GREMLIN Database
PDXY - Pyridoxamine kinase
UniProt: P77150 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13940
Length: 287 (246)
Sequences: 6210 (4348)
Seq/√Len: 277.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_R139_A3.2331.00
23_E33_V2.8671.00
160_N163_E2.7271.00
91_E135_H2.7041.00
156_H170_E2.6931.00
53_C56_P2.6171.00
50_W66_G2.5931.00
29_L233_K2.5881.00
239_T242_E2.5231.00
180_L226_T2.5041.00
233_K238_A2.4391.00
65_Q96_I2.3551.00
84_L93_I2.2321.00
150_L181_V2.1761.00
61_T95_G2.1211.00
81_S111_C2.1191.00
40_Q59_H2.1041.00
31_A232_V2.0961.00
130_E134_R2.0721.00
122_C126_P2.0461.00
205_W241_Q2.0441.00
40_Q55_M1.9871.00
5_I31_A1.9621.00
165_V204_A1.9561.00
26_M232_V1.9511.00
233_K236_Q1.9181.00
193_R208_S1.9111.00
26_M33_V1.8961.00
117_H121_G1.8831.00
60_L89_Q1.8811.00
51_T62_E1.8461.00
7_A35_P1.8311.00
11_H20_S1.8221.00
26_M31_A1.7881.00
158_V167_A1.7811.00
178_I240_L1.7361.00
151_E157_A1.7351.00
54_V85_G1.7251.00
98_R135_H1.7121.00
161_V206_H1.6771.00
61_T92_H1.6641.00
64_V96_I1.6401.00
96_I99_Q1.6291.00
230_L244_L1.6251.00
238_A246_H1.6251.00
248_T252_Y1.5881.00
159_N163_E1.5761.00
172_I199_V1.5721.00
61_T96_I1.5291.00
233_K246_H1.5181.00
108_K141_D1.5111.00
97_V109_Y1.5061.00
5_I26_M1.5011.00
20_S35_P1.4991.00
7_A26_M1.4951.00
90_G132_H1.4861.00
65_Q69_A1.4701.00
36_L64_V1.4681.00
252_Y256_V1.4461.00
81_S109_Y1.4431.00
124_V128_V1.4411.00
57_P92_H1.4371.00
4_N77_D1.4361.00
111_C140_S1.4331.00
253_E256_V1.4171.00
168_A181_V1.4151.00
195_E206_H1.4041.00
54_V86_S1.4021.00
143_I171_L1.3901.00
199_V204_A1.3771.00
165_V206_H1.3621.00
210_P256_V1.3571.00
87_A127_G1.3481.00
53_C59_H1.3381.00
55_M59_H1.3261.00
207_I245_E1.3051.00
154_C171_L1.3021.00
194_F248_T1.2901.00
178_I200_T1.2901.00
4_N72_K1.2871.00
4_N34_W1.2741.00
19_N37_N1.2641.00
11_H41_F1.2531.00
151_E158_V1.2321.00
141_D177_Q1.2211.00
168_A199_V1.2101.00
122_C129_A1.2101.00
131_F135_H1.2021.00
156_H166_L1.1951.00
209_R248_T1.1951.00
36_L60_L1.1871.00
205_W245_E1.1871.00
68_A99_Q1.1831.00
58_S62_E1.1821.00
4_N75_T1.1771.00
110_F231_L1.1761.00
238_A242_E1.1561.00
65_Q99_Q1.1561.00
197_L206_H1.1551.00
45_T71_D1.1511.00
50_W69_A1.1501.00
86_S89_Q1.1441.00
170_E173_A1.1431.00
241_Q245_E1.1331.00
209_R252_Y1.1301.00
25_P225_V1.1261.00
234_L240_L1.1181.00
151_E167_A1.1151.00
68_A76_C1.1051.00
94_L135_H1.0991.00
5_I235_L1.0961.00
137_L143_I1.0951.00
57_P88_E1.0931.00
29_L229_L1.0871.00
51_T59_H1.0761.00
90_G131_F1.0681.00
164_A197_L1.0661.00
133_V153_L1.0581.00
142_I240_L1.0451.00
11_H37_N1.0431.00
95_G135_H1.0431.00
166_L170_E1.0361.00
84_L90_G1.0361.00
169_R173_A1.0361.00
42_S62_E1.0351.00
154_C170_E1.0281.00
29_L232_V1.0281.00
242_E245_E1.0271.00
31_A236_Q1.0231.00
92_H95_G1.0201.00
170_E174_Q1.0131.00
42_S59_H1.0121.00
25_P29_L1.0121.00
91_E131_F1.0121.00
245_E249_A1.0071.00
25_P229_L1.0061.00
178_I198_L1.0041.00
161_V165_V1.0011.00
34_W72_K0.9981.00
8_I93_I0.9951.00
142_I230_L0.9911.00
133_V174_Q0.9881.00
165_V169_R0.9731.00
94_L139_A0.9721.00
34_W76_C0.9641.00
59_H62_E0.9621.00
207_I244_L0.9621.00
87_A131_F0.9611.00
172_I201_A0.9611.00
142_I180_L0.9611.00
87_A91_E0.9581.00
172_I179_V0.9571.00
203_E241_Q0.9501.00
116_G152_I0.9391.00
219_P255_M0.9381.00
212_V255_M0.9341.00
122_C152_I0.9331.00
129_A152_I0.9271.00
39_V83_Y0.9241.00
195_E208_S0.9231.00
4_N76_C0.9201.00
78_A231_L0.9121.00
163_E166_L0.9111.00
110_F234_L0.9091.00
166_L169_R0.9091.00
141_D240_L0.9071.00
14_Y41_F0.9031.00
3_K77_D0.8981.00
88_E91_E0.8941.00
225_V250_A0.8941.00
68_A96_I0.8881.00
11_H35_P0.8741.00
230_L247_V0.8701.00
212_V252_Y0.8661.00
141_D178_I0.8611.00
193_R210_P0.8601.00
161_V197_L0.8591.00
85_G89_Q0.8581.00
253_E257_T0.8571.00
172_I176_P0.8561.00
95_G99_Q0.8551.00
207_I248_T0.8501.00
90_G124_V0.8501.00
169_R204_A0.8431.00
196_M248_T0.8421.00
13_V35_P0.8391.00
100_V107_A0.8391.00
143_I179_V0.8391.00
29_L236_Q0.8341.00
229_L250_A0.8291.00
142_I178_I0.8220.99
57_P61_T0.8110.99
156_H163_E0.8090.99
31_A235_L0.8050.99
14_Y72_K0.8030.99
62_E66_G0.7970.99
198_L207_I0.7960.99
81_S84_L0.7950.99
13_V41_F0.7920.99
50_W62_E0.7880.99
61_T65_Q0.7870.99
62_E65_Q0.7860.99
13_V42_S0.7850.99
16_H220_V0.7840.99
164_A186_R0.7780.99
249_A253_E0.7780.99
79_V107_A0.7720.99
5_I232_V0.7670.99
162_E165_V0.7620.99
234_L237_G0.7620.99
200_T203_E0.7620.99
10_S38_T0.7570.99
34_W67_I0.7550.99
197_L204_A0.7520.99
180_L198_L0.7480.99
26_M231_L0.7470.99
161_V195_E0.7400.99
213_D217_R0.7370.99
72_K75_T0.7360.99
142_I244_L0.7360.99
214_F219_P0.7350.99
79_V109_Y0.7300.99
147_L186_R0.7300.99
148_V185_A0.7270.99
194_F211_L0.7180.99
80_L228_G0.7180.99
198_L244_L0.7110.99
172_I175_G0.7090.98
20_S23_E0.7050.98
218_Q260_A0.7030.98
234_L243_A0.7000.98
79_V97_V0.6990.98
6_L34_W0.6970.98
39_V54_V0.6950.98
137_L176_P0.6950.98
94_L98_R0.6930.98
133_V155_E0.6920.98
21_A225_V0.6890.98
94_L136_G0.6860.98
242_E246_H0.6860.98
146_N149_E0.6830.98
238_A243_A0.6830.98
26_M228_G0.6820.98
80_L227_S0.6820.98
199_V202_D0.6820.98
251_V255_M0.6810.98
259_K262_Q0.6790.98
147_L151_E0.6780.98
172_I178_I0.6730.98
92_H96_I0.6700.98
68_A100_V0.6700.98
38_T89_Q0.6690.98
248_T251_V0.6680.98
25_P250_A0.6670.98
9_Q22_A0.6660.98
140_S143_I0.6660.98
214_F218_Q0.6650.98
172_I200_T0.6650.98
81_S97_V0.6620.98
57_P60_L0.6560.97
11_H19_N0.6560.97
72_K76_C0.6510.97
181_V197_L0.6510.97
236_Q246_H0.6490.97
5_I231_L0.6480.97
28_R250_A0.6470.97
72_K77_D0.6460.97
11_H40_Q0.6440.97
198_L240_L0.6430.97
24_F32_N0.6420.97
12_V18_G0.6410.97
86_S125_A0.6400.97
7_A227_S0.6400.97
172_I177_Q0.6360.97
115_M124_V0.6360.97
85_G125_A0.6350.97
150_L167_A0.6340.97
200_T205_W0.6320.97
69_A100_V0.6230.97
96_I100_V0.6220.97
60_L92_H0.6220.97
81_S227_S0.6210.97
132_H137_L0.6200.96
95_G98_R0.6200.96
83_Y123_I0.6170.96
180_L244_L0.6160.96
169_R199_V0.6150.96
129_A133_V0.6140.96
239_T243_A0.6130.96
158_V163_E0.6090.96
246_H249_A0.6090.96
43_N220_V0.6090.96
153_L171_L0.6080.96
158_V164_A0.6070.96
22_A80_L0.6060.96
117_H123_I0.6020.96
29_L246_H0.6000.96
110_F142_I0.5980.96
94_L111_C0.5950.96
56_P59_H0.5950.96
14_Y32_N0.5930.95
19_N35_P0.5890.95
49_K69_A0.5840.95
116_G121_G0.5830.95
111_C136_G0.5830.95
68_A79_V0.5820.95
90_G136_G0.5800.95
142_I247_V0.5790.95
36_L67_I0.5760.95
8_I64_V0.5760.95
156_H167_A0.5750.95
7_A33_V0.5750.95
90_G128_V0.5720.95
169_R172_I0.5710.94
78_A227_S0.5700.94
112_D146_N0.5700.94
198_L241_Q0.5680.94
116_G122_C0.5670.94
225_V254_I0.5670.94
150_L171_L0.5670.94
168_A179_V0.5670.94
148_V151_E0.5660.94
91_E95_G0.5650.94
187_A192_D0.5640.94
39_V85_G0.5610.94
17_A220_V0.5600.94
162_E166_L0.5580.94
218_Q259_K0.5570.94
91_E134_R0.5560.94
154_C179_V0.5550.94
200_T204_A0.5550.94
210_P252_Y0.5540.94
244_L247_V0.5530.93
250_A254_I0.5520.93
135_H139_A0.5520.93
101_K141_D0.5470.93
43_N66_G0.5450.93
65_Q100_V0.5440.93
24_F27_R0.5420.93
218_Q258_T0.5370.92
46_Q50_W0.5340.92
257_T260_A0.5340.92
185_A211_L0.5330.92
6_L36_L0.5330.92
161_V208_S0.5320.92
51_T58_S0.5320.92
207_I241_Q0.5310.92
66_G69_A0.5310.92
44_H66_G0.5310.92
180_L230_L0.5300.92
109_Y139_A0.5290.92
226_T247_V0.5220.91
247_V251_V0.5210.91
44_H50_W0.5190.91
43_N49_K0.5180.91
165_V199_V0.5160.91
43_N117_H0.5150.91
10_S17_A0.5130.91
112_D145_P0.5110.91
67_I76_C0.5110.91
135_H138_P0.5110.91
126_P129_A0.5060.90
147_L158_V0.5050.90
150_L158_V0.5040.90
145_P149_E0.5030.90
12_V22_A0.5010.90
4_N32_N0.5010.90
237_G243_A0.5000.90
134_R174_Q0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pzsA 2 0.9965 100 0.346 Contact Map
2yxtA 3 0.9686 100 0.373 Contact Map
3rm5A 2 0.9268 100 0.391 Contact Map
2ddmA 2 0.9233 100 0.394 Contact Map
2i5bA 2 0.9303 100 0.395 Contact Map
3mbhA 5 0.9617 100 0.409 Contact Map
3zs7A 2 0.9233 100 0.417 Contact Map
3h74A 2 0.9233 100 0.417 Contact Map
4s1hA 2 0.9512 100 0.419 Contact Map
1ub0A 2 0.8571 100 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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