GREMLIN Database
OMPL - Porin OmpL
UniProt: P76773 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13374
Length: 230 (218)
Sequences: 250 (175)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_T206_R5.4431.00
188_T204_E4.2351.00
164_F187_I3.8180.99
28_E39_V3.4110.98
127_N147_E2.9790.95
27_R223_R2.8640.94
92_G107_Y2.7130.92
27_R40_M2.6070.91
207_W220_N2.5840.90
147_E186_E2.5630.90
149_G165_E2.3160.84
28_E37_G2.2100.81
47_F52_G2.1940.81
149_G167_H2.1900.81
119_N153_N2.1600.80
92_G106_V2.1420.79
40_M223_R2.0170.75
89_I110_V1.9970.74
147_E167_H1.9780.73
6_A11_S1.9250.71
180_G203_F1.8740.69
184_H209_D1.8670.69
110_V122_V1.8640.69
41_L74_I1.8230.67
52_G77_W1.8040.66
7_I16_A1.7490.63
207_W218_E1.7230.62
88_T111_N1.7200.62
179_N216_H1.6970.61
58_T71_Y1.6680.60
148_I224_I1.6570.59
70_G180_G1.6560.59
71_Y96_N1.6430.58
99_S224_I1.6410.58
96_N147_E1.6350.58
13_L16_A1.6190.57
84_T118_F1.6070.57
89_I215_Y1.5950.56
106_V124_N1.5930.56
26_N39_V1.5870.56
210_R215_Y1.5540.54
25_E40_M1.5460.54
40_M123_R1.5450.54
199_W226_T1.5130.52
124_N146_Y1.5000.51
96_N188_T1.4690.50
215_Y218_E1.4460.49
145_T149_G1.4410.48
170_M182_D1.4330.48
114_F119_N1.4120.47
114_F117_W1.4070.47
10_L15_S1.3800.45
187_I207_W1.3740.45
178_S184_H1.3710.45
112_Y201_P1.3700.45
27_R221_Q1.3620.44
180_G218_E1.3600.44
206_R221_Q1.3270.43
27_R73_E1.3150.42
73_E92_G1.3090.42
8_I12_S1.3080.42
25_E223_R1.3070.42
149_G186_E1.3000.41
10_L14_T1.2980.41
25_E202_Y1.2970.41
91_P108_L1.2920.41
178_S185_W1.2850.41
96_N206_R1.2770.40
11_S16_A1.2550.39
151_Y163_T1.2540.39
80_L89_I1.2530.39
10_L17_S1.2500.39
205_L220_N1.2250.38
101_G146_Y1.2150.37
153_N163_T1.2140.37
39_V219_Q1.2080.37
26_N164_F1.1940.36
46_N52_G1.1940.36
127_N167_H1.1930.36
104_G208_L1.1920.36
49_M116_P1.1640.35
127_N186_E1.1640.35
55_L69_H1.1630.35
100_I140_L1.1440.34
73_E105_A1.1410.34
40_M206_R1.1370.34
11_S24_V1.1350.34
86_K112_Y1.1250.33
7_I11_S1.1240.33
122_V149_G1.1230.33
22_A44_G1.1150.33
92_G123_R1.1120.33
139_E226_T1.1080.33
47_F53_I1.0930.32
190_T229_F1.0810.31
89_I108_L1.0780.31
5_N11_S1.0770.31
15_S114_F1.0770.31
53_I57_N1.0760.31
71_Y97_D1.0730.31
204_E223_R1.0690.31
24_V37_G1.0690.31
82_K179_N1.0550.30
31_N203_F1.0520.30
126_Y165_E1.0470.30
37_G211_N1.0450.30
109_D165_E1.0440.30
10_L13_L1.0440.30
41_L90_Q1.0220.29
118_F195_I1.0120.28
85_D214_P1.0100.28
40_M56_T1.0060.28
38_E42_R1.0050.28
6_A15_S0.9930.28
44_G58_T0.9880.27
24_V97_D0.9860.27
206_R223_R0.9710.27
207_W219_Q0.9680.27
22_A45_Y0.9590.26
178_S215_Y0.9550.26
192_R200_L0.9550.26
175_F178_S0.9540.26
5_N9_L0.9510.26
15_S21_G0.9480.26
66_E147_E0.9460.26
18_V181_K0.9450.26
184_H218_E0.9400.26
12_S138_G0.9400.26
23_Y202_Y0.9390.26
115_V118_F0.9370.26
56_T105_A0.9350.25
8_I11_S0.9320.25
44_G56_T0.9290.25
42_R54_M0.9220.25
16_A21_G0.9150.25
104_G218_E0.9140.25
213_E217_R0.9110.25
162_Y189_N0.8980.24
140_L224_I0.8910.24
70_G96_N0.8840.24
16_A19_F0.8820.23
93_G104_G0.8800.23
6_A12_S0.8800.23
114_F118_F0.8740.23
5_N12_S0.8740.23
126_Y147_E0.8740.23
49_M126_Y0.8640.23
14_T80_L0.8610.23
179_N224_I0.8590.23
155_K189_N0.8580.23
79_P163_T0.8560.23
24_V202_Y0.8550.23
171_R188_T0.8520.22
180_G214_P0.8480.22
82_K85_D0.8420.22
54_M105_A0.8340.22
108_L183_H0.8300.22
94_L107_Y0.8240.21
151_Y165_E0.8230.21
137_S155_K0.8210.21
60_N147_E0.8200.21
137_S162_Y0.8190.21
138_G210_R0.8090.21
7_I10_L0.8090.21
41_L53_I0.8090.21
111_N114_F0.8070.21
109_D166_P0.8070.21
12_S84_T0.8060.21
178_S210_R0.8050.21
84_T181_K0.8010.21
167_H186_E0.8010.21
50_G194_R0.7970.21
35_D55_L0.7960.21
27_R123_R0.7920.20
67_L115_V0.7920.20
78_Y199_W0.7910.20
89_I214_P0.7900.20
158_D187_I0.7890.20
28_E185_W0.7850.20
30_Y72_N0.7840.20
18_V34_S0.7730.20
41_L99_S0.7710.20
39_V228_Y0.7710.20
14_T21_G0.7690.20
53_I102_S0.7670.20
31_N208_L0.7610.19
29_A206_R0.7600.19
202_Y227_K0.7600.19
16_A50_G0.7570.19
25_E221_Q0.7560.19
37_G164_F0.7550.19
126_Y186_E0.7540.19
5_N13_L0.7540.19
63_R210_R0.7530.19
75_E151_Y0.7470.19
155_K161_S0.7440.19
214_P226_T0.7440.19
42_R109_D0.7390.19
176_N215_Y0.7390.19
104_G191_F0.7390.19
119_N166_P0.7370.19
91_P125_R0.7360.19
158_D215_Y0.7280.18
23_Y44_G0.7250.18
74_I97_D0.7230.18
108_L203_F0.7200.18
65_D139_E0.7180.18
87_L110_V0.7180.18
125_R186_E0.7110.18
73_E223_R0.7100.18
215_Y219_Q0.7070.18
66_E175_F0.7050.18
90_Q110_V0.7020.18
40_M71_Y0.6980.18
85_D89_I0.6900.17
143_N202_Y0.6900.17
21_G25_E0.6890.17
77_W216_H0.6870.17
123_R201_P0.6840.17
34_S87_L0.6810.17
180_G207_W0.6760.17
29_A40_M0.6720.17
31_N43_V0.6700.17
162_Y222_I0.6690.17
18_V148_I0.6680.17
178_S209_D0.6670.17
98_K129_N0.6660.17
122_V191_F0.6640.17
29_A196_N0.6640.17
94_L105_A0.6620.17
80_L230_F0.6600.16
173_N179_N0.6580.16
30_Y145_T0.6530.16
115_V144_D0.6510.16
22_A88_T0.6500.16
137_S227_K0.6490.16
17_S195_I0.6450.16
147_E165_E0.6450.16
47_F72_N0.6430.16
92_G223_R0.6410.16
211_N218_E0.6390.16
8_I18_V0.6340.16
205_L222_I0.6310.16
119_N163_T0.6300.16
89_I174_D0.6280.16
113_K120_L0.6260.16
58_T149_G0.6240.15
6_A14_T0.6190.15
60_N70_G0.6180.15
27_R206_R0.6170.15
86_K115_V0.6160.15
23_Y206_R0.6120.15
32_L220_N0.6120.15
5_N87_L0.6090.15
111_N165_E0.6090.15
226_T230_F0.6070.15
55_L156_I0.6060.15
130_N191_F0.6060.15
30_Y112_Y0.6050.15
126_Y146_Y0.6020.15
71_Y199_W0.5990.15
59_Y80_L0.5960.15
28_E38_E0.5960.15
49_M78_Y0.5940.15
96_N186_E0.5930.15
40_M221_Q0.5920.15
127_N218_E0.5910.15
203_F222_I0.5870.15
8_I82_K0.5860.15
82_K142_N0.5850.15
219_Q228_Y0.5840.14
87_L113_K0.5820.14
118_F154_F0.5790.14
41_L100_I0.5770.14
148_I181_K0.5710.14
51_A76_G0.5700.14
74_I169_F0.5610.14
18_V32_L0.5580.14
155_K179_N0.5580.14
49_M150_T0.5560.14
91_P147_E0.5560.14
193_Y201_P0.5520.14
53_I74_I0.5490.14
83_P142_N0.5460.14
67_L226_T0.5450.14
112_Y141_D0.5450.14
170_M184_H0.5440.14
75_E94_L0.5440.14
55_L70_G0.5430.13
27_R199_W0.5420.13
121_T151_Y0.5420.13
153_N175_F0.5420.13
125_R147_E0.5400.13
12_S15_S0.5370.13
188_T205_L0.5260.13
53_I146_Y0.5250.13
65_D181_K0.5250.13
24_V60_N0.5240.13
54_M75_E0.5240.13
9_L13_L0.5200.13
191_F205_L0.5190.13
85_D215_Y0.5170.13
6_A10_L0.5160.13
24_V193_Y0.5150.13
169_F184_H0.5150.13
94_L109_D0.5130.13
86_K108_L0.5120.13
24_V139_E0.5110.13
13_L41_L0.5100.13
43_V53_I0.5100.13
132_S191_F0.5090.13
22_A41_L0.5090.13
70_G127_N0.5090.13
58_T168_Y0.5080.13
87_L119_N0.5060.13
26_N126_Y0.5060.13
43_V111_N0.5050.13
8_I178_S0.5040.13
18_V132_S0.5030.13
28_E228_Y0.5030.13
127_N207_W0.5020.13
201_P223_R0.5020.13
24_V98_K0.5020.13
207_W224_I0.5020.13
120_L181_K0.5010.13
59_Y70_G0.5000.13
30_Y35_D0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fqeA 1 0.7304 100 0.183 Contact Map
2wjrA 1 0.8652 100 0.197 Contact Map
3nb3A 2 0.5696 98.9 0.839 Contact Map
2x9kA 1 0.8652 98 0.878 Contact Map
3dwoX 1 0.9913 97.3 0.895 Contact Map
3pguA 1 0.9435 97.2 0.895 Contact Map
2k0lA 1 0.7261 97.2 0.896 Contact Map
1ormA 1 0.6304 97.1 0.897 Contact Map
3bs0A 1 0.9304 97 0.899 Contact Map
3bryA 1 0.9174 96.9 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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