GREMLIN Database
YFCU - Putative outer membrane usher protein YfcU
UniProt: P77196 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14124
Length: 881 (775)
Sequences: 2621 (1980)
Seq/√Len: 71.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_C123_C5.2141.00
646_D662_S4.7391.00
261_E275_V4.6841.00
687_L719_V4.4821.00
679_T715_V4.4441.00
783_A815_V4.3691.00
178_I197_G4.2821.00
305_A345_E4.2721.00
767_A807_V4.2351.00
340_H352_E4.0951.00
297_I309_V4.0491.00
369_V397_W4.0361.00
274_Y390_F4.0271.00
369_V395_A4.0241.00
648_S660_G3.9161.00
344_E350_V3.5821.00
690_D758_K3.5811.00
667_A678_R3.4601.00
342_R350_V3.3461.00
306_K344_E3.3431.00
671_T676_L3.3181.00
620_Q635_Y3.2941.00
302_H349_Q3.2911.00
785_V802_V3.2851.00
207_P248_R3.2211.00
373_I393_A3.2021.00
63_K80_D3.1461.00
549_H559_M3.0761.00
622_N633_D3.0331.00
785_V813_M3.0041.00
310_S315_V2.9221.00
66_L83_W2.9151.00
66_L136_A2.8991.00
686_R754_I2.8841.00
69_Q142_A2.8731.00
343_I351_Q2.8611.00
210_M244_Y2.8421.00
825_I829_D2.8391.00
526_Y546_M2.8001.00
178_I195_I2.7881.00
594_Y605_S2.7331.00
302_H351_Q2.7221.00
210_M246_A2.7121.00
645_V663_L2.6991.00
202_G211_R2.6241.00
308_T315_V2.6081.00
180_A195_I2.6021.00
435_D460_R2.5651.00
823_C827_L2.5551.00
135_K144_V2.5401.00
548_S560_S2.5381.00
785_V815_V2.5201.00
643_A663_L2.5171.00
677_H709_N2.5081.00
771_L815_V2.4961.00
171_G754_I2.4921.00
214_W239_W2.4811.00
137_D140_Q2.4671.00
169_I688_L2.4561.00
203_V210_M2.4531.00
83_W95_A2.4281.00
134_I145_I2.4261.00
108_K111_V2.4141.00
170_S203_V2.3821.00
690_D756_Y2.3651.00
310_S340_H2.3441.00
250_L253_L2.3311.00
667_A676_L2.3311.00
63_K82_Y2.3261.00
672_H677_H2.3261.00
258_A280_S2.3121.00
773_L779_P2.3121.00
262_D274_Y2.3101.00
565_G576_K2.2891.00
65_N80_D2.2871.00
636_Y647_L2.2791.00
34_Q37_S2.2681.00
298_S327_R2.2521.00
687_L727_A2.2461.00
441_T492_Y2.2301.00
182_T193_N2.2111.00
527_L545_I2.1751.00
531_R541_T2.1731.00
522_G547_L2.1691.00
308_T344_E2.1611.00
666_G679_T2.1551.00
125_K128_Q2.1221.00
666_G682_M2.1221.00
417_S437_T2.1161.00
688_L713_K2.1101.00
823_C829_D2.1081.00
787_N791_Q2.0621.00
174_A201_V2.0571.00
725_N749_L2.0461.00
126_P132_V2.0451.00
172_I203_V2.0451.00
176_Y665_G2.0391.00
673_G756_Y2.0311.00
283_D370_R2.0151.00
68_V81_I2.0101.00
310_S342_R2.0091.00
247_W256_K2.0081.00
562_S579_Y2.0001.00
438_H457_N1.9671.00
159_W162_P1.9581.00
307_V343_I1.9461.00
691_A694_V1.9311.00
269_F408_G1.9271.00
674_G756_Y1.9161.00
406_Y435_D1.9131.00
596_G603_D1.9091.00
258_A262_D1.8641.00
724_R746_Q1.8611.00
69_Q144_V1.8581.00
301_A321_V1.8561.00
76_A79_Y1.8471.00
640_G645_V1.8441.00
825_I831_L1.8431.00
672_H713_K1.8371.00
771_L802_V1.8351.00
552_N555_S1.8321.00
274_Y374_M1.8201.00
624_G631_S1.8181.00
458_S482_S1.8091.00
249_A256_K1.8041.00
779_P815_V1.7981.00
737_N765_Q1.7881.00
309_V328_I1.7871.00
765_Q809_P1.7721.00
59_V93_S1.7671.00
288_P723_Y1.7481.00
674_G690_D1.7421.00
410_L489_M1.7401.00
70_L152_L1.7381.00
691_A761_V1.7311.00
684_G751_E1.7291.00
434_F461_V1.7251.00
682_M686_R1.7221.00
137_D144_V1.7141.00
209_R750_T1.7071.00
563_L578_M1.7061.00
248_R257_L1.7041.00
249_A722_Y1.6961.00
403_W424_R1.6951.00
341_I353_Y1.6871.00
129_L132_V1.6841.00
69_Q74_P1.6831.00
212_A241_W1.6791.00
812_H826_N1.6781.00
594_Y607_V1.6701.00
343_I353_Y1.6541.00
593_S608_G1.6510.99
59_V138_L1.6420.99
706_V714_A1.6380.99
773_L777_S1.6330.99
98_T101_L1.6310.99
551_F559_M1.6290.99
783_A817_W1.6260.99
811_E829_D1.6230.99
262_D374_M1.6170.99
340_H354_D1.6150.99
598_Y602_T1.6070.99
67_Q77_E1.6070.99
167_D251_P1.6030.99
430_G463_Y1.6020.99
566_Y577_G1.5890.99
613_V619_Y1.5880.99
445_K452_G1.5840.99
250_L279_V1.5770.99
836_F839_L1.5730.99
342_R352_E1.5720.99
651_Y657_T1.5700.99
666_G686_R1.5660.99
377_R389_F1.5650.99
255_A371_Y1.5610.99
812_H828_P1.5540.99
771_L779_P1.5520.99
699_V716_V1.5500.99
772_R778_H1.5450.99
274_Y278_S1.5450.99
101_L105_F1.5440.99
212_A244_Y1.5360.99
399_I405_L1.5350.99
173_I686_R1.5140.99
341_I355_I1.5040.99
621_L634_G1.4960.99
283_D368_Q1.4960.99
416_Q440_H1.4950.99
823_C831_L1.4930.99
308_T318_E1.4910.99
172_I671_T1.4910.99
440_H453_S1.4900.99
284_Q751_E1.4890.99
556_I584_M1.4820.99
275_V379_Q1.4820.99
625_T630_T1.4810.99
839_L842_P1.4770.99
398_G404_S1.4750.99
827_L831_L1.4730.99
169_I756_Y1.4720.99
617_T638_H1.4560.99
640_G643_A1.4530.99
670_T688_L1.4500.99
81_I95_A1.4500.99
741_T760_A1.4500.99
552_N556_I1.4480.99
822_H825_I1.4470.99
667_A671_T1.4410.99
634_G649_A1.4370.99
509_M532_H1.4360.99
522_G549_H1.4340.99
785_V804_L1.4310.99
268_I419_A1.4230.98
590_S609_Y1.4220.98
644_Q664_Q1.4180.98
836_F840_L1.4170.98
372_K394_E1.4120.98
697_V708_T1.4060.98
278_S372_K1.4040.98
561_V580_I1.3940.98
157_P332_G1.3850.98
406_Y421_G1.3750.98
771_L796_V1.3740.98
173_I754_I1.3730.98
818_S823_C1.3650.98
136_A143_L1.3650.98
440_H455_D1.3650.98
249_A750_T1.3630.98
177_S664_Q1.3630.98
201_V212_A1.3620.98
366_P401_N1.3540.98
270_D488_T1.3530.98
770_V801_S1.3500.98
306_K318_E1.3280.98
208_W248_R1.3260.98
599_G602_T1.3210.98
146_S322_P1.3170.97
377_R387_G1.3160.97
355_I363_L1.3120.97
83_W93_S1.3110.97
475_T511_T1.3070.97
698_P733_K1.3070.97
99_P103_A1.3010.97
338_T354_D1.2980.97
259_L277_G1.2940.97
213_D243_R1.2910.97
297_I339_L1.2850.97
690_D713_K1.2730.97
136_A141_S1.2660.97
749_L755_G1.2580.97
769_A804_L1.2540.97
282_D751_E1.2490.97
769_A827_L1.2460.96
670_T754_I1.2430.96
279_V373_I1.2380.96
556_I582_L1.2370.96
470_L516_Q1.2360.96
677_H711_F1.2330.96
170_S205_L1.2330.96
780_P817_W1.2320.96
45_D48_I1.2230.96
560_S581_S1.2190.96
828_P831_L1.2180.96
457_N483_E1.2150.96
378_P493_L1.2090.96
458_S480_R1.2080.96
146_S323_A1.2080.96
814_S824_D1.2020.96
108_K153_E1.2000.96
154_Y329_Q1.1980.96
250_L257_L1.1920.95
835_L839_L1.1920.95
309_V319_T1.1880.95
180_A661_L1.1860.95
61_P85_A1.1860.95
304_T345_E1.1850.95
147_L152_L1.1810.95
458_S535_W1.1690.95
771_L827_L1.1670.95
680_Q705_A1.1560.95
695_A710_M1.1550.95
403_W422_V1.1510.95
152_L322_P1.1410.94
747_A755_G1.1380.94
68_V343_I1.1330.94
769_A802_V1.1330.94
173_I202_G1.1330.94
305_A347_N1.1300.94
103_A153_E1.1280.94
639_D644_Q1.1270.94
67_Q74_P1.1180.94
261_E379_Q1.1150.94
170_S754_I1.1130.93
598_Y603_D1.1090.93
750_T753_A1.1070.93
528_N544_N1.1030.93
375_M389_F1.1010.93
813_M827_L1.1000.93
164_R724_R1.0980.93
436_V459_F1.0950.93
472_S481_F1.0920.93
606_Q620_Q1.0910.93
338_T356_S1.0890.93
328_I331_L1.0890.93
670_T686_R1.0870.93
175_D200_T1.0860.93
308_T342_R1.0800.92
525_V547_L1.0800.92
507_K535_W1.0790.92
306_K320_Q1.0790.92
708_T766_K1.0760.92
81_I143_L1.0660.92
836_F841_L1.0650.92
275_V377_R1.0600.92
27_V31_D1.0560.92
519_R522_G1.0560.92
808_K811_E1.0540.91
364_T395_A1.0530.91
241_W261_E1.0470.91
784_E792_T1.0460.91
169_I754_I1.0440.91
677_H688_L1.0430.91
79_Y104_Q1.0410.91
677_H713_K1.0380.91
294_A365_R1.0370.91
200_T213_D1.0370.91
398_G430_G1.0370.91
72_K144_V1.0370.91
296_D327_R1.0320.91
780_P783_A1.0290.90
823_C826_N1.0290.90
635_Y648_S1.0260.90
100_E104_Q1.0250.90
508_E533_T1.0250.90
491_E494_D1.0250.90
272_F410_L1.0220.90
512_A527_L1.0210.90
680_Q706_V1.0180.90
86_G92_K1.0130.90
427_S432_V1.0120.90
488_T491_E1.0060.89
208_W246_A1.0060.89
391_S411_G1.0050.89
167_D207_P1.0040.89
67_Q142_A1.0040.89
309_V317_Y1.0020.89
639_D680_Q1.0000.89
129_L151_Y1.0000.89
81_I309_V1.0000.89
209_R752_G0.9950.89
810_G828_P0.9920.89
364_T369_V0.9900.89
278_S374_M0.9860.88
218_Y237_K0.9860.88
307_V321_V0.9860.88
254_K286_L0.9830.88
304_T323_A0.9830.88
551_F608_G0.9830.88
637_S644_Q0.9690.88
596_G605_S0.9650.87
666_G715_V0.9640.87
70_L75_L0.9630.87
27_V30_E0.9610.87
592_V609_Y0.9600.87
262_D278_S0.9580.87
263_Y273_N0.9560.87
291_R723_Y0.9530.87
212_A239_W0.9530.87
827_L830_P0.9520.87
343_I355_I0.9490.86
688_L756_Y0.9480.86
698_P730_D0.9470.86
150_A327_R0.9390.86
75_L105_F0.9360.86
86_G94_Y0.9330.86
454_L485_N0.9310.85
37_S41_E0.9310.85
133_E146_S0.9270.85
820_V823_C0.9270.85
169_I673_G0.9230.85
672_H675_A0.9230.85
617_T636_Y0.9220.85
742_Q745_V0.9200.85
242_S379_Q0.9200.85
592_V607_V0.9200.85
738_A763_S0.9180.85
745_V757_R0.9160.84
694_V761_V0.9150.84
563_L576_K0.9110.84
708_T712_G0.9100.84
170_S673_G0.9100.84
561_V578_M0.9090.84
696_D707_Y0.9070.84
767_A806_G0.9070.84
287_P398_G0.9060.84
703_G706_V0.9050.84
515_N526_Y0.9030.84
411_G788_D0.9020.84
544_N564_T0.9020.84
741_T762_I0.9000.83
158_D289_N0.8990.83
209_R753_A0.8990.83
51_K54_S0.8970.83
407_G419_A0.8970.83
102_V107_L0.8960.83
173_I666_G0.8960.83
595_N606_Q0.8930.83
132_V147_L0.8850.82
687_L755_G0.8850.82
313_G340_H0.8840.82
433_A462_S0.8830.82
691_A697_V0.8830.82
796_V802_V0.8810.82
245_Y752_G0.8780.82
107_L147_L0.8780.82
726_Q744_V0.8780.82
361_P390_F0.8770.82
28_W31_D0.8770.82
443_L487_M0.8750.82
206_G248_R0.8730.82
32_D55_S0.8730.82
632_V651_Y0.8710.81
299_G326_F0.8700.81
608_G622_N0.8700.81
584_M592_V0.8680.81
156_W289_N0.8680.81
559_M580_I0.8670.81
326_F345_E0.8660.81
623_I632_V0.8650.81
303_T349_Q0.8640.81
180_A193_N0.8630.81
830_P833_A0.8610.81
670_T682_M0.8570.80
456_G483_E0.8570.80
390_F489_M0.8550.80
49_D53_F0.8550.80
425_D431_A0.8530.80
30_E33_I0.8520.80
670_T715_V0.8520.80
818_S825_I0.8490.80
337_G398_G0.8490.80
71_N712_G0.8480.80
68_V79_Y0.8480.80
719_V723_Y0.8480.80
772_R840_L0.8450.79
677_H715_V0.8370.79
807_V811_E0.8370.79
608_G620_Q0.8350.79
775_D778_H0.8330.78
404_S430_G0.8310.78
800_G827_L0.8290.78
281_T371_Y0.8290.78
255_A279_V0.8290.78
264_L274_Y0.8280.78
775_D779_P0.8280.78
700_E728_Y0.8280.78
364_T368_Q0.8280.78
246_A259_L0.8260.78
489_M493_L0.8250.78
33_I38_R0.8240.78
204_N211_R0.8230.78
50_L54_S0.8220.77
649_A657_T0.8210.77
280_S372_K0.8210.77
299_G665_G0.8200.77
277_G774_Q0.8190.77
36_D39_F0.8190.77
283_D291_R0.8180.77
360_M370_R0.8150.77
674_G678_R0.8130.77
363_L398_G0.8130.77
390_F410_L0.8100.76
168_G675_A0.8090.76
766_K805_A0.8060.76
518_F547_L0.8060.76
698_P707_Y0.8050.76
487_M495_A0.8040.76
413_E600_S0.8030.76
472_S514_Y0.8010.76
654_G657_T0.8000.76
735_P738_A0.7980.75
439_S487_M0.7980.75
608_G633_D0.7970.75
112_A151_Y0.7940.75
454_L487_M0.7930.75
414_N442_K0.7920.75
584_M601_G0.7920.75
39_F57_G0.7900.75
813_M825_I0.7900.75
631_S657_T0.7880.74
95_A101_L0.7870.74
295_P299_G0.7870.74
207_P750_T0.7860.74
272_F461_V0.7830.74
817_W825_I0.7830.74
458_S479_Y0.7820.74
72_K642_L0.7820.74
458_S806_G0.7810.74
399_I422_V0.7800.74
145_I775_D0.7800.74
358_A363_L0.7790.74
442_K453_S0.7780.73
764_G806_G0.7770.73
102_V145_I0.7770.73
166_D169_I0.7740.73
182_T191_D0.7730.73
299_G337_G0.7730.73
302_H345_E0.7720.73
626_S815_V0.7720.73
176_Y299_G0.7720.73
175_D686_R0.7710.73
281_T370_R0.7710.73
689_I716_V0.7710.73
708_T757_R0.7670.72
786_K816_F0.7660.72
167_D750_T0.7650.72
331_L365_R0.7640.72
255_A281_T0.7610.72
730_D733_K0.7610.72
364_T396_S0.7590.72
461_V478_G0.7590.72
521_A547_L0.7590.72
256_K282_D0.7580.72
564_T577_G0.7580.72
375_M391_S0.7570.71
95_A143_L0.7560.71
672_H688_L0.7540.71
504_G537_R0.7530.71
281_T286_L0.7510.71
301_A326_F0.7500.71
671_T688_L0.7490.71
364_T398_G0.7490.71
173_I211_R0.7450.70
406_Y460_R0.7450.70
373_I833_A0.7440.70
740_A743_S0.7440.70
257_L279_V0.7440.70
413_E485_N0.7430.70
437_T458_S0.7420.70
277_G628_K0.7410.70
561_V770_V0.7400.70
46_T49_D0.7390.70
181_Q658_S0.7390.70
95_A209_R0.7390.70
370_R396_S0.7390.70
285_M293_Y0.7390.70
214_W241_W0.7390.70
445_K454_L0.7380.70
361_P464_S0.7380.70
517_N522_G0.7370.69
797_D801_S0.7350.69
513_T528_N0.7350.69
295_P365_R0.7350.69
301_A712_G0.7350.69
190_D453_S0.7340.69
294_A783_A0.7330.69
582_L809_P0.7320.69
666_G671_T0.7320.69
138_L141_S0.7320.69
173_I670_T0.7320.69
309_V339_L0.7320.69
420_L434_F0.7300.69
218_Y277_G0.7300.69
204_N208_W0.7290.69
378_P489_M0.7280.68
396_S766_K0.7280.68
515_N564_T0.7270.68
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161_P164_R0.5040.42
810_G829_D0.5040.42
307_V331_L0.5040.42
689_I727_A0.5040.42
665_G678_R0.5040.42
174_A595_N0.5030.42
520_D526_Y0.5030.42
59_V368_Q0.5030.42
178_I193_N0.5030.42
284_Q684_G0.5020.42
175_D735_P0.5020.42
439_S671_T0.5020.42
292_G358_A0.5010.42
324_G376_G0.5010.42
52_R471_N0.5010.42
426_L431_A0.5000.42
258_A374_M0.5000.42
99_P174_A0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfzB 2 0.8524 100 0.144 Contact Map
3fipA 1 0.504 100 0.49 Contact Map
3fcgA 2 0.0851 100 0.852 Contact Map
4b0mA 1 0.1476 99.9 0.86 Contact Map
3bwuD 1 0.1362 99.9 0.87 Contact Map
3l48A 1 0.0988 99.6 0.911 Contact Map
2xetA 1 0.0953 99.6 0.912 Contact Map
3e8vA 1 0.0726 93.5 0.969 Contact Map
3phsA 1 0.2123 90.6 0.971 Contact Map
4oq1A 1 0.2316 89.9 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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