GREMLIN Database
EPMC - Elongation factor P hydroxylase
UniProt: P76938 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14116
Length: 182 (169)
Sequences: 369 (221)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_K141_Q4.4631.00
107_L150_I3.9111.00
9_Q164_Y3.5401.00
9_Q165_Y3.3530.99
70_A73_E3.1980.99
45_N73_E3.1890.99
108_F157_F3.1540.99
120_C129_P3.0680.99
141_Q145_Y2.8980.98
100_K145_Y2.6550.97
15_N25_R2.3780.94
107_L158_I2.3440.94
65_C108_F2.3070.93
28_K52_G2.1680.91
104_L154_P2.0860.89
30_D51_H2.0790.89
66_I154_P1.9850.86
54_Y164_Y1.9510.85
28_K50_A1.9430.85
111_A158_I1.9360.85
39_D46_R1.8670.83
155_A159_K1.8610.82
21_D156_R1.8300.81
104_L108_F1.8200.81
139_H143_M1.7500.78
145_Y154_P1.7410.78
168_P174_Q1.7360.78
28_K51_H1.7340.78
34_I75_V1.7300.77
66_I157_F1.6780.75
5_H9_Q1.6650.75
65_C151_P1.6250.73
11_I49_F1.6210.73
144_D148_N1.5580.69
36_L108_F1.5310.68
5_H164_Y1.5150.67
65_C104_L1.4630.64
87_D96_D1.4580.64
70_A89_Q1.4480.64
87_D90_T1.4290.63
150_I158_I1.4160.62
100_K154_P1.4040.61
27_I51_H1.4040.61
61_I95_E1.3760.60
89_Q172_A1.3600.59
69_K73_E1.3560.58
55_A114_Y1.3490.58
151_P154_P1.3120.56
66_I145_Y1.2380.51
41_E163_N1.2350.51
15_N62_S1.2350.51
159_K162_Q1.2280.51
30_D52_G1.2010.49
93_Q96_D1.1840.48
118_V131_R1.1750.48
130_D151_P1.1460.46
125_G130_D1.1320.45
54_Y109_C1.1200.44
17_C75_V1.0990.43
8_E166_H1.0990.43
7_Y28_K1.0940.43
50_A53_F1.0800.42
25_R44_Y1.0770.42
120_C131_R1.0730.42
135_Q142_V1.0700.41
28_K111_A1.0580.41
89_Q166_H1.0470.40
88_A92_S1.0350.39
120_C130_D1.0320.39
82_C90_T1.0300.39
17_C92_S1.0240.39
66_I100_K1.0190.38
106_W135_Q1.0150.38
13_I145_Y1.0040.38
65_C154_P1.0030.38
19_A25_R1.0000.37
22_F130_D0.9880.37
163_N171_T0.9880.37
130_D133_V0.9830.36
118_V128_E0.9780.36
30_D50_A0.9740.36
82_C108_F0.9730.36
162_Q167_T0.9720.36
49_F95_E0.9680.36
117_N137_R0.9620.35
87_D141_Q0.9610.35
54_Y165_Y0.9590.35
17_C157_F0.9570.35
7_Y10_L0.9530.35
13_I168_P0.9360.34
117_N135_Q0.9230.33
66_I104_L0.9220.33
36_L39_D0.9160.33
69_K154_P0.9140.33
62_S90_T0.9130.33
22_F153_R0.9110.33
88_A126_D0.9100.33
53_F145_Y0.9040.32
46_R77_F0.8960.32
5_H165_Y0.8940.32
110_V139_H0.8810.31
107_L142_V0.8760.31
61_I87_D0.8750.31
82_C111_A0.8510.29
13_I165_Y0.8460.29
12_E16_S0.8430.29
155_A158_I0.8430.29
109_C114_Y0.8410.29
15_N19_A0.8400.29
93_Q114_Y0.8380.29
95_E114_Y0.8380.29
62_S66_I0.8370.29
34_I48_V0.8360.29
128_E131_R0.8340.29
77_F104_L0.8240.28
49_F52_G0.8200.28
167_T174_Q0.8100.27
58_I171_T0.8070.27
99_V137_R0.8010.27
106_W139_H0.8010.27
53_F97_V0.8000.27
138_V151_P0.7880.26
43_P173_E0.7830.26
109_C165_Y0.7820.26
24_T149_G0.7810.26
146_L158_I0.7740.26
42_V46_R0.7700.26
115_P135_Q0.7690.26
36_L153_R0.7650.25
145_Y151_P0.7630.25
54_Y133_V0.7590.25
17_C28_K0.7550.25
10_L47_I0.7510.25
34_I42_V0.7510.25
104_L141_Q0.7510.25
92_S150_I0.7480.25
55_A65_C0.7460.25
14_F26_L0.7430.24
73_E138_V0.7430.24
104_L150_I0.7380.24
125_G128_E0.7370.24
8_E12_E0.7350.24
142_V150_I0.7320.24
55_A109_C0.7310.24
158_I162_Q0.7310.24
52_G117_N0.7310.24
37_P75_V0.7270.24
66_I129_P0.7250.24
30_D89_Q0.7250.24
47_I77_F0.7190.23
144_D160_A0.7120.23
12_E144_D0.7110.23
132_V154_P0.7070.23
100_K106_W0.7060.23
77_F150_I0.7050.23
47_I147_T0.7040.23
11_I160_A0.7010.23
48_V55_A0.6960.22
25_R146_L0.6890.22
130_D138_V0.6880.22
77_F118_V0.6860.22
120_C126_D0.6860.22
107_L120_C0.6840.22
84_D123_L0.6840.22
16_S173_E0.6840.22
110_V146_L0.6830.22
113_G152_E0.6820.22
104_L161_L0.6700.21
130_D158_I0.6690.21
70_A163_N0.6630.21
143_M172_A0.6610.21
89_Q96_D0.6600.21
131_R137_R0.6600.21
126_D129_P0.6590.21
139_H142_V0.6580.21
24_T153_R0.6570.21
136_R139_H0.6520.21
77_F139_H0.6480.20
74_L140_A0.6440.20
87_D131_R0.6420.20
95_E131_R0.6390.20
117_N138_V0.6370.20
90_T129_P0.6340.20
164_Y167_T0.6310.20
118_V130_D0.6310.20
34_I131_R0.6310.20
152_E169_E0.6270.20
53_F124_E0.6260.20
58_I90_T0.6250.20
69_K74_L0.6220.19
21_D109_C0.6220.19
125_G165_Y0.6200.19
65_C126_D0.6200.19
74_L157_F0.6190.19
40_A148_N0.6180.19
8_E143_M0.6170.19
87_D100_K0.6140.19
50_A54_Y0.6110.19
135_Q141_Q0.6110.19
61_I157_F0.6090.19
19_A44_Y0.6090.19
74_L133_V0.6050.19
55_A95_E0.5970.19
17_C142_V0.5960.19
40_A144_D0.5960.19
111_A114_Y0.5940.18
115_P166_H0.5900.18
11_I52_G0.5850.18
104_L107_L0.5820.18
16_S166_H0.5820.18
10_L54_Y0.5780.18
131_R135_Q0.5760.18
13_I17_C0.5750.18
90_T118_V0.5740.18
141_Q154_P0.5720.18
64_W122_N0.5710.18
6_H11_I0.5690.18
40_A110_V0.5690.18
148_N159_K0.5660.17
135_Q139_H0.5660.17
103_A145_Y0.5660.17
25_R111_A0.5630.17
133_V137_R0.5630.17
46_R99_V0.5630.17
65_C162_Q0.5610.17
117_N131_R0.5600.17
138_V146_L0.5580.17
24_T64_W0.5570.17
107_L126_D0.5540.17
143_M152_E0.5530.17
31_D34_I0.5500.17
36_L42_V0.5500.17
166_H174_Q0.5490.17
118_V129_P0.5470.17
77_F151_P0.5430.17
84_D122_N0.5380.17
45_N70_A0.5310.16
41_E89_Q0.5300.16
115_P147_T0.5250.16
10_L155_A0.5240.16
41_E166_H0.5240.16
92_S115_P0.5240.16
137_R158_I0.5230.16
7_Y17_C0.5220.16
42_V107_L0.5190.16
110_V174_Q0.5170.16
10_L109_C0.5140.16
82_C135_Q0.5140.16
21_D136_R0.5130.16
20_D168_P0.5120.16
36_L46_R0.5080.16
170_L173_E0.5050.15
41_E113_G0.5000.15
53_F93_Q0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdnA 1 0.7637 100 0.245 Contact Map
4hxiA 1 0.7857 34.8 0.962 Contact Map
4eozA 2 0.6099 20.4 0.966 Contact Map
2if5A 2 0.5989 19.9 0.966 Contact Map
4cxiA 1 0.6703 18.1 0.967 Contact Map
3b84A 1 0.5989 18 0.967 Contact Map
3i3nA 2 0.8187 17.9 0.967 Contact Map
2q81A 5 0.6099 16.8 0.967 Contact Map
2ihcA 3 0.5989 14.2 0.968 Contact Map
4u77A 2 0.6099 13.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.