GREMLIN Database
EUTD - Ethanolamine utilization protein EutD
UniProt: P77218 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14188
Length: 338 (318)
Sequences: 3052 (1674)
Seq/√Len: 93.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_V234_V4.1261.00
80_F115_K3.9231.00
17_V118_V3.6671.00
174_T177_Q3.6651.00
220_Q223_E3.4611.00
48_P52_R3.1321.00
100_L109_A2.8801.00
80_F110_M2.7711.00
16_R41_T2.7671.00
82_H93_P2.5951.00
35_H65_L2.5711.00
223_E227_E2.5651.00
43_I116_A2.5221.00
34_L316_A2.4881.00
86_A89_G2.3351.00
33_Y313_I2.3021.00
14_P41_T2.2471.00
47_N69_D2.2241.00
175_A220_Q2.2011.00
19_F316_A2.1991.00
16_R43_I2.1841.00
111_V116_A2.1641.00
165_A266_V2.1581.00
176_A224_I2.1161.00
83_R112_S2.0501.00
183_L229_A2.0341.00
83_R113_A2.0171.00
78_E97_L2.0111.00
172_Q217_N1.9551.00
202_L275_I1.9521.00
226_R234_V1.9471.00
233_V257_P1.8821.00
198_R261_K1.8731.00
118_V319_A1.8681.00
110_M115_K1.8541.00
23_L50_E1.8521.00
187_E229_A1.8421.00
176_A220_Q1.7871.00
164_F280_A1.7731.00
79_E113_A1.7661.00
201_M222_T1.7601.00
32_Q36_Q1.7461.00
131_L169_V1.7081.00
179_A224_I1.6991.00
85_L89_G1.6971.00
34_L40_A1.6971.00
204_F212_H1.6951.00
80_F113_A1.6881.00
75_A115_K1.6841.00
43_I66_Q1.6681.00
172_Q214_C1.6511.00
180_D228_R1.6421.00
246_P250_A1.6401.00
107_A119_C1.6271.00
183_L228_R1.6261.00
83_R86_A1.6201.00
84_W99_K1.6121.00
138_I300_M1.5961.00
83_R109_A1.5951.00
25_Q54_F1.5871.00
276_G279_I1.5731.00
87_R112_S1.5671.00
54_F58_H1.5491.00
216_A219_Q1.5481.00
93_P97_L1.5381.00
226_R257_P1.5331.00
25_Q58_H1.5241.00
16_R66_Q1.5221.00
121_A130_V1.5131.00
25_Q29_K1.4981.00
224_I228_R1.4971.00
190_R196_E1.4951.00
81_A85_L1.4861.00
245_V282_R1.4781.00
13_A324_Q1.4701.00
79_E115_K1.4631.00
71_H101_T1.4431.00
41_T66_Q1.4381.00
32_Q60_V1.4351.00
46_A51_L1.4341.00
225_V232_L1.4270.99
272_A275_I1.3990.99
55_A62_M1.3990.99
95_D98_E1.3940.99
201_M225_V1.3790.99
84_W136_R1.3700.99
75_A79_E1.3700.99
120_I315_L1.3620.99
62_M65_L1.3480.99
81_A97_L1.3450.99
172_Q213_P1.3420.99
183_L225_V1.3330.99
78_E82_H1.3290.99
73_N106_F1.3060.99
301_H319_A1.3050.99
201_M234_V1.3010.99
22_A44_L1.3010.99
173_P181_I1.2980.99
54_F57_S1.2920.99
175_A222_T1.2900.99
155_P286_Y1.2870.99
112_S298_A1.2850.99
48_P69_D1.2840.99
141_Q187_E1.2810.99
45_V68_I1.2720.99
48_P72_G1.2720.99
14_P320_A1.2710.99
240_F265_M1.2700.99
240_F279_I1.2600.99
182_A201_M1.2570.99
244_F265_M1.2570.99
146_T177_Q1.2530.99
269_S272_A1.2500.99
178_L218_V1.2450.99
272_A276_G1.2410.99
18_V111_V1.2400.99
164_F267_F1.2340.98
5_R9_L1.2250.98
7_R317_L1.2250.98
52_R56_L1.2090.98
114_G298_A1.2060.98
29_K309_V1.1930.98
104_L121_A1.1890.98
92_T95_D1.1820.98
150_I188_T1.1710.98
8_E11_L1.1700.98
14_P38_G1.1650.98
134_G300_M1.1610.98
18_V110_M1.1450.98
265_M279_I1.1390.97
242_A248_V1.1320.97
98_E101_T1.1280.97
188_T294_Q1.1260.97
280_A284_G1.1230.97
235_D257_P1.1160.97
235_D256_S1.1150.97
216_A220_Q1.1150.97
55_A60_V1.1010.97
176_A228_R1.0980.97
187_E190_R1.0980.97
198_R233_V1.0950.97
85_L93_P1.0930.97
151_F167_C1.0920.97
186_A232_L1.0860.97
240_F244_F1.0850.97
207_N238_L1.0830.97
53_Q57_S1.0820.97
155_P160_P1.0740.96
289_V314_E1.0690.96
163_G189_W1.0660.96
24_D124_L1.0650.96
33_Y310_Q1.0560.96
47_N71_H1.0540.96
235_D238_L1.0510.96
222_T226_R1.0490.96
204_F271_E1.0400.96
219_Q223_E1.0370.96
34_L39_L1.0360.96
121_A125_S1.0330.95
165_A185_S1.0230.95
144_C184_A1.0170.95
69_D72_G1.0160.95
28_L60_V1.0160.95
84_W100_L1.0150.95
213_P216_A1.0110.95
134_G296_L1.0110.95
321_V324_Q1.0100.95
224_I227_E1.0090.95
76_M79_E1.0040.95
47_N50_E1.0010.95
14_P324_Q0.9990.95
249_A259_Q0.9990.95
76_M81_A0.9930.94
190_R197_P0.9860.94
212_H215_V0.9840.94
18_V116_A0.9780.94
238_L253_A0.9750.94
303_L312_I0.9670.94
15_A117_D0.9640.93
40_A316_A0.9610.93
145_K176_A0.9550.93
178_L181_I0.9520.93
223_E226_R0.9510.93
211_R216_A0.9490.93
82_H86_A0.9460.93
81_A93_P0.9460.93
32_Q65_L0.9460.93
109_A113_A0.9400.93
149_S293_I0.9370.92
233_V259_Q0.9340.92
208_G237_E0.9290.92
17_V316_A0.9270.92
49_F53_Q0.9250.92
247_E251_Q0.9230.92
33_Y36_Q0.9220.92
200_A262_A0.9190.92
186_A199_V0.9150.92
145_K180_D0.9120.91
124_L251_Q0.9120.91
133_A139_G0.9110.91
33_Y37_Q0.9080.91
7_R37_Q0.9070.91
210_A215_V0.9060.91
229_A232_L0.9010.91
189_W195_E0.8960.91
36_Q61_A0.8920.90
68_I73_N0.8890.90
19_F120_I0.8860.90
73_N76_M0.8860.90
146_T181_I0.8820.90
207_N253_A0.8800.90
175_A217_N0.8790.90
28_L54_F0.8750.90
150_I163_G0.8730.90
138_I297_A0.8720.89
22_A28_L0.8710.89
15_A323_R0.8710.89
150_I165_A0.8700.89
153_M164_F0.8680.89
102_D129_N0.8600.89
103_P125_S0.8580.89
49_F52_R0.8570.89
256_S259_Q0.8570.89
26_R123_N0.8560.89
112_S137_I0.8520.88
51_L67_V0.8460.88
233_V258_L0.8450.88
249_A255_A0.8440.88
24_D123_N0.8420.88
29_K60_V0.8420.88
178_L221_A0.8420.88
139_G297_A0.8420.88
147_L296_L0.8410.88
171_P212_H0.8400.88
179_A225_V0.8340.87
19_F31_A0.8270.87
27_V312_I0.8270.87
47_N51_L0.8240.87
201_M218_V0.8120.86
85_L90_E0.8100.86
28_L32_Q0.8090.86
75_A80_F0.8090.86
135_L147_L0.8080.86
153_M288_A0.8050.85
214_C269_S0.8040.85
182_A199_V0.7970.85
148_S294_Q0.7950.85
204_F210_A0.7940.85
83_R87_R0.7930.84
313_I317_L0.7930.84
277_Y288_A0.7900.84
149_S167_C0.7880.84
132_R136_R0.7870.84
107_A300_M0.7860.84
146_T170_V0.7860.84
138_I296_L0.7830.84
141_Q297_A0.7800.83
279_I284_G0.7750.83
249_A258_L0.7710.83
104_L119_C0.7710.83
287_R314_E0.7690.83
163_G185_S0.7650.82
17_V319_A0.7570.82
105_M133_A0.7530.81
222_T234_V0.7530.81
235_D253_A0.7470.81
240_F283_L0.7460.81
258_L261_K0.7460.81
53_Q56_L0.7450.81
222_T225_V0.7430.80
196_E233_V0.7420.80
292_L315_L0.7410.80
16_R117_D0.7400.80
207_N255_A0.7370.80
24_D44_L0.7370.80
149_S165_A0.7360.80
50_E53_Q0.7360.80
15_A320_A0.7350.80
178_L201_M0.7320.79
85_L100_L0.7320.79
307_C311_E0.7320.79
155_P162_L0.7280.79
175_A179_A0.7280.79
42_P316_A0.7250.79
148_S181_I0.7250.79
48_P67_V0.7230.79
150_I294_Q0.7230.79
19_F34_L0.7220.78
82_H85_L0.7210.78
45_V107_A0.7200.78
206_S242_A0.7200.78
7_R39_L0.7190.78
38_G64_G0.7180.78
4_E8_E0.7180.78
108_A119_C0.7160.78
250_A255_A0.7100.77
23_L54_F0.7100.77
301_H322_P0.7070.77
202_L268_P0.7070.77
8_E12_R0.7060.77
149_S168_S0.7040.77
73_N80_F0.7040.77
18_V45_V0.7030.77
270_L274_N0.7020.77
44_L51_L0.7010.76
150_I189_W0.6990.76
29_K58_H0.6950.76
268_P275_I0.6940.76
7_R11_L0.6930.76
230_P234_V0.6900.75
23_L124_L0.6870.75
145_K177_Q0.6860.75
169_V293_I0.6850.75
239_Q306_G0.6850.75
176_A223_E0.6840.75
184_A187_E0.6810.74
133_A136_R0.6800.74
23_L103_P0.6790.74
162_L244_F0.6790.74
189_W264_V0.6780.74
88_A91_K0.6760.74
104_L125_S0.6720.73
45_V106_F0.6710.73
214_C271_E0.6710.73
25_Q57_S0.6690.73
44_L65_L0.6690.73
79_E83_R0.6660.73
29_K33_Y0.6650.73
284_G313_I0.6560.72
176_A179_A0.6560.72
239_Q274_N0.6520.71
28_L51_L0.6510.71
156_Q159_G0.6500.71
319_A322_P0.6500.71
211_R219_Q0.6490.71
27_V123_N0.6480.71
17_V301_H0.6470.71
18_V43_I0.6460.70
35_H64_G0.6460.70
190_R232_L0.6450.70
182_A225_V0.6440.70
3_I314_E0.6400.70
16_R42_P0.6400.70
190_R231_K0.6390.70
19_F42_P0.6350.69
31_A44_L0.6330.69
240_F276_G0.6280.68
212_H216_A0.6270.68
108_A300_M0.6260.68
76_M100_L0.6260.68
50_E54_F0.6250.68
182_A264_V0.6250.68
24_D27_V0.6220.68
292_L318_V0.6220.68
125_S129_N0.6210.67
310_Q314_E0.6200.67
84_W109_A0.6190.67
199_V264_V0.6190.67
168_S304_S0.6150.67
188_T292_L0.6150.67
61_A64_G0.6060.66
112_S297_A0.6020.65
101_T266_V0.6000.65
45_V110_M0.6000.65
87_R109_A0.5980.65
219_Q222_T0.5980.65
82_H97_L0.5970.64
10_A15_A0.5970.64
173_P177_Q0.5940.64
171_P204_F0.5910.64
240_F275_I0.5910.64
207_N237_E0.5900.63
52_R67_V0.5900.63
142_P297_A0.5900.63
84_W137_I0.5880.63
179_A183_L0.5840.63
94_P98_E0.5840.63
21_D123_N0.5820.62
225_V229_A0.5800.62
160_P285_G0.5790.62
33_Y309_V0.5790.62
267_F276_G0.5780.62
73_N110_M0.5770.62
225_V228_R0.5770.62
15_A324_Q0.5760.62
140_L147_L0.5750.61
202_L274_N0.5740.61
94_P97_L0.5740.61
127_T149_S0.5720.61
78_E93_P0.5710.61
274_N277_Y0.5700.61
104_L130_V0.5700.61
249_A260_G0.5700.61
204_F239_Q0.5690.61
35_H42_P0.5680.61
209_S239_Q0.5670.60
160_P286_Y0.5670.60
155_P284_G0.5650.60
247_E250_A0.5640.60
37_Q313_I0.5630.60
205_S208_G0.5620.60
162_L283_L0.5610.60
55_A61_A0.5600.59
252_K304_S0.5580.59
237_E279_I0.5580.59
251_Q292_L0.5560.59
108_A139_G0.5540.59
220_Q224_I0.5540.59
114_G247_E0.5530.59
241_D278_K0.5530.59
31_A42_P0.5520.58
306_G311_E0.5510.58
237_E283_L0.5510.58
162_L286_Y0.5500.58
201_M232_L0.5500.58
219_Q238_L0.5490.58
40_A317_L0.5490.58
132_R135_L0.5490.58
34_L313_I0.5470.58
24_D54_F0.5470.58
63_D143_G0.5460.58
82_H89_G0.5460.58
81_A100_L0.5460.58
68_I110_M0.5450.57
240_F280_A0.5450.57
32_Q55_A0.5430.57
154_L289_V0.5430.57
154_L161_A0.5410.57
198_R262_A0.5400.57
56_L59_G0.5400.57
123_N312_I0.5400.57
154_L287_R0.5400.57
26_R312_I0.5400.57
29_K308_S0.5390.57
221_A225_V0.5390.57
69_D73_N0.5390.57
151_F277_Y0.5380.56
248_V282_R0.5350.56
153_M218_V0.5350.56
31_A65_L0.5350.56
276_G280_A0.5350.56
251_Q254_P0.5350.56
146_T149_S0.5350.56
18_V107_A0.5340.56
84_W96_A0.5320.56
22_A45_V0.5310.55
89_G95_D0.5300.55
150_I185_S0.5290.55
146_T169_V0.5290.55
10_A317_L0.5280.55
99_K105_M0.5260.55
6_C317_L0.5220.54
89_G255_A0.5210.54
9_L194_G0.5200.54
100_L137_I0.5180.54
242_A252_K0.5170.54
127_T304_S0.5160.53
177_Q180_D0.5160.53
213_P219_Q0.5130.53
103_P124_L0.5130.53
22_A43_I0.5120.53
266_V273_G0.5120.53
182_A221_A0.5110.53
99_K102_D0.5110.53
189_W197_P0.5100.53
99_K136_R0.5070.52
181_I184_A0.5060.52
73_N78_E0.5060.52
129_N132_R0.5060.52
155_P285_G0.5040.52
151_F168_S0.5040.52
187_E191_A0.5030.52
152_L289_V0.5030.52
21_D27_V0.5020.51
70_P103_P0.5020.51
102_D121_A0.5010.51
233_V261_K0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e4rA 2 0.9467 100 0.404 Contact Map
1td9A 3 0.9467 100 0.414 Contact Map
1vmiA 2 0.9527 100 0.418 Contact Map
1r5jA 4 0.9586 100 0.42 Contact Map
2af4C 2 0.9615 100 0.43 Contact Map
1ycoA 2 0.8018 100 0.481 Contact Map
3uf6A 2 0.8373 100 0.487 Contact Map
4jqpA 2 0.858 100 0.586 Contact Map
3lxyA 2 0.8462 100 0.606 Contact Map
1yxoA 2 0.8402 100 0.61 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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