EUTD - ECOLI - GREMLIN Contacts

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EUTD - Ethanolamine utilization protein EutD

UniProt:	P77218	Sequences: MIIERCRELALRAPARVVFPDALDQRVLKAAQYLHQQGLATPILVANPFELRQFALSHGVAMDGLQVIDPHGNLAMREEFAHRWLARAGEKTPPDALEKLTDPLMFAAAMVSAGKADVCIAGNLSSTANVLRAGLRIIGLQPGCKTLSSIFLMLPQYSGPALGFADCSVVPQPTAAQLADIALASAETWRAITGEEPRVAMLSFSSNGSARHPCVANVQQATEIVRERAPKLVVDGELQFDAAFVPEVAAQKAPASPLQGKANVMVFPSLEAGNIGYKIAQRLGGYRAVGPLIQGLAAPMHDLSRGCSVQEIIELALVAAVPRQTEVNRESSLQTLVE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14188
Length:	338 (318)
Sequences:	3052 (1674)
Seq/√Len:	93.9

ECOLI - EUTD PTA MAO2
BACSU - PTAS PTB
HALSA - Q9HPI2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
225_V	234_V	4.126	1.00
80_F	115_K	3.923	1.00
17_V	118_V	3.667	1.00
174_T	177_Q	3.665	1.00
220_Q	223_E	3.461	1.00
48_P	52_R	3.132	1.00
100_L	109_A	2.880	1.00
80_F	110_M	2.771	1.00
16_R	41_T	2.767	1.00
82_H	93_P	2.595	1.00
35_H	65_L	2.571	1.00
223_E	227_E	2.565	1.00
43_I	116_A	2.522	1.00
34_L	316_A	2.488	1.00
86_A	89_G	2.335	1.00
33_Y	313_I	2.302	1.00
14_P	41_T	2.247	1.00
47_N	69_D	2.224	1.00
175_A	220_Q	2.201	1.00
19_F	316_A	2.199	1.00
16_R	43_I	2.184	1.00
111_V	116_A	2.164	1.00
165_A	266_V	2.158	1.00
176_A	224_I	2.116	1.00
83_R	112_S	2.050	1.00
183_L	229_A	2.034	1.00
83_R	113_A	2.017	1.00
78_E	97_L	2.011	1.00
172_Q	217_N	1.955	1.00
202_L	275_I	1.952	1.00
226_R	234_V	1.947	1.00
233_V	257_P	1.882	1.00
198_R	261_K	1.873	1.00
118_V	319_A	1.868	1.00
110_M	115_K	1.854	1.00
23_L	50_E	1.852	1.00
187_E	229_A	1.842	1.00
176_A	220_Q	1.787	1.00
164_F	280_A	1.773	1.00
79_E	113_A	1.766	1.00
201_M	222_T	1.760	1.00
32_Q	36_Q	1.746	1.00
131_L	169_V	1.708	1.00
179_A	224_I	1.699	1.00
85_L	89_G	1.697	1.00
34_L	40_A	1.697	1.00
204_F	212_H	1.695	1.00
80_F	113_A	1.688	1.00
75_A	115_K	1.684	1.00
43_I	66_Q	1.668	1.00
172_Q	214_C	1.651	1.00
180_D	228_R	1.642	1.00
246_P	250_A	1.640	1.00
107_A	119_C	1.627	1.00
183_L	228_R	1.626	1.00
83_R	86_A	1.620	1.00
84_W	99_K	1.612	1.00
138_I	300_M	1.596	1.00
83_R	109_A	1.595	1.00
25_Q	54_F	1.587	1.00
276_G	279_I	1.573	1.00
87_R	112_S	1.567	1.00
54_F	58_H	1.549	1.00
216_A	219_Q	1.548	1.00
93_P	97_L	1.538	1.00
226_R	257_P	1.533	1.00
25_Q	58_H	1.524	1.00
16_R	66_Q	1.522	1.00
121_A	130_V	1.513	1.00
25_Q	29_K	1.498	1.00
224_I	228_R	1.497	1.00
190_R	196_E	1.495	1.00
81_A	85_L	1.486	1.00
245_V	282_R	1.478	1.00
13_A	324_Q	1.470	1.00
79_E	115_K	1.463	1.00
71_H	101_T	1.443	1.00
41_T	66_Q	1.438	1.00
32_Q	60_V	1.435	1.00
46_A	51_L	1.434	1.00
225_V	232_L	1.427	0.99
272_A	275_I	1.399	0.99
55_A	62_M	1.399	0.99
95_D	98_E	1.394	0.99
201_M	225_V	1.379	0.99
84_W	136_R	1.370	0.99
75_A	79_E	1.370	0.99
120_I	315_L	1.362	0.99
62_M	65_L	1.348	0.99
81_A	97_L	1.345	0.99
172_Q	213_P	1.342	0.99
183_L	225_V	1.333	0.99
78_E	82_H	1.329	0.99
73_N	106_F	1.306	0.99
301_H	319_A	1.305	0.99
201_M	234_V	1.301	0.99
22_A	44_L	1.301	0.99
173_P	181_I	1.298	0.99
54_F	57_S	1.292	0.99
175_A	222_T	1.290	0.99
155_P	286_Y	1.287	0.99
112_S	298_A	1.285	0.99
48_P	69_D	1.284	0.99
141_Q	187_E	1.281	0.99
45_V	68_I	1.272	0.99
48_P	72_G	1.272	0.99
14_P	320_A	1.271	0.99
240_F	265_M	1.270	0.99
240_F	279_I	1.260	0.99
182_A	201_M	1.257	0.99
244_F	265_M	1.257	0.99
146_T	177_Q	1.253	0.99
269_S	272_A	1.250	0.99
178_L	218_V	1.245	0.99
272_A	276_G	1.241	0.99
18_V	111_V	1.240	0.99
164_F	267_F	1.234	0.98
5_R	9_L	1.225	0.98
7_R	317_L	1.225	0.98
52_R	56_L	1.209	0.98
114_G	298_A	1.206	0.98
29_K	309_V	1.193	0.98
104_L	121_A	1.189	0.98
92_T	95_D	1.182	0.98
150_I	188_T	1.171	0.98
8_E	11_L	1.170	0.98
14_P	38_G	1.165	0.98
134_G	300_M	1.161	0.98
18_V	110_M	1.145	0.98
265_M	279_I	1.139	0.97
242_A	248_V	1.132	0.97
98_E	101_T	1.128	0.97
188_T	294_Q	1.126	0.97
280_A	284_G	1.123	0.97
235_D	257_P	1.116	0.97
235_D	256_S	1.115	0.97
216_A	220_Q	1.115	0.97
55_A	60_V	1.101	0.97
176_A	228_R	1.098	0.97
187_E	190_R	1.098	0.97
198_R	233_V	1.095	0.97
85_L	93_P	1.093	0.97
151_F	167_C	1.092	0.97
186_A	232_L	1.086	0.97
240_F	244_F	1.085	0.97
207_N	238_L	1.083	0.97
53_Q	57_S	1.082	0.97
155_P	160_P	1.074	0.96
289_V	314_E	1.069	0.96
163_G	189_W	1.066	0.96
24_D	124_L	1.065	0.96
33_Y	310_Q	1.056	0.96
47_N	71_H	1.054	0.96
235_D	238_L	1.051	0.96
222_T	226_R	1.049	0.96
204_F	271_E	1.040	0.96
219_Q	223_E	1.037	0.96
34_L	39_L	1.036	0.96
121_A	125_S	1.033	0.95
165_A	185_S	1.023	0.95
144_C	184_A	1.017	0.95
69_D	72_G	1.016	0.95
28_L	60_V	1.016	0.95
84_W	100_L	1.015	0.95
213_P	216_A	1.011	0.95
134_G	296_L	1.011	0.95
321_V	324_Q	1.010	0.95
224_I	227_E	1.009	0.95
76_M	79_E	1.004	0.95
47_N	50_E	1.001	0.95
14_P	324_Q	0.999	0.95
249_A	259_Q	0.999	0.95
76_M	81_A	0.993	0.94
190_R	197_P	0.986	0.94
212_H	215_V	0.984	0.94
18_V	116_A	0.978	0.94
238_L	253_A	0.975	0.94
303_L	312_I	0.967	0.94
15_A	117_D	0.964	0.93
40_A	316_A	0.961	0.93
145_K	176_A	0.955	0.93
178_L	181_I	0.952	0.93
223_E	226_R	0.951	0.93
211_R	216_A	0.949	0.93
82_H	86_A	0.946	0.93
81_A	93_P	0.946	0.93
32_Q	65_L	0.946	0.93
109_A	113_A	0.940	0.93
149_S	293_I	0.937	0.92
233_V	259_Q	0.934	0.92
208_G	237_E	0.929	0.92
17_V	316_A	0.927	0.92
49_F	53_Q	0.925	0.92
247_E	251_Q	0.923	0.92
33_Y	36_Q	0.922	0.92
200_A	262_A	0.919	0.92
186_A	199_V	0.915	0.92
145_K	180_D	0.912	0.91
124_L	251_Q	0.912	0.91
133_A	139_G	0.911	0.91
33_Y	37_Q	0.908	0.91
7_R	37_Q	0.907	0.91
210_A	215_V	0.906	0.91
229_A	232_L	0.901	0.91
189_W	195_E	0.896	0.91
36_Q	61_A	0.892	0.90
68_I	73_N	0.889	0.90
19_F	120_I	0.886	0.90
73_N	76_M	0.886	0.90
146_T	181_I	0.882	0.90
207_N	253_A	0.880	0.90
175_A	217_N	0.879	0.90
28_L	54_F	0.875	0.90
150_I	163_G	0.873	0.90
138_I	297_A	0.872	0.89
22_A	28_L	0.871	0.89
15_A	323_R	0.871	0.89
150_I	165_A	0.870	0.89
153_M	164_F	0.868	0.89
102_D	129_N	0.860	0.89
103_P	125_S	0.858	0.89
49_F	52_R	0.857	0.89
256_S	259_Q	0.857	0.89
26_R	123_N	0.856	0.89
112_S	137_I	0.852	0.88
51_L	67_V	0.846	0.88
233_V	258_L	0.845	0.88
249_A	255_A	0.844	0.88
24_D	123_N	0.842	0.88
29_K	60_V	0.842	0.88
178_L	221_A	0.842	0.88
139_G	297_A	0.842	0.88
147_L	296_L	0.841	0.88
171_P	212_H	0.840	0.88
179_A	225_V	0.834	0.87
19_F	31_A	0.827	0.87
27_V	312_I	0.827	0.87
47_N	51_L	0.824	0.87
201_M	218_V	0.812	0.86
85_L	90_E	0.810	0.86
28_L	32_Q	0.809	0.86
75_A	80_F	0.809	0.86
135_L	147_L	0.808	0.86
153_M	288_A	0.805	0.85
214_C	269_S	0.804	0.85
182_A	199_V	0.797	0.85
148_S	294_Q	0.795	0.85
204_F	210_A	0.794	0.85
83_R	87_R	0.793	0.84
313_I	317_L	0.793	0.84
277_Y	288_A	0.790	0.84
149_S	167_C	0.788	0.84
132_R	136_R	0.787	0.84
107_A	300_M	0.786	0.84
146_T	170_V	0.786	0.84
138_I	296_L	0.783	0.84
141_Q	297_A	0.780	0.83
279_I	284_G	0.775	0.83
249_A	258_L	0.771	0.83
104_L	119_C	0.771	0.83
287_R	314_E	0.769	0.83
163_G	185_S	0.765	0.82
17_V	319_A	0.757	0.82
105_M	133_A	0.753	0.81
222_T	234_V	0.753	0.81
235_D	253_A	0.747	0.81
240_F	283_L	0.746	0.81
258_L	261_K	0.746	0.81
53_Q	56_L	0.745	0.81
222_T	225_V	0.743	0.80
196_E	233_V	0.742	0.80
292_L	315_L	0.741	0.80
16_R	117_D	0.740	0.80
207_N	255_A	0.737	0.80
24_D	44_L	0.737	0.80
149_S	165_A	0.736	0.80
50_E	53_Q	0.736	0.80
15_A	320_A	0.735	0.80
178_L	201_M	0.732	0.79
85_L	100_L	0.732	0.79
307_C	311_E	0.732	0.79
155_P	162_L	0.728	0.79
175_A	179_A	0.728	0.79
42_P	316_A	0.725	0.79
148_S	181_I	0.725	0.79
48_P	67_V	0.723	0.79
150_I	294_Q	0.723	0.79
19_F	34_L	0.722	0.78
82_H	85_L	0.721	0.78
45_V	107_A	0.720	0.78
206_S	242_A	0.720	0.78
7_R	39_L	0.719	0.78
38_G	64_G	0.718	0.78
4_E	8_E	0.718	0.78
108_A	119_C	0.716	0.78
250_A	255_A	0.710	0.77
23_L	54_F	0.710	0.77
301_H	322_P	0.707	0.77
202_L	268_P	0.707	0.77
8_E	12_R	0.706	0.77
149_S	168_S	0.704	0.77
73_N	80_F	0.704	0.77
18_V	45_V	0.703	0.77
270_L	274_N	0.702	0.77
44_L	51_L	0.701	0.76
150_I	189_W	0.699	0.76
29_K	58_H	0.695	0.76
268_P	275_I	0.694	0.76
7_R	11_L	0.693	0.76
230_P	234_V	0.690	0.75
23_L	124_L	0.687	0.75
145_K	177_Q	0.686	0.75
169_V	293_I	0.685	0.75
239_Q	306_G	0.685	0.75
176_A	223_E	0.684	0.75
184_A	187_E	0.681	0.74
133_A	136_R	0.680	0.74
23_L	103_P	0.679	0.74
162_L	244_F	0.679	0.74
189_W	264_V	0.678	0.74
88_A	91_K	0.676	0.74
104_L	125_S	0.672	0.73
45_V	106_F	0.671	0.73
214_C	271_E	0.671	0.73
25_Q	57_S	0.669	0.73
44_L	65_L	0.669	0.73
79_E	83_R	0.666	0.73
29_K	33_Y	0.665	0.73
284_G	313_I	0.656	0.72
176_A	179_A	0.656	0.72
239_Q	274_N	0.652	0.71
28_L	51_L	0.651	0.71
156_Q	159_G	0.650	0.71
319_A	322_P	0.650	0.71
211_R	219_Q	0.649	0.71
27_V	123_N	0.648	0.71
17_V	301_H	0.647	0.71
18_V	43_I	0.646	0.70
35_H	64_G	0.646	0.70
190_R	232_L	0.645	0.70
182_A	225_V	0.644	0.70
3_I	314_E	0.640	0.70
16_R	42_P	0.640	0.70
190_R	231_K	0.639	0.70
19_F	42_P	0.635	0.69
31_A	44_L	0.633	0.69
240_F	276_G	0.628	0.68
212_H	216_A	0.627	0.68
108_A	300_M	0.626	0.68
76_M	100_L	0.626	0.68
50_E	54_F	0.625	0.68
182_A	264_V	0.625	0.68
24_D	27_V	0.622	0.68
292_L	318_V	0.622	0.68
125_S	129_N	0.621	0.67
310_Q	314_E	0.620	0.67
84_W	109_A	0.619	0.67
199_V	264_V	0.619	0.67
168_S	304_S	0.615	0.67
188_T	292_L	0.615	0.67
61_A	64_G	0.606	0.66
112_S	297_A	0.602	0.65
101_T	266_V	0.600	0.65
45_V	110_M	0.600	0.65
87_R	109_A	0.598	0.65
219_Q	222_T	0.598	0.65
82_H	97_L	0.597	0.64
10_A	15_A	0.597	0.64
173_P	177_Q	0.594	0.64
171_P	204_F	0.591	0.64
240_F	275_I	0.591	0.64
207_N	237_E	0.590	0.63
52_R	67_V	0.590	0.63
142_P	297_A	0.590	0.63
84_W	137_I	0.588	0.63
179_A	183_L	0.584	0.63
94_P	98_E	0.584	0.63
21_D	123_N	0.582	0.62
225_V	229_A	0.580	0.62
160_P	285_G	0.579	0.62
33_Y	309_V	0.579	0.62
267_F	276_G	0.578	0.62
73_N	110_M	0.577	0.62
225_V	228_R	0.577	0.62
15_A	324_Q	0.576	0.62
140_L	147_L	0.575	0.61
202_L	274_N	0.574	0.61
94_P	97_L	0.574	0.61
127_T	149_S	0.572	0.61
78_E	93_P	0.571	0.61
274_N	277_Y	0.570	0.61
104_L	130_V	0.570	0.61
249_A	260_G	0.570	0.61
204_F	239_Q	0.569	0.61
35_H	42_P	0.568	0.61
209_S	239_Q	0.567	0.60
160_P	286_Y	0.567	0.60
155_P	284_G	0.565	0.60
247_E	250_A	0.564	0.60
37_Q	313_I	0.563	0.60
205_S	208_G	0.562	0.60
162_L	283_L	0.561	0.60
55_A	61_A	0.560	0.59
252_K	304_S	0.558	0.59
237_E	279_I	0.558	0.59
251_Q	292_L	0.556	0.59
108_A	139_G	0.554	0.59
220_Q	224_I	0.554	0.59
114_G	247_E	0.553	0.59
241_D	278_K	0.553	0.59
31_A	42_P	0.552	0.58
306_G	311_E	0.551	0.58
237_E	283_L	0.551	0.58
162_L	286_Y	0.550	0.58
201_M	232_L	0.550	0.58
219_Q	238_L	0.549	0.58
40_A	317_L	0.549	0.58
132_R	135_L	0.549	0.58
34_L	313_I	0.547	0.58
24_D	54_F	0.547	0.58
63_D	143_G	0.546	0.58
82_H	89_G	0.546	0.58
81_A	100_L	0.546	0.58
68_I	110_M	0.545	0.57
240_F	280_A	0.545	0.57
32_Q	55_A	0.543	0.57
154_L	289_V	0.543	0.57
154_L	161_A	0.541	0.57
198_R	262_A	0.540	0.57
56_L	59_G	0.540	0.57
123_N	312_I	0.540	0.57
154_L	287_R	0.540	0.57
26_R	312_I	0.540	0.57
29_K	308_S	0.539	0.57
221_A	225_V	0.539	0.57
69_D	73_N	0.539	0.57
151_F	277_Y	0.538	0.56
248_V	282_R	0.535	0.56
153_M	218_V	0.535	0.56
31_A	65_L	0.535	0.56
276_G	280_A	0.535	0.56
251_Q	254_P	0.535	0.56
146_T	149_S	0.535	0.56
18_V	107_A	0.534	0.56
84_W	96_A	0.532	0.56
22_A	45_V	0.531	0.55
89_G	95_D	0.530	0.55
150_I	185_S	0.529	0.55
146_T	169_V	0.529	0.55
10_A	317_L	0.528	0.55
99_K	105_M	0.526	0.55
6_C	317_L	0.522	0.54
89_G	255_A	0.521	0.54
9_L	194_G	0.520	0.54
100_L	137_I	0.518	0.54
242_A	252_K	0.517	0.54
127_T	304_S	0.516	0.53
177_Q	180_D	0.516	0.53
213_P	219_Q	0.513	0.53
103_P	124_L	0.513	0.53
22_A	43_I	0.512	0.53
266_V	273_G	0.512	0.53
182_A	221_A	0.511	0.53
99_K	102_D	0.511	0.53
189_W	197_P	0.510	0.53
99_K	136_R	0.507	0.52
181_I	184_A	0.506	0.52
73_N	78_E	0.506	0.52
129_N	132_R	0.506	0.52
155_P	285_G	0.504	0.52
151_F	168_S	0.504	0.52
187_E	191_A	0.503	0.52
152_L	289_V	0.503	0.52
21_D	27_V	0.502	0.51
70_P	103_P	0.502	0.51
102_D	121_A	0.501	0.51
233_V	261_K	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4e4rA	2	0.9467	100	0.404	Contact Map
1td9A	3	0.9467	100	0.414	Contact Map
1vmiA	2	0.9527	100	0.418	Contact Map
1r5jA	4	0.9586	100	0.42	Contact Map
2af4C	2	0.9615	100	0.43	Contact Map
1ycoA	2	0.8018	100	0.481	Contact Map
3uf6A	2	0.8373	100	0.487	Contact Map
4jqpA	2	0.858	100	0.586	Contact Map
3lxyA	2	0.8462	100	0.606	Contact Map
1yxoA	2	0.8402	100	0.61	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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