GREMLIN Database
ZIPA - Cell division protein ZipA
UniProt: P77173 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14169
Length: 328 (319)
Sequences: 669 (626)
Seq/√Len: 35.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_L217_Q5.3261.00
217_Q229_Y4.3091.00
62_G66_V3.7321.00
245_L268_I3.6021.00
224_G230_H3.3741.00
207_L298_G3.2881.00
5_L9_L3.2681.00
230_H244_S3.1901.00
93_Q96_Y3.0781.00
221_F245_L3.0191.00
216_I245_L2.9711.00
199_V298_G2.8401.00
224_G269_F2.7621.00
23_H26_W2.7621.00
185_M188_P2.6361.00
213_L229_Y2.6131.00
248_M265_G2.5971.00
320_I323_V2.5621.00
283_K317_Q2.4011.00
58_E62_G2.3781.00
207_L296_V2.3040.99
64_G67_R2.2890.99
128_P131_Q2.2470.99
116_Q122_A2.2140.99
199_V300_V2.1690.99
103_Q107_Q2.0950.99
150_P153_V2.0230.98
92_Y96_Y2.0200.98
69_H72_N2.0080.98
221_F317_Q1.9630.98
101_P114_P1.9600.98
35_M41_L1.9080.98
23_H27_T1.8480.97
308_M313_L1.8320.97
213_L237_G1.8310.97
247_N263_T1.7360.96
127_Q130_Y1.6940.95
63_V66_V1.6660.95
59_D62_G1.6460.94
302_D306_R1.6450.94
90_H95_P1.6390.94
87_S90_H1.6340.94
20_L283_K1.6020.93
134_P137_P1.5920.93
294_D308_M1.5800.93
210_E259_K1.5750.93
244_S269_F1.5690.93
141_P146_V1.5640.93
290_Q310_P1.5610.93
213_L255_D1.5320.92
228_I246_A1.5270.92
139_Q144_P1.5180.91
276_G281_N1.5160.91
110_E113_V1.5110.91
293_A300_V1.5090.91
181_P184_V1.5050.91
141_P150_P1.4930.91
85_R90_H1.4800.90
62_G65_E1.4730.90
247_N251_P1.4620.90
121_P124_P1.4580.90
145_Q152_P1.4560.90
115_P126_Q1.4470.89
232_H241_A1.4430.89
144_P154_H1.4380.89
61_E66_V1.4300.89
65_E68_V1.4290.89
273_P285_M1.4110.88
217_Q222_I1.3970.88
213_L261_F1.3950.87
64_G68_V1.3920.87
213_L222_I1.3920.87
193_A272_V1.3890.87
159_P163_A1.3720.87
202_H299_V1.3530.86
67_R71_V1.3510.86
196_I250_K1.3340.85
62_G68_V1.3340.85
151_Q154_H1.3280.85
281_N284_L1.3270.85
141_P144_P1.3160.84
287_Q291_H1.3140.84
144_P151_Q1.3140.84
110_E114_P1.3140.84
147_A150_P1.3070.84
143_S152_P1.2830.83
72_N75_P1.2830.83
212_L266_V1.2790.82
183_P186_D1.2740.82
60_D72_N1.2590.81
58_E61_E1.2540.81
209_G230_H1.2390.80
12_V16_A1.2340.80
104_P112_Q1.2320.80
87_S91_Q1.2310.80
152_P155_S1.2260.80
211_L268_I1.2210.79
219_A288_S1.2200.79
230_H252_G1.2180.79
228_I269_F1.2170.79
96_Y122_A1.2120.79
70_R73_H1.2110.79
152_P156_A1.2060.79
219_A287_Q1.2000.78
114_P117_H1.1970.78
139_Q142_V1.1930.78
90_H94_P1.1800.77
16_A23_H1.1800.77
250_K253_T1.1740.77
314_R317_Q1.1730.77
194_V228_I1.1710.76
282_F320_I1.1700.76
224_G244_S1.1600.76
138_L153_V1.1590.76
89_Q93_Q1.1560.75
215_S219_A1.1500.75
296_V317_Q1.1470.75
197_M293_A1.1450.75
109_P114_P1.1440.75
150_P154_H1.1320.74
104_P107_Q1.1290.74
59_D74_A1.1270.74
100_Q106_Q1.1260.74
162_Q172_A1.1230.73
254_F258_M1.1100.72
203_H207_L1.1060.72
66_V69_H1.1050.72
21_L290_Q1.1050.72
248_M300_V1.1030.72
245_L272_V1.0950.71
103_Q108_P1.0950.71
158_Q170_V1.0940.71
127_Q131_Q1.0930.71
173_P177_P1.0920.71
53_Y60_D1.0870.71
12_V290_Q1.0810.70
59_D63_V1.0780.70
159_P175_P1.0760.70
110_E130_Y1.0650.69
230_H269_F1.0650.69
98_S122_A1.0650.69
146_V150_P1.0570.69
120_H133_Q1.0540.68
146_V152_P1.0530.68
141_P147_A1.0500.68
147_A151_Q1.0340.67
215_S295_E1.0280.66
124_P128_P1.0250.66
107_Q110_E1.0240.66
199_V305_R1.0200.66
149_A154_H1.0180.66
136_Q146_V1.0170.66
184_V187_K1.0160.66
271_Q291_H1.0150.65
204_G291_H1.0130.65
219_A291_H1.0110.65
209_G265_G1.0100.65
149_A152_P1.0080.65
316_Y320_I1.0070.65
199_V311_Q1.0070.65
80_E83_A1.0060.65
97_A111_A1.0040.65
4_D20_L1.0010.64
147_A152_P0.9960.64
214_N271_Q0.9940.64
167_A181_P0.9920.64
251_P263_T0.9900.63
16_A19_A0.9890.63
249_V264_P0.9870.63
289_A320_I0.9850.63
138_L147_A0.9840.63
214_N217_Q0.9810.63
151_Q156_A0.9790.63
4_D8_I0.9750.62
143_S146_V0.9750.62
146_V156_A0.9740.62
209_G244_S0.9740.62
200_A301_L0.9730.62
139_Q147_A0.9710.62
11_I44_M0.9700.62
255_D266_V0.9690.62
232_H276_G0.9630.61
65_E69_H0.9630.61
7_L23_H0.9620.61
286_L310_P0.9610.61
106_Q109_P0.9590.61
102_R108_P0.9570.61
288_S317_Q0.9570.61
116_Q119_P0.9490.60
221_F288_S0.9450.60
74_A77_N0.9420.60
138_L143_S0.9400.59
139_Q143_S0.9350.59
218_Q284_L0.9350.59
121_P128_P0.9340.59
80_E84_A0.9300.59
4_D16_A0.9220.58
286_L290_Q0.9190.58
219_A268_I0.9150.57
111_A117_H0.9130.57
113_V132_P0.9130.57
195_I242_L0.9060.57
322_E325_D0.9060.57
235_P296_V0.9060.57
73_H76_A0.9010.56
167_A172_A0.8980.56
103_Q106_Q0.8930.55
148_P152_P0.8920.55
165_Q169_P0.8900.55
258_M313_L0.8880.55
12_V28_S0.8780.54
171_A174_Q0.8760.54
89_Q131_Q0.8760.54
118_A160_A0.8740.54
167_A178_V0.8740.54
124_P127_Q0.8740.54
9_L220_G0.8690.53
139_Q154_H0.8680.53
198_N313_L0.8650.53
128_P133_Q0.8630.53
54_D58_E0.8600.53
122_A135_E0.8570.52
10_I317_Q0.8570.52
167_A174_Q0.8560.52
22_V197_M0.8530.52
107_Q113_V0.8520.52
5_L13_G0.8510.52
217_Q313_L0.8420.51
246_A252_G0.8420.51
61_E65_E0.8390.51
106_Q128_P0.8300.50
115_P118_A0.8290.50
138_L142_V0.8280.50
106_Q122_A0.8250.50
242_L274_S0.8210.49
247_N265_G0.8210.49
161_Q164_F0.8190.49
72_N76_A0.8180.49
54_D57_V0.8150.49
196_I267_T0.8100.48
109_P112_Q0.8090.48
107_Q149_A0.8040.48
106_Q111_A0.8040.48
25_F225_D0.8020.48
87_S94_P0.8000.48
6_R264_P0.7990.47
54_D67_R0.7980.47
218_Q283_K0.7970.47
69_H76_A0.7970.47
138_L141_P0.7970.47
221_F243_F0.7970.47
213_L231_R0.7940.47
7_L26_W0.7890.47
100_Q123_Q0.7870.46
107_Q116_Q0.7870.46
108_P128_P0.7840.46
102_R106_Q0.7830.46
223_F226_M0.7830.46
4_D7_L0.7820.46
63_V68_V0.7810.46
142_V147_A0.7810.46
7_L14_A0.7810.46
195_I323_V0.7790.46
123_Q132_P0.7770.46
112_Q117_H0.7760.45
86_P92_Y0.7750.45
81_H84_A0.7710.45
252_G269_F0.7700.45
134_P145_Q0.7700.45
272_V323_V0.7700.45
267_T271_Q0.7690.45
135_E138_L0.7670.45
218_Q259_K0.7670.45
246_A269_F0.7660.45
178_V181_P0.7630.44
111_A115_P0.7610.44
60_D65_E0.7580.44
13_G24_G0.7540.44
275_Y281_N0.7520.43
13_G297_G0.7500.43
53_Y58_E0.7500.43
139_Q152_P0.7490.43
274_S281_N0.7470.43
8_I221_F0.7440.43
85_R88_P0.7420.43
235_P284_L0.7400.42
11_I250_K0.7380.42
247_N266_V0.7370.42
137_P147_A0.7360.42
161_Q181_P0.7350.42
126_Q144_P0.7310.42
237_G242_L0.7310.42
301_L316_Y0.7300.42
15_I29_R0.7270.41
306_R312_K0.7270.41
87_S116_Q0.7270.41
174_Q207_L0.7260.41
249_V286_L0.7250.41
239_G282_F0.7250.41
125_V149_A0.7230.41
21_L266_V0.7230.41
248_M286_L0.7230.41
79_Q82_E0.7230.41
236_D271_Q0.7210.41
198_N282_F0.7190.41
108_P133_Q0.7160.40
134_P146_V0.7120.40
193_A323_V0.7090.40
108_P114_P0.7060.40
246_A251_P0.7040.39
166_P171_A0.7040.39
55_E60_D0.7030.39
143_S147_A0.7020.39
207_L313_L0.6990.39
243_F285_M0.6960.39
230_H243_F0.6950.39
134_P138_L0.6930.39
31_E36_F0.6910.38
191_K200_A0.6910.38
131_Q158_Q0.6890.38
140_Q146_V0.6860.38
284_L288_S0.6850.38
292_I307_M0.6850.38
141_P148_P0.6840.38
214_N218_Q0.6820.38
6_R196_I0.6820.38
168_E172_A0.6820.38
19_A300_V0.6820.38
233_L296_V0.6810.38
131_Q135_E0.6800.37
144_P150_P0.6780.37
121_P126_Q0.6780.37
23_H28_S0.6770.37
233_L260_D0.6760.37
226_M269_F0.6760.37
89_Q92_Y0.6740.37
228_I251_P0.6730.37
209_G254_F0.6720.37
243_F273_P0.6710.37
141_P152_P0.6670.36
20_L310_P0.6660.36
100_Q108_P0.6650.36
136_Q144_P0.6620.36
229_Y245_L0.6600.36
20_L27_T0.6580.36
134_P144_P0.6530.35
193_A319_I0.6500.35
144_P148_P0.6500.35
20_L253_T0.6460.35
137_P143_S0.6460.35
57_V60_D0.6450.35
284_L291_H0.6430.35
272_V317_Q0.6430.35
147_A153_V0.6420.34
283_K294_D0.6420.34
140_Q144_P0.6410.34
59_D66_V0.6410.34
139_Q145_Q0.6400.34
106_Q129_A0.6390.34
137_P146_V0.6390.34
33_S36_F0.6380.34
141_P154_H0.6370.34
37_R313_L0.6340.34
102_R111_A0.6340.34
21_L25_F0.6310.34
99_A108_P0.6300.34
54_D60_D0.6290.33
83_A90_H0.6230.33
101_P119_P0.6230.33
14_A18_I0.6210.33
74_A86_P0.6200.33
197_M245_L0.6200.33
195_I316_Y0.6190.33
117_H124_P0.6180.33
131_Q154_H0.6170.33
90_H129_A0.6140.32
241_A267_T0.6100.32
303_D320_I0.6100.32
122_A127_Q0.6090.32
149_A153_V0.6070.32
83_A96_Y0.6050.32
83_A87_S0.6050.32
67_R70_R0.6030.32
118_A125_V0.6020.31
197_M301_L0.6020.31
209_G224_G0.6010.31
107_Q120_H0.6000.31
264_P287_Q0.5990.31
126_Q138_L0.5990.31
105_V115_P0.5980.31
144_P147_A0.5980.31
32_R37_R0.5980.31
108_P112_Q0.5980.31
103_Q133_Q0.5980.31
224_G228_I0.5980.31
103_Q113_V0.5980.31
148_P151_Q0.5960.31
102_R105_V0.5960.31
265_G277_D0.5960.31
289_A298_G0.5960.31
90_H93_Q0.5950.31
242_L295_E0.5930.31
293_A298_G0.5920.31
107_Q132_P0.5910.31
132_P136_Q0.5900.31
144_P149_A0.5860.30
301_L307_M0.5830.30
196_I319_I0.5770.30
312_K323_V0.5770.30
10_I20_L0.5760.30
193_A196_I0.5740.29
67_R306_R0.5730.29
140_Q143_S0.5720.29
26_W30_K0.5720.29
219_A272_V0.5720.29
105_V112_Q0.5720.29
60_D67_R0.5710.29
101_P134_P0.5700.29
100_Q111_A0.5630.29
143_S149_A0.5610.28
298_G310_P0.5610.28
214_N267_T0.5610.28
152_P163_A0.5600.28
124_P135_E0.5600.28
118_A142_V0.5590.28
76_A83_A0.5590.28
287_Q312_K0.5570.28
8_I20_L0.5560.28
280_Q297_G0.5500.28
145_Q169_P0.5470.28
100_Q107_Q0.5460.27
137_P152_P0.5450.27
88_P91_Q0.5450.27
25_F276_G0.5430.27
147_A183_P0.5420.27
141_P151_Q0.5420.27
143_S150_P0.5400.27
107_Q130_Y0.5400.27
223_F253_T0.5390.27
145_Q156_A0.5360.27
16_A294_D0.5340.27
101_P128_P0.5320.27
84_A97_A0.5320.27
73_H85_R0.5310.26
226_M271_Q0.5300.26
142_V145_Q0.5290.26
146_V149_A0.5280.26
132_P163_A0.5270.26
120_H124_P0.5270.26
143_S156_A0.5250.26
197_M263_T0.5250.26
224_G232_H0.5250.26
245_L266_V0.5240.26
149_A160_A0.5230.26
158_Q172_A0.5230.26
137_P145_Q0.5230.26
90_H97_A0.5220.26
4_D26_W0.5220.26
92_Y98_S0.5210.26
82_E86_P0.5200.26
295_E304_Q0.5200.26
130_Y142_V0.5200.26
136_Q147_A0.5180.26
134_P154_H0.5180.26
271_Q275_Y0.5180.26
149_A155_S0.5160.25
195_I303_D0.5160.25
138_L144_P0.5150.25
145_Q154_H0.5150.25
137_P141_P0.5120.25
86_P90_H0.5110.25
14_A19_A0.5080.25
209_G320_I0.5050.25
142_V148_P0.5040.25
6_R10_I0.5030.25
211_L215_S0.5010.24
281_N305_R0.5010.24
283_K291_H0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f46A 2 0.4268 100 0.441 Contact Map
4um9B 2 0 72.8 0.948 Contact Map
5a2fA 1 0 71.2 0.949 Contact Map
2m20A 2 0.1616 68.1 0.95 Contact Map
1pi7A 1 0.0518 66.8 0.95 Contact Map
1s7qA 1 0 53.3 0.954 Contact Map
2l16A 1 0.1555 38.2 0.958 Contact Map
2l2tA 2 0.1037 36 0.959 Contact Map
4pypA 1 0.0884 32.4 0.96 Contact Map
3n28A 1 0.2134 31.6 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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