GREMLIN Database
ECPB - Probable fimbrial chaperone EcpB
UniProt: P77188 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13564
Length: 222 (201)
Sequences: 343 (240)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_V139_T7.2841.00
58_L110_I3.6801.00
105_E192_P3.4150.99
161_N175_C3.4030.99
8_L11_L3.1070.99
21_L24_G2.8330.98
176_L190_L2.6510.97
94_R175_C2.6380.97
43_N137_I2.4400.95
145_P164_N2.3070.93
45_T136_R2.2830.93
105_E145_P2.1800.91
111_V138_G2.1610.90
21_L26_I2.1140.89
114_D165_A2.0330.88
143_V175_C2.0280.87
81_A87_A2.0160.87
38_S189_Y1.9490.85
94_R161_N1.9250.84
39_K107_Y1.8940.83
50_L115_Q1.8930.83
17_P125_A1.8320.81
61_P85_L1.7870.80
43_N136_R1.7680.79
39_K139_T1.7580.78
43_N49_R1.7450.78
144_A165_A1.6680.75
41_I86_P1.6350.73
45_T89_A1.6240.73
57_R106_R1.6210.72
8_L16_S1.6190.72
43_N113_F1.6180.72
76_L193_G1.5960.71
24_G27_S1.5830.71
108_Y187_N1.5730.70
143_V161_N1.5520.69
80_P145_P1.5480.69
78_L95_F1.5320.68
42_K108_Y1.5270.68
75_E133_A1.5130.67
88_Q179_A1.5100.67
91_E111_V1.5060.67
107_Y150_Y1.4980.66
61_P66_Q1.4860.65
97_Y191_M1.4550.64
78_L84_L1.4270.62
24_G43_N1.4170.62
51_I190_L1.4050.61
41_I95_F1.3840.60
55_L110_I1.3820.60
107_Y139_T1.3770.59
137_I157_G1.3740.59
203_T206_N1.3690.59
109_R140_I1.3670.59
20_A23_V1.3630.59
99_G106_R1.3570.58
107_Y112_W1.3550.58
100_P146_R1.3530.58
39_K150_Y1.3420.57
128_S178_A1.3310.57
80_P163_G1.3010.55
94_R138_G1.2700.53
45_T137_I1.2670.53
49_R91_E1.2640.53
105_E164_N1.2510.52
186_E208_G1.2450.52
79_T87_A1.2380.51
162_T178_A1.2380.51
85_L89_A1.2310.51
6_L16_S1.2300.51
23_V83_L1.2110.50
50_L171_A1.2110.50
108_Y190_L1.2100.50
155_A159_L1.2070.49
42_K169_I1.2050.49
112_W139_T1.2040.49
120_A123_D1.2030.49
84_L137_I1.2000.49
43_N108_Y1.1940.49
118_S198_F1.1700.47
107_Y191_M1.1610.47
101_A111_V1.1580.46
21_L53_I1.1370.45
17_P147_Q1.1180.44
25_D166_T1.1120.44
51_I167_L1.1050.43
20_A192_P1.0920.43
142_V166_T1.0790.42
99_G107_Y1.0600.41
39_K191_M1.0560.40
62_L135_A1.0540.40
104_K147_Q1.0500.40
18_A191_M1.0420.40
140_I191_M1.0350.39
59_S69_S1.0310.39
10_L33_D1.0290.39
6_L9_A1.0280.39
61_P65_G1.0270.39
128_S197_R1.0210.38
102_D114_D1.0110.38
8_L12_F1.0100.38
25_D140_I1.0020.37
10_L147_Q0.9860.36
79_T84_L0.9820.36
113_F136_R0.9810.36
16_S169_I0.9800.36
127_R139_T0.9790.36
19_Q125_A0.9780.36
104_K153_Q0.9590.35
40_T169_I0.9570.35
159_L169_I0.9500.35
34_S63_D0.9460.34
118_S134_S0.9410.34
11_L14_G0.9400.34
48_G84_L0.9310.34
13_S126_N0.9310.34
129_A138_G0.9280.33
81_A198_F0.9280.33
58_L140_I0.9230.33
147_Q162_T0.9070.32
168_R189_Y0.9020.32
112_W143_V0.8900.31
94_R143_V0.8890.31
110_I141_L0.8750.31
58_L160_T0.8740.31
7_P10_L0.8710.30
39_K141_L0.8660.30
157_G167_L0.8640.30
53_I115_Q0.8590.30
145_P163_G0.8510.29
52_N136_R0.8390.29
160_T207_K0.8370.29
159_L195_S0.8340.29
32_S197_R0.8300.28
17_P198_F0.8300.28
49_R136_R0.8260.28
27_S142_V0.8210.28
25_D191_M0.8210.28
21_L210_V0.8180.28
6_L41_I0.8160.28
9_A12_F0.8140.28
17_P76_L0.8130.28
82_S136_R0.8070.27
13_S151_H0.8020.27
55_L84_L0.7990.27
99_G102_D0.7960.27
41_I152_F0.7930.27
136_R173_G0.7880.26
50_L90_S0.7860.26
25_D192_P0.7810.26
32_S53_I0.7780.26
138_G168_R0.7760.26
156_N197_R0.7730.26
159_L179_A0.7670.25
30_M153_Q0.7610.25
82_S170_L0.7610.25
20_A100_P0.7610.25
40_T57_R0.7550.25
161_N167_L0.7540.25
126_N165_A0.7530.25
79_T199_T0.7530.25
50_L93_I0.7520.25
76_L185_K0.7520.25
11_L64_D0.7500.25
23_V119_D0.7500.25
18_A33_D0.7460.24
54_R192_P0.7440.24
13_S16_S0.7440.24
88_Q127_R0.7390.24
113_F120_A0.7360.24
107_Y189_Y0.7340.24
15_I193_G0.7340.24
154_Y172_Y0.7340.24
10_L13_S0.7330.24
190_L203_T0.7310.24
46_D151_H0.7250.24
10_L156_N0.7240.24
89_A208_G0.7240.24
196_R209_R0.7230.23
82_S191_M0.7190.23
149_N164_N0.7190.23
6_L10_L0.7170.23
86_P89_A0.7150.23
80_P105_E0.7140.23
62_L65_G0.7120.23
14_G179_A0.7090.23
87_A119_D0.7090.23
41_I177_K0.7040.23
158_S195_S0.7030.23
121_Q124_N0.7020.23
44_S87_A0.7020.23
25_D105_E0.7000.22
53_I151_H0.7000.22
11_L158_S0.7000.22
108_Y203_T0.6990.22
176_L204_A0.6980.22
53_I119_D0.6960.22
12_F199_T0.6940.22
45_T82_S0.6930.22
172_Y206_N0.6920.22
68_I138_G0.6920.22
43_N173_G0.6870.22
39_K96_F0.6820.22
97_Y189_Y0.6780.22
12_F15_I0.6740.21
69_S203_T0.6660.21
74_D143_V0.6650.21
108_Y153_Q0.6640.21
9_A178_A0.6580.21
59_S146_R0.6570.21
14_G122_R0.6570.21
96_F142_V0.6560.21
58_L207_K0.6550.21
52_N117_L0.6550.21
133_A167_L0.6540.21
21_L49_R0.6520.21
46_D128_S0.6510.21
138_G172_Y0.6510.21
161_N164_N0.6480.20
62_L120_A0.6480.20
11_L160_T0.6460.20
75_E106_R0.6460.20
21_L48_G0.6460.20
140_I159_L0.6430.20
15_I73_P0.6400.20
27_S53_I0.6370.20
82_S111_V0.6350.20
99_G150_Y0.6340.20
161_N195_S0.6340.20
26_I141_L0.6330.20
29_F85_L0.6300.20
152_F166_T0.6290.20
82_S210_V0.6280.20
106_R142_V0.6270.20
51_I202_D0.6260.20
107_Y142_V0.6240.19
77_L132_T0.6230.19
112_W208_G0.6230.19
65_G160_T0.6140.19
58_L154_Y0.6080.19
55_L86_P0.6050.19
115_Q125_A0.6050.19
53_I185_K0.6000.19
18_A54_R0.5990.19
55_L162_T0.5990.19
24_G112_W0.5930.18
84_L94_R0.5910.18
39_K152_F0.5900.18
66_Q82_S0.5890.18
55_L193_G0.5860.18
67_V167_L0.5820.18
111_V130_V0.5820.18
123_D200_R0.5810.18
70_M173_G0.5810.18
24_G39_K0.5770.18
141_L196_R0.5740.18
58_L66_Q0.5730.18
6_L147_Q0.5720.18
27_S49_R0.5710.18
105_E189_Y0.5660.17
23_V76_L0.5650.17
19_Q191_M0.5600.17
30_M156_N0.5580.17
21_L66_Q0.5570.17
33_D197_R0.5560.17
50_L131_A0.5550.17
161_N176_L0.5530.17
9_A126_N0.5520.17
104_K124_N0.5510.17
93_I141_L0.5510.17
58_L81_A0.5500.17
8_L180_N0.5480.17
43_N84_L0.5450.17
46_D194_K0.5440.17
6_L15_I0.5440.17
44_S113_F0.5430.17
206_N209_R0.5420.17
48_G86_P0.5410.17
7_P14_G0.5410.17
32_S54_R0.5400.17
23_V192_P0.5400.17
109_R163_G0.5400.17
85_L145_P0.5380.16
27_S187_N0.5370.16
145_P192_P0.5360.16
121_Q178_A0.5350.16
87_A112_W0.5290.16
120_A209_R0.5250.16
75_E171_A0.5240.16
6_L146_R0.5230.16
26_I49_R0.5230.16
51_I159_L0.5220.16
67_V128_S0.5190.16
80_P192_P0.5160.16
123_D128_S0.5140.16
38_S192_P0.5130.16
21_L27_S0.5090.16
49_R137_I0.5090.16
19_Q22_D0.5040.15
45_T83_L0.5030.15
42_K97_Y0.5020.15
197_R207_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ncdA 2 0.8739 100 0.527 Contact Map
3q48A 1 0.7973 99.9 0.623 Contact Map
4djmA 1 0.8423 99.9 0.666 Contact Map
4ay0A 2 0.7703 99.8 0.688 Contact Map
2co7B 1 0.8063 99.7 0.727 Contact Map
1l4iA 2 0.7793 99.5 0.762 Contact Map
2xg5A 1 0.8468 99.5 0.768 Contact Map
1klfA 1 0.8288 99.3 0.783 Contact Map
3gfuC 1 0.8198 99.1 0.801 Contact Map
2qsvA 1 0.7883 84.3 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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