GREMLIN Database
PINQ - Putative DNA-invertase from lambdoid prophage Qin
UniProt: P77170 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13824
Length: 196 (179)
Sequences: 9801 (7382)
Seq/√Len: 551.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_G55_R3.2011.00
37_I59_R3.0801.00
159_A180_S2.8011.00
163_R176_E2.7251.00
39_E52_G2.6091.00
56_L66_L2.5951.00
8_C21_R2.3431.00
124_E131_R2.3041.00
21_R25_E2.2891.00
111_K126_D2.1821.00
6_A24_I2.1661.00
159_A163_R2.1281.00
176_E180_S2.0221.00
21_R38_E1.9911.00
44_S125_R1.9791.00
138_R142_A1.9011.00
168_V176_E1.8761.00
163_R168_V1.8751.00
171_S175_R1.8641.00
22_R26_S1.8461.00
78_A115_Q1.8311.00
139_A144_K1.8241.00
79_M86_E1.8131.00
112_M123_F1.7801.00
115_Q119_A1.7311.00
21_R36_I1.7241.00
81_I118_S1.6531.00
88_L93_I1.6481.00
122_E126_D1.6451.00
129_L133_H1.6261.00
82_R115_Q1.6051.00
79_M83_K1.6021.00
111_K122_E1.5761.00
164_I173_I1.5651.00
89_T111_K1.5531.00
168_V172_A1.5091.00
87_Q91_T1.4961.00
5_F59_R1.4811.00
125_R128_L1.4701.00
97_C101_G1.4691.00
112_M119_A1.4541.00
60_L66_L1.4451.00
53_F84_T1.4321.00
85_V114_M1.4291.00
5_F56_L1.4201.00
35_Q55_R1.4081.00
107_S110_G1.4071.00
6_A36_I1.4061.00
60_L93_I1.3951.00
132_T136_I1.3781.00
72_D121_A1.3661.00
184_I187_A1.3381.00
12_T15_Q1.3171.00
49_E54_N1.3051.00
125_R129_L1.3001.00
75_G81_I1.2961.00
162_E166_S1.2821.00
169_S172_A1.2761.00
68_V95_V1.2751.00
68_V97_C1.2681.00
137_V141_G1.2681.00
28_G33_P1.2451.00
163_R173_I1.2441.00
25_E36_I1.2421.00
78_A82_R1.2341.00
138_R141_G1.2221.00
160_V173_I1.1721.00
157_K161_F1.1661.00
55_R59_R1.1511.00
78_A118_S1.1401.00
86_E90_E1.1391.00
65_Q96_H1.1391.00
151_V154_E1.1191.00
19_N69_T1.1171.00
22_R138_R1.1011.00
124_E128_L1.0971.00
171_S181_R1.0921.00
41_I51_P1.0921.00
69_T134_S1.0851.00
159_A176_E1.0851.00
6_A33_P1.0831.00
135_G139_A1.0801.00
35_Q59_R1.0731.00
53_F56_L1.0671.00
161_F165_K1.0551.00
41_I47_T1.0481.00
159_A162_E1.0411.00
8_C36_I1.0371.00
85_V95_V1.0331.00
8_C17_T1.0231.00
176_E179_T1.0231.00
136_I146_F1.0191.00
72_D131_R1.0011.00
25_E29_F0.9941.00
174_A184_I0.9821.00
37_I52_G0.9821.00
164_I170_I0.9741.00
65_Q94_R0.9721.00
37_I56_L0.9631.00
23_E69_T0.9501.00
71_L121_A0.9441.00
57_L84_T0.9421.00
136_I140_R0.9351.00
69_T99_A0.9201.00
24_I67_I0.9161.00
112_M120_V0.9151.00
156_Q159_A0.9121.00
133_H136_I0.9111.00
5_F37_I0.9101.00
127_L131_R0.9091.00
10_I15_Q0.9021.00
74_L84_T0.9001.00
61_K87_Q0.8961.00
8_C38_E0.8911.00
94_R106_T0.8901.00
172_A175_R0.8851.00
116_V119_A0.8841.00
170_I185_L0.8781.00
8_C24_I0.8771.00
140_R146_F0.8731.00
68_V74_L0.8691.00
43_G76_C0.8691.00
108_P130_E0.8681.00
152_L155_E0.8671.00
83_K87_Q0.8551.00
57_L87_Q0.8551.00
43_G75_G0.8541.00
128_L132_T0.8511.00
19_N134_S0.8511.00
123_F126_D0.8511.00
174_A178_K0.8461.00
163_R166_S0.8441.00
157_K160_V0.8441.00
33_P36_I0.8431.00
56_L60_L0.8421.00
62_C92_G0.8391.00
66_L88_L0.8391.00
27_A67_I0.8301.00
123_F127_L0.8251.00
137_V140_R0.8251.00
80_D83_K0.8251.00
158_Q162_E0.8211.00
129_L132_T0.8171.00
179_T184_I0.8131.00
181_R185_L0.8121.00
23_E26_S0.8081.00
4_I65_Q0.8051.00
153_N156_Q0.8001.00
157_K187_A0.7911.00
38_E52_G0.7901.00
17_T38_E0.7871.00
18_E22_R0.7841.00
27_A98_L0.7831.00
172_A176_E0.7811.00
19_N70_K0.7781.00
173_I177_F0.7761.00
115_Q126_D0.7751.00
23_E134_S0.7701.00
44_S129_L0.7681.00
10_I40_H0.7561.00
26_S29_F0.7541.00
61_K91_T0.7531.00
112_M116_V0.7521.00
27_A96_H0.7481.00
116_V120_V0.7441.00
127_L130_E0.7441.00
55_R58_A0.7441.00
163_R180_S0.7431.00
4_I28_G0.7421.00
7_Y39_E0.7421.00
19_N138_R0.7361.00
130_E134_S0.7351.00
56_L59_R0.7331.00
77_N86_E0.7321.00
162_E165_K0.7291.00
124_E127_L0.7281.00
44_S47_T0.7211.00
17_T40_H0.7151.00
120_V123_F0.7141.00
78_A122_E0.7131.00
113_M116_V0.7091.00
96_H104_D0.7001.00
113_M117_I0.7001.00
160_V184_I0.6981.00
19_N23_E0.6971.00
23_E99_A0.6951.00
156_Q160_V0.6951.00
71_L97_C0.6921.00
152_L156_Q0.6921.00
28_G67_I0.6891.00
60_L88_L0.6841.00
53_F74_L0.6841.00
109_T112_M0.6821.00
22_R25_E0.6811.00
84_T88_L0.6781.00
170_I174_A0.6771.00
128_L135_G0.6741.00
156_Q182_Q0.6721.00
25_E33_P0.6711.00
156_Q177_F0.6711.00
182_Q185_L0.6671.00
158_Q161_F0.6651.00
133_H137_V0.6651.00
24_I28_G0.6621.00
70_K131_R0.6601.00
160_V177_F0.6591.00
70_K99_A0.6511.00
161_F164_I0.6451.00
47_T54_N0.6411.00
136_I139_A0.6411.00
170_I184_I0.6381.00
160_V187_A0.6321.00
168_V173_I0.6221.00
179_T183_T0.6201.00
179_T187_A0.6181.00
113_M120_V0.6171.00
132_T135_G0.6161.00
170_I181_R0.6141.00
71_L114_M0.6131.00
77_N80_D0.6101.00
112_M115_Q0.6061.00
54_N58_A0.6051.00
48_S80_D0.6011.00
16_T40_H0.5941.00
117_I120_V0.5941.00
87_Q90_E0.5921.00
139_A146_F0.5901.00
169_S175_R0.5901.00
94_R104_D0.5901.00
81_I114_M0.5891.00
131_R134_S0.5881.00
174_A177_F0.5861.00
167_G173_I0.5841.00
154_E158_Q0.5831.00
145_R150_P0.5821.00
129_L136_I0.5790.99
182_Q186_R0.5790.99
58_A62_C0.5780.99
67_I98_L0.5690.99
75_G84_T0.5680.99
175_R179_T0.5670.99
47_T53_F0.5630.99
79_M82_R0.5620.99
22_R141_G0.5600.99
53_F57_L0.5590.99
145_R148_R0.5560.99
164_I169_S0.5560.99
70_K127_L0.5560.99
181_R184_I0.5530.99
78_A119_A0.5530.99
28_G34_Q0.5470.99
109_T123_F0.5430.99
48_S75_G0.5430.99
104_D107_S0.5410.99
83_K86_E0.5400.99
24_I98_L0.5340.99
151_V155_E0.5320.99
108_P123_F0.5290.99
134_S137_V0.5270.99
43_G80_D0.5230.99
173_I176_E0.5210.99
178_K184_I0.5140.99
13_L40_H0.5100.99
115_Q122_E0.5090.99
53_F80_D0.5080.99
183_T187_A0.5080.99
75_G118_S0.5020.99
96_H102_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uj3X 2 0.6327 100 0.199 Contact Map
4bqqA 2 0.9337 100 0.201 Contact Map
1gdtA 2 0.9337 100 0.203 Contact Map
2r0qC 3 0.9031 100 0.213 Contact Map
3g13A 2 0.7449 100 0.295 Contact Map
3guvA 2 0.7041 100 0.315 Contact Map
2gm5A 4 0.6327 100 0.377 Contact Map
3lhkA 2 0.7143 100 0.412 Contact Map
3ilxA 2 0.6633 100 0.428 Contact Map
3bvpA 4 0.6378 100 0.442 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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