GREMLIN Database
CUSF - Cation efflux system protein CusF
UniProt: P77214 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14234
Length: 110 (99)
Sequences: 582 (463)
Seq/√Len: 46.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_G92_F3.8761.00
25_H28_E2.9611.00
42_G56_I2.7021.00
45_K55_T2.6571.00
75_I81_M2.5911.00
47_I86_T2.5651.00
41_T59_D2.5601.00
43_V57_H2.4931.00
40_A61_I2.4141.00
91_A107_K2.2601.00
56_I92_F2.1271.00
49_L82_S2.0871.00
12_L15_V1.8700.99
41_T91_A1.8510.99
45_K57_H1.8090.99
63_A66_W1.8040.99
44_V54_I1.7520.98
44_V56_I1.6620.98
85_K88_D1.6470.98
18_F21_Q1.4590.95
61_I94_F1.3840.93
13_F16_I1.3360.92
27_H30_M1.3330.92
48_D51_S1.3220.92
60_P68_E1.2920.91
25_H30_M1.2780.90
10_F15_V1.2440.89
64_V94_F1.2160.88
39_S66_W1.2090.88
61_I93_N1.1950.87
48_D53_K1.1710.86
47_I65_N1.1680.86
16_I19_N1.1580.85
40_A94_F1.1540.85
9_M13_F1.1520.85
94_F101_S1.1470.85
84_I106_I1.1300.84
46_G55_T1.1110.83
40_A66_W1.1070.83
25_H29_T1.1030.82
46_G66_W1.0880.81
46_G86_T1.0850.81
38_I63_A1.0720.81
9_M16_I1.0710.80
78_Q100_L1.0480.79
63_A95_V1.0210.77
40_A92_F1.0170.77
24_E27_H1.0130.77
17_G20_A1.0070.76
95_V104_Q1.0030.76
14_T26_H0.9940.75
39_S93_N0.9870.75
56_I90_V0.9710.73
9_M15_V0.9560.72
61_I97_Q0.9510.72
44_V84_I0.9440.71
66_W93_N0.9280.70
90_V93_N0.9250.70
87_G104_Q0.9170.69
17_G23_N0.9130.69
49_L90_V0.8920.67
40_A63_A0.8660.65
54_I84_I0.8650.65
23_N27_H0.8610.64
19_N22_A0.8580.64
53_K74_T0.8550.64
58_H69_M0.8500.63
19_N29_T0.8490.63
53_K72_R0.8330.62
66_W94_F0.8320.62
96_Q101_S0.8280.61
96_Q99_N0.8270.61
14_T82_S0.8190.60
16_I23_N0.8080.59
24_E49_L0.8030.59
67_P76_T0.8020.59
62_A65_N0.7850.57
57_H68_E0.7740.56
82_S105_D0.7740.56
87_G99_N0.7700.56
54_I83_E0.7550.54
18_F23_N0.7550.54
61_I72_R0.7530.54
33_A103_L0.7520.54
55_T68_E0.7490.54
63_A76_T0.7470.53
66_W101_S0.7450.53
73_F84_I0.7430.53
75_I92_F0.7400.53
49_L89_K0.7350.52
9_M23_N0.7200.51
64_V68_E0.7120.50
15_V18_F0.7120.50
72_R94_F0.7110.50
93_N107_K0.7100.50
44_V74_T0.7040.49
97_Q102_L0.6840.47
33_A52_K0.6840.47
50_E106_I0.6690.46
12_L18_F0.6650.45
44_V90_V0.6510.44
66_W72_R0.6440.43
17_G22_A0.6440.43
52_K81_M0.6380.43
39_S63_A0.6370.43
10_F18_F0.6360.42
57_H70_T0.6250.41
80_K106_I0.6250.41
14_T18_F0.6250.41
60_P64_V0.6200.41
24_E30_M0.6180.41
39_S60_P0.6160.40
37_V50_E0.6150.40
12_L19_N0.6120.40
77_P95_V0.6100.40
38_I94_F0.6080.40
12_L20_A0.6050.39
11_S16_I0.6050.39
100_L104_Q0.6020.39
56_I88_D0.5940.38
50_E82_S0.5920.38
46_G72_R0.5910.38
93_N105_D0.5800.37
38_I62_A0.5780.37
21_Q30_M0.5780.37
61_I106_I0.5780.37
82_S89_K0.5740.37
14_T20_A0.5720.36
11_S59_D0.5610.35
38_I66_W0.5590.35
13_F21_Q0.5590.35
66_W95_V0.5530.35
9_M96_Q0.5510.34
23_N26_H0.5420.34
95_V107_K0.5420.34
61_I101_S0.5400.33
59_D99_N0.5380.33
46_G68_E0.5370.33
55_T72_R0.5360.33
83_E103_L0.5360.33
57_H72_R0.5340.33
19_N26_H0.5260.32
94_F103_L0.5140.31
70_T81_M0.5140.31
24_E28_E0.5120.31
24_E29_T0.5080.31
67_P73_F0.5020.30
40_A43_V0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vb2X 1 0.6818 100 0.277 Contact Map
2qcpX 1 0.7273 99.9 0.298 Contact Map
2l55A 1 0.6727 99.9 0.352 Contact Map
2wtpA 2 0.5455 97.1 0.796 Contact Map
1c9oA 2 0.5636 64.8 0.89 Contact Map
2lxjA 1 0.5818 62 0.892 Contact Map
3a0jA 1 0.5727 59.6 0.894 Contact Map
3ts2A 1 0.6818 58.5 0.895 Contact Map
3i2zB 2 0.6091 54.8 0.897 Contact Map
3camA 2 0.5727 54.5 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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