GREMLIN Database
CUSC - Cation efflux system protein CusC
UniProt: P77211 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14233
Length: 457 (398)
Sequences: 18433 (14080)
Seq/√Len: 705.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_A169_V2.9841.00
297_I359_Q2.7221.00
69_E248_S2.6911.00
201_E205_L2.5611.00
194_Q225_R2.4541.00
187_E228_I2.4451.00
201_E218_R2.4031.00
187_E232_Q2.3641.00
86_E358_R2.2401.00
79_M365_N2.2281.00
402_Q433_R2.1991.00
82_L357_I2.1581.00
76_D368_Q2.1291.00
183_L232_Q2.1251.00
90_Q354_I2.1221.00
409_R413_Q2.1211.00
180_Y235_L2.1181.00
91_Y151_Y2.1131.00
83_K361_Q2.1071.00
418_S421_E2.0701.00
157_A285_E2.0481.00
208_S416_A2.0111.00
211_V403_I2.0051.00
403_I406_Q1.9851.00
222_E225_R1.9781.00
190_L228_I1.9721.00
89_A350_A1.9591.00
146_A296_N1.9501.00
202_K410_A1.9071.00
204_L214_L1.9031.00
395_Q436_L1.8971.00
182_Q434_Q1.8921.00
194_Q221_I1.8691.00
190_L221_I1.8401.00
68_S72_V1.8311.00
190_L225_R1.8301.00
149_Q288_H1.8261.00
195_Q198_A1.8211.00
62_Q65_T1.8181.00
156_E284_M1.8171.00
304_F352_L1.8151.00
181_A184_Q1.8091.00
294_N359_Q1.7871.00
183_L228_I1.7791.00
388_N443_R1.7691.00
183_L235_L1.7541.00
358_R361_Q1.7511.00
436_L440_N1.7081.00
222_E396_R1.6971.00
179_A238_A1.6931.00
178_L441_Y1.6861.00
84_V158_Q1.6811.00
287_E366_Y1.6801.00
308_I338_I1.6751.00
78_R364_V1.6671.00
197_Y218_R1.6651.00
176_Q235_L1.6651.00
171_Q445_V1.6411.00
150_N292_A1.6151.00
402_Q406_Q1.6111.00
368_Q372_N1.5911.00
215_E403_I1.5721.00
311_T335_I1.5691.00
110_W122_R1.5541.00
153_A289_A1.5541.00
197_Y201_E1.5531.00
150_N296_N1.5421.00
194_Q198_A1.5381.00
366_Y370_I1.5371.00
204_L211_V1.5331.00
235_L239_N1.5291.00
179_A231_R1.5281.00
183_L187_E1.5231.00
290_L366_Y1.5191.00
142_N145_E1.5051.00
290_L363_V1.5021.00
197_Y221_I1.5001.00
288_H291_M1.4951.00
67_I166_V1.4851.00
229_A389_D1.4831.00
375_K379_D1.4701.00
359_Q363_V1.4661.00
387_L439_L1.4651.00
139_R307_S1.4531.00
91_Y148_R1.4521.00
344_N348_N1.4441.00
171_Q449_S1.4401.00
178_L437_L1.4391.00
65_T68_S1.4371.00
191_R195_Q1.4351.00
143_M299_A1.4321.00
228_I232_Q1.4311.00
152_L155_E1.4291.00
297_I352_L1.4271.00
429_L433_R1.4191.00
156_E159_R1.4171.00
98_R144_S1.4121.00
93_L354_I1.4111.00
82_L364_V1.4051.00
82_L360_Q1.4001.00
361_Q365_N1.3971.00
66_L169_V1.3951.00
86_E361_Q1.3861.00
188_E433_R1.3771.00
170_A448_I1.3761.00
291_M294_N1.3731.00
152_L288_H1.3661.00
182_Q438_D1.3641.00
83_K86_E1.3631.00
188_E191_R1.3611.00
221_I225_R1.3481.00
69_E246_L1.3321.00
198_A202_K1.3321.00
85_Q88_R1.3251.00
387_L446_N1.3221.00
285_E289_A1.3221.00
154_T157_A1.3141.00
89_A353_D1.3131.00
360_Q363_V1.3111.00
82_L85_Q1.3071.00
61_N66_L1.3001.00
297_I356_E1.2991.00
398_L436_L1.2981.00
202_K205_L1.2941.00
176_Q239_N1.2941.00
410_A413_Q1.2931.00
64_K68_S1.2911.00
84_V155_E1.2891.00
354_I358_R1.2881.00
153_A292_A1.2841.00
391_I436_L1.2811.00
295_A298_G1.2781.00
149_Q291_M1.2761.00
351_N354_I1.2761.00
206_T414_H1.2741.00
145_E295_A1.2691.00
398_L433_R1.2681.00
71_L166_V1.2661.00
431_A435_T1.2621.00
244_L375_K1.2591.00
184_Q188_E1.2571.00
190_L194_Q1.2551.00
81_T158_Q1.2511.00
156_E288_H1.2401.00
286_A362_S1.2391.00
79_M364_V1.2371.00
237_Q383_L1.2361.00
160_A164_L1.2301.00
408_A417_V1.2291.00
405_L409_R1.2271.00
405_L429_L1.2261.00
396_R399_A1.2261.00
90_Q93_L1.2211.00
215_E218_R1.2161.00
146_A299_A1.2141.00
197_Y214_L1.2121.00
367_E370_I1.2041.00
409_R426_E1.2031.00
69_E73_N1.1941.00
392_S396_R1.1941.00
187_E191_R1.1861.00
229_A232_Q1.1861.00
406_Q410_A1.1821.00
193_Y224_T1.1801.00
402_Q429_L1.1771.00
159_R162_H1.1771.00
180_Y239_N1.1771.00
175_N445_V1.1761.00
240_N379_D1.1741.00
178_L438_D1.1711.00
211_V215_E1.1671.00
218_R396_R1.1651.00
149_Q152_L1.1621.00
301_R352_L1.1621.00
93_L351_N1.1611.00
411_L417_V1.1571.00
67_I71_L1.1561.00
201_E214_L1.1521.00
88_R151_Y1.1491.00
91_Y95_D1.1481.00
395_Q399_A1.1471.00
438_D442_A1.1401.00
384_R443_R1.1281.00
71_L162_H1.1261.00
184_Q187_E1.1241.00
311_T337_K1.1241.00
89_A357_I1.1181.00
186_A224_T1.1151.00
108_G124_F1.1141.00
149_Q295_A1.1081.00
160_A282_D1.1071.00
313_G333_N1.1061.00
167_S452_T1.1051.00
164_L168_N1.1011.00
63_V170_A1.0991.00
219_G401_L1.0991.00
81_T85_Q1.0971.00
347_R351_N1.0901.00
92_R350_A1.0881.00
398_L429_L1.0871.00
355_A358_R1.0871.00
220_V223_S1.0861.00
67_I170_A1.0861.00
395_Q440_N1.0831.00
424_D427_R1.0821.00
168_N171_Q1.0741.00
198_A201_E1.0741.00
191_R194_Q1.0721.00
158_Q162_H1.0701.00
169_V242_L1.0701.00
412_Y419_Y1.0611.00
80_A161_V1.0551.00
78_R81_T1.0521.00
348_N352_L1.0511.00
237_Q382_A1.0431.00
142_N295_A1.0421.00
289_A365_N1.0411.00
352_L356_E1.0361.00
398_L402_Q1.0321.00
236_A382_A1.0301.00
65_T69_E1.0251.00
388_N392_S1.0231.00
343_F346_G1.0191.00
89_A92_R1.0191.00
84_V151_Y1.0181.00
287_E291_M1.0161.00
286_A369_K1.0141.00
300_A303_A1.0121.00
222_E400_S1.0111.00
185_I437_L1.0101.00
290_L359_Q1.0081.00
96_A347_R1.0071.00
85_Q360_Q1.0071.00
167_S448_I1.0061.00
70_A165_L1.0051.00
443_R447_E1.0041.00
447_E451_Y1.0011.00
417_V421_E1.0001.00
75_R364_V0.9951.00
227_D230_K0.9951.00
364_V367_E0.9941.00
353_D356_E0.9931.00
66_L246_L0.9921.00
218_R222_E0.9901.00
77_L165_L0.9901.00
304_F348_N0.9881.00
151_Y155_E0.9841.00
140_L144_S0.9781.00
362_S365_N0.9771.00
181_A440_N0.9741.00
410_A414_H0.9711.00
172_S238_A0.9691.00
183_L231_R0.9691.00
157_A289_A0.9671.00
441_Y445_V0.9601.00
391_I443_R0.9601.00
314_I330_G0.9551.00
200_V209_S0.9511.00
230_K234_E0.9511.00
304_F349_Q0.9471.00
284_M287_E0.9461.00
203_Q209_S0.9451.00
293_A355_A0.9431.00
214_L218_R0.9401.00
389_D392_S0.9371.00
390_Q442_A0.9331.00
233_G383_L0.9331.00
391_I395_Q0.9321.00
296_N300_A0.9301.00
280_R453_A0.9261.00
186_A231_R0.9261.00
133_D136_F0.9251.00
135_D138_G0.9251.00
440_N444_Q0.9241.00
141_K145_E0.9221.00
85_Q357_I0.9221.00
230_K390_Q0.9221.00
283_I373_A0.9201.00
385_Q389_D0.9181.00
105_E127_G0.9181.00
233_G237_Q0.9161.00
218_R400_S0.9151.00
95_D144_S0.9001.00
303_A351_N0.8921.00
399_A402_Q0.8911.00
202_K206_T0.8901.00
233_G386_S0.8881.00
144_S148_R0.8871.00
181_A437_L0.8871.00
381_L385_Q0.8861.00
229_A393_A0.8851.00
394_Q439_L0.8841.00
146_A150_N0.8841.00
293_A296_N0.8781.00
372_N376_E0.8771.00
175_N241_A0.8761.00
391_I440_N0.8741.00
176_Q180_Y0.8721.00
164_L452_T0.8691.00
449_S452_T0.8661.00
232_Q389_D0.8661.00
142_N298_G0.8661.00
244_L368_Q0.8631.00
287_E370_I0.8631.00
174_F448_I0.8621.00
212_L408_A0.8611.00
93_L350_A0.8611.00
286_A289_A0.8601.00
296_N299_A0.8601.00
239_N243_Q0.8601.00
179_A182_Q0.8591.00
399_A403_I0.8581.00
280_R376_E0.8581.00
82_L361_Q0.8541.00
159_R284_M0.8521.00
401_L432_T0.8511.00
147_E150_N0.8501.00
225_R393_A0.8481.00
297_I301_R0.8461.00
223_S397_Y0.8451.00
108_G122_R0.8441.00
204_L209_S0.8401.00
236_A239_N0.8361.00
200_V217_A0.8311.00
280_R373_A0.8291.00
215_E400_S0.8281.00
216_Q424_D0.8271.00
356_E360_Q0.8241.00
94_T147_E0.8231.00
190_L224_T0.8221.00
209_S213_A0.8201.00
357_I360_Q0.8191.00
220_V427_R0.8191.00
87_A154_T0.8161.00
300_A355_A0.8141.00
365_N369_K0.8121.00
91_Y144_S0.8111.00
98_R140_L0.8071.00
223_S435_T0.8041.00
99_Y345_A0.8031.00
103_N344_N0.8011.00
75_R371_Q0.8001.00
102_L130_A0.7991.00
182_Q186_A0.7971.00
226_S390_Q0.7971.00
383_L449_S0.7961.00
172_S245_L0.7931.00
290_L294_N0.7931.00
391_I439_L0.7921.00
142_N302_A0.7911.00
210_N213_A0.7891.00
163_I281_P0.7881.00
374_F378_A0.7881.00
79_M368_Q0.7871.00
81_T162_H0.7861.00
240_N378_A0.7861.00
79_M83_K0.7851.00
98_R141_K0.7851.00
424_D428_S0.7821.00
380_A446_N0.7811.00
314_I332_W0.7811.00
234_E238_A0.7811.00
275_Q278_L0.7801.00
365_N368_Q0.7781.00
186_A227_D0.7761.00
66_L242_L0.7721.00
86_E90_Q0.7721.00
195_Q199_F0.7721.00
222_E393_A0.7691.00
171_Q175_N0.7681.00
186_A228_I0.7681.00
367_E371_Q0.7671.00
277_L374_F0.7641.00
405_L426_E0.7621.00
358_R362_S0.7601.00
444_Q447_E0.7581.00
150_N153_A0.7581.00
390_Q394_Q0.7571.00
142_N299_A0.7551.00
176_Q238_A0.7531.00
179_A234_E0.7521.00
303_A348_N0.7511.00
237_Q379_D0.7511.00
174_F441_Y0.7511.00
392_S395_Q0.7511.00
131_S309_S0.7501.00
272_L454_L0.7501.00
292_A296_N0.7501.00
369_K372_N0.7491.00
276_I377_V0.7481.00
167_S449_S0.7441.00
195_Q409_R0.7431.00
377_V450_L0.7381.00
78_R367_E0.7381.00
106_G126_T0.7321.00
283_I366_Y0.7321.00
75_R367_E0.7311.00
232_Q236_A0.7291.00
293_A362_S0.7291.00
223_S227_D0.7281.00
79_M361_Q0.7271.00
160_A285_E0.7271.00
387_L390_Q0.7261.00
165_L169_V0.7261.00
56_T64_K0.7201.00
284_M288_H0.7201.00
203_Q208_S0.7201.00
385_Q388_N0.7191.00
260_S263_L0.7171.00
175_N238_A0.7161.00
99_Y343_F0.7161.00
435_T438_D0.7111.00
380_A453_A0.7101.00
70_A246_L0.7101.00
96_A345_A0.7081.00
193_Y217_A0.7061.00
187_E190_L0.7061.00
298_G301_R0.7051.00
148_R152_L0.7041.00
384_R388_N0.7041.00
238_A241_A0.7021.00
182_Q234_E0.7001.00
241_A375_K0.7001.00
216_Q421_E0.6991.00
397_Y401_L0.6991.00
349_Q353_D0.6981.00
282_D373_A0.6981.00
384_R447_E0.6971.00
283_I370_I0.6941.00
294_N298_G0.6941.00
179_A235_L0.6881.00
133_D309_S0.6881.00
146_A292_A0.6861.00
384_R450_L0.6841.00
406_Q409_R0.6831.00
86_E357_I0.6811.00
55_R64_K0.6811.00
80_A83_K0.6811.00
84_V88_R0.6771.00
243_Q248_S0.6761.00
145_E148_R0.6761.00
168_N172_S0.6751.00
273_S374_F0.6741.00
178_L182_Q0.6741.00
104_G340_I0.6731.00
341_P344_N0.6721.00
248_S252_L0.6721.00
175_N179_A0.6691.00
383_L446_N0.6671.00
312_S332_W0.6641.00
156_E281_P0.6631.00
170_A451_Y0.6611.00
69_E72_V0.6601.00
271_G274_S0.6591.00
356_E359_Q0.6591.00
67_I169_V0.6591.00
309_S337_K0.6581.00
107_S125_S0.6581.00
387_L442_A0.6571.00
240_N382_A0.6551.00
155_E159_R0.6531.00
153_A157_A0.6531.00
274_S278_L0.6521.00
189_T193_Y0.6521.00
421_E424_D0.6501.00
161_V164_L0.6491.00
77_L162_H0.6451.00
135_D305_F0.6451.00
226_S394_Q0.6441.00
186_A434_Q0.6431.00
76_D79_M0.6431.00
386_S389_D0.6411.00
411_L416_A0.6341.00
127_G313_G0.6341.00
143_M146_A0.6311.00
215_E407_R0.6261.00
363_V367_E0.6261.00
420_L424_D0.6261.00
307_S339_E0.6251.00
271_G275_Q0.6231.00
231_R234_E0.6231.00
204_L210_N0.6221.00
86_E354_I0.6201.00
234_E237_Q0.6191.00
139_R302_A0.6181.00
296_N358_R0.6171.00
216_Q220_V0.6171.00
277_L370_I0.6171.00
167_S171_Q0.6171.00
275_Q279_Q0.6161.00
157_A160_A0.6161.00
286_A366_Y0.6141.00
442_A446_N0.6111.00
162_H166_V0.6111.00
446_N449_S0.6071.00
212_L407_R0.6051.00
348_N351_N0.6001.00
88_R155_E0.6001.00
92_R353_D0.6001.00
175_N178_L0.5991.00
139_R143_M0.5971.00
136_F140_L0.5961.00
185_I434_Q0.5961.00
360_Q364_V0.5951.00
133_D140_L0.5941.00
403_I407_R0.5931.00
75_R368_Q0.5901.00
353_D357_I0.5881.00
193_Y220_V0.5871.00
232_Q386_S0.5861.00
379_D383_L0.5851.00
225_R396_R0.5831.00
244_L372_N0.5831.00
393_A396_R0.5831.00
153_A285_E0.5821.00
294_N363_V0.5821.00
74_N245_L0.5801.00
394_Q397_Y0.5781.00
199_F203_Q0.5771.00
344_N347_R0.5771.00
378_A382_A0.5751.00
401_L428_S0.5751.00
312_S334_F0.5731.00
428_S431_A0.5711.00
241_A379_D0.5701.00
408_A425_A0.5701.00
289_A293_A0.5681.00
194_Q197_Y0.5661.00
407_R411_L0.5641.00
229_A233_G0.5641.00
145_E149_Q0.5631.00
83_K157_A0.5621.00
77_L158_Q0.5621.00
372_N375_K0.5611.00
259_N262_S0.5611.00
296_N355_A0.5601.00
293_A359_Q0.5591.00
104_G128_L0.5591.00
177_Q181_A0.5571.00
129_N313_G0.5571.00
442_A445_V0.5571.00
177_Q180_Y0.5571.00
300_A351_N0.5561.00
346_G350_A0.5561.00
196_S419_Y0.5561.00
105_E129_N0.5551.00
404_T425_A0.5531.00
323_S326_N0.5521.00
82_L86_E0.5511.00
369_K373_A0.5511.00
405_L422_V0.5501.00
394_Q435_T0.5491.00
87_A90_Q0.5471.00
178_L442_A0.5471.00
294_N297_I0.5461.00
136_F309_S0.5451.00
85_Q89_A0.5431.00
387_L443_R0.5431.00
95_D99_Y0.5421.00
139_R303_A0.5381.00
152_L156_E0.5361.00
133_D139_R0.5351.00
90_Q150_N0.5351.00
61_N69_E0.5341.00
137_F305_F0.5321.00
409_R422_V0.5321.00
427_R431_A0.5271.00
182_Q231_R0.5241.00
382_A385_Q0.5231.00
92_R95_D0.5221.00
165_L245_L0.5211.00
186_A190_L0.5201.00
376_E379_D0.5191.00
89_A354_I0.5191.00
382_A386_S0.5181.00
185_I430_F0.5181.00
350_A353_D0.5181.00
161_V165_L0.5151.00
198_A406_Q0.5141.00
224_T227_D0.5131.00
76_D161_V0.5120.99
134_L310_L0.5120.99
172_S242_L0.5120.99
129_N311_T0.5090.99
201_E204_L0.5080.99
75_R247_G0.5070.99
200_V204_L0.5070.99
73_N247_G0.5070.99
225_R389_D0.5060.99
189_T430_F0.5050.99
197_Y217_A0.5050.99
110_W120_T0.5050.99
308_I336_P0.5040.99
103_N341_P0.5030.99
276_I373_A0.5020.99
180_Y184_Q0.5000.99
270_A274_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mt4A 3 0.9628 100 0.16 Contact Map
4k7rA 3 0.9387 100 0.167 Contact Map
3d5kA 3 0.9628 100 0.171 Contact Map
4mt0A 3 0.954 100 0.177 Contact Map
1yc9A 3 0.8796 100 0.191 Contact Map
1ek9A 3 0.8643 100 0.258 Contact Map
4tkoB 1 0.3545 68.1 0.941 Contact Map
3zbiC 1 0.0613 44 0.949 Contact Map
4dk0A 5 0.3195 37.8 0.951 Contact Map
3fppA 3 0.3063 37.6 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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