GREMLIN Database
PAAY - Phenylacetic acid degradation protein PaaY
UniProt: P77181 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13747
Length: 196 (157)
Sequences: 5651 (3301)
Seq/√Len: 263.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G55_G3.7691.00
55_G77_D3.7081.00
64_M72_T2.9991.00
33_K54_D2.6941.00
54_D76_E2.6271.00
94_N112_N2.5451.00
127_M133_I2.5431.00
92_R111_E2.5431.00
14_P33_K2.4441.00
77_D94_N2.2951.00
108_V126_E2.2911.00
75_G93_R2.2781.00
116_G134_V2.2321.00
70_Q106_G2.1721.00
30_I51_V2.1231.00
93_R111_E2.0781.00
112_N130_N2.0191.00
32_G54_D1.9101.00
111_E129_A1.8301.00
76_E93_R1.8031.00
145_S148_E1.7781.00
39_P166_C1.7191.00
12_V30_I1.7031.00
35_V76_E1.6581.00
16_E34_G1.6121.00
122_K125_A1.5831.00
130_N149_L1.5811.00
74_V78_G1.5801.00
28_D49_R1.5631.00
55_G160_Q1.5161.00
92_R108_V1.5141.00
20_H39_P1.5111.00
103_V107_A1.5091.00
110_G129_A1.5051.00
63_V83_S1.4771.00
86_L89_C1.4751.00
110_G126_E1.4701.00
22_T40_N1.4691.00
37_V43_L1.4621.00
113_S131_Y1.4161.00
128_P140_A1.4101.00
90_I108_V1.3951.00
40_N61_N1.3771.00
51_V73_V1.3741.00
61_N83_S1.3641.00
30_I49_R1.3581.00
131_Y143_E1.3431.00
128_P131_Y1.3331.00
131_Y140_A1.3281.00
119_A138_A1.3261.00
73_V90_I1.3161.00
115_V121_V1.2981.00
83_S100_N1.2931.00
105_D123_A1.2851.00
25_L29_V1.2671.00
85_I100_N1.2511.00
13_V17_S1.2461.00
134_V141_I1.2441.00
31_L37_V1.2011.00
133_I140_A1.2001.00
95_A129_A1.1821.00
58_I64_M1.1811.00
113_S129_A1.1811.00
16_E33_K1.1731.00
35_V56_A1.1671.00
112_N149_L1.1501.00
115_V127_M1.1121.00
102_V118_S1.1071.00
56_A78_G1.0981.00
31_L35_V1.0861.00
41_A62_C1.0811.00
91_I95_A1.0791.00
133_I138_A1.0711.00
48_G71_D1.0711.00
19_V23_A1.0521.00
110_G128_P1.0451.00
14_P17_S1.0431.00
146_E150_A1.0351.00
120_F136_S1.0261.00
29_V43_L1.0021.00
32_G76_E0.9991.00
150_A154_Q0.9971.00
53_K76_E0.9961.00
32_G51_V0.9961.00
24_V40_N0.9891.00
106_G124_K0.9791.00
154_Q158_E0.9791.00
58_I62_C0.9701.00
85_I99_M0.9551.00
58_I80_I0.9511.00
79_H155_G0.9451.00
75_G90_I0.9441.00
22_T39_P0.9371.00
48_G69_E0.9351.00
165_R169_T0.9341.00
15_E33_K0.9281.00
152_K155_G0.9201.00
43_L52_V0.9171.00
72_T86_L0.9141.00
95_A113_S0.9131.00
25_L31_L0.9041.00
112_N142_R0.8971.00
62_C84_A0.8881.00
35_V54_D0.8851.00
135_G138_A0.8791.00
128_P133_I0.8731.00
140_A143_E0.8711.00
150_A153_K0.8681.00
121_V138_A0.8671.00
146_E149_L0.8611.00
75_G92_R0.8531.00
56_A76_E0.8460.99
162_L165_R0.8460.99
34_G164_T0.8300.99
142_R148_E0.8240.99
130_N143_E0.8190.99
157_H161_V0.8140.99
97_V103_V0.8020.99
91_I97_V0.7950.99
154_Q157_H0.7810.99
112_N153_K0.7720.99
115_V133_I0.7710.99
29_V45_G0.7700.99
43_L50_I0.7680.99
101_A115_V0.7640.99
102_V120_F0.7600.99
165_R168_Q0.7540.99
49_R71_D0.7490.99
122_K138_A0.7490.99
95_A111_E0.7440.99
119_A136_S0.7420.99
12_V28_D0.7370.99
85_I102_V0.7330.99
130_N146_E0.7330.99
92_R95_A0.7250.98
52_V56_A0.7220.98
109_I113_S0.7150.98
59_Q81_G0.7110.98
49_R73_V0.7070.98
24_V42_S0.7020.98
80_I86_L0.6990.98
127_M140_A0.6980.98
97_V115_V0.6960.98
88_G105_D0.6940.98
113_S133_I0.6930.98
92_R113_S0.6890.98
56_A93_R0.6830.98
158_E162_L0.6800.98
17_S163_V0.6800.98
102_V117_A0.6770.98
48_G70_Q0.6760.98
122_K136_S0.6760.98
56_A74_V0.6730.97
107_A121_V0.6680.97
18_F39_P0.6650.97
112_N144_L0.6640.97
120_F134_V0.6630.97
13_V25_L0.6620.97
86_L91_I0.6620.97
74_V80_I0.6540.97
37_V41_A0.6510.97
94_N111_E0.6460.97
92_R129_A0.6460.97
132_L144_L0.6410.97
14_P32_G0.6390.97
59_Q82_H0.6390.97
43_L64_M0.6340.96
77_D160_Q0.6340.96
13_V31_L0.6330.96
77_D153_K0.6280.96
81_G98_G0.6270.96
144_L148_E0.6260.96
55_G76_E0.6240.96
17_S31_L0.6240.96
34_G54_D0.6220.96
92_R110_G0.6130.96
66_G69_E0.6110.96
114_I144_L0.6090.95
94_N153_K0.6040.95
74_V86_L0.6030.95
148_E151_W0.6000.95
40_N83_S0.5990.95
113_S127_M0.5980.95
42_S61_N0.5960.95
17_S35_V0.5930.95
66_G70_Q0.5930.95
60_D82_H0.5880.95
61_N85_I0.5870.95
66_G72_T0.5870.95
13_V16_E0.5840.94
65_H87_H0.5840.94
23_A41_A0.5820.94
104_M120_F0.5750.94
28_D51_V0.5750.94
78_G111_E0.5740.94
151_W155_G0.5730.94
122_K134_V0.5720.94
64_M74_V0.5700.94
152_K156_T0.5700.94
157_H160_Q0.5680.94
56_A75_G0.5650.93
120_F137_P0.5650.93
101_A119_A0.5640.93
84_A101_A0.5630.93
164_T169_T0.5620.93
164_T168_Q0.5610.93
98_G101_A0.5590.93
70_Q88_G0.5590.93
14_P31_L0.5560.93
128_P143_E0.5540.93
24_V39_P0.5520.93
115_V138_A0.5510.92
161_V164_T0.5510.92
18_F163_V0.5470.92
48_G66_G0.5450.92
96_L114_I0.5420.92
103_V115_V0.5380.92
81_G99_M0.5330.91
97_V101_A0.5300.91
122_K137_P0.5290.91
57_N79_H0.5200.90
34_G160_Q0.5140.90
125_A133_I0.5120.89
47_F158_E0.5110.89
156_T159_Y0.5090.89
158_E161_V0.5080.89
47_F66_G0.5060.89
53_K93_R0.5060.89
42_S60_D0.5060.89
47_F105_D0.5050.89
91_I103_V0.5050.89
127_M131_Y0.5040.89
32_G35_V0.5040.89
100_N117_A0.5020.89
82_H99_M0.5010.88
13_V19_V0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v3wA 3 0.8827 100 0.376 Contact Map
4n27A 3 0.8776 100 0.395 Contact Map
1xhdA 3 0.8673 100 0.4 Contact Map
3r3rA 3 0.8724 100 0.402 Contact Map
3ixcA 3 0.8316 100 0.405 Contact Map
3r1wA 3 0.8827 100 0.411 Contact Map
4r36A 3 0.9847 100 0.412 Contact Map
3hsqA 3 0.9847 100 0.413 Contact Map
1j2zA 3 0.9745 100 0.414 Contact Map
3r0sA 3 0.949 100 0.425 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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