GREMLIN Database
YAFZ - UPF0380 protein YafZ
UniProt: P77206 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13338
Length: 273 (264)
Sequences: 238 (126)
Seq/√Len: 7.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_D147_S5.1691.00
183_L224_I4.2410.98
22_R55_D3.8460.96
22_R58_Q3.5690.94
184_A205_L3.3070.91
79_E85_L2.9170.85
182_A263_V2.9070.85
45_Y107_H2.9020.85
14_I67_A2.6210.78
77_R108_D2.4190.72
191_R247_A2.3910.71
22_R26_F2.3430.69
185_K201_E2.3210.68
45_Y106_S2.3210.68
55_D59_R2.1880.64
137_V207_P2.1160.61
114_Q131_G2.1100.61
82_K252_D2.0540.58
56_S77_R2.0390.58
48_I112_S2.0050.57
228_L242_R1.9970.56
162_R199_V1.9890.56
182_A268_L1.9710.55
171_Q179_A1.9700.55
97_Q171_Q1.9490.54
32_V253_G1.9410.54
180_Q223_R1.9280.53
191_R248_V1.8990.52
16_R197_Q1.8560.51
122_A131_G1.8120.49
38_H41_R1.7820.48
54_L87_L1.7740.47
183_L247_A1.7640.47
257_L260_A1.7630.47
156_V230_K1.7260.45
84_M122_A1.6380.42
135_G139_V1.6330.42
191_R194_E1.6310.42
183_L264_M1.6010.40
29_V117_P1.5860.40
62_F149_V1.5820.40
8_F131_G1.5450.38
172_S206_S1.5420.38
139_V230_K1.5360.38
211_Q223_R1.5240.37
19_P92_Q1.5180.37
48_I216_D1.5160.37
24_E32_V1.4970.36
236_R240_G1.4950.36
25_L89_R1.4710.35
53_L110_T1.4590.35
70_T184_A1.4580.35
14_I25_L1.4250.34
84_M91_G1.4210.34
29_V134_F1.4210.34
98_V254_D1.4040.33
214_S244_H1.3990.33
170_M265_A1.3880.32
128_L154_Y1.3860.32
220_T224_I1.3720.32
142_K148_Q1.3720.32
110_T244_H1.3710.32
35_E204_I1.3690.32
97_Q179_A1.3550.31
204_I207_P1.3530.31
106_S138_R1.3420.31
53_L190_Y1.3410.31
56_S59_R1.3410.31
32_V85_L1.3320.30
34_S37_K1.3270.30
188_L192_F1.3260.30
128_L255_V1.3210.30
228_L247_A1.3150.30
185_K267_A1.3080.30
98_V122_A1.3020.29
101_I133_S1.2990.29
6_S9_G1.2980.29
48_I161_D1.2950.29
86_R100_E1.2930.29
81_T150_I1.2850.29
156_V248_V1.2680.28
74_D85_L1.2560.28
123_V224_I1.2440.28
16_R25_L1.2410.27
150_I154_Y1.2370.27
227_N230_K1.2330.27
6_S207_P1.2180.27
215_N219_T1.2140.27
114_Q138_R1.2070.26
47_Y107_H1.2060.26
191_R195_D1.2010.26
7_R207_P1.1990.26
18_R24_E1.1990.26
82_K149_V1.1980.26
59_R249_R1.1910.26
115_M153_A1.1900.26
160_F188_L1.1880.26
103_L113_Y1.1870.26
25_L67_A1.1860.26
70_T259_R1.1850.26
65_F112_S1.1850.26
134_F148_Q1.1830.26
245_T264_M1.1760.25
28_V72_V1.1760.25
80_H249_R1.1610.25
210_W213_E1.1590.25
180_Q220_T1.1570.25
47_Y140_P1.1510.25
139_V183_L1.1400.24
94_T194_E1.1350.24
46_T142_K1.1290.24
101_I120_F1.1220.24
114_Q122_A1.1170.24
19_P89_R1.1020.23
198_P236_R1.1010.23
32_V197_Q1.0990.23
119_L191_R1.0940.23
70_T205_L1.0870.23
103_L127_G1.0790.23
143_G149_V1.0750.22
89_R157_L1.0690.22
8_F255_V1.0620.22
140_P148_Q1.0600.22
156_V252_D1.0470.22
87_L250_G1.0460.22
182_A247_A1.0450.22
41_R62_F1.0450.22
128_L242_R1.0410.21
7_R194_E1.0350.21
12_N254_D1.0320.21
202_S205_L1.0320.21
145_V205_L1.0200.21
87_L122_A1.0190.21
36_D80_H1.0190.21
77_R204_I1.0140.21
161_D165_E1.0100.21
8_F114_Q1.0100.21
8_F122_A1.0060.21
216_D219_T1.0050.21
183_L265_A1.0040.20
34_S132_E0.9970.20
24_E148_Q0.9930.20
81_T248_V0.9820.20
163_V248_V0.9760.20
51_I235_G0.9750.20
65_F131_G0.9750.20
170_M269_L0.9740.20
152_G198_P0.9730.20
37_K222_Q0.9700.20
80_H167_R0.9670.20
41_R47_Y0.9590.19
117_P135_G0.9580.19
9_G195_D0.9490.19
22_R36_D0.9480.19
233_L245_T0.9480.19
41_R109_G0.9460.19
182_A267_A0.9450.19
101_I157_L0.9440.19
185_K189_T0.9430.19
66_F89_R0.9390.19
87_L157_L0.9330.19
72_V77_R0.9290.19
158_G162_R0.9220.18
132_E259_R0.9200.18
84_M123_V0.9170.18
70_T80_H0.9120.18
67_A190_Y0.9120.18
9_G85_L0.9110.18
99_P110_T0.9090.18
82_K143_G0.9040.18
21_T165_E0.9020.18
54_L81_T0.8980.18
63_Q172_S0.8960.18
26_F33_F0.8950.18
226_E231_G0.8920.18
109_G117_P0.8880.18
135_G230_K0.8850.18
84_M174_L0.8770.17
100_E113_Y0.8730.17
11_A229_I0.8690.17
250_G253_G0.8650.17
31_S251_I0.8630.17
53_L89_R0.8630.17
32_V89_R0.8620.17
36_D238_A0.8560.17
26_F36_D0.8550.17
196_H234_S0.8520.17
116_L125_Q0.8510.17
67_A191_R0.8500.17
8_F68_C0.8470.17
215_N248_V0.8470.17
85_L137_V0.8450.17
18_R21_T0.8440.17
21_T24_E0.8430.17
9_G202_S0.8430.17
67_A136_E0.8410.17
171_Q201_E0.8410.17
204_I241_G0.8400.17
178_P224_I0.8400.17
65_F115_M0.8360.16
165_E172_S0.8350.16
145_V193_G0.8300.16
117_P190_Y0.8280.16
202_S239_K0.8260.16
6_S173_L0.8260.16
52_S55_D0.8240.16
10_A13_L0.8210.16
80_H110_T0.8200.16
109_G113_Y0.8200.16
35_E265_A0.8160.16
173_L193_G0.8070.16
138_R142_K0.8030.16
56_S155_E0.8000.16
129_V205_L0.8000.16
115_M122_A0.7960.16
47_Y192_F0.7930.15
204_I228_L0.7930.15
72_V201_E0.7870.15
72_V130_C0.7860.15
9_G12_N0.7830.15
37_K46_T0.7820.15
238_A247_A0.7810.15
179_A182_A0.7810.15
48_I62_F0.7780.15
221_Y265_A0.7760.15
105_N124_C0.7750.15
105_N126_N0.7750.15
84_M161_D0.7730.15
183_L234_S0.7710.15
46_T137_V0.7620.15
145_V152_G0.7620.15
90_E222_Q0.7610.15
180_Q215_N0.7590.15
51_I158_G0.7580.15
107_H127_G0.7570.15
47_Y160_F0.7540.15
58_Q97_Q0.7540.15
29_V66_F0.7530.15
21_T254_D0.7520.15
184_A268_L0.7510.15
91_G256_K0.7500.15
71_R216_D0.7490.15
55_D194_E0.7470.15
154_Y242_R0.7460.15
59_R85_L0.7420.14
25_L90_E0.7390.14
155_E190_Y0.7380.14
159_I162_R0.7370.14
9_G14_I0.7350.14
53_L264_M0.7330.14
163_V266_E0.7280.14
208_R227_N0.7260.14
190_Y254_D0.7210.14
87_L101_I0.7210.14
48_I149_V0.7200.14
93_I233_L0.7200.14
24_E129_V0.7150.14
176_P179_A0.7150.14
145_V151_E0.7150.14
28_V71_R0.7120.14
26_F168_D0.7080.14
248_V257_L0.7050.14
112_S170_M0.7020.14
205_L256_K0.6980.14
95_G133_S0.6960.14
37_K47_Y0.6950.14
173_L182_A0.6870.13
182_A191_R0.6860.13
7_R76_G0.6820.13
7_R96_K0.6820.13
25_L29_V0.6790.13
29_V230_K0.6790.13
258_N261_L0.6730.13
25_L253_G0.6680.13
37_K110_T0.6670.13
29_V33_F0.6670.13
125_Q184_A0.6670.13
18_R148_Q0.6660.13
20_L24_E0.6660.13
167_R268_L0.6660.13
92_Q223_R0.6660.13
107_H112_S0.6660.13
57_L86_R0.6630.13
68_C131_G0.6580.13
14_I199_V0.6570.13
125_Q133_S0.6510.13
43_E177_P0.6490.13
58_Q192_F0.6490.13
220_T267_A0.6490.13
67_A119_L0.6490.13
58_Q193_G0.6470.13
49_P69_Q0.6380.12
70_T74_D0.6370.12
101_I149_V0.6360.12
89_R136_E0.6350.12
113_Y145_V0.6310.12
213_E248_V0.6300.12
114_Q120_F0.6300.12
192_F198_P0.6300.12
40_S62_F0.6300.12
47_Y58_Q0.6280.12
162_R206_S0.6260.12
27_R202_S0.6250.12
81_T260_A0.6240.12
37_K253_G0.6200.12
94_T191_R0.6170.12
65_F68_C0.6130.12
63_Q196_H0.6120.12
64_P100_E0.6100.12
212_D218_W0.6050.12
104_L129_V0.6050.12
18_R95_G0.6020.12
126_N231_G0.6010.12
124_C231_G0.6010.12
105_N231_G0.6010.12
243_S268_L0.6000.12
77_R81_T0.6000.12
12_N159_I0.5980.12
26_F77_R0.5960.12
88_R111_S0.5950.12
34_S140_P0.5910.12
234_S244_H0.5900.12
227_N266_E0.5850.12
158_G199_V0.5840.12
97_Q119_L0.5830.12
157_L218_W0.5830.12
77_R80_H0.5810.12
70_T167_R0.5790.11
53_L85_L0.5770.11
67_A89_R0.5770.11
213_E244_H0.5750.11
87_L198_P0.5750.11
172_S177_P0.5740.11
76_G247_A0.5720.11
76_G85_L0.5720.11
10_A166_K0.5720.11
222_Q247_A0.5660.11
219_T249_R0.5660.11
70_T145_V0.5660.11
91_G243_S0.5650.11
12_N241_G0.5650.11
53_L253_G0.5650.11
62_F157_L0.5640.11
33_F224_I0.5620.11
214_S230_K0.5600.11
174_L266_E0.5590.11
13_L55_D0.5590.11
9_G222_Q0.5580.11
23_E257_L0.5570.11
16_R117_P0.5570.11
161_D173_L0.5520.11
7_R140_P0.5520.11
8_F102_I0.5520.11
44_R108_D0.5510.11
112_S164_E0.5490.11
32_V129_V0.5480.11
160_F170_M0.5470.11
16_R67_A0.5460.11
63_Q90_E0.5460.11
146_V199_V0.5460.11
45_Y138_R0.5450.11
162_R165_E0.5450.11
36_D195_D0.5450.11
173_L263_V0.5430.11
116_L144_D0.5430.11
131_G170_M0.5430.11
69_Q227_N0.5430.11
21_T154_Y0.5410.11
202_S213_E0.5380.11
189_T269_L0.5380.11
147_S150_I0.5380.11
179_A197_Q0.5380.11
178_P181_Q0.5370.11
53_L182_A0.5350.11
12_N16_R0.5330.11
186_A263_V0.5250.11
37_K140_P0.5250.11
20_L44_R0.5240.11
128_L138_R0.5220.11
32_V186_A0.5220.11
78_R248_V0.5140.10
100_E127_G0.5140.10
16_R241_G0.5140.10
68_C93_I0.5140.10
38_H49_P0.5140.10
176_P201_E0.5100.10
168_D172_S0.5070.10
12_N247_A0.5070.10
29_V159_I0.5060.10
79_E108_D0.5050.10
67_A125_Q0.5040.10
34_S117_P0.5040.10
139_V152_G0.5040.10
57_L69_Q0.5030.10
47_Y115_M0.5030.10
187_A261_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pdiA 1 0.5348 26.6 0.975 Contact Map
3aekA 1 0.5495 19.5 0.976 Contact Map
3sgiA 1 0 19 0.977 Contact Map
3u7qA 1 0.5714 17.6 0.977 Contact Map
3slrA 2 0.6081 15.2 0.978 Contact Map
2fhoA 1 0.1612 13.9 0.978 Contact Map
4wesB 2 0.6007 11 0.979 Contact Map
4a0eA 1 0.3663 9.5 0.98 Contact Map
3u7qB 2 0.6117 9.4 0.98 Contact Map
1twfK 1 0.2637 7.7 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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