GREMLIN Database
DSBG - Thiol:disulfide interchange protein DsbG
UniProt: P77202 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13535
Length: 248 (220)
Sequences: 1507 (1186)
Seq/√Len: 80.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_K178_Q4.1161.00
152_V209_M3.8091.00
71_Y79_N3.7561.00
171_D174_K3.4341.00
156_K159_S3.3151.00
117_I148_R3.1801.00
125_F162_T3.1311.00
135_Q238_Q2.8061.00
160_P164_A2.6301.00
198_Q201_V2.4841.00
125_F159_S2.4571.00
221_Y231_Q2.3731.00
105_H205_N2.2991.00
114_A146_Q2.2251.00
135_Q235_L2.1921.00
117_I146_Q2.1731.00
109_D177_Q2.1281.00
166_I179_Y2.0971.00
79_N82_N2.0911.00
105_H204_D2.0761.00
110_G114_A2.0621.00
168_A198_Q2.0511.00
158_E162_T2.0211.00
24_V28_E1.9891.00
208_L212_L1.9601.00
240_T243_I1.8671.00
109_D149_T1.8441.00
108_L148_R1.8421.00
207_K211_D1.8381.00
25_K29_K1.8231.00
68_I72_M1.8221.00
106_W148_R1.7981.00
159_S163_A1.7851.00
12_P17_A1.7761.00
154_V159_S1.7691.00
50_K53_D1.7501.00
65_K74_N1.7401.00
11_L14_I1.7171.00
131_Q135_Q1.6871.00
219_A231_Q1.6561.00
110_G146_Q1.6371.00
124_P162_T1.6231.00
78_E83_T1.6231.00
118_V220_I1.6121.00
139_W145_V1.5631.00
65_K75_E1.5130.99
20_L24_V1.5050.99
111_K146_Q1.5020.99
19_E22_A1.4930.99
212_L221_Y1.4930.99
132_F220_I1.4860.99
106_W150_L1.4820.99
125_F156_K1.4670.99
125_F154_V1.4670.99
222_Y232_A1.4590.99
119_Y150_L1.4580.99
59_Y81_S1.4460.99
119_Y148_R1.4360.99
20_L23_P1.4330.99
151_L163_A1.4210.99
100_R211_D1.4160.99
135_Q138_P1.3800.99
42_G47_Y1.3720.99
178_Q182_S1.3550.99
9_A16_F1.3550.99
9_A13_A1.3350.98
142_S239_K1.3300.98
71_Y85_I1.3290.98
171_D175_T1.3150.98
137_R141_D1.2950.98
176_W180_E1.2860.98
125_F155_I1.2800.98
48_L62_P1.2740.98
36_K39_D1.2590.98
138_P141_D1.2570.98
167_L201_V1.2560.98
204_D207_K1.2540.98
132_F241_L1.2500.98
84_L88_E1.2450.98
124_P166_I1.2090.97
50_K84_L1.1910.97
160_P203_S1.1680.96
23_P26_A1.1660.96
178_Q183_G1.1660.96
44_M47_Y1.1620.96
44_M72_M1.1580.96
111_K114_A1.1540.96
138_P238_Q1.1460.96
12_P16_F1.1350.96
10_L17_A1.1220.95
122_A133_W1.1210.95
116_V223_M1.1100.95
151_L205_N1.1090.95
25_K28_E1.1060.95
142_S242_N1.0980.95
159_S162_T1.0950.95
137_R140_V1.0890.95
17_A20_L1.0840.95
237_D240_T1.0790.94
136_A147_L1.0780.94
203_S207_K1.0750.94
87_K90_Y1.0570.94
127_P154_V1.0540.94
195_S198_Q1.0510.94
107_L149_T1.0500.94
236_P244_I1.0490.93
8_L14_I1.0440.93
106_W119_Y1.0360.93
130_K183_G1.0320.93
207_K210_D1.0310.93
202_L205_N1.0300.93
214_A221_Y1.0220.93
197_E201_V1.0160.92
131_Q235_L0.9950.92
116_V242_N0.9910.91
67_A72_M0.9910.91
11_L16_F0.9880.91
10_L14_I0.9740.91
103_Q150_L0.9680.90
182_S185_K0.9540.90
112_K170_K0.9370.89
97_M100_R0.9350.89
22_A25_K0.9340.89
98_W119_Y0.9280.88
133_W149_T0.9210.88
127_P156_K0.9160.88
107_L176_W0.9140.88
232_A236_P0.9130.88
72_M80_L0.9050.87
120_V133_W0.9040.87
196_T199_M0.9040.87
8_L11_L0.8970.87
18_E21_P0.8900.86
61_T64_G0.8850.86
202_L206_E0.8830.86
120_V132_F0.8820.86
84_L87_K0.8820.86
118_V147_L0.8780.86
136_A139_W0.8780.86
167_L172_P0.8750.85
147_L220_I0.8700.85
236_P240_T0.8630.85
17_A24_V0.8520.84
126_C218_P0.8490.84
219_A237_D0.8390.83
120_V220_I0.8370.83
138_P142_S0.8300.82
21_P24_V0.8300.82
135_Q237_D0.8290.82
47_Y72_M0.8260.82
13_A17_A0.8220.82
14_I18_E0.8190.81
10_L13_A0.8150.81
108_L146_Q0.8140.81
97_M101_M0.8100.81
153_G209_M0.8080.80
129_C218_P0.8080.80
164_A202_L0.8080.80
160_P202_L0.8030.80
28_E33_T0.7980.80
80_L164_A0.7960.79
200_K204_D0.7960.79
56_V85_I0.7940.79
21_P26_A0.7850.78
168_A225_K0.7780.78
216_V219_A0.7780.78
220_I241_L0.7740.78
175_T178_Q0.7720.77
47_Y60_L0.7670.77
118_V139_W0.7670.77
81_S84_L0.7650.77
51_Y58_I0.7630.77
9_A12_P0.7580.76
9_A17_A0.7510.75
151_L167_L0.7490.75
47_Y68_I0.7470.75
57_T72_M0.7450.75
118_V136_A0.7420.74
68_I141_D0.7380.74
108_L111_K0.7360.74
153_G214_A0.7310.73
124_P163_A0.7240.73
126_C129_C0.7240.73
121_F208_L0.7220.72
12_P18_E0.7210.72
124_P151_L0.7200.72
184_G239_K0.7170.72
232_A244_I0.7160.72
239_K243_I0.7140.72
16_F19_E0.7110.71
72_M79_N0.7040.71
10_L15_A0.7040.71
240_T244_I0.7000.70
11_L18_E0.6910.69
135_Q139_W0.6900.69
149_T176_W0.6870.69
33_T39_D0.6860.69
15_A18_E0.6850.68
122_A127_P0.6840.68
53_D56_V0.6820.68
125_F130_K0.6820.68
14_I17_A0.6810.68
198_Q225_K0.6790.68
122_A180_E0.6740.67
108_L172_P0.6650.66
109_D133_W0.6640.66
58_I63_D0.6620.66
169_S185_K0.6620.66
122_A149_T0.6600.66
111_K118_V0.6600.66
11_L19_E0.6600.66
127_P157_P0.6590.66
200_K203_S0.6580.65
11_L17_A0.6550.65
127_P130_K0.6520.65
25_K200_K0.6500.64
8_L13_A0.6470.64
238_Q241_L0.6460.64
119_Y146_Q0.6440.64
136_A140_V0.6420.63
109_D180_E0.6410.63
41_P48_L0.6410.63
82_N86_E0.6410.63
122_A176_W0.6400.63
73_Y77_G0.6370.63
61_T65_K0.6360.63
118_V241_L0.6350.63
79_N83_T0.6330.62
105_H108_L0.6330.62
61_T66_H0.6310.62
24_V27_I0.6290.62
165_A169_S0.6290.62
16_F20_L0.6280.62
44_M68_I0.6270.62
175_T179_Y0.6260.62
69_S73_Y0.6240.61
55_G73_Y0.6230.61
110_G140_V0.6230.61
127_P159_S0.6150.60
130_K134_Q0.6140.60
178_Q185_K0.6140.60
14_I19_E0.6100.60
27_I35_I0.6100.60
15_A21_P0.6100.60
51_Y67_A0.6090.59
113_D146_Q0.6090.59
41_P45_K0.6020.59
111_K143_G0.5970.58
125_F163_A0.5940.58
74_N78_E0.5920.57
222_Y226_E0.5920.57
178_Q215_N0.5900.57
102_E148_R0.5900.57
90_Y212_L0.5900.57
22_A26_A0.5860.57
123_D126_C0.5850.56
11_L28_E0.5830.56
118_V245_M0.5830.56
58_I69_S0.5810.56
150_L205_N0.5810.56
128_Y234_G0.5800.56
128_Y157_P0.5800.56
55_G221_Y0.5800.56
23_P60_L0.5760.55
13_A243_I0.5700.54
216_V233_V0.5690.54
177_Q181_A0.5670.54
226_E244_I0.5660.54
17_A22_A0.5640.54
9_A14_I0.5640.54
91_A97_M0.5620.53
58_I233_V0.5620.53
202_L219_A0.5600.53
59_Y216_V0.5600.53
102_E106_W0.5590.53
152_V206_E0.5590.53
85_I88_E0.5570.53
12_P19_E0.5560.53
164_A200_K0.5540.52
133_W177_Q0.5540.52
132_F136_A0.5540.52
151_L182_S0.5510.52
102_E168_A0.5500.52
11_L22_A0.5490.52
23_P28_E0.5490.52
128_Y131_Q0.5480.52
172_P175_T0.5470.52
66_H232_A0.5470.52
98_W212_L0.5470.52
143_G147_L0.5460.51
26_A161_A0.5450.51
59_Y70_G0.5440.51
173_A221_Y0.5380.50
21_P68_I0.5360.50
177_Q180_E0.5340.50
131_Q216_V0.5330.50
9_A15_A0.5330.50
37_T41_P0.5320.50
114_A148_R0.5310.49
23_P27_I0.5300.49
23_P30_Q0.5290.49
143_G148_R0.5280.49
107_L167_L0.5280.49
42_G46_G0.5270.49
99_Q197_E0.5270.49
161_A164_A0.5260.49
23_P48_L0.5230.48
36_K50_K0.5220.48
38_F57_T0.5180.48
83_T88_E0.5170.48
196_T200_K0.5170.48
130_K180_E0.5170.48
197_E200_K0.5160.47
221_Y233_V0.5160.47
34_I79_N0.5150.47
82_N85_I0.5140.47
55_G58_I0.5120.47
24_V62_P0.5120.47
105_H151_L0.5110.47
223_M226_E0.5110.47
42_G48_L0.5100.47
107_L166_I0.5090.47
120_V225_K0.5090.47
73_Y172_P0.5080.46
82_N89_I0.5080.46
124_P148_R0.5070.46
59_Y79_N0.5060.46
133_W153_G0.5050.46
66_H143_G0.5040.46
74_N77_G0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v58A 2 0.9234 100 0.234 Contact Map
3tdgA 2 0.7742 100 0.347 Contact Map
4ml1A 4 0.8065 100 0.352 Contact Map
1t3bA 2 0.8185 100 0.365 Contact Map
4npbA 2 0.8266 100 0.383 Contact Map
1eejA 2 0.8226 100 0.412 Contact Map
4pwoA 1 0.8226 100 0.421 Contact Map
3f4sA 1 0.6008 99.9 0.592 Contact Map
3ghaA 1 0.6048 99.9 0.594 Contact Map
3gmfA 1 0.5645 99.9 0.598 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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