870.12
118_V444_V0.5860.12
187_M376_I0.5860.12
372_T465_G0.5860.12
168_H183_M0.5850.12
260_I365_I0.5850.12
76_S303_E0.5850.12
402_N417_S0.5850.12
398_T417_S0.5840.12
292_C321_R0.5830.12
261_I271_R0.5830.12
89_V180_Y0.5830.12
284_S428_G0.5800.12
120_G200_V0.5790.12
157_M387_A0.5780.12
198_Q266_S0.5780.12
454_P457_A0.5780.12
170_V241_C0.5750.12
171_K440_K0.5740.12
148_C191_L0.5740.12
156_S379_L0.5730.12
234_A323_S0.5730.12
234_A411_G0.5720.12
393_Q453_H0.5720.12
298_A316_V0.5720.12
116_G243_N0.5710.12
92_G249_T0.5710.12
124_F201_I0.5710.12
301_G309_T0.5700.12
305_S410_L0.5700.12
165_M185_E0.5680.12
262_Q268_E0.5670.12
311_M362_T0.5660.12
435_T439_H0.5650.12
151_H392_R0.5650.12
106_T317_E0.5640.12
323_S330_F0.5630.12
188_A379_L0.5630.12
117_A227_L0.5620.12
233_Q295_A0.5570.12
187_M282_Y0.5570.12
80_L348_E0.5570.12
188_A436_A0.5550.12
201_I231_L0.5540.12
356_D374_P0.5540.12
368_F398_T0.5530.12
315_G334_A0.5530.12
142_E468_E0.5510.12
344_G381_G0.5510.12
437_I465_G0.5510.12
241_C248_G0.5510.12
286_P340_P0.5500.12
116_G195_A0.5490.12
111_C454_P0.5490.12
110_M313_R0.5480.12
225_I287_T0.5480.12
304_Y466_W0.5480.12
230_M272_E0.5470.12
158_A401_E0.5460.12
313_R356_D0.5450.12
66_N245_N0.5440.12
172_N307_V0.5440.12
384_V409_L0.5440.12
261_I341_M0.5440.12
207_M276_F0.5430.12
64_A68_Q0.5430.12
62_I163_A0.5420.12
332_G457_A0.5420.12
84_D220_K0.5410.12
234_A241_C0.5410.12
231_L298_A0.5410.12
309_T422_T0.5400.12
217_D264_G0.5400.12
201_I212_G0.5390.12
290_A454_P0.5390.12
67_Q338_I0.5390.12
160_V422_T0.5390.12
122_L163_A0.5380.12
252_L292_C0.5380.12
234_A432_V0.5370.12
230_M415_V0.5360.12
66_N353_D0.5350.12
120_G185_E0.5330.11
138_A250_T0.5330.11
310_T444_V0.5330.11
108_E197_D0.5320.11
354_I407_I0.5320.11
104_P192_R0.5320.11
140_S172_N0.5320.11
313_R340_P0.5300.11
250_T281_D0.5290.11
189_K365_I0.5290.11
112_G117_A0.5280.11
243_N368_F0.5270.11
143_I217_D0.5250.11
113_A315_G0.5240.11
82_G181_T0.5240.11
334_A377_V0.5240.11
63_A135_A0.5240.11
159_G362_T0.5230.11
156_S315_G0.5220.11
253_I277_V0.5220.11
404_N461_K0.5200.11
240_E446_M0.5200.11
64_A385_E0.5190.11
315_G374_P0.5160.11
293_K359_I0.5150.11
133_E217_D0.5150.11
321_R344_G0.5140.11
221_I273_V0.5140.11
356_D387_A0.5130.11
110_M435_T0.5130.11
371_A410_L0.5130.11
115_K348_E0.5110.11
392_R409_L0.5110.11
192_R195_A0.5110.11
184_S192_R0.5100.11
110_M356_D0.5090.11
71_E202_D0.5070.11
98_I118_V0.5070.11
95_A163_A0.5070.11
158_A410_L0.5070.11
375_A453_H0.5070.11
101_A389_D0.5060.11
133_E173_K0.5060.11
270_Q402_N0.5050.11
180_Y236_H0.5050.11
297_D310_T0.5030.11
164_S301_G0.5030.11
136_E144_T0.5030.11
107_W394_M0.5010.11
73_I415_V0.5000.11
224_E256_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3clqA 2 0.8877 100 0.119 Contact Map
3dmyA 2 0.1123 99.4 0.93 Contact Map
3ktsA 1 0.2987 23.9 0.985 Contact Map
3ht4A 4 0.2691 18.1 0.986 Contact Map
4to8A 2 0.1589 15.6 0.986 Contact Map
3pm6A 2 0.1589 12 0.987 Contact Map
4hh0A 2 0.2542 11 0.987 Contact Map
3elfA 4 0.1758 10.8 0.987 Contact Map
2yvqA 2 0.1886 10.7 0.987 Contact Map
1gvfA 3 0.1568 10.1 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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