GREMLIN Database
GLXR - 2-hydroxy-3-oxopropionate reductase
UniProt: P77161 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13265
Length: 292 (277)
Sequences: 11368 (7277)
Seq/√Len: 437.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_K150_E3.7011.00
70_E102_R3.4501.00
139_E143_E3.3851.00
27_H46_V3.1251.00
113_D141_V2.8871.00
39_L45_S2.8411.00
113_D144_R2.7601.00
17_I41_L2.7041.00
74_F106_Q2.5931.00
233_A273_Q2.3431.00
47_E51_Q2.2801.00
143_E146_K2.2321.00
36_D40_S2.2171.00
107_V112_G2.1501.00
4_G52_V2.1251.00
35_A45_S2.1041.00
88_T145_V2.0501.00
20_A43_A2.0481.00
210_S215_E1.9931.00
13_T37_E1.9881.00
48_T51_Q1.9801.00
196_D199_R1.9411.00
139_E158_L1.9371.00
24_H151_L1.9321.00
80_T107_V1.9311.00
98_I248_A1.8541.00
61_I89_I1.8461.00
113_D138_D1.8231.00
25_Q44_V1.8071.00
245_S248_A1.8001.00
18_N21_R1.7991.00
22_A151_L1.7871.00
84_L87_K1.7811.00
233_A267_A1.7271.00
108_N138_D1.7081.00
190_A200_V1.6971.00
104_A162_N1.6671.00
138_D141_V1.6591.00
105_R109_E1.6431.00
73_L89_I1.6381.00
62_M92_M1.6351.00
83_S87_K1.6301.00
133_I152_L1.6281.00
115_L137_G1.6121.00
28_V43_A1.6071.00
271_G274_L1.5951.00
88_T141_V1.5821.00
33_P36_D1.5741.00
106_Q109_E1.5651.00
142_F146_K1.5511.00
133_I153_G1.5441.00
102_R106_Q1.5351.00
104_A108_N1.5191.00
18_N129_G1.5061.00
117_A133_I1.4941.00
115_L145_V1.4761.00
198_V202_Q1.4751.00
50_R54_E1.4611.00
52_V56_S1.4611.00
36_D39_L1.4601.00
27_H44_V1.4601.00
142_F158_L1.4541.00
60_F92_M1.4531.00
65_D68_Q1.4371.00
219_E223_K1.4231.00
232_I266_C1.4091.00
159_V168_C1.4081.00
74_F78_G1.4051.00
178_L182_A1.4011.00
123_E127_R1.4011.00
170_V241_L1.3971.00
27_H55_A1.3751.00
124_I128_E1.3561.00
66_T99_E1.3561.00
50_R82_A1.3491.00
205_M215_E1.3431.00
33_P47_E1.3391.00
57_D84_L1.3321.00
257_A261_E1.3301.00
21_R41_L1.3261.00
260_Q264_N1.3241.00
233_A272_S1.3221.00
100_T114_Y1.3051.00
55_A84_L1.3021.00
101_K162_N1.2961.00
191_S197_P1.2921.00
274_L281_Q1.2911.00
130_T154_K1.2861.00
62_M119_V1.2811.00
49_A82_A1.2801.00
88_T144_R1.2791.00
115_L142_F1.2761.00
17_I127_R1.2721.00
107_V114_Y1.2641.00
90_V145_V1.2411.00
258_T261_E1.2341.00
21_R127_R1.2311.00
14_P127_R1.2301.00
236_Q267_A1.2141.00
81_K110_L1.2121.00
78_G81_K1.2071.00
246_A253_L1.2031.00
67_P71_E1.1981.00
70_E74_F1.1981.00
247_K257_A1.1981.00
138_D161_G1.1951.00
58_I88_T1.1901.00
16_A26_L1.1821.00
145_V149_F1.1791.00
4_G56_S1.1781.00
58_I148_L1.1751.00
177_A239_L1.1711.00
5_F15_M1.1691.00
70_E106_Q1.1681.00
177_A235_H1.1681.00
92_M133_I1.1621.00
37_E40_S1.1571.00
244_Q248_A1.1561.00
87_K112_G1.1541.00
96_S99_E1.1491.00
193_A249_L1.1451.00
101_K167_T1.1441.00
5_F60_F1.1311.00
83_S112_G1.1311.00
261_E264_N1.1261.00
106_Q110_L1.1241.00
188_L192_K1.1221.00
38_L43_A1.1181.00
5_F16_A1.1181.00
63_V72_V1.1131.00
80_T110_L1.1091.00
53_T82_A1.0991.00
17_I21_R1.0941.00
27_H56_S1.0931.00
252_N257_A1.0931.00
66_T96_S1.0791.00
89_I107_V1.0731.00
10_I123_E1.0661.00
236_Q264_N1.0661.00
161_G164_D1.0651.00
20_A42_G1.0651.00
92_M152_L1.0601.00
60_F148_L1.0511.00
50_R78_G1.0511.00
243_L257_A1.0401.00
104_A138_D1.0341.00
101_K105_R1.0301.00
70_E99_E1.0251.00
240_N260_Q1.0241.00
175_I186_A1.0221.00
135_V142_F1.0191.00
105_R108_N1.0181.00
244_Q247_K1.0011.00
116_D163_G1.0001.00
83_S89_I0.9981.00
126_A131_L0.9861.00
158_L161_G0.9861.00
30_T34_V0.9771.00
37_E41_L0.9771.00
46_V52_V0.9721.00
73_L79_C0.9681.00
230_F234_L0.9671.00
171_A190_A0.9651.00
115_L135_V0.9631.00
264_N268_A0.9551.00
46_V51_Q0.9551.00
187_L201_R0.9541.00
232_I267_A0.9521.00
150_E156_I0.9461.00
199_R202_Q0.9461.00
212_R216_V0.9461.00
31_I68_Q0.9451.00
205_M214_L0.9411.00
120_S172_N0.9401.00
171_A186_A0.9401.00
73_L107_V0.9311.00
33_P45_S0.9291.00
69_V95_I0.9261.00
68_Q71_E0.9241.00
60_F90_V0.9221.00
51_Q54_E0.9171.00
143_E158_L0.9161.00
137_G142_F0.9161.00
240_N244_Q0.9151.00
134_M203_A0.9111.00
85_K111_G0.9051.00
8_L38_L0.9041.00
159_V164_D0.9021.00
74_F103_F0.8991.00
120_S134_M0.8961.00
201_R218_G0.8911.00
99_E102_R0.8851.00
18_N152_L0.8841.00
88_T113_D0.8841.00
178_L255_N0.8831.00
271_G281_Q0.8791.00
13_T17_I0.8771.00
240_N264_N0.8761.00
100_T166_Q0.8741.00
274_L278_A0.8711.00
192_K251_L0.8701.00
5_F26_L0.8691.00
167_T193_A0.8691.00
159_V203_A0.8671.00
236_Q260_Q0.8601.00
8_L28_V0.8561.00
267_A272_S0.8531.00
59_I79_C0.8521.00
102_R105_R0.8511.00
70_E103_F0.8511.00
95_I99_E0.8501.00
167_T245_S0.8491.00
96_S244_Q0.8471.00
19_L60_F0.8381.00
227_N274_L0.8341.00
58_I144_R0.8281.00
168_C195_A0.8271.00
116_D165_G0.8261.00
147_P150_E0.8261.00
15_M152_L0.8251.00
179_N211_S0.8221.00
34_V37_E0.8201.00
198_V223_K0.8171.00
181_E255_N0.8091.00
136_G165_G0.8031.00
141_V144_R0.8011.00
27_H52_V0.8001.00
90_V117_A0.7981.00
94_S241_L0.7861.00
101_K163_G0.7851.00
139_E161_G0.7841.00
231_K273_Q0.7821.00
64_P68_Q0.7821.00
231_K234_L0.7811.00
61_I69_V0.7791.00
192_K249_L0.7751.00
184_S279_L0.7741.00
255_N259_C0.7731.00
265_T282_A0.7721.00
265_T268_A0.7711.00
205_M210_S0.7701.00
218_G221_M0.7701.00
15_M131_L0.7701.00
266_C278_A0.7661.00
115_L141_V0.7641.00
179_N183_V0.7631.00
20_A41_L0.7561.00
3_L24_H0.7551.00
15_M92_M0.7531.00
98_I101_K0.7511.00
91_D114_Y0.7491.00
174_I256_T0.7481.00
141_V145_V0.7451.00
113_D140_A0.7381.00
122_G125_G0.7381.00
226_F281_Q0.7381.00
190_A195_A0.7381.00
174_I242_A0.7341.00
74_F80_T0.7311.00
58_I90_V0.7301.00
28_V35_A0.7271.00
232_I278_A0.7261.00
201_R205_M0.7241.00
61_I73_L0.7221.00
142_F156_I0.7221.00
198_V222_I0.7161.00
13_T41_L0.7151.00
183_V214_L0.7141.00
175_I183_V0.7141.00
243_L260_Q0.7131.00
245_S249_L0.7131.00
31_I34_V0.7131.00
146_K156_I0.7121.00
103_F114_Y0.7121.00
63_V68_Q0.7101.00
15_M62_M0.7061.00
5_F62_M0.7061.00
80_T112_G0.7051.00
218_G222_I0.7031.00
19_L26_L0.7021.00
261_E265_T0.6961.00
3_L148_L0.6911.00
262_L265_T0.6901.00
51_Q55_A0.6851.00
6_I29_T0.6821.00
20_A26_L0.6801.00
117_A135_V0.6751.00
74_F81_K0.6741.00
149_F156_I0.6731.00
157_T203_A0.6721.00
188_L191_S0.6701.00
265_T269_N0.6681.00
247_K260_Q0.6681.00
49_A53_T0.6671.00
59_I83_S0.6661.00
24_H148_L0.6661.00
201_R204_L0.6641.00
3_L19_L0.6631.00
136_G158_L0.6611.00
6_I49_A0.6611.00
266_C282_A0.6601.00
175_I182_A0.6571.00
80_T106_Q0.6571.00
168_C200_V0.6551.00
189_F253_L0.6500.99
175_I179_N0.6470.99
278_A281_Q0.6470.99
30_T33_P0.6470.99
171_A189_F0.6460.99
135_V149_F0.6430.99
179_N213_I0.6420.99
84_L112_G0.6380.99
170_V242_A0.6370.99
36_D45_S0.6360.99
99_E103_F0.6340.99
167_T195_A0.6310.99
63_V69_V0.6310.99
178_L259_C0.6300.99
140_A143_E0.6300.99
69_V93_S0.6290.99
269_N282_A0.6290.99
155_N206_G0.6290.99
67_P70_E0.6290.99
69_V99_E0.6280.99
95_I166_Q0.6280.99
85_K110_L0.6250.99
96_S241_L0.6230.99
114_Y162_N0.6180.99
195_A200_V0.6180.99
79_C83_S0.6150.99
125_G130_T0.6110.99
71_E78_G0.6100.99
264_N267_A0.6090.99
180_I276_H0.6090.99
11_M15_M0.6080.99
135_V156_I0.6060.99
175_I204_L0.6050.99
95_I100_T0.6050.99
6_I52_V0.6030.99
13_T38_L0.6010.99
146_K158_L0.6010.99
149_F153_G0.6010.99
50_R81_K0.5990.99
16_A28_V0.5990.99
236_Q240_N0.5960.99
56_S59_I0.5950.99
69_V91_D0.5940.99
266_C271_G0.5940.99
240_N247_K0.5920.99
9_G64_P0.5900.99
212_R215_E0.5890.99
155_N202_Q0.5860.99
117_A149_F0.5850.99
261_E268_A0.5820.99
14_P123_E0.5810.99
17_I20_A0.5750.99
8_L16_A0.5720.99
204_L209_A0.5690.99
52_V55_A0.5670.99
61_I91_D0.5660.99
139_E142_F0.5660.99
72_V78_G0.5640.99
188_L251_L0.5620.98
225_T228_P0.5610.98
243_L247_K0.5600.98
90_V149_F0.5600.98
220_R225_T0.5590.98
71_E74_F0.5580.98
201_R222_I0.5580.98
58_I145_V0.5550.98
97_P167_T0.5530.98
140_A144_R0.5530.98
252_N265_T0.5520.98
69_V103_F0.5510.98
30_T68_Q0.5510.98
14_P129_G0.5510.98
29_T49_A0.5500.98
35_A39_L0.5500.98
125_G128_E0.5490.98
187_L218_G0.5490.98
176_V213_I0.5450.98
184_S221_M0.5410.98
73_L103_F0.5380.98
174_I189_F0.5380.98
217_H275_D0.5370.98
44_V55_A0.5310.98
98_I102_R0.5290.98
148_L151_L0.5280.98
200_V204_L0.5270.98
18_N22_A0.5260.98
4_G27_H0.5260.98
59_I87_K0.5260.98
91_D100_T0.5210.98
208_F213_I0.5210.98
213_I217_H0.5200.98
50_R53_T0.5190.97
49_A52_V0.5180.97
121_G131_L0.5180.97
157_T206_G0.5170.97
217_H220_R0.5160.97
141_V162_N0.5130.97
32_G35_A0.5120.97
197_P222_I0.5120.97
255_N258_T0.5120.97
139_E146_K0.5090.97
17_I37_E0.5090.97
73_L80_T0.5080.97
147_P151_L0.5080.97
20_A38_L0.5080.97
54_E82_A0.5040.97
159_V199_R0.5040.97
164_D167_T0.5030.97
60_F149_F0.5030.97
16_A43_A0.5030.97
11_M62_M0.5020.97
172_N207_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3obbA 4 0.9795 100 0.358 Contact Map
1vpdA 1 1 100 0.359 Contact Map
3ckyA 4 1 100 0.359 Contact Map
3dojA 3 0.9829 100 0.363 Contact Map
3pefA 5 0.976 100 0.364 Contact Map
3pduA 4 0.976 100 0.365 Contact Map
1yb4A 4 0.9932 100 0.369 Contact Map
4gbjA 2 0.9863 100 0.375 Contact Map
3g0oA 3 0.9623 100 0.375 Contact Map
2uyyA 3 0.976 100 0.375 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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