GREMLIN Database
YLBE - Uncharacterized protein YlbE
UniProt: P77129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13398
Length: 419 (406)
Sequences: 282 (180)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_A106_S5.7801.00
115_E122_R5.4541.00
197_L201_L5.3961.00
315_M380_N4.4180.99
53_E262_M3.9720.98
142_E146_T3.7310.97
74_D77_Q3.7300.97
267_V270_L3.6220.97
13_I346_E3.5190.96
25_D164_G3.3030.94
114_V235_A3.2190.93
337_S362_C3.0640.91
50_R53_E3.0470.91
267_V367_I3.0040.90
367_I409_L2.9820.90
42_L106_S2.9750.90
128_N231_N2.8870.89
25_D113_V2.8470.88
341_A347_R2.8280.87
128_N382_G2.7200.85
171_D174_A2.6370.83
27_Q31_S2.6330.83
116_N121_N2.6330.83
205_I215_I2.6310.83
11_A15_Q2.6160.83
154_V217_E2.5730.82
100_P231_N2.5250.80
240_A351_L2.4820.79
59_K79_L2.4500.78
71_W107_A2.4330.78
382_G392_Q2.4130.77
37_N41_T2.4100.77
179_G193_S2.3710.76
237_C308_F2.3650.76
283_Q292_Q2.3530.75
68_F152_R2.3420.75
367_I412_L2.3370.75
28_P31_S2.3180.74
231_N382_G2.2980.74
347_R359_Q2.2660.72
151_M155_L2.1920.70
252_I345_L2.1610.69
62_C82_L2.1480.68
251_S412_L2.1090.67
63_V75_E2.0710.65
214_H217_E2.0090.63
268_S271_G1.9810.62
160_S164_G1.9650.61
63_V67_L1.9640.61
241_M255_A1.9080.59
26_V156_M1.8960.58
298_D381_T1.8870.58
286_F292_Q1.8140.55
30_S108_S1.8120.54
202_A219_M1.8040.54
100_P128_N1.7810.53
16_I241_M1.7750.53
20_R171_D1.7610.52
79_L83_E1.7290.51
40_K71_W1.7230.51
16_I252_I1.7150.50
56_G172_L1.7100.50
341_A359_Q1.7020.50
149_R152_R1.6800.49
212_K215_I1.6710.48
258_R298_D1.6400.47
15_Q161_A1.6180.46
42_L71_W1.6100.46
38_E71_W1.5900.45
156_M232_L1.5830.45
284_G383_I1.5790.44
22_H174_A1.5690.44
260_G301_D1.5590.44
127_L228_F1.5510.43
40_K86_E1.5380.43
128_N324_F1.5370.43
258_R381_T1.5110.42
261_N393_I1.4970.41
23_W197_L1.4840.40
270_L367_I1.4810.40
376_T400_A1.4760.40
36_L194_S1.4710.40
100_P132_G1.4610.39
55_T261_N1.4380.38
197_L244_G1.4340.38
130_G382_G1.4260.38
5_V368_R1.4210.38
90_I94_H1.4160.38
213_Q217_E1.4140.37
188_Q321_V1.4060.37
158_V205_I1.4060.37
66_C71_W1.3950.37
403_A407_Q1.3920.37
44_H260_G1.3860.36
114_V222_L1.3770.36
282_P296_N1.3760.36
19_A119_D1.3670.36
44_H301_D1.3480.35
248_R252_I1.3420.35
193_S235_A1.3400.35
37_N71_W1.3360.34
200_A251_S1.3190.34
41_T88_N1.3110.33
101_M298_D1.3100.33
16_I247_I1.2990.33
101_M258_R1.2960.33
282_P398_V1.2920.33
262_M299_M1.2880.33
6_A368_R1.2850.32
101_M381_T1.2840.32
252_I346_E1.2820.32
155_L228_F1.2800.32
106_S268_S1.2760.32
83_E111_M1.2660.32
299_M393_I1.2640.32
271_G297_P1.2600.31
65_A303_A1.2500.31
254_T303_A1.2490.31
10_A14_E1.2430.31
150_W221_F1.2360.31
188_Q279_V1.2360.31
128_N134_V1.2340.30
127_L155_L1.2300.30
67_L281_T1.2280.30
172_L193_S1.2180.30
16_I123_A1.2160.30
116_N242_D1.2110.30
137_F299_M1.2100.30
158_V252_I1.2080.30
40_K118_T1.1970.29
337_S361_A1.1910.29
245_A266_R1.1890.29
21_P123_A1.1810.29
286_F383_I1.1760.28
71_W400_A1.1740.28
261_N299_M1.1720.28
92_C190_N1.1630.28
277_A400_A1.1630.28
68_F153_D1.1590.28
76_A241_M1.1590.28
90_I95_V1.1550.28
32_L158_V1.1440.27
227_Q321_V1.1400.27
277_A280_N1.1310.27
134_V231_N1.1170.26
257_T313_A1.1160.26
180_I316_I1.1050.26
63_V200_A1.1040.26
104_I400_A1.0910.26
92_C304_I1.0900.25
237_C362_C1.0890.25
296_N299_M1.0870.25
125_C230_L1.0870.25
245_A254_T1.0790.25
47_P264_G1.0720.25
25_D160_S1.0710.25
188_Q227_Q1.0650.25
288_T323_R1.0630.25
190_N384_A1.0600.24
136_R144_V1.0570.24
128_N392_Q1.0490.24
71_W318_A1.0490.24
103_G129_E1.0490.24
21_P172_L1.0470.24
357_D371_V1.0320.24
251_S409_L1.0310.24
93_H257_T1.0200.23
225_T321_V1.0180.23
161_A210_H1.0160.23
127_L156_M1.0120.23
19_A116_N1.0070.23
119_D243_A1.0030.23
10_A52_Q1.0020.23
134_V382_G1.0010.23
59_K386_K0.9980.23
20_R255_A0.9960.23
276_T342_E0.9950.22
248_R407_Q0.9940.22
263_F312_G0.9940.22
12_V15_Q0.9920.22
43_L92_C0.9920.22
132_G229_F0.9890.22
128_N132_G0.9840.22
18_R116_N0.9780.22
248_R268_S0.9750.22
71_W347_R0.9740.22
19_A239_A0.9720.22
162_A242_D0.9710.22
383_I393_I0.9700.22
55_T353_I0.9670.22
5_V107_A0.9660.22
127_L317_A0.9650.22
93_H304_I0.9640.22
151_M203_P0.9600.21
352_Q361_A0.9580.21
231_N392_Q0.9530.21
17_R363_L0.9520.21
35_E323_R0.9480.21
49_M87_V0.9430.21
12_V316_I0.9430.21
75_E140_Y0.9350.21
121_N239_A0.9350.21
66_C82_L0.9330.21
270_L390_I0.9330.21
59_K123_A0.9310.21
18_R266_R0.9260.20
27_Q113_V0.9250.20
16_I240_A0.9250.20
244_G254_T0.9230.20
175_M367_I0.9230.20
256_M263_F0.9230.20
87_V342_E0.9190.20
284_G404_C0.9130.20
240_A346_E0.9120.20
125_C235_A0.9110.20
16_I67_L0.9110.20
60_G136_R0.9070.20
163_L363_L0.9040.20
130_G231_N0.9030.20
68_F151_M0.9020.20
12_V252_I0.9000.20
59_K117_V0.9000.20
40_K347_R0.9000.20
22_H169_G0.8950.20
41_T310_I0.8950.20
199_R219_M0.8940.20
314_A361_A0.8920.20
67_L75_E0.8870.19
130_G230_L0.8840.19
16_I211_D0.8840.19
28_P164_G0.8840.19
66_C81_I0.8840.19
280_N404_C0.8840.19
159_L317_A0.8810.19
22_H171_D0.8780.19
10_A77_Q0.8760.19
14_E18_R0.8750.19
285_L324_F0.8750.19
179_G383_I0.8750.19
136_R231_N0.8750.19
53_E261_N0.8740.19
106_S243_A0.8710.19
25_D28_P0.8690.19
245_A272_E0.8650.19
249_A393_I0.8610.19
267_V412_L0.8570.19
112_L228_F0.8570.19
134_V229_F0.8550.19
107_A320_G0.8540.18
283_Q290_F0.8510.18
59_K169_G0.8490.18
38_E213_Q0.8480.18
42_L160_S0.8470.18
11_A14_E0.8460.18
193_S357_D0.8420.18
186_F310_I0.8400.18
211_D214_H0.8400.18
107_A232_L0.8380.18
23_W332_A0.8380.18
181_T352_Q0.8370.18
33_I111_M0.8370.18
324_F395_A0.8340.18
229_F232_L0.8320.18
385_H390_I0.8300.18
266_R337_S0.8300.18
104_I280_N0.8290.18
80_A252_I0.8270.18
249_A367_I0.8270.18
175_M244_G0.8260.18
19_A126_N0.8260.18
15_Q121_N0.8240.18
173_T313_A0.8230.18
194_S222_L0.8210.18
272_E278_P0.8210.18
181_T320_G0.8200.18
60_G315_M0.8190.18
92_C305_T0.8160.18
54_M385_H0.8130.17
63_V268_S0.8110.17
110_P233_A0.8100.17
232_L237_C0.8080.17
339_E399_R0.8080.17
168_R346_E0.8070.17
96_N414_E0.8060.17
6_A170_I0.8050.17
55_T385_H0.8040.17
73_K87_V0.8030.17
125_C392_Q0.8030.17
267_V297_P0.8020.17
203_P375_I0.8020.17
13_I393_I0.8020.17
250_G316_I0.8010.17
321_V397_T0.7970.17
237_C337_S0.7970.17
117_V369_R0.7960.17
153_D262_M0.7950.17
181_T286_F0.7940.17
13_I70_G0.7930.17
38_E390_I0.7930.17
12_V330_M0.7920.17
112_L127_L0.7900.17
45_A136_R0.7880.17
143_D180_I0.7880.17
344_Y365_L0.7860.17
10_A414_E0.7830.17
134_V392_Q0.7820.17
176_M324_F0.7820.17
81_I84_Q0.7820.17
17_R31_S0.7770.17
131_I356_W0.7740.16
99_G103_G0.7730.16
179_G196_L0.7720.16
67_L140_Y0.7720.16
288_T356_W0.7700.16
195_A323_R0.7640.16
44_H259_N0.7610.16
176_M353_I0.7600.16
145_L149_R0.7600.16
158_V210_H0.7580.16
12_V250_G0.7560.16
132_G231_N0.7550.16
279_V321_V0.7530.16
60_G388_A0.7520.16
175_M214_H0.7510.16
201_L318_A0.7510.16
48_P155_L0.7510.16
168_R375_I0.7460.16
310_I362_C0.7460.16
136_R315_M0.7460.16
102_G186_F0.7450.16
87_V120_G0.7440.16
19_A121_N0.7420.16
70_G252_I0.7410.16
353_I359_Q0.7390.16
76_A87_V0.7340.16
143_D390_I0.7320.16
205_I255_A0.7310.15
225_T233_A0.7300.15
96_N142_E0.7300.15
140_Y380_N0.7290.15
313_A365_L0.7280.15
186_F233_A0.7280.15
94_H200_A0.7250.15
207_R216_A0.7230.15
22_H65_A0.7210.15
188_Q313_A0.7210.15
139_A144_V0.7200.15
32_L200_A0.7200.15
163_L179_G0.7180.15
179_G268_S0.7180.15
37_N141_G0.7170.15
55_T320_G0.7160.15
259_N301_D0.7160.15
73_K77_Q0.7150.15
73_K80_A0.7130.15
108_S246_M0.7130.15
87_V211_D0.7110.15
255_A357_D0.7100.15
349_M412_L0.7100.15
50_R372_E0.7090.15
135_M365_L0.7090.15
110_P372_E0.7080.15
71_W235_A0.7070.15
331_E357_D0.7070.15
16_I106_S0.7050.15
28_P198_M0.7050.15
317_A411_A0.7040.15
42_L277_A0.7030.15
74_D331_E0.6990.15
127_L367_I0.6980.15
194_S317_A0.6970.15
179_G235_A0.6970.15
176_M243_A0.6930.15
128_N221_F0.6920.15
116_N239_A0.6920.15
61_A129_E0.6910.15
100_P136_R0.6910.15
185_E227_Q0.6900.15
197_L407_Q0.6900.15
229_F382_G0.6890.15
64_G305_T0.6890.15
228_F316_I0.6880.15
205_I310_I0.6870.15
10_A283_Q0.6870.15
26_V152_R0.6870.15
322_T397_T0.6860.14
55_T296_N0.6860.14
121_N243_A0.6840.14
52_Q141_G0.6840.14
67_L74_D0.6810.14
109_M133_K0.6810.14
61_A321_V0.6790.14
330_M355_S0.6780.14
215_I348_N0.6770.14
188_Q322_T0.6760.14
144_V150_W0.6740.14
242_D245_A0.6720.14
240_A400_A0.6680.14
201_L335_A0.6650.14
368_R385_H0.6620.14
167_E273_R0.6620.14
179_G254_T0.6600.14
223_S235_A0.6580.14
111_M148_H0.6550.14
231_N324_F0.6540.14
170_I232_L0.6540.14
286_F295_A0.6530.14
136_R150_W0.6500.14
369_R407_Q0.6490.14
237_C380_N0.6490.14
100_P134_V0.6470.14
80_A161_A0.6460.14
185_E392_Q0.6430.14
179_G186_F0.6430.14
111_M124_Y0.6430.14
20_R173_T0.6420.14
197_L237_C0.6420.14
321_V376_T0.6420.14
301_D319_P0.6410.14
262_M283_Q0.6410.14
301_D333_A0.6410.14
80_A214_H0.6400.14
347_R400_A0.6390.14
10_A80_A0.6390.14
159_L290_F0.6390.14
110_P385_H0.6380.13
237_C266_R0.6370.13
54_M298_D0.6370.13
161_A201_L0.6370.13
96_N310_I0.6350.13
177_A324_F0.6330.13
31_S334_R0.6330.13
136_R260_G0.6320.13
149_R217_E0.6280.13
60_G188_Q0.6260.13
154_V157_P0.6240.13
205_I387_E0.6240.13
13_I82_L0.6210.13
102_G321_V0.6210.13
106_S244_G0.6190.13
107_A390_I0.6180.13
43_L404_C0.6170.13
278_P297_P0.6160.13
100_P301_D0.6160.13
284_G379_I0.6150.13
383_I411_A0.6120.13
271_G386_K0.6110.13
68_F82_L0.6100.13
156_M237_C0.6100.13
243_A246_M0.6100.13
344_Y363_L0.6090.13
208_L215_I0.6090.13
284_G315_M0.6070.13
348_N363_L0.6070.13
34_S385_H0.6070.13
62_C390_I0.6050.13
351_L409_L0.6050.13
176_M351_L0.6040.13
260_G319_P0.6030.13
93_H101_M0.6030.13
93_H381_T0.6030.13
338_E355_S0.6030.13
146_T337_S0.6020.13
131_I134_V0.6010.13
216_A220_D0.6010.13
138_G148_H0.6000.13
19_A248_R0.5970.13
249_A412_L0.5970.13
16_I19_A0.5970.13
273_R414_E0.5960.13
18_R402_L0.5960.13
80_A167_E0.5960.13
211_D215_I0.5950.13
24_L70_G0.5950.13
23_W135_M0.5950.13
66_C107_A0.5920.13
11_A32_L0.5920.13
268_S386_K0.5910.13
86_E283_Q0.5900.13
190_N226_D0.5900.13
195_A226_D0.5890.13
258_R301_D0.5890.13
131_I227_Q0.5870.12
124_Y181_T0.5870.12
171_D201_L0.5850.12
20_R267_V0.5850.12
304_I307_T0.5840.12
27_Q223_S0.5830.12
57_P301_D0.5810.12
273_R407_Q0.5800.12
237_C313_A0.5770.12
400_A403_A0.5770.12
54_M258_R0.5760.12
23_W148_H0.5760.12
50_R262_M0.5760.12
30_S239_A0.5750.12
186_F279_V0.5750.12
127_L262_M0.5740.12
99_G304_I0.5740.12
109_M129_E0.5730.12
48_P136_R0.5730.12
6_A79_L0.5730.12
131_I321_V0.5730.12
175_M217_E0.5720.12
86_E114_V0.5710.12
246_M254_T0.5700.12
7_Q212_K0.5700.12
92_C99_G0.5690.12
208_L211_D0.5690.12
101_M389_G0.5690.12
90_I279_V0.5670.12
160_S194_S0.5670.12
238_K304_I0.5670.12
137_F359_Q0.5650.12
88_N207_R0.5650.12
105_T152_R0.5650.12
102_G347_R0.5650.12
250_G356_W0.5640.12
64_G242_D0.5630.12
328_G395_A0.5630.12
111_M359_Q0.5620.12
65_A254_T0.5620.12
349_M388_A0.5610.12
86_E200_A0.5610.12
67_L179_G0.5610.12
256_M307_T0.5580.12
105_T125_C0.5570.12
357_D390_I0.5560.12
217_E293_E0.5560.12
164_G237_C0.5540.12
125_C226_D0.5540.12
32_L172_L0.5540.12
115_E293_E0.5530.12
6_A76_A0.5530.12
184_D189_R0.5520.12
207_R213_Q0.5510.12
294_Q304_I0.5500.12
7_Q331_E0.5500.12
52_Q88_N0.5500.12
93_H258_R0.5490.12
258_R304_I0.5480.12
306_E326_G0.5470.12
64_G190_N0.5470.12
290_F303_A0.5470.12
23_W293_E0.5460.12
261_N337_S0.5440.12
95_V338_E0.5440.12
100_P260_G0.5430.12
7_Q11_A0.5420.12
255_A267_V0.5410.12
55_T400_A0.5410.12
237_C305_T0.5400.12
295_A379_I0.5400.12
65_A244_G0.5380.12
82_L195_A0.5370.12
51_W247_I0.5370.12
279_V301_D0.5360.12
92_C384_A0.5360.12
201_L351_L0.5350.12
93_H298_D0.5340.12
313_A344_Y0.5340.12
296_N381_T0.5340.12
254_T368_R0.5330.12
266_R289_G0.5330.12
186_F193_S0.5300.11
132_G324_F0.5300.11
103_G384_A0.5300.11
80_A84_Q0.5300.11
68_F145_L0.5300.11
32_L96_N0.5290.11
324_F332_A0.5280.11
15_Q335_A0.5270.11
151_M221_F0.5270.11
118_T121_N0.5270.11
136_R282_P0.5270.11
159_L228_F0.5270.11
197_L213_Q0.5270.11
27_Q32_L0.5260.11
24_L63_V0.5250.11
132_G392_Q0.5240.11
17_R355_S0.5230.11
345_L414_E0.5230.11
84_Q116_N0.5220.11
381_T385_H0.5210.11
161_A209_D0.5200.11
95_V158_V0.5190.11
246_M250_G0.5170.11
44_H258_R0.5170.11
64_G144_V0.5170.11
284_G380_N0.5160.11
137_F284_G0.5150.11
243_A261_N0.5140.11
111_M382_G0.5120.11
64_G135_M0.5120.11
8_A269_G0.5120.11
114_V223_S0.5110.11
193_S240_A0.5100.11
260_G333_A0.5100.11
120_G256_M0.5090.11
357_D369_R0.5070.11
156_M176_M0.5050.11
279_V322_T0.5050.11
198_M222_L0.5050.11
70_G80_A0.5030.11
114_V186_F0.5020.11
211_D217_E0.5020.11
104_I368_R0.5020.11
316_I356_W0.5020.11
175_M196_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3clqA 2 0.9905 100 0.011 Contact Map
4c23A 1 0.2148 26.9 0.982 Contact Map
3pm6A 2 0.1814 21.9 0.983 Contact Map
2xwvA 1 0.2005 13.1 0.985 Contact Map
1q7eA 2 0.2053 11.6 0.985 Contact Map
4to8A 2 0.1814 10.2 0.985 Contact Map
1ofdA 1 0.1384 10 0.986 Contact Map
3ktsA 1 0.1718 9.8 0.986 Contact Map
1ea0A 1 0.1504 9.7 0.986 Contact Map
2fiqA 4 0.1862 9.1 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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