GREMLIN Database
RHMD - L-rhamnonate dehydratase
UniProt: P77215 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14085
Length: 401 (335)
Sequences: 11693 (6779)
Seq/√Len: 370.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_K114_Q3.7151.00
163_E374_R3.5621.00
263_K293_D3.3671.00
228_D231_Y3.1711.00
107_D110_L3.0341.00
260_R264_R3.0261.00
255_Q258_S2.8361.00
76_Q143_L2.8261.00
68_V135_C2.8231.00
71_E77_T2.7881.00
285_R289_E2.7341.00
72_A143_L2.5521.00
69_E77_T2.5231.00
261_E264_R2.4281.00
281_L307_T2.3401.00
90_F94_K2.3361.00
237_H240_A2.3241.00
180_G212_K2.3051.00
365_L388_E2.2511.00
137_D306_T2.2411.00
236_A247_I2.2371.00
237_H265_N2.2261.00
261_E265_N2.2171.00
72_A76_Q2.2061.00
288_S320_Q2.1501.00
109_K310_E2.1391.00
302_C311_I2.1291.00
218_W245_K2.0691.00
207_A242_Y2.0471.00
57_S81_V1.9961.00
69_E79_F1.9781.00
76_Q147_V1.9761.00
236_A266_A1.9741.00
180_G184_G1.9581.00
208_D211_E1.9531.00
145_G152_V1.9381.00
74_N147_V1.9331.00
165_Q188_T1.9301.00
294_I321_L1.9001.00
111_I140_L1.8981.00
176_A212_K1.8931.00
70_V140_L1.8891.00
238_A241_P1.8841.00
235_L239_C1.8481.00
289_E318_R1.8481.00
82_S135_C1.8341.00
240_A267_P1.8301.00
371_V378_S1.8191.00
233_T265_N1.7931.00
284_F311_I1.7861.00
151_P154_K1.7741.00
150_L154_K1.7651.00
103_K110_L1.7641.00
203_A238_A1.7481.00
89_C93_E1.7461.00
314_I318_R1.7221.00
204_A207_A1.7181.00
251_L262_L1.7041.00
313_A316_K1.6601.00
183_G217_F1.6281.00
76_Q146_K1.6061.00
230_N261_E1.5961.00
229_V261_E1.5931.00
288_S314_I1.5841.00
287_L292_I1.5671.00
95_H127_G1.5631.00
122_Y282_Q1.5401.00
163_E378_S1.5361.00
87_M90_F1.5171.00
72_A147_V1.5151.00
198_G201_K1.5151.00
146_K388_E1.5061.00
137_D141_W1.4911.00
309_V313_A1.4911.00
97_N101_E1.4771.00
233_T261_E1.4641.00
229_V262_L1.4641.00
152_V385_F1.4621.00
106_S147_V1.4521.00
188_T220_M1.4501.00
285_R314_I1.4211.00
240_A268_V1.4201.00
207_A241_P1.4191.00
181_F185_K1.4181.00
103_K111_I1.3991.00
229_V258_S1.3871.00
307_T310_E1.3871.00
288_S318_R1.3821.00
73_E105_V1.3791.00
207_A211_E1.3761.00
283_S286_T1.3601.00
200_R204_A1.3351.00
201_K204_A1.3321.00
221_L244_L1.3261.00
142_D146_K1.3231.00
203_A207_A1.3211.00
159_A162_D1.3101.00
54_S59_G1.3091.00
94_K98_R1.3051.00
144_F148_V1.2991.00
234_K238_A1.2961.00
273_T294_I1.2951.00
110_L114_Q1.2931.00
234_K237_H1.2881.00
145_G155_L1.2851.00
251_L258_S1.2831.00
180_G183_G1.2811.00
150_L155_L1.2731.00
220_M245_K1.2681.00
286_T289_E1.2651.00
250_C272_V1.2581.00
115_M133_I1.2531.00
165_Q374_R1.2501.00
254_Q283_S1.2501.00
203_A242_Y1.2491.00
178_E181_F1.2451.00
138_L305_L1.2421.00
233_T262_L1.2401.00
220_M246_W1.2331.00
67_V79_F1.2291.00
284_F295_M1.2221.00
366_N382_K1.2191.00
260_R291_G1.2131.00
190_W217_F1.2101.00
177_K180_G1.2051.00
106_S144_F1.1991.00
209_M213_C1.1951.00
263_K290_T1.1911.00
113_D117_S1.1871.00
104_C107_D1.1841.00
274_S287_L1.1771.00
281_L314_I1.1771.00
193_H224_W1.1581.00
231_Y234_K1.1541.00
310_E313_A1.1471.00
95_H98_R1.1381.00
109_K309_V1.1311.00
237_H267_P1.1261.00
271_M342_P1.1261.00
87_M92_V1.1241.00
176_A180_G1.1211.00
203_A241_P1.1211.00
310_E316_K1.1191.00
167_Y170_G1.1171.00
250_C262_L1.1151.00
206_V242_Y1.1041.00
213_C219_L1.1041.00
313_A317_S1.1011.00
280_T283_S1.1011.00
177_K181_F1.0991.00
273_T296_Q1.0911.00
141_W306_T1.0901.00
299_V308_L1.0901.00
295_M315_A1.0861.00
223_C247_I1.0851.00
106_S148_V1.0801.00
179_M213_C1.0711.00
232_A236_A1.0701.00
227_Q235_L1.0671.00
210_R214_G1.0571.00
173_P176_A1.0371.00
290_T320_Q1.0281.00
262_L272_V1.0271.00
96_L136_V1.0251.00
227_Q232_A1.0221.00
285_R318_R1.0211.00
331_S334_A1.0171.00
176_A213_C1.0051.00
206_V221_L1.0041.00
206_V210_R1.0041.00
108_I144_F0.9981.00
215_E243_N0.9931.00
314_I317_S0.9921.00
249_E296_Q0.9901.00
179_M190_W0.9891.00
210_R219_L0.9861.00
192_P209_M0.9861.00
148_V155_L0.9821.00
268_V271_M0.9761.00
204_A208_D0.9711.00
302_C308_L0.9671.00
288_S295_M0.9671.00
152_V305_L0.9621.00
340_N349_T0.9611.00
176_A211_E0.9571.00
111_I114_Q0.9541.00
190_W218_W0.9521.00
194_D198_G0.9441.00
154_K381_D0.9431.00
99_F114_Q0.9421.00
182_I185_K0.9391.00
144_F155_L0.9381.00
256_Y291_G0.9351.00
309_V338_F0.9341.00
339_T344_S0.9281.00
103_K107_D0.9241.00
70_V78_G0.9211.00
213_C217_F0.9201.00
111_I115_M0.9191.00
281_L310_E0.9171.00
292_I295_M0.9101.00
79_F358_P0.9051.00
189_H220_M0.9051.00
156_L309_V0.9051.00
298_D325_H0.9021.00
208_D212_K0.9001.00
112_H116_L0.9001.00
112_H115_M0.9001.00
382_K388_E0.9001.00
264_R290_T0.8981.00
183_G190_W0.8981.00
203_A206_V0.8971.00
87_M91_I0.8961.00
52_E59_G0.8941.00
374_R378_S0.8911.00
112_H137_D0.8911.00
230_N234_K0.8911.00
71_E75_G0.8861.00
251_L259_Y0.8851.00
207_A210_R0.8841.00
166_F169_T0.8781.00
279_G283_S0.8771.00
378_S381_D0.8731.00
181_F184_G0.8711.00
360_F363_I0.8661.00
356_M360_F0.8661.00
210_R216_D0.8651.00
232_A251_L0.8641.00
201_K205_M0.8621.00
229_V251_L0.8581.00
153_Y379_V0.8571.00
152_V156_L0.8551.00
341_T379_V0.8531.00
223_C227_Q0.8521.00
274_S292_I0.8521.00
91_I95_H0.8491.00
206_V239_C0.8461.00
179_M182_I0.8431.00
370_P375_I0.8421.00
94_K97_N0.8421.00
275_G298_D0.8351.00
105_V144_F0.8321.00
278_H284_F0.8321.00
105_V140_L0.8291.00
297_P308_L0.8271.00
99_F103_K0.8261.00
308_L339_T0.8201.00
258_S261_E0.8191.00
233_T266_A0.8171.00
316_K345_E0.8161.00
227_Q247_I0.8151.00
124_G127_G0.8131.00
194_D197_A0.8101.00
357_R360_F0.8061.00
100_I103_K0.8041.00
71_E79_F0.8031.00
261_E290_T0.8011.00
257_E286_T0.8011.00
259_Y272_V0.7981.00
141_W305_L0.7961.00
89_C92_V0.7941.00
78_G142_D0.7941.00
98_R101_E0.7911.00
229_V233_T0.7891.00
305_L309_V0.7891.00
179_M209_M0.7851.00
333_H358_P0.7841.00
240_A266_A0.7831.00
202_D205_M0.7811.00
244_L268_V0.7791.00
116_L307_T0.7791.00
309_V342_P0.7771.00
257_E260_R0.7751.00
259_Y274_S0.7741.00
163_E372_N0.7711.00
338_F344_S0.7621.00
176_A208_D0.7621.00
55_R67_V0.7601.00
256_Y287_L0.7571.00
168_A187_P0.7561.00
152_V155_L0.7511.00
70_V100_I0.7501.00
256_Y286_T0.7491.00
199_I235_L0.7481.00
297_P312_A0.7481.00
149_G383_P0.7471.00
96_L115_M0.7441.00
223_C236_A0.7441.00
195_G199_I0.7441.00
197_A201_K0.7441.00
168_A182_I0.7401.00
278_H287_L0.7381.00
259_Y262_L0.7361.00
93_E97_N0.7361.00
72_A105_V0.7361.00
105_V147_V0.7351.00
148_V151_P0.7331.00
232_A262_L0.7321.00
312_A316_K0.7311.00
263_K272_V0.7281.00
278_H283_S0.7271.00
371_V374_R0.7261.00
113_D116_L0.7261.00
262_L266_A0.7231.00
369_V378_S0.7201.00
109_K306_T0.7191.00
114_Q117_S0.7191.00
312_A322_V0.7191.00
282_Q286_T0.7171.00
295_M320_Q0.7161.00
200_R238_A0.7151.00
156_L305_L0.7141.00
194_D212_K0.7121.00
210_R243_N0.7121.00
154_K159_A0.7121.00
233_T237_H0.7090.99
281_L311_I0.7080.99
105_V143_L0.7080.99
52_E100_I0.7050.99
78_G146_K0.7040.99
282_Q285_R0.7030.99
92_V136_V0.7020.99
358_P362_P0.7020.99
202_D227_Q0.7000.99
366_N388_E0.7000.99
334_A337_T0.6980.99
145_G150_L0.6950.99
183_G186_M0.6950.99
141_W152_V0.6940.99
112_H306_T0.6910.99
196_D202_D0.6860.99
167_Y171_A0.6860.99
198_G202_D0.6860.99
113_D310_E0.6850.99
197_A200_R0.6820.99
297_P322_V0.6800.99
168_A171_A0.6800.99
159_A381_D0.6740.99
78_G139_A0.6740.99
144_F147_V0.6730.99
284_F320_Q0.6720.99
108_I140_L0.6720.99
210_R213_C0.6720.99
109_K113_D0.6710.99
145_G383_P0.6710.99
188_T372_N0.6680.99
323_V340_N0.6680.99
178_E182_I0.6680.99
312_A338_F0.6600.99
77_T146_K0.6590.99
199_I203_A0.6590.99
296_Q325_H0.6570.99
77_T388_E0.6550.99
169_T202_D0.6550.99
202_D207_A0.6530.99
92_V97_N0.6510.99
81_V330_Y0.6500.99
179_M212_K0.6470.99
88_G91_I0.6460.99
141_W156_L0.6430.99
108_I111_I0.6410.99
176_A179_M0.6410.99
95_H99_F0.6400.99
51_Y178_E0.6400.99
73_E76_Q0.6400.99
235_L238_A0.6360.99
171_A209_M0.6360.99
90_F95_H0.6360.99
71_E74_N0.6360.99
150_L158_G0.6340.99
143_L147_V0.6320.99
295_M311_I0.6300.99
299_V305_L0.6300.99
284_F315_A0.6270.99
205_M208_D0.6220.99
170_G182_I0.6210.99
315_A320_Q0.6200.99
163_E371_V0.6200.99
233_T251_L0.6190.99
352_D355_T0.6190.99
206_V213_C0.6170.99
100_I136_V0.6170.99
355_T358_P0.6160.99
133_I304_G0.6150.99
210_R242_Y0.6140.99
68_V92_V0.6140.99
202_D210_R0.6120.98
335_V385_F0.6120.98
205_M209_M0.6110.98
107_D154_K0.6090.98
188_T218_W0.6040.98
161_R164_I0.6030.98
338_F342_P0.6020.98
249_E275_G0.6020.98
183_G213_C0.6020.98
292_I320_Q0.6010.98
189_H193_H0.6000.98
151_P155_L0.6000.98
116_L133_I0.5990.98
80_A135_C0.5970.98
108_I306_T0.5960.98
174_D177_K0.5960.98
266_A272_V0.5950.98
82_S131_N0.5940.98
194_D201_K0.5920.98
100_I111_I0.5910.98
189_H218_W0.5900.98
74_N105_V0.5880.98
127_G304_G0.5880.98
263_K291_G0.5870.98
179_M183_G0.5860.98
312_A343_F0.5840.98
104_C154_K0.5830.98
281_L285_R0.5830.98
197_A205_M0.5830.98
183_G212_K0.5820.98
110_L113_D0.5820.98
260_R290_T0.5750.98
49_R52_E0.5720.98
214_G217_F0.5710.98
202_D206_V0.5690.98
162_D381_D0.5670.98
203_A210_R0.5670.98
96_L100_I0.5670.98
245_K271_M0.5660.98
249_E277_H0.5630.97
67_V358_P0.5620.97
283_S291_G0.5610.97
72_A75_G0.5600.97
308_L324_P0.5560.97
145_G148_V0.5530.97
105_V108_I0.5530.97
166_F170_G0.5520.97
236_A239_C0.5520.97
375_I378_S0.5520.97
146_K382_K0.5520.97
335_V339_T0.5510.97
339_T342_P0.5500.97
166_F375_I0.5470.97
194_D210_R0.5460.97
340_N345_E0.5460.97
203_A235_L0.5440.97
343_F346_F0.5430.97
175_L179_M0.5420.97
192_P206_V0.5420.97
284_F297_P0.5420.97
140_L144_F0.5410.97
172_R176_A0.5410.97
146_K385_F0.5410.97
153_Y381_D0.5380.97
337_T340_N0.5380.97
210_R215_E0.5380.97
326_G329_V0.5380.97
340_N346_F0.5370.97
194_D202_D0.5370.97
249_E276_E0.5370.97
108_I155_L0.5360.97
177_K212_K0.5360.97
188_T193_H0.5360.97
99_F118_A0.5350.97
91_I94_K0.5350.97
195_G198_G0.5350.97
259_Y292_I0.5340.96
291_G320_Q0.5340.96
175_L205_M0.5330.96
154_K157_G0.5310.96
80_A139_A0.5310.96
334_A339_T0.5290.96
205_M212_K0.5270.96
91_I128_L0.5260.96
334_A387_V0.5260.96
236_A262_L0.5260.96
234_K265_N0.5250.96
83_T300_G0.5240.96
66_L89_C0.5240.96
97_N136_V0.5230.96
206_V349_T0.5230.96
55_R69_E0.5220.96
244_L247_I0.5210.96
315_A322_V0.5180.96
345_E348_M0.5170.96
206_V209_M0.5170.96
255_Q319_G0.5160.96
165_Q218_W0.5160.96
339_T343_F0.5140.96
259_Y291_G0.5130.96
122_Y129_V0.5130.96
366_N369_V0.5120.96
234_K243_N0.5120.96
246_W323_V0.5070.95
188_T216_D0.5050.95
321_L347_L0.5050.95
225_M253_P0.5040.95
101_E104_C0.5040.95
316_K344_S0.5040.95
225_M277_H0.5030.95
157_G162_D0.5030.95
194_D206_V0.5030.95
194_D203_A0.5020.95
138_L385_F0.5020.95
195_G202_D0.5000.95
327_S330_Y0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dgbA 5 0.8853 100 0.235 Contact Map
3s5sA 2 0.8653 100 0.236 Contact Map
3ekgA 5 0.9252 100 0.239 Contact Map
3fcpA 5 0.8504 100 0.239 Contact Map
3cyjA 5 0.8778 100 0.239 Contact Map
1wufA 2 0.8728 100 0.241 Contact Map
3i4kA 4 0.8803 100 0.242 Contact Map
1wueA 2 0.8778 100 0.242 Contact Map
1sjdA 5 0.8678 100 0.242 Contact Map
2p3zA 5 0.9651 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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