GREMLIN Database
YAGT - Putative xanthine dehydrogenase YagT iron-sulfur-binding subunit
UniProt: P77165 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13559
Length: 229 (190)
Sequences: 611 (406)
Seq/√Len: 29.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_N129_A4.5081.00
152_K222_D4.1351.00
66_K130_E3.4181.00
167_C202_R3.3311.00
148_A152_K3.0701.00
196_A221_E3.0521.00
199_I217_L2.9351.00
126_H129_A2.9061.00
61_M78_T2.8951.00
144_H170_V2.7671.00
76_V89_N2.7581.00
110_L171_A2.7081.00
80_T85_T2.4740.99
110_L167_C2.4610.99
134_I166_I2.2720.99
199_I220_I2.2680.99
77_D80_T2.2560.99
24_T55_T2.2390.99
80_T89_N2.2150.98
115_R175_E2.1830.98
153_H222_D2.0890.98
65_L72_E1.9140.96
63_L76_V1.8480.95
38_T42_Y1.8190.95
167_C194_T1.8040.94
196_A217_L1.7860.94
137_L170_V1.7290.93
146_M223_A1.7140.93
173_L202_R1.7080.93
194_T202_R1.7040.92
173_L192_P1.6410.91
95_T168_S1.6400.91
62_P75_E1.5920.90
118_A207_I1.5730.89
214_A218_A1.5720.89
198_E202_R1.5530.88
203_M220_I1.5460.88
172_V191_A1.5410.88
172_V202_R1.5310.88
146_M170_V1.5220.87
172_V192_P1.5190.87
196_A218_A1.5120.87
192_P202_R1.5110.87
165_Q212_A1.5010.87
100_D215_N1.4940.86
66_K71_T1.4620.85
112_N121_T1.4550.85
59_E78_T1.4440.84
86_L109_V1.3790.81
77_D101_H1.3730.81
103_Q169_S1.3690.81
117_N168_S1.3590.80
28_L32_S1.3510.80
67_V90_L1.3460.80
117_N126_H1.3390.79
64_T73_Q1.3150.78
76_V85_T1.2620.75
103_Q212_A1.2570.75
111_V116_L1.2530.75
27_D30_K1.2510.75
167_C192_P1.2400.74
173_L194_T1.2360.74
64_T71_T1.2170.72
39_A95_T1.2120.72
101_H160_Y1.2110.72
85_T131_I1.1940.71
58_P78_T1.1900.71
80_T224_A1.1800.70
85_T89_N1.1710.70
211_G214_A1.1540.68
165_Q203_M1.1510.68
172_V194_T1.1420.68
95_T155_G1.1420.68
191_A202_R1.1390.67
110_L202_R1.1350.67
138_G155_G1.1310.67
81_T109_V1.1280.67
199_I221_E1.1210.66
121_T126_H1.1160.66
31_V129_A1.1070.65
77_D89_N1.1060.65
103_Q146_M1.1000.65
117_N124_V1.1000.65
79_R115_R1.0990.65
146_M169_S1.0850.63
195_T198_E1.0790.63
36_A39_A1.0740.63
94_G135_E1.0710.62
30_K35_T1.0540.61
117_N129_A1.0500.61
79_R175_E1.0460.61
45_S48_A1.0420.60
146_M173_L1.0390.60
167_C191_A1.0330.60
50_S142_N1.0290.59
172_V220_I1.0260.59
60_I75_E1.0150.58
101_H212_A1.0120.58
116_L126_H1.0090.58
173_L191_A1.0070.58
23_L62_P0.9870.56
155_G225_G0.9780.55
191_A194_T0.9740.55
46_T49_A0.9700.55
101_H146_M0.9520.53
211_G218_A0.9510.53
146_M166_I0.9500.53
126_H131_I0.9480.53
193_E224_A0.9480.53
84_D97_K0.9480.53
30_K152_K0.9360.52
114_R191_A0.9360.52
167_C172_V0.9000.49
29_I32_S0.8880.48
81_T101_H0.8850.48
200_R203_M0.8790.48
103_Q202_R0.8780.48
167_C198_E0.8770.47
97_K165_Q0.8740.47
74_L85_T0.8720.47
138_G141_D0.8570.46
214_A221_E0.8540.46
126_H215_N0.8270.44
85_T196_A0.8220.43
144_H166_I0.8210.43
150_F162_T0.8160.43
68_N135_E0.8140.43
84_D201_E0.8050.42
70_K130_E0.8040.42
139_S142_N0.8020.42
202_R224_A0.8010.42
27_D34_A0.8000.41
169_S203_M0.7990.41
140_P146_M0.7990.41
24_T59_E0.7970.41
56_P146_M0.7860.40
36_A42_Y0.7830.40
93_I151_I0.7690.39
23_L55_T0.7690.39
103_Q160_Y0.7690.39
27_D218_A0.7600.38
100_D201_E0.7590.38
92_L147_Q0.7560.38
203_M216_I0.7480.38
218_A222_D0.7470.38
95_T156_F0.7410.37
28_L221_E0.7410.37
30_K222_D0.7400.37
203_M212_A0.7400.37
97_K201_E0.7360.37
59_E131_I0.7360.37
101_H117_N0.7350.37
122_L198_E0.7320.36
31_V224_A0.7290.36
83_L105_G0.7290.36
92_L95_T0.7260.36
71_T197_D0.7250.36
70_K73_Q0.7180.35
51_V54_A0.7170.35
105_G216_I0.7070.35
63_L85_T0.6950.34
23_L28_L0.6920.34
67_V72_E0.6910.33
50_S64_T0.6910.33
141_D195_T0.6910.33
23_L60_I0.6890.33
29_I48_A0.6870.33
221_E224_A0.6810.33
98_G212_A0.6750.32
193_E202_R0.6750.32
37_A78_T0.6740.32
194_T217_L0.6730.32
27_D130_E0.6730.32
169_S201_E0.6720.32
100_D103_Q0.6710.32
116_L125_M0.6680.32
66_K73_Q0.6670.32
31_V155_G0.6610.31
50_S54_A0.6570.31
22_S195_T0.6530.31
55_T128_G0.6510.31
169_S212_A0.6500.31
57_A71_T0.6480.31
120_L165_Q0.6470.30
37_A53_A0.6440.30
121_T215_N0.6410.30
88_E166_I0.6400.30
35_T40_V0.6350.30
154_D212_A0.6290.29
77_D131_I0.6260.29
42_Y45_S0.6260.29
165_Q201_E0.6240.29
146_M171_A0.6220.29
48_A70_K0.6220.29
165_Q216_I0.6200.29
60_I130_E0.6180.29
116_L121_T0.6170.29
83_L97_K0.6120.28
169_S202_R0.6100.28
165_Q169_S0.6090.28
97_K203_M0.6090.28
193_E199_I0.6080.28
42_Y49_A0.6070.28
65_L73_Q0.6070.28
79_R166_I0.6010.27
34_A38_T0.5990.27
111_V126_H0.5990.27
56_P71_T0.5960.27
116_L131_I0.5950.27
132_T144_H0.5930.27
52_P59_E0.5930.27
57_A131_I0.5870.27
56_P75_E0.5860.27
200_R215_N0.5840.26
134_I143_L0.5800.26
24_T128_G0.5800.26
22_S41_V0.5800.26
118_A174_K0.5800.26
105_G206_N0.5790.26
55_T71_T0.5790.26
28_L138_G0.5790.26
37_A93_I0.5780.26
56_P70_K0.5760.26
121_T129_A0.5760.26
46_T51_V0.5750.26
192_P224_A0.5750.26
22_S70_K0.5730.26
38_T222_D0.5700.26
28_L222_D0.5680.25
111_V129_A0.5670.25
103_Q201_E0.5670.25
113_G171_A0.5650.25
67_V207_I0.5650.25
83_L216_I0.5650.25
41_V130_E0.5640.25
110_L174_K0.5640.25
143_L147_Q0.5640.25
41_V127_Q0.5600.25
85_T211_G0.5580.25
27_D31_V0.5580.25
114_R174_K0.5570.25
33_A37_A0.5550.25
149_A154_D0.5550.25
22_S46_T0.5520.25
78_T192_P0.5500.24
217_L221_E0.5480.24
97_K115_R0.5450.24
31_V34_A0.5440.24
175_E202_R0.5430.24
89_N215_N0.5360.24
109_V131_I0.5340.23
60_I78_T0.5320.23
150_F154_D0.5310.23
67_V172_V0.5290.23
48_A64_T0.5290.23
120_L212_A0.5270.23
33_A59_E0.5250.23
91_H138_G0.5240.23
48_A51_V0.5240.23
65_L130_E0.5230.23
81_T103_Q0.5230.23
45_S52_P0.5220.23
105_G120_L0.5210.23
61_M112_N0.5200.23
45_S50_S0.5190.23
125_M131_I0.5170.23
95_T117_N0.5130.22
48_A112_N0.5110.22
98_G165_Q0.5100.22
198_E224_A0.5100.22
34_A217_L0.5100.22
44_H65_L0.5080.22
34_A54_A0.5080.22
43_P218_A0.5080.22
110_L114_R0.5070.22
40_V57_A0.5060.22
74_L103_Q0.5060.22
155_G220_I0.5050.22
207_I211_G0.5030.22
110_L198_E0.5020.22
36_A171_A0.5020.22
50_S53_A0.5020.22
40_V49_A0.5020.22
42_Y46_T0.5010.22
34_A51_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uncA 2 0.655 100 0.338 Contact Map
3zyvA 3 0.6594 100 0.342 Contact Map
2w3sA 1 0.6507 100 0.371 Contact Map
3nvwA 1 0.6638 100 0.375 Contact Map
1dgjA 1 0.6769 100 0.384 Contact Map
4usaA 2 0.6769 100 0.395 Contact Map
1n62A 1 0.6769 100 0.442 Contact Map
3hrdD 1 0.6856 100 0.447 Contact Map
1rm6C 1 0.6812 100 0.483 Contact Map
1t3qA 1 0.6856 100 0.486 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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