GREMLIN Database
MHPC - 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
UniProt: P77044 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20275
Length: 288 (256)
Sequences: 61173 (50358)
Seq/√Len: 3147.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_D67_R4.7451.00
109_H133_K4.2371.00
74_P95_I3.4051.00
97_K123_F2.9241.00
57_N278_N2.8901.00
273_H276_A2.8161.00
109_H132_G2.6711.00
260_H280_L2.6631.00
237_R263_R2.5401.00
138_G239_D2.5281.00
107_K132_G2.4831.00
232_L284_F2.4091.00
137_M277_F2.3931.00
262_F280_L2.3471.00
29_N48_A2.2861.00
25_R80_D2.1861.00
97_K127_W2.1731.00
97_K130_R2.1711.00
123_F127_W2.1291.00
97_K101_D2.1181.00
110_L120_S2.0391.00
237_R261_I1.9791.00
27_H78_K1.9381.00
28_F99_V1.9241.00
60_P278_N1.9231.00
100_V108_I1.9071.00
101_D130_R1.9051.00
37_T69_I1.8881.00
122_A126_K1.8541.00
31_C70_L1.8441.00
37_T105_I1.8341.00
37_T67_R1.8321.00
117_G139_G1.8281.00
30_D69_I1.8191.00
109_H285_L1.8071.00
251_L257_S1.8041.00
244_M261_I1.7931.00
65_G282_L1.7801.00
124_T134_L1.7431.00
265_C273_H1.7321.00
27_H48_A1.7131.00
42_H73_C1.6751.00
94_R126_K1.6671.00
46_P50_G1.6271.00
280_L283_N1.6151.00
109_H135_V1.6091.00
232_L260_H1.6011.00
66_Y109_H1.5951.00
90_D126_K1.5891.00
93_A122_A1.5771.00
41_L96_L1.5601.00
249_R253_G1.5571.00
231_T254_I1.5561.00
42_H76_W1.5391.00
41_L73_C1.5361.00
73_C119_S1.5261.00
71_L96_L1.5211.00
36_E109_H1.4751.00
123_F131_V1.4731.00
127_W130_R1.4421.00
120_S134_L1.4131.00
48_A72_D1.3981.00
121_V136_L1.3831.00
88_R91_L1.3771.00
27_H72_D1.3741.00
36_E132_G1.3601.00
123_F130_R1.3551.00
96_L123_F1.3531.00
276_A280_L1.3381.00
122_A125_L1.3321.00
22_K98_S1.3171.00
64_A282_L1.3111.00
60_P282_L1.2921.00
235_W247_G1.2911.00
135_V281_V1.2871.00
69_I99_V1.2851.00
111_L137_M1.2811.00
113_N270_Q1.2721.00
279_Q283_N1.2671.00
31_C58_I1.2591.00
244_M248_L1.2571.00
24_L74_P1.2551.00
41_L120_S1.2501.00
45_G76_W1.2471.00
38_V66_Y1.2421.00
114_S267_H1.2331.00
32_G67_R1.2271.00
223_R226_E1.2051.00
101_D127_W1.2011.00
26_I95_I1.2001.00
52_A56_R1.2001.00
48_A78_K1.1991.00
209_S212_A1.1881.00
136_L139_G1.1851.00
40_L111_L1.1811.00
40_L68_V1.1781.00
99_V103_L1.1761.00
58_I70_L1.1731.00
210_L213_N1.1691.00
276_A279_Q1.1621.00
60_P64_A1.1621.00
135_V232_L1.1401.00
248_L252_S1.1231.00
206_F209_S1.1191.00
211_E214_P1.1151.00
251_L259_L1.1151.00
262_F265_C1.1151.00
105_I108_I1.1121.00
234_V262_F1.1061.00
235_W259_L1.1051.00
235_W261_I1.1031.00
254_I257_S1.1021.00
125_L223_R1.0951.00
41_L110_L1.0941.00
232_L258_E1.0901.00
48_A70_L1.0891.00
36_E66_Y1.0791.00
39_V100_V1.0731.00
31_C62_V1.0601.00
43_G114_S1.0581.00
185_T188_L1.0571.00
111_L281_V1.0471.00
112_G120_S1.0461.00
108_I131_V1.0461.00
277_F281_V1.0281.00
28_F103_L1.0241.00
45_G114_S1.0221.00
258_E280_L1.0151.00
71_L99_V1.0141.00
166_T169_N1.0091.00
90_D122_A1.0071.00
262_F276_A1.0041.00
60_P275_D0.9911.00
249_R252_S0.9871.00
50_G270_Q0.9781.00
133_K230_Q0.9751.00
266_G272_E0.9741.00
34_G67_R0.9661.00
248_L251_L0.9621.00
206_F210_L0.9591.00
225_A253_G0.9581.00
113_N268_W0.9571.00
108_I130_R0.9571.00
260_H283_N0.9551.00
97_K126_K0.9521.00
59_D62_V0.9521.00
137_M270_Q0.9521.00
72_D77_G0.9481.00
93_A119_S0.9481.00
56_R59_D0.9451.00
100_V123_F0.9401.00
52_A70_L0.9391.00
235_W244_M0.9361.00
97_K100_V0.9301.00
33_Q67_R0.9291.00
186_D190_E0.9241.00
159_N163_R0.9211.00
39_V108_I0.9141.00
69_I103_L0.9071.00
248_L259_L0.9061.00
137_M269_A0.9021.00
265_C272_E0.8951.00
66_Y285_L0.8921.00
73_C115_M0.8921.00
91_L94_R0.8881.00
98_S101_D0.8851.00
24_L80_D0.8841.00
62_V68_V0.8841.00
209_S213_N0.8841.00
100_V105_I0.8831.00
98_S102_Q0.8831.00
165_P169_N0.8811.00
248_L261_I0.8811.00
191_A195_N0.8801.00
207_V210_L0.8801.00
275_D279_Q0.8791.00
58_I62_V0.8741.00
38_V111_L0.8731.00
156_K159_N0.8451.00
41_L71_L0.8441.00
93_A126_K0.8421.00
36_E107_K0.8401.00
208_K212_A0.8391.00
160_Q164_Q0.8351.00
62_V65_G0.8311.00
190_E194_N0.8301.00
265_C269_A0.8181.00
38_V68_V0.8171.00
208_K211_E0.8161.00
134_L231_T0.8141.00
210_L214_P0.8121.00
40_L51_W0.8111.00
237_R264_D0.8061.00
260_H276_A0.7981.00
233_I257_S0.7971.00
203_L206_F0.7921.00
173_M177_F0.7921.00
236_G269_A0.7911.00
155_I159_N0.7901.00
37_T66_Y0.7841.00
113_N138_G0.7821.00
246_A249_R0.7811.00
122_A223_R0.7811.00
112_G117_G0.7791.00
49_T52_A0.7771.00
58_I68_V0.7771.00
92_N115_M0.7751.00
234_V280_L0.7751.00
204_E208_K0.7751.00
94_R97_K0.7731.00
228_K255_A0.7711.00
124_T131_V0.7621.00
37_T108_I0.7601.00
26_I79_S0.7551.00
57_N60_P0.7531.00
36_E133_K0.7531.00
172_L175_D0.7471.00
94_R98_S0.7461.00
220_F223_R0.7451.00
93_A123_F0.7421.00
86_G91_L0.7411.00
177_F181_T0.7361.00
110_L123_F0.7321.00
73_C92_N0.7301.00
278_N282_L0.7281.00
193_L197_L0.7261.00
264_D273_H0.7211.00
39_V96_L0.7201.00
110_L131_V0.7191.00
199_R202_H0.7181.00
155_I158_L0.7161.00
158_L162_Y0.7161.00
48_A71_L0.7161.00
29_N52_A0.7131.00
44_S115_M0.7121.00
199_R203_L0.7111.00
193_L196_M0.7101.00
133_K284_F0.7101.00
72_D78_K0.7081.00
138_G269_A0.7071.00
38_V109_H0.7051.00
247_G259_L0.7011.00
27_H79_S0.7011.00
177_F180_D0.7001.00
38_V285_L0.7001.00
113_N137_M0.6961.00
45_G115_M0.6961.00
172_L176_I0.6951.00
279_Q282_L0.6931.00
179_F182_S0.6921.00
57_N277_F0.6921.00
66_Y282_L0.6871.00
176_I179_F0.6871.00
152_T156_K0.6851.00
138_G235_W0.6831.00
188_L191_A0.6831.00
138_G236_G0.6751.00
74_P92_N0.6731.00
124_T229_A0.6711.00
90_D94_R0.6701.00
187_A191_A0.6701.00
274_A278_N0.6691.00
125_L226_E0.6671.00
245_D248_L0.6671.00
135_V285_L0.6671.00
262_F273_H0.6661.00
154_G158_L0.6651.00
73_C76_W0.6651.00
26_I74_P0.6641.00
31_C59_D0.6631.00
192_R195_N0.6621.00
108_I132_G0.6611.00
171_K175_D0.6581.00
121_V141_T0.6581.00
237_R244_M0.6581.00
42_H71_L0.6561.00
207_V211_E0.6561.00
69_I105_I0.6491.00
111_L135_V0.6481.00
191_A194_N0.6481.00
133_K285_L0.6471.00
30_D33_Q0.6461.00
118_H140_G0.6411.00
202_H205_N0.6391.00
92_N119_S0.6381.00
108_I123_F0.6371.00
117_G136_L0.6351.00
135_V284_F0.6341.00
39_V71_L0.6331.00
222_P225_A0.6281.00
173_M176_I0.6281.00
171_K174_M0.6271.00
239_D267_H0.6261.00
176_I180_D0.6261.00
67_R105_I0.6251.00
142_G145_S0.6251.00
30_D103_L0.6211.00
160_Q163_R0.6181.00
238_N264_D0.6171.00
178_V182_S0.6161.00
89_S122_A0.6141.00
234_V277_F0.6141.00
112_G116_G0.6141.00
166_T170_L0.6121.00
35_D67_R0.6091.00
201_D204_E0.6081.00
154_G157_R0.6061.00
131_V229_A0.6041.00
106_A130_R0.6031.00
152_T159_N0.6021.00
135_V234_V0.6011.00
114_S268_W0.6011.00
206_F213_N0.5991.00
192_R197_L0.5981.00
40_L70_L0.5961.00
175_D179_F0.5961.00
104_D107_K0.5961.00
192_R196_M0.5941.00
250_L254_I0.5931.00
209_S214_P0.5911.00
154_G159_N0.5901.00
61_L281_V0.5891.00
184_L189_F0.5881.00
219_D223_R0.5831.00
178_V181_T0.5811.00
29_N70_L0.5781.00
175_D178_V0.5771.00
203_L207_V0.5761.00
91_L95_I0.5751.00
136_L233_I0.5701.00
118_H121_V0.5671.00
46_P268_W0.5671.00
93_A97_K0.5611.00
22_K91_L0.5581.00
269_A277_F0.5551.00
126_K223_R0.5541.00
121_V139_G0.5521.00
174_M177_F0.5511.00
133_K232_L0.5491.00
87_S91_L0.5491.00
124_T227_I0.5481.00
202_H206_F0.5481.00
165_P170_L0.5471.00
100_V130_R0.5461.00
157_R160_Q0.5461.00
187_A190_E0.5421.00
44_S76_W0.5421.00
73_C96_L0.5411.00
221_G249_R0.5401.00
203_L209_S0.5391.00
156_K160_Q0.5391.00
39_V110_L0.5371.00
58_I61_L0.5371.00
251_L254_I0.5351.00
22_K94_R0.5331.00
200_R203_L0.5321.00
208_K213_N0.5281.00
247_G251_L0.5251.00
44_S114_S0.5221.00
40_L61_L0.5221.00
201_D206_F0.5211.00
43_G113_N0.5211.00
219_D222_P0.5211.00
233_I259_L0.5181.00
52_A59_D0.5171.00
186_D189_F0.5171.00
205_N208_K0.5161.00
278_N283_N0.5161.00
29_N49_T0.5161.00
50_G113_N0.5151.00
51_W58_I0.5141.00
49_T78_K0.5141.00
233_I247_G0.5141.00
38_V61_L0.5131.00
221_G253_G0.5131.00
144_M148_T0.5111.00
89_S119_S0.5111.00
157_R161_L0.5101.00
203_L210_L0.5091.00
65_G68_V0.5051.00
94_R127_W0.5051.00
270_Q277_F0.5031.00
216_Q219_D0.5021.00
120_S136_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pujA 4 0.9792 100 0.16 Contact Map
1u2eA 2 0.9792 100 0.161 Contact Map
1ehyA 1 0.9167 100 0.177 Contact Map
2wueA 4 0.9549 100 0.188 Contact Map
4inzA 1 0.9236 100 0.188 Contact Map
3oosA 1 0.9306 100 0.202 Contact Map
4opmA 2 0.9653 100 0.211 Contact Map
3om8A 4 0.9097 100 0.212 Contact Map
1iupA 2 0.9167 100 0.213 Contact Map
4ns4A 1 0.9062 100 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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