GREMLIN Database
TFAR - Tail fiber assembly protein homolog from lambdoid prophage Rac
UniProt: P77163 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13371
Length: 191 (184)
Sequences: 436 (303)
Seq/√Len: 22.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_D171_R5.4391.00
132_T136_L4.3891.00
45_I58_F3.1581.00
122_K126_I2.8580.99
152_D168_K2.7640.99
69_E92_P2.6810.99
6_S10_R2.6650.99
150_A176_R2.5830.99
150_A172_V2.5440.98
104_G107_Q2.4890.98
93_L97_V2.2730.97
43_T58_F2.0930.95
17_L43_T2.0770.94
156_A160_E2.0700.94
156_A172_V2.0550.94
172_V176_R2.0310.94
30_A36_T1.9150.91
89_E94_P1.8790.91
76_V97_V1.8540.90
51_P67_L1.8170.89
151_A156_A1.8010.89
147_L156_A1.7950.88
156_A176_R1.7710.88
168_K171_R1.7490.87
152_D171_R1.7300.86
168_K176_R1.6880.85
150_A156_A1.6690.84
173_L176_R1.6680.84
156_A168_K1.6380.83
108_K117_D1.6310.83
150_A168_K1.6270.83
147_L150_A1.6190.82
104_G116_K1.6130.82
149_D168_K1.5870.81
147_L168_K1.5650.80
74_K93_L1.5350.79
155_I172_V1.5210.78
10_R35_H1.5060.78
71_H74_K1.5020.77
116_K121_E1.4950.77
140_A167_W1.4550.75
178_D181_T1.4480.75
75_T84_A1.4300.74
110_N113_A1.4250.73
149_D156_A1.4220.73
147_L172_V1.4220.73
168_K172_V1.4220.73
160_E176_R1.4080.73
51_P54_F1.3790.71
95_E119_E1.3780.71
150_A175_N1.3770.71
128_E132_T1.3450.69
172_V175_N1.3420.69
147_L176_R1.3260.68
151_A176_R1.3190.67
160_E175_N1.3150.67
160_E172_V1.3140.67
137_M145_A1.2920.66
149_D152_D1.2780.65
155_I169_K1.2570.64
147_L175_N1.2560.64
14_I24_F1.2220.61
60_S79_V1.2150.61
16_N33_P1.2040.60
147_L151_A1.1990.60
158_E161_I1.1820.59
11_T48_P1.1800.59
165_E169_K1.1780.58
141_S171_R1.1740.58
151_A171_R1.1690.58
33_P37_G1.1510.57
56_A67_L1.1430.56
10_R30_A1.1430.56
55_V90_L1.1400.56
147_L160_E1.1180.54
152_D176_R1.1180.54
147_L171_R1.1170.54
10_R36_T1.1040.53
149_D176_R1.0980.53
102_P107_Q1.0590.50
133_K148_Q1.0590.50
152_D156_A1.0540.50
9_P31_Y1.0520.50
167_W191_P1.0480.50
94_P97_V1.0460.50
148_Q152_D1.0380.49
168_K174_L1.0300.48
18_L38_L1.0270.48
166_A169_K1.0260.48
150_A171_R1.0180.48
31_Y37_G1.0080.47
6_S35_H1.0070.47
16_N28_G0.9950.46
26_G57_V0.9900.46
30_A35_H0.9880.46
32_I36_T0.9850.45
28_G39_P0.9820.45
107_Q116_K0.9820.45
11_T17_L0.9810.45
76_V93_L0.9740.45
11_T43_T0.9530.43
150_A160_E0.9510.43
79_V96_N0.9490.43
45_I56_A0.9480.43
17_L26_G0.9380.42
41_N161_I0.9330.42
71_H97_V0.9220.41
151_A160_E0.9190.41
141_S149_D0.9140.41
169_K172_V0.9140.41
57_V66_H0.9120.40
78_D82_G0.9120.40
151_A172_V0.8970.39
149_D172_V0.8970.39
78_D97_V0.8890.39
120_A124_F0.8880.39
84_A99_W0.8830.39
106_F124_F0.8790.38
182_A185_I0.8780.38
160_E163_L0.8770.38
43_T57_V0.8730.38
35_H42_S0.8640.37
50_I56_A0.8550.37
32_I37_G0.8490.36
130_E133_K0.8490.36
26_G29_D0.8480.36
37_G40_A0.8400.36
169_K173_L0.8390.36
143_H146_P0.8390.36
111_G183_Q0.8380.36
147_L164_L0.8270.35
146_P175_N0.8240.35
154_E173_L0.8220.35
146_P171_R0.8210.35
141_S150_A0.8200.35
14_I25_I0.8140.34
39_P48_P0.8070.34
148_Q163_L0.8070.34
20_G42_S0.8000.33
155_I165_E0.7940.33
162_S186_E0.7890.33
119_E159_E0.7880.33
148_Q168_K0.7810.32
147_L152_D0.7810.32
174_L177_V0.7800.32
141_S144_I0.7780.32
23_E47_P0.7760.32
38_L55_V0.7730.32
157_T160_E0.7720.32
10_R58_F0.7680.31
32_I38_L0.7670.31
89_E96_N0.7640.31
150_A165_E0.7610.31
84_A115_V0.7590.31
153_L167_W0.7510.30
47_P65_W0.7490.30
77_Y93_L0.7470.30
167_W170_Y0.7440.30
147_L153_L0.7410.30
16_N37_G0.7410.30
148_Q169_K0.7390.30
157_T171_R0.7380.30
41_N82_G0.7330.29
133_K155_I0.7320.29
71_H76_V0.7300.29
68_V90_L0.7290.29
147_L167_W0.7270.29
156_A173_L0.7250.29
156_A175_N0.7220.29
144_I150_A0.7190.29
145_A152_D0.7180.29
8_Q20_G0.7170.28
16_N38_L0.7120.28
94_P189_A0.7100.28
133_K144_I0.7090.28
151_A173_L0.7030.28
59_N63_S0.6990.27
31_Y77_Y0.6970.27
122_K125_R0.6890.27
155_I168_K0.6890.27
17_L39_P0.6890.27
130_E179_T0.6870.27
188_P191_P0.6860.27
160_E169_K0.6850.27
171_R175_N0.6770.26
78_D81_S0.6750.26
7_E10_R0.6640.26
171_R176_R0.6600.25
16_N26_G0.6600.25
93_L99_W0.6590.25
121_E125_R0.6590.25
70_D91_G0.6580.25
100_L121_E0.6550.25
14_I38_L0.6520.25
95_E123_L0.6520.25
143_H147_L0.6510.25
159_E162_S0.6500.25
32_I43_T0.6480.25
85_L105_E0.6470.25
10_R34_P0.6410.24
129_A185_I0.6400.24
10_R43_T0.6390.24
153_L157_T0.6350.24
26_G51_P0.6300.24
34_P95_E0.6250.24
65_W102_P0.6240.24
157_T175_N0.6200.23
133_K171_R0.6190.23
152_D172_V0.6180.23
163_L181_T0.6150.23
104_G121_E0.6130.23
41_N89_E0.6090.23
134_N184_D0.6070.23
150_A169_K0.6050.23
9_P34_P0.6020.23
130_E148_Q0.6020.23
12_I31_Y0.5970.22
24_F87_I0.5960.22
108_K112_T0.5950.22
63_S166_A0.5940.22
151_A168_K0.5910.22
160_E165_E0.5910.22
22_N58_F0.5900.22
152_D157_T0.5890.22
30_A87_I0.5870.22
96_N105_E0.5850.22
48_P56_A0.5840.22
21_T28_G0.5770.21
157_T161_I0.5770.21
46_A68_V0.5750.21
79_V86_F0.5730.21
9_P54_F0.5720.21
48_P67_L0.5700.21
143_H167_W0.5700.21
30_A34_P0.5670.21
36_T42_S0.5650.21
133_K149_D0.5640.21
10_R45_I0.5640.21
108_K113_A0.5630.21
152_D163_L0.5610.21
38_L46_A0.5590.21
30_A37_G0.5580.20
103_E107_Q0.5580.20
17_L30_A0.5580.20
18_L41_N0.5580.20
12_I42_S0.5560.20
141_S168_K0.5550.20
87_I115_V0.5550.20
24_F56_A0.5540.20
179_T182_A0.5530.20
155_I173_L0.5520.20
155_I171_R0.5520.20
128_E142_E0.5470.20
161_I165_E0.5450.20
76_V99_W0.5440.20
140_A191_P0.5420.20
149_D167_W0.5390.20
22_N66_H0.5370.20
139_V190_L0.5360.20
98_T114_W0.5350.19
37_G42_S0.5310.19
181_T190_L0.5270.19
14_I28_G0.5250.19
152_D175_N0.5220.19
86_F90_L0.5210.19
88_S96_N0.5200.19
31_Y36_T0.5180.19
130_E180_S0.5170.19
14_I64_S0.5170.19
145_A149_D0.5170.19
165_E172_V0.5150.19
93_L96_N0.5120.19
16_N41_N0.5070.18
27_E46_A0.5030.18
132_T135_N0.5010.18
12_I18_L0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kz6A 1 0.5026 99.6 0.761 Contact Map
3kvpA 3 0.2094 14.5 0.96 Contact Map
1mdaH 1 0.4346 14.2 0.96 Contact Map
2lieA 1 0.466 7 0.966 Contact Map
4wsfA 1 0.5812 6.4 0.966 Contact Map
1r6vA 1 0.4607 6.4 0.966 Contact Map
1aa0A 3 0.267 6.2 0.966 Contact Map
4dnyA 1 0.4921 5.7 0.967 Contact Map
4h10B 1 0.3246 5.4 0.967 Contact Map
1egxA 1 0.5864 5.1 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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