GREMLIN Database
YAHF - Uncharacterized protein YahF
UniProt: P77187 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13590
Length: 515 (404)
Sequences: 2698 (2028)
Seq/√Len: 100.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_T106_S4.7891.00
305_A319_L4.2871.00
102_A106_S4.1501.00
191_N250_E4.1461.00
342_Y426_A4.1451.00
134_L162_K3.9711.00
378_R382_I3.8611.00
110_H114_S3.8461.00
131_R154_A3.7771.00
165_L233_G3.6031.00
107_A114_S3.3511.00
148_S152_E3.2441.00
105_G132_Q3.2201.00
121_V129_E3.2181.00
309_V319_L2.9901.00
308_A312_S2.9161.00
193_G217_S2.8011.00
117_A133_A2.7981.00
133_A138_L2.7441.00
374_D422_D2.7151.00
131_R158_L2.6531.00
88_F107_A2.5781.00
130_A140_V2.5111.00
153_L157_Q2.4911.00
121_V125_F2.4871.00
327_P500_N2.4821.00
131_R135_Q2.4301.00
142_L155_L2.3191.00
217_S249_T2.3181.00
269_E317_E2.3061.00
371_I424_E2.2781.00
117_A138_L2.2461.00
340_Q426_A2.2261.00
130_A158_L2.1791.00
131_R161_E2.1621.00
377_F421_R2.1241.00
202_S219_L2.1141.00
87_L98_E2.1121.00
105_G135_Q2.1051.00
128_R132_Q2.0831.00
252_I272_R2.0501.00
347_F353_C2.0321.00
119_I129_E2.0321.00
80_L83_E2.0241.00
234_L239_A2.0141.00
86_E101_Y1.9691.00
110_H136_N1.9481.00
253_A329_I1.9421.00
246_D249_T1.9401.00
371_I422_D1.9381.00
341_K366_D1.9351.00
416_L428_I1.8791.00
104_I133_A1.8541.00
269_E278_V1.8401.00
427_V505_A1.8291.00
101_Y108_K1.8211.00
312_S317_E1.8091.00
92_A100_R1.8061.00
193_G249_T1.8041.00
344_R425_V1.7871.00
368_Y425_V1.7601.00
485_Q489_D1.7521.00
244_E272_R1.7201.00
94_S97_H1.7061.00
372_Q376_E1.7041.00
254_L280_V1.6941.00
320_D328_L1.6701.00
305_A309_V1.6691.00
280_V317_E1.6661.00
431_D434_L1.6581.00
134_L158_L1.6511.00
285_R362_E1.6491.00
241_G271_A1.6181.00
157_Q161_E1.6001.00
417_I421_R1.5821.00
93_Q100_R1.5771.00
154_A157_Q1.5541.00
156_K232_G1.5531.00
447_I451_K1.5461.00
236_M256_S1.5341.00
127_A154_A1.5201.00
130_A164_L1.5171.00
433_V436_F1.5091.00
356_T429_V1.5031.00
159_A166_M1.5011.00
324_L503_L1.4991.00
194_I216_V1.4951.00
193_G243_L1.4901.00
371_I374_D1.4711.00
107_A110_H1.4621.00
95_G100_R1.4591.00
429_V501_T1.4481.00
261_P264_A1.4431.00
171_C221_G1.4421.00
123_G144_S1.4391.00
280_V312_S1.4281.00
384_R394_G1.4241.00
370_N425_V1.4191.00
420_A428_I1.4171.00
434_L437_G1.4121.00
84_I109_K1.3981.00
240_I252_I1.3941.00
134_L164_L1.3871.00
192_I251_I1.3780.99
444_G448_E1.3720.99
103_T132_Q1.3720.99
343_I360_V1.3690.99
220_I243_L1.3650.99
167_M174_A1.3620.99
396_D411_N1.3620.99
346_L419_E1.3420.99
128_R131_R1.3350.99
107_A136_N1.3270.99
410_T414_S1.3260.99
105_G136_N1.3210.99
176_I218_Q1.3160.99
369_S372_Q1.3140.99
104_I136_N1.3100.99
385_S394_G1.3060.99
344_R419_E1.2840.99
195_V243_L1.2800.99
167_M234_L1.2750.99
256_S280_V1.2680.99
245_N271_A1.2610.99
81_L84_I1.2580.99
218_Q243_L1.2560.99
258_P300_G1.2510.99
152_E232_G1.2490.99
178_G248_Q1.2450.99
279_V320_D1.2450.99
237_L268_L1.2350.99
441_D444_G1.2300.99
414_S417_I1.2270.99
167_M239_A1.2250.99
360_V365_G1.2220.99
119_I130_A1.2220.99
241_G264_A1.2070.99
85_E98_E1.2010.99
266_K311_L1.2010.99
377_F418_E1.1980.99
93_Q102_A1.1950.99
108_K136_N1.1920.99
448_E452_E1.1840.98
87_L101_Y1.1830.98
127_A134_L1.1550.98
293_Q350_G1.1550.98
323_T500_N1.1540.98
89_N92_A1.1530.98
265_R269_E1.1510.98
231_I236_M1.1470.98
244_E271_A1.1440.98
119_I126_A1.1340.98
437_G440_E1.1240.98
363_K506_R1.1230.98
352_L471_L1.1230.98
238_D264_A1.1200.98
279_V332_V1.1130.98
129_E132_Q1.1080.98
331_D508_F1.1080.98
152_E224_G1.1000.97
151_D155_L1.0980.97
413_I417_I1.0880.97
122_N125_F1.0790.97
281_C355_E1.0740.97
468_A494_L1.0690.97
286_G290_V1.0690.97
149_V224_G1.0640.97
341_K509_I1.0530.97
343_I505_A1.0520.97
239_A243_L1.0450.97
370_N419_E1.0420.96
278_V317_E1.0370.96
141_M174_A1.0330.96
293_Q297_F1.0320.96
293_Q354_D1.0300.96
297_F350_G1.0280.96
147_V224_G1.0260.96
342_Y366_D1.0220.96
190_G215_G1.0210.96
180_A183_F1.0170.96
145_D394_G1.0140.96
196_G202_S1.0140.96
87_L100_R1.0120.96
322_H499_T1.0100.96
244_E268_L1.0060.96
156_K160_H0.9990.96
140_V159_A0.9980.96
433_V437_G0.9930.95
108_K114_S0.9930.95
123_G147_V0.9920.95
346_L416_L0.9890.95
116_L141_M0.9880.95
231_I260_A0.9830.95
294_G354_D0.9790.95
438_S441_D0.9710.95
104_I117_A0.9700.95
127_A151_D0.9690.95
126_A142_L0.9670.95
309_V313_G0.9650.95
372_Q375_P0.9620.95
104_I107_A0.9600.94
285_R321_L0.9570.94
377_F382_I0.9450.94
381_D385_S0.9430.94
496_S500_N0.9420.94
109_K114_S0.9390.94
241_G268_L0.9340.94
294_G298_A0.9320.94
201_G355_E0.9270.93
296_Q302_K0.9260.93
149_V152_E0.9250.93
356_T501_T0.9250.93
263_V267_V0.9230.93
253_A325_N0.9210.93
443_V446_T0.9180.93
142_L166_M0.9170.93
244_E275_R0.9170.93
130_A155_L0.9140.93
265_R317_E0.9100.93
331_D504_L0.9100.93
240_I268_L0.9090.93
433_V438_S0.9050.93
374_D423_P0.9040.92
127_A158_L0.8990.92
194_I205_L0.8970.92
159_A162_K0.8960.92
446_T449_T0.8930.92
218_Q242_M0.8900.92
86_E108_K0.8890.92
235_M238_D0.8880.92
297_F303_E0.8870.92
196_G255_I0.8870.92
360_V502_G0.8790.91
132_Q135_Q0.8780.91
235_M261_P0.8770.91
206_S219_L0.8700.91
434_L442_P0.8690.91
285_R305_A0.8690.91
296_Q301_T0.8680.91
422_D425_V0.8670.91
218_Q249_T0.8670.91
446_T450_I0.8650.91
125_F129_E0.8640.91
289_P361_M0.8630.91
294_G297_F0.8630.91
154_A158_L0.8620.91
130_A159_A0.8570.90
140_V164_L0.8560.90
222_T239_A0.8540.90
192_I329_I0.8530.90
467_L505_A0.8520.90
158_L162_K0.8520.90
122_N144_S0.8490.90
423_P464_L0.8450.90
420_A464_L0.8440.90
86_E114_S0.8440.90
380_K414_S0.8410.89
468_A492_V0.8410.89
147_V151_D0.8400.89
109_K136_N0.8370.89
436_F439_H0.8360.89
259_P308_A0.8360.89
286_G361_M0.8360.89
377_F380_K0.8350.89
330_A488_L0.8350.89
120_S143_F0.8350.89
188_R210_H0.8320.89
156_K159_A0.8310.89
497_S500_N0.8300.89
364_H506_R0.8220.88
343_I427_V0.8210.88
131_R162_K0.8210.88
376_E380_K0.8200.88
468_A487_L0.8180.88
86_E109_K0.8150.88
86_E89_N0.8150.88
94_S98_E0.8130.88
427_V465_I0.8120.88
371_I423_P0.8090.88
350_G392_D0.8090.88
414_S418_E0.8080.88
378_R381_D0.8030.87
134_L137_D0.8010.87
431_D435_G0.7900.86
435_G438_S0.7890.86
408_D411_N0.7890.86
132_Q136_N0.7870.86
311_L315_K0.7850.86
240_I254_L0.7850.86
375_P387_K0.7840.86
441_D445_S0.7810.86
486_M490_A0.7810.86
137_D162_K0.7800.86
107_A138_L0.7790.86
506_R510_C0.7790.86
344_R422_D0.7790.86
344_R370_N0.7770.85
170_D224_G0.7760.85
290_V298_A0.7760.85
344_R368_Y0.7740.85
88_F104_I0.7700.85
259_P265_R0.7670.85
282_F305_A0.7660.85
179_A182_C0.7650.85
171_C293_Q0.7640.84
216_V219_L0.7640.84
193_G218_Q0.7640.84
171_C350_G0.7640.84
209_I326_Q0.7610.84
152_E156_K0.7590.84
436_F440_E0.7590.84
179_A183_F0.7570.84
195_V254_L0.7550.84
147_V152_E0.7540.84
191_N333_R0.7530.84
195_V239_A0.7530.84
180_A348_C0.7520.84
222_T231_I0.7520.84
286_G362_E0.7510.83
343_I501_T0.7470.83
320_D325_N0.7470.83
249_T252_I0.7440.83
212_F330_A0.7440.83
90_T100_R0.7420.83
244_E276_K0.7410.83
127_A131_R0.7400.83
447_I486_M0.7390.82
92_A102_A0.7380.82
328_L507_E0.7370.82
436_F442_P0.7360.82
268_L272_R0.7350.82
374_D377_F0.7350.82
80_L85_E0.7340.82
482_Q485_Q0.7330.82
107_A133_A0.7320.82
89_N122_N0.7320.82
220_I239_A0.7280.82
241_G270_R0.7270.81
298_A350_G0.7270.81
135_Q162_K0.7170.81
448_E451_K0.7150.80
282_F319_L0.7140.80
93_Q99_A0.7130.80
119_I133_A0.7130.80
249_T276_K0.7120.80
413_I452_E0.7120.80
291_D294_G0.7100.80
321_L362_E0.7070.80
114_S137_D0.7060.80
138_L164_L0.7060.80
374_D424_E0.7040.79
374_D418_E0.7030.79
94_S99_A0.7020.79
199_G392_D0.7000.79
294_G299_R0.7000.79
445_S448_E0.6990.79
110_H138_L0.6970.79
370_N374_D0.6950.78
298_A303_E0.6940.78
170_D298_A0.6910.78
363_K503_L0.6890.78
236_M254_L0.6890.78
445_S449_T0.6880.78
330_A334_A0.6880.78
350_G354_D0.6870.78
379_L387_K0.6870.78
486_M489_D0.6860.78
484_S488_L0.6820.77
134_L161_E0.6800.77
200_T395_D0.6780.77
196_G200_T0.6770.77
244_E278_V0.6770.77
86_E133_A0.6760.77
104_I138_L0.6730.76
342_Y368_Y0.6720.76
215_G249_T0.6720.76
447_I453_A0.6710.76
160_H233_G0.6700.76
87_L99_A0.6700.76
293_Q298_A0.6690.76
244_E252_I0.6680.76
134_L159_A0.6670.76
417_I452_E0.6670.76
393_F415_R0.6650.75
170_D297_F0.6640.75
237_L264_A0.6630.75
437_G441_D0.6630.75
161_E164_L0.6600.75
130_A166_M0.6560.74
438_S442_P0.6550.74
124_L151_D0.6550.74
240_I272_R0.6530.74
209_I216_V0.6530.74
428_I450_I0.6520.74
283_L354_D0.6490.74
418_E421_R0.6490.74
387_K391_L0.6480.73
443_V447_I0.6470.73
88_F101_Y0.6470.73
359_A363_K0.6460.73
89_N100_R0.6450.73
193_G277_P0.6450.73
382_I385_S0.6440.73
190_G249_T0.6440.73
290_V350_G0.6410.73
298_A301_T0.6400.73
422_D464_L0.6400.73
447_I450_I0.6380.72
328_L504_L0.6370.72
86_E107_A0.6340.72
146_N149_V0.6340.72
357_M360_V0.6340.72
114_S138_L0.6340.72
417_I461_G0.6340.72
344_R416_L0.6330.72
290_V297_F0.6330.72
146_N298_A0.6320.72
147_V169_P0.6320.72
434_L439_H0.6320.72
448_E485_Q0.6310.71
373_P376_E0.6310.71
436_F441_D0.6300.71
307_K311_L0.6290.71
368_Y424_E0.6280.71
293_Q299_R0.6270.71
378_R387_K0.6270.71
195_V222_T0.6270.71
343_I365_G0.6240.71
235_M264_A0.6230.71
296_Q300_G0.6220.70
158_L161_E0.6220.70
313_G510_C0.6220.70
451_K486_M0.6210.70
444_G486_M0.6210.70
345_G356_T0.6210.70
81_L85_E0.6200.70
343_I502_G0.6200.70
176_I242_M0.6190.70
170_D350_G0.6190.70
145_D384_R0.6180.70
125_F128_R0.6160.70
170_D294_G0.6140.69
255_I283_L0.6140.69
434_L438_S0.6130.69
276_K313_G0.6120.69
289_P292_E0.6110.69
293_Q386_I0.6110.69
243_L252_I0.6100.69
149_V298_A0.6100.69
126_A144_S0.6100.69
335_R508_F0.6080.69
294_G303_E0.6060.68
319_L322_H0.6060.68
172_G203_Q0.6040.68
202_S395_D0.6040.68
144_S171_C0.6020.68
290_V302_K0.5990.68
373_P377_F0.5990.68
437_G442_P0.5990.68
348_C397_D0.5980.67
200_T348_C0.5980.67
97_H100_R0.5960.67
292_E388_H0.5960.67
262_A311_L0.5940.67
439_H442_P0.5940.67
284_D298_A0.5940.67
149_V170_D0.5920.67
151_D154_A0.5920.67
449_T452_E0.5910.67
435_G439_H0.5910.67
359_A503_L0.5910.67
290_V293_Q0.5900.66
433_V442_P0.5900.66
449_T453_A0.5890.66
243_L249_T0.5870.66
294_G300_G0.5860.66
349_G394_G0.5860.66
202_S221_G0.5850.66
258_P303_E0.5850.66
431_D436_F0.5830.65
196_G394_G0.5820.65
427_V509_I0.5820.65
447_I452_E0.5820.65
444_G447_I0.5820.65
434_L440_E0.5810.65
437_G443_V0.5810.65
397_D411_N0.5810.65
412_R430_M0.5800.65
83_E89_N0.5800.65
435_G440_E0.5790.65
467_L508_F0.5790.65
224_G298_A0.5770.65
284_D297_F0.5770.65
146_N170_D0.5760.65
178_G218_Q0.5750.64
444_G449_T0.5750.64
175_I192_I0.5740.64
294_G350_G0.5740.64
432_F436_F0.5740.64
359_A362_E0.5730.64
144_S147_V0.5720.64
177_N428_I0.5720.64
287_E361_M0.5720.64
134_L155_L0.5720.64
131_R134_L0.5710.64
122_N199_G0.5700.64
251_I329_I0.5700.64
432_F438_S0.5690.64
473_T496_S0.5680.63
233_G495_A0.5670.63
172_G348_C0.5670.63
284_D303_E0.5660.63
442_P446_T0.5650.63
451_K490_A0.5640.63
440_E444_G0.5630.63
334_A430_M0.5630.63
293_Q353_C0.5630.63
251_I279_V0.5620.63
303_E350_G0.5620.63
269_E336_L0.5600.62
357_M367_V0.5570.62
452_E455_A0.5550.62
351_T395_D0.5550.62
484_S496_S0.5540.62
324_L507_E0.5530.61
252_I277_P0.5510.61
287_E292_E0.5510.61
170_D199_G0.5510.61
207_V472_G0.5500.61
346_L415_R0.5500.61
145_D200_T0.5480.61
153_L231_I0.5470.61
281_C325_N0.5470.61
177_N189_R0.5470.61
200_T352_L0.5450.60
258_P299_R0.5440.60
94_S510_C0.5440.60
170_D299_R0.5440.60
336_L462_R0.5440.60
231_I349_G0.5430.60
431_D437_G0.5400.60
217_S242_M0.5400.60
126_A130_A0.5400.60
240_I278_V0.5390.59
368_Y371_I0.5390.59
325_N329_I0.5350.59
194_I253_A0.5340.59
375_P388_H0.5330.59
104_I164_L0.5330.59
369_S425_V0.5320.58
450_I454_K0.5310.58
145_D298_A0.5300.58
172_G200_T0.5300.58
170_D257_K0.5300.58
292_E369_S0.5300.58
297_F300_G0.5270.58
451_K489_D0.5270.58
155_L160_H0.5270.58
297_F358_F0.5260.58
290_V294_G0.5250.57
375_P385_S0.5250.57
235_M306_L0.5240.57
481_E485_Q0.5240.57
318_N507_E0.5240.57
87_L103_T0.5240.57
205_L258_P0.5230.57
376_E379_L0.5230.57
251_I332_V0.5220.57
367_V391_L0.5220.57
286_G291_D0.5220.57
446_T452_E0.5210.57
345_G367_V0.5200.57
415_R419_E0.5180.56
85_E88_F0.5180.56
344_R367_V0.5170.56
120_S144_S0.5170.56
183_F199_G0.5170.56
386_I391_L0.5170.56
286_G289_P0.5160.56
155_L164_L0.5160.56
368_Y422_D0.5160.56
183_F200_T0.5150.56
200_T349_G0.5130.56
369_S375_P0.5130.56
170_D183_F0.5100.55
437_G446_T0.5090.55
323_T497_S0.5090.55
366_D489_D0.5090.55
241_G267_V0.5090.55
187_V200_T0.5080.55
142_L159_A0.5070.55
192_I209_I0.5070.55
485_Q488_L0.5060.55
465_I468_A0.5050.55
432_F437_G0.5040.54
307_K314_V0.5040.54
140_V162_K0.5040.54
121_V183_F0.5030.54
310_M319_L0.5030.54
101_Y107_A0.5020.54
172_G196_G0.5020.54
301_T304_A0.5010.54
155_L166_M0.5010.54
156_K163_G0.5010.54
379_L382_I0.5010.54
264_A268_L0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2csuA 2 0.8039 100 0.434 Contact Map
3dmyA 2 0.7359 100 0.476 Contact Map
3pffA 2 0.5748 100 0.636 Contact Map
3mwdB 1 0.5359 100 0.643 Contact Map
2fp4A 1 0.5553 100 0.687 Contact Map
2nu8A 1 0.5243 100 0.689 Contact Map
2yv1A 1 0.4893 100 0.69 Contact Map
1oi7A 1 0.501 100 0.696 Contact Map
2yv2A 1 0.4913 100 0.699 Contact Map
3ff4A 1 0.2175 99.8 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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