GREMLIN Database
RCLA - Probable pyridine nucleotide-disulfide oxidoreductase RclA
UniProt: P77212 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13580
Length: 441 (416)
Sequences: 16627 (10984)
Seq/√Len: 538.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_G243_V4.5141.00
277_D281_H3.9221.00
34_Q98_Q3.5371.00
160_H183_K3.4121.00
267_A275_V3.0331.00
185_T217_I2.9761.00
392_A406_V2.9261.00
183_K215_D2.7641.00
103_N106_S2.7391.00
206_A210_R2.6671.00
354_D385_K2.6051.00
4_Y30_A2.4981.00
130_Q257_A2.4641.00
107_L111_R2.4531.00
354_D384_N2.4341.00
383_D386_T2.4301.00
132_V253_Q2.4281.00
30_A95_I2.4111.00
4_Y93_D2.3701.00
108_R117_E2.3651.00
405_I424_F2.3641.00
18_L124_F2.3551.00
5_Q28_R2.3221.00
130_Q255_A2.3081.00
137_P224_R2.2721.00
387_Q417_S2.2661.00
120_G123_I2.2281.00
199_R346_E2.2091.00
157_L182_S2.1951.00
388_R413_G2.1941.00
6_A22_L2.1881.00
7_V118_I2.1381.00
162_G187_L2.1361.00
217_I239_A2.1251.00
356_Q384_N2.1121.00
269_N273_A2.0881.00
7_V32_I2.0841.00
122_K286_N2.0551.00
160_H244_D2.0451.00
226_S233_Q2.0381.00
14_A290_M2.0181.00
310_V314_L2.0021.00
233_Q240_Q1.9731.00
32_I118_I1.9621.00
191_S219_N1.9231.00
343_M351_S1.9011.00
409_V414_L1.8811.00
343_M348_A1.8781.00
130_Q253_Q1.8771.00
171_V186_I1.8711.00
104_N284_A1.8051.00
147_D150_G1.8031.00
345_E349_R1.7871.00
189_A221_H1.7841.00
394_L399_S1.7451.00
106_S117_E1.7411.00
178_A183_K1.7231.00
281_H285_D1.7131.00
5_Q121_E1.7101.00
7_V120_G1.6761.00
161_L182_S1.6711.00
35_S38_M1.6501.00
288_W313_E1.6481.00
355_I381_I1.6481.00
380_A392_A1.6481.00
107_L286_N1.6471.00
346_E350_E1.6271.00
145_V225_I1.6201.00
124_F314_L1.6161.00
267_A283_T1.6051.00
28_R93_D1.6041.00
161_L177_F1.6011.00
231_Q242_A1.5981.00
146_Y245_A1.5791.00
217_I220_A1.5711.00
185_T215_D1.5641.00
6_A27_W1.5121.00
7_V30_A1.5111.00
178_A214_V1.5071.00
141_T227_H1.5061.00
415_P418_I1.5001.00
171_V334_M1.4991.00
122_K314_L1.4931.00
125_I293_V1.4861.00
7_V107_L1.4851.00
179_N212_Q1.4791.00
159_G244_D1.4791.00
95_I118_I1.4761.00
192_L202_A1.4691.00
279_R313_E1.4551.00
102_I117_E1.4471.00
223_E235_H1.4441.00
353_A390_L1.4421.00
337_P400_H1.4361.00
345_E379_K1.4331.00
200_D359_T1.4141.00
347_Q350_E1.4141.00
278_K322_T1.4071.00
30_A118_I1.4031.00
21_T312_D1.3961.00
127_T293_V1.3871.00
101_F123_I1.3851.00
204_N395_L1.3841.00
208_I211_D1.3831.00
100_E110_H1.3761.00
280_L294_T1.3731.00
95_I116_L1.3671.00
106_S119_H1.3601.00
84_H96_D1.3601.00
124_F290_M1.3571.00
220_A237_E1.3541.00
348_A355_I1.3541.00
6_A124_F1.3391.00
100_E108_R1.3291.00
281_H286_N1.3171.00
159_G183_K1.3071.00
146_Y154_L1.3061.00
199_R203_D1.3051.00
227_H230_N1.2991.00
228_H231_Q1.2951.00
207_T210_R1.2921.00
101_F263_N1.2831.00
354_D383_D1.2811.00
192_L199_R1.2791.00
144_G227_H1.2641.00
73_E77_F1.2641.00
9_I99_A1.2621.00
307_Y311_R1.2601.00
198_D379_K1.2491.00
412_A418_I1.2441.00
187_L241_L1.2271.00
206_A216_I1.2261.00
9_I125_I1.2251.00
102_I108_R1.2231.00
160_H242_A1.2151.00
269_N275_V1.2081.00
207_T211_D1.2061.00
274_I293_V1.2031.00
72_N76_N1.2031.00
32_I99_A1.2021.00
225_I246_L1.2001.00
166_G193_F1.1981.00
39_Y94_V1.1961.00
135_P139_I1.1961.00
224_R235_H1.1931.00
284_A287_I1.1881.00
226_S235_H1.1851.00
164_L246_L1.1851.00
348_A381_I1.1811.00
84_H88_D1.1801.00
51_T54_L1.1791.00
50_P54_L1.1731.00
25_A312_D1.1671.00
345_E357_V1.1581.00
151_L177_F1.1511.00
188_E218_L1.1441.00
111_R116_L1.1431.00
357_V381_I1.1371.00
133_V147_D1.1301.00
269_N295_G1.1301.00
264_A284_A1.1281.00
4_Y95_I1.1241.00
206_A218_L1.1241.00
201_I395_L1.1231.00
73_E76_N1.1231.00
141_T144_G1.1231.00
224_R233_Q1.1211.00
46_I149_T1.1201.00
236_S239_A1.1181.00
14_A303_S1.1141.00
380_A406_V1.1121.00
110_H117_E1.1011.00
217_I241_L1.1001.00
228_H242_A1.0961.00
162_G234_V1.0931.00
348_A353_A1.0881.00
200_D379_K1.0871.00
406_V433_L1.0841.00
197_E340_R1.0781.00
160_H185_T1.0761.00
220_A239_A1.0691.00
201_I377_V1.0641.00
161_L245_A1.0621.00
404_N425_T1.0611.00
344_T347_Q1.0581.00
383_D388_R1.0571.00
280_L310_V1.0541.00
211_D375_R1.0521.00
122_K288_W1.0511.00
233_Q242_A1.0471.00
50_P53_T1.0461.00
228_H233_Q1.0441.00
11_F39_Y1.0401.00
221_H236_S1.0381.00
74_V78_L1.0381.00
197_E330_Y1.0371.00
5_Q30_A1.0361.00
414_L418_I1.0351.00
339_S403_I1.0351.00
290_M310_V1.0351.00
362_V396_C1.0341.00
378_L432_S1.0321.00
193_F206_A1.0261.00
192_L206_A1.0241.00
261_P266_I1.0221.00
359_T377_V1.0151.00
56_H60_Q1.0151.00
311_R315_L1.0121.00
223_E238_H1.0101.00
226_S240_Q1.0081.00
266_I274_I1.0021.00
85_N89_M1.0021.00
338_L395_L1.0011.00
208_I212_Q0.9961.00
387_Q416_Y0.9961.00
21_T25_A0.9931.00
327_N410_M0.9901.00
20_V90_P0.9881.00
331_S425_T0.9851.00
166_G188_E0.9831.00
349_R355_I0.9831.00
49_I54_L0.9811.00
235_H238_H0.9801.00
378_L394_L0.9781.00
347_Q351_S0.9751.00
330_Y340_R0.9731.00
205_I395_L0.9721.00
310_V313_E0.9711.00
404_N430_S0.9671.00
220_A236_S0.9621.00
345_E355_I0.9561.00
144_G245_A0.9541.00
235_H240_Q0.9541.00
35_S46_I0.9531.00
164_L248_I0.9521.00
356_Q387_Q0.9521.00
51_T55_V0.9511.00
203_D206_A0.9501.00
210_R215_D0.9461.00
138_G141_T0.9451.00
276_V294_T0.9441.00
146_Y150_G0.9441.00
204_N208_I0.9431.00
98_Q258_S0.9411.00
51_T58_A0.9411.00
8_I19_A0.9401.00
186_I216_I0.9361.00
353_A383_D0.9351.00
205_I338_L0.9321.00
93_D116_L0.9291.00
268_V275_V0.9291.00
312_D317_E0.9251.00
193_F218_L0.9211.00
32_I95_I0.9151.00
31_L87_A0.9151.00
136_I139_I0.9151.00
164_L250_S0.9141.00
25_A315_L0.9131.00
359_T379_K0.9111.00
175_S179_N0.9111.00
22_L311_R0.9091.00
223_E236_S0.9081.00
76_N81_K0.9031.00
11_F31_L0.9031.00
171_V209_L0.9001.00
105_H286_N0.8981.00
398_D401_E0.8981.00
160_H243_V0.8981.00
162_G241_L0.8971.00
231_Q234_V0.8971.00
204_N207_T0.8911.00
256_T268_V0.8851.00
101_F107_L0.8851.00
27_W315_L0.8851.00
341_V410_M0.8831.00
87_A91_N0.8821.00
103_N108_R0.8821.00
281_H288_W0.8811.00
201_I393_S0.8801.00
101_F125_I0.8801.00
274_I289_A0.8791.00
49_I52_K0.8791.00
281_H313_E0.8781.00
27_W122_K0.8761.00
160_H182_S0.8761.00
7_V109_V0.8751.00
104_N287_I0.8701.00
343_M347_Q0.8691.00
309_I313_E0.8681.00
309_I323_D0.8651.00
140_T143_P0.8591.00
146_Y151_L0.8591.00
76_N79_R0.8571.00
178_A212_Q0.8541.00
405_I408_M0.8511.00
389_M406_V0.8501.00
27_W121_E0.8501.00
132_V250_S0.8481.00
279_R318_G0.8481.00
164_L222_V0.8481.00
289_A293_V0.8481.00
254_P273_A0.8471.00
150_G153_N0.8461.00
185_T243_V0.8461.00
266_I283_T0.8441.00
276_V289_A0.8431.00
5_Q27_W0.8421.00
409_V419_L0.8391.00
108_R119_H0.8371.00
21_T24_K0.8341.00
383_D390_L0.8341.00
123_I287_I0.8331.00
187_L217_I0.8301.00
101_F110_H0.8281.00
331_S400_H0.8271.00
215_D239_A0.8271.00
156_E245_A0.8271.00
193_F216_I0.8271.00
356_Q382_V0.8261.00
87_A92_I0.8261.00
275_V283_T0.8261.00
4_Y28_R0.8221.00
133_V139_I0.8211.00
324_D411_D0.8201.00
297_L328_V0.8181.00
49_I53_T0.8181.00
124_F310_V0.8171.00
191_S199_R0.8171.00
83_F87_A0.8151.00
18_L307_Y0.8141.00
56_H59_Q0.8121.00
163_I170_G0.8101.00
190_A195_P0.8091.00
188_E195_P0.8081.00
231_Q240_Q0.8081.00
226_S231_Q0.8061.00
266_I284_A0.8051.00
187_L220_A0.8051.00
209_L214_V0.8001.00
145_V248_I0.7991.00
134_P248_I0.7991.00
22_L27_W0.7981.00
17_T304_L0.7971.00
208_I375_R0.7951.00
104_N107_L0.7941.00
72_N75_V0.7941.00
97_G112_P0.7931.00
7_V123_I0.7921.00
52_K55_V0.7911.00
278_K321_S0.7901.00
143_P227_H0.7891.00
27_W314_L0.7891.00
192_L346_E0.7871.00
282_T289_A0.7871.00
339_S399_S0.7841.00
18_L311_R0.7821.00
174_A186_I0.7811.00
264_A287_I0.7811.00
281_H284_A0.7801.00
161_L247_L0.7801.00
411_D421_D0.7771.00
104_N286_N0.7761.00
30_A93_D0.7761.00
158_P182_S0.7741.00
353_A381_I0.7741.00
54_L58_A0.7731.00
57_D70_R0.7721.00
32_I111_R0.7721.00
208_I395_L0.7701.00
101_F120_G0.7681.00
170_G188_E0.7671.00
345_E381_I0.7651.00
203_D207_T0.7621.00
75_V78_L0.7591.00
23_A92_I0.7591.00
82_N86_L0.7571.00
18_L310_V0.7561.00
50_P56_H0.7521.00
349_R352_G0.7501.00
86_L90_P0.7501.00
261_P268_V0.7491.00
70_R73_E0.7481.00
4_Y7_V0.7471.00
209_L216_I0.7461.00
87_A94_V0.7451.00
389_M392_A0.7441.00
305_D308_R0.7441.00
133_V248_I0.7431.00
414_L419_L0.7421.00
174_A214_V0.7421.00
16_K31_L0.7421.00
273_A298_Q0.7411.00
85_N88_D0.7411.00
81_K85_N0.7401.00
258_S261_P0.7401.00
192_L203_D0.7381.00
132_V135_P0.7351.00
98_Q116_L0.7351.00
21_T311_R0.7351.00
23_A29_V0.7291.00
374_T397_V0.7261.00
197_E338_L0.7231.00
55_V176_M0.7221.00
34_Q255_A0.7191.00
408_M414_L0.7181.00
358_V382_V0.7171.00
361_P364_A0.7171.00
45_N79_R0.7131.00
20_V24_K0.7111.00
49_I58_A0.7101.00
6_A311_R0.7101.00
276_V280_L0.7091.00
113_E116_L0.7071.00
388_R415_P0.7061.00
257_A262_E0.6981.00
341_V407_K0.6971.00
163_I247_L0.6961.00
41_G97_G0.6961.00
392_A410_M0.6941.00
51_T56_H0.6941.00
280_L313_E0.6931.00
302_I328_V0.6931.00
9_I259_L0.6921.00
261_P264_A0.6921.00
198_D393_S0.6911.00
136_I140_T0.6881.00
189_A195_P0.6871.00
74_V77_F0.6841.00
137_P141_T0.6841.00
43_C48_C0.6831.00
136_I222_V0.6831.00
416_Y420_R0.6831.00
408_M412_A0.6821.00
75_V79_R0.6821.00
71_K75_V0.6791.00
265_G284_A0.6791.00
280_L309_I0.6731.00
77_F369_R0.6721.00
111_R118_I0.6711.00
137_P140_T0.6711.00
408_M422_Q0.6691.00
126_N290_M0.6691.00
418_I421_D0.6671.00
101_F264_A0.6671.00
290_M307_Y0.6661.00
175_S212_Q0.6661.00
5_Q118_I0.6661.00
173_F247_L0.6641.00
344_T393_S0.6641.00
81_K84_H0.6641.00
139_I248_I0.6631.00
162_G232_V0.6621.00
110_H114_G0.6621.00
100_E263_N0.6611.00
205_I334_M0.6611.00
406_V410_M0.6601.00
194_L205_I0.6601.00
25_A317_E0.6571.00
312_D321_S0.6561.00
179_N335_T0.6541.00
168_Y332_V0.6531.00
123_I286_N0.6531.00
394_L402_M0.6521.00
127_T259_L0.6521.00
264_A268_V0.6521.00
201_I338_L0.6521.00
389_M410_M0.6521.00
11_F33_E0.6481.00
48_C52_K0.6461.00
256_T293_V0.6451.00
264_A283_T0.6451.00
102_I106_S0.6451.00
105_H119_H0.6421.00
171_V193_F0.6411.00
223_E233_Q0.6401.00
231_Q235_H0.6401.00
408_M419_L0.6381.00
139_I145_V0.6381.00
51_T173_F0.6361.00
58_A179_N0.6361.00
22_L314_L0.6351.00
361_P377_V0.6331.00
382_V416_Y0.6321.00
53_T56_H0.6321.00
100_E258_S0.6311.00
154_L245_A0.6271.00
176_M180_F0.6271.00
70_R74_V0.6271.00
83_F86_L0.6241.00
382_V387_Q0.6211.00
71_K153_N0.6201.00
87_A90_P0.6191.00
411_D422_Q0.6191.00
407_K411_D0.6191.00
348_A390_L0.6161.00
111_R114_G0.6151.00
38_M79_R0.6141.00
312_D316_G0.6131.00
204_N377_V0.6121.00
35_S149_T0.6111.00
21_T308_R0.6111.00
8_I18_L0.6111.00
50_P58_A0.6101.00
268_V274_I0.6081.00
51_T57_D0.6071.00
362_V432_S0.6071.00
386_T413_G0.6071.00
201_I204_N0.6061.00
22_L29_V0.6051.00
134_P139_I0.6041.00
18_L290_M0.6041.00
326_K351_S0.6031.00
355_I390_L0.6031.00
145_V246_L0.6001.00
401_E430_S0.5991.00
337_P398_D0.5981.00
306_D325_R0.5981.00
99_A102_I0.5971.00
4_Y122_K0.5971.00
135_P140_T0.5971.00
33_E38_M0.5971.00
38_M46_I0.5961.00
273_A295_G0.5961.00
141_T150_G0.5931.00
381_I384_N0.5931.00
262_E268_V0.5921.00
23_A91_N0.5921.00
86_L89_M0.5891.00
305_D309_I0.5891.00
177_F182_S0.5850.99
8_I29_V0.5830.99
392_A403_I0.5820.99
72_N153_N0.5800.99
308_R312_D0.5790.99
14_A126_N0.5790.99
343_M353_A0.5790.99
168_Y330_Y0.5770.99
417_S421_D0.5750.99
124_F311_R0.5750.99
361_P375_R0.5740.99
93_D96_D0.5740.99
373_D397_V0.5730.99
22_L315_L0.5730.99
105_H284_A0.5720.99
108_R111_R0.5720.99
32_I97_G0.5680.99
288_W314_L0.5670.99
337_P429_M0.5670.99
9_I107_L0.5640.99
335_T397_V0.5630.99
257_A263_N0.5630.99
215_D218_L0.5620.99
160_H231_Q0.5620.99
39_Y84_H0.5600.99
302_I306_D0.5590.99
71_K74_V0.5590.99
160_H178_A0.5580.99
193_F202_A0.5560.99
6_A314_L0.5550.99
242_A245_A0.5540.99
346_E349_R0.5530.99
392_A433_L0.5530.99
366_P370_V0.5520.99
279_R322_T0.5500.99
294_T306_D0.5500.99
49_I55_V0.5490.99
234_V241_L0.5490.99
149_T252_R0.5480.99
197_E332_V0.5470.99
41_G152_L0.5470.99
270_E275_V0.5460.99
133_V138_G0.5440.99
170_G189_A0.5440.99
426_H431_E0.5440.99
182_S244_D0.5430.99
54_L57_D0.5430.99
129_A252_R0.5420.99
212_Q335_T0.5420.99
50_P57_D0.5410.99
23_A28_R0.5410.99
225_I232_V0.5400.99
24_K90_P0.5400.99
232_V246_L0.5400.99
405_I430_S0.5400.99
104_N264_A0.5400.99
8_I15_G0.5390.99
343_M391_G0.5380.99
55_V58_A0.5340.99
175_S209_L0.5340.99
274_I282_T0.5330.99
49_I56_H0.5330.99
394_L403_I0.5320.99
48_C51_T0.5310.99
352_G355_I0.5310.99
25_A311_R0.5300.99
45_N48_C0.5290.99
19_A92_I0.5280.99
258_S262_E0.5270.99
149_T152_L0.5250.99
367_R370_V0.5230.99
290_M314_L0.5220.99
47_G50_P0.5220.99
410_M414_L0.5200.99
202_A206_A0.5190.99
97_G109_V0.5190.99
312_D319_K0.5170.99
18_L22_L0.5150.99
266_I287_I0.5150.99
366_P369_R0.5140.99
189_A250_S0.5130.99
354_D357_V0.5120.99
154_L177_F0.5120.99
185_T241_L0.5120.99
162_G246_L0.5110.99
6_A18_L0.5100.99
408_M424_F0.5080.99
107_L112_P0.5070.99
144_G232_V0.5060.99
97_G113_E0.5060.99
121_E286_N0.5060.99
148_S252_R0.5060.99
104_N265_G0.5010.98
173_F176_M0.5010.98
402_M429_M0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9864 100 0.166 Contact Map
3ladA 2 0.9909 100 0.178 Contact Map
3urhA 2 0.9796 100 0.179 Contact Map
2a8xA 2 0.9864 100 0.184 Contact Map
1zmdA 4 0.9841 100 0.188 Contact Map
1ebdA 2 0.9819 100 0.189 Contact Map
3ic9A 2 0.9841 100 0.19 Contact Map
2qaeA 2 0.9819 100 0.193 Contact Map
1xdiA 3 0.9841 100 0.193 Contact Map
1dxlA 2 0.9864 100 0.193 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0134 seconds.