GREMLIN Database
HLDE - Bifunctional protein HldE
UniProt: P76658 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13416
Length: 477 (462)
Sequences: 893 (623)
Seq/√Len: 29.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
382_R415_D7.2281.00
381_K386_D5.0691.00
393_L411_S4.3001.00
374_V397_M4.2601.00
232_R238_S4.0771.00
376_S411_S3.9601.00
376_S413_E3.8951.00
343_V367_G3.6701.00
73_T79_A3.6491.00
390_V468_I3.5191.00
425_L449_N3.3571.00
436_K439_E3.3561.00
433_G455_V3.2871.00
148_V271_A3.1651.00
50_P82_L3.1211.00
437_P447_W3.1191.00
325_E419_R2.9081.00
340_E369_R2.8871.00
443_S447_W2.8531.00
351_I391_N2.8441.00
378_A382_R2.8371.00
289_A293_V2.7491.00
422_A445_E2.7391.00
395_Q462_C2.6921.00
238_S248_H2.6841.00
357_V399_V2.6721.00
440_I455_V2.6591.00
60_I65_A2.6591.00
175_L267_I2.6471.00
41_V109_V2.6191.00
344_M373_A2.5080.99
148_V267_I2.4960.99
378_A413_E2.4900.99
145_G172_V2.4830.99
341_K428_L2.4480.99
218_K222_D2.4240.99
297_K307_E2.3680.99
358_S459_E2.2720.99
60_I272_A2.2280.98
418_Q445_E2.2020.98
75_I80_R2.1900.98
419_R422_A2.1020.98
109_V367_G2.0930.98
336_R342_V2.0840.97
199_F230_V2.0730.97
293_V296_G2.0500.97
12_G145_G2.0460.97
354_A395_Q1.9970.97
344_M441_A1.9910.97
12_G66_N1.9690.96
190_T226_S1.9680.96
359_Y458_F1.9360.96
273_T278_N1.9250.96
217_M220_I1.8890.95
62_S302_T1.8530.95
354_A462_C1.8490.95
161_Q165_Q1.8420.95
429_L442_G1.8230.94
55_N59_N1.8070.94
180_G185_R1.7990.94
60_I67_A1.7970.94
146_A173_P1.7960.94
425_L448_A1.7840.94
335_A408_W1.7670.93
446_V453_V1.7600.93
332_V371_I1.7570.93
422_A448_A1.7540.93
75_I99_P1.7460.93
418_Q441_A1.7410.93
445_E449_N1.7380.93
433_G458_F1.7320.93
109_V117_I1.7310.93
149_L157_L1.7270.93
29_T111_S1.7060.92
348_V380_T1.6860.92
366_L456_L1.6780.92
109_V119_L1.6770.91
341_K452_E1.6750.91
50_P85_S1.6630.91
260_T335_A1.6590.91
54_A153_A1.6550.91
446_V450_G1.6510.91
358_S362_N1.6500.91
362_N365_K1.6490.91
149_L160_V1.6420.91
57_A69_L1.6340.90
109_V343_V1.6330.90
14_M144_I1.6220.90
54_A57_A1.6210.90
173_P190_T1.6150.90
251_T269_V1.5800.89
362_N457_N1.5620.88
361_A405_A1.5550.88
50_P54_A1.5510.88
24_Y343_V1.5310.87
227_A280_L1.5270.87
15_V367_G1.5090.86
110_L298_L1.5000.86
232_R235_Q1.4920.86
101_H373_A1.4760.85
191_L284_C1.4710.85
24_Y367_G1.4700.85
15_V343_V1.4690.85
87_A131_Q1.4660.85
13_V146_A1.4580.84
437_P443_S1.4460.84
399_V405_A1.4430.84
340_E367_G1.4300.83
138_N166_L1.4240.83
229_L237_M1.4230.83
397_M411_S1.4180.83
216_G240_L1.4160.83
392_P395_Q1.4090.82
362_N456_L1.4070.82
196_L235_Q1.4060.82
466_N469_K1.4010.82
335_A369_R1.3890.81
267_I271_A1.3880.81
82_L284_C1.3850.81
192_L225_L1.3840.81
378_A381_K1.3800.81
29_T32_I1.3790.81
336_R339_G1.3630.80
369_R408_W1.3570.80
82_L103_T1.3510.80
328_L332_V1.3470.79
265_T300_T1.3460.79
241_Q281_E1.3390.79
48_E81_A1.3370.79
57_A61_A1.3370.79
329_K424_I1.3360.79
187_R224_E1.3310.78
178_P258_D1.3310.78
358_S398_I1.3300.78
176_I189_A1.3300.78
433_G456_L1.3290.78
83_S97_S1.3270.78
340_E343_V1.3240.78
29_T260_T1.3150.78
282_E285_F1.3140.78
391_N395_Q1.3120.77
25_W43_V1.3110.77
265_T294_V1.3060.77
197_S201_A1.2870.76
378_A415_D1.2730.75
380_T393_L1.2620.75
361_A398_I1.2580.74
168_R226_S1.2570.74
333_A337_K1.2550.74
446_V451_G1.2540.74
343_V366_L1.2490.74
229_L239_L1.2480.74
216_G241_Q1.2450.74
325_E423_G1.2340.73
333_A336_R1.2210.72
294_V300_T1.2190.72
249_M289_A1.2190.72
374_V411_S1.2130.72
208_T211_E1.2100.71
203_V219_L1.2090.71
371_I424_I1.2080.71
15_V24_Y1.2030.71
147_L167_A1.1960.71
335_A340_E1.1950.70
11_A275_A1.1770.69
49_R260_T1.1730.69
49_R367_G1.1690.69
212_I220_I1.1640.68
232_R248_H1.1570.68
324_T327_E1.1490.67
59_N300_T1.1480.67
340_E408_W1.1460.67
77_D80_R1.1450.67
16_V147_L1.1430.67
220_I242_P1.1390.67
441_A458_F1.1360.66
130_P134_H1.1300.66
175_L274_L1.1290.66
329_K338_R1.1270.66
70_V137_I1.1250.66
240_L467_I1.1250.66
24_Y49_R1.1140.65
438_E443_S1.1120.65
391_N402_A1.1120.65
381_K394_E1.1090.65
425_L445_E1.1090.65
23_R48_E1.1080.65
269_V290_A1.1050.64
466_N470_K1.0970.64
366_L454_L1.0940.63
213_V238_S1.0880.63
146_A271_A1.0860.63
433_G457_N1.0800.62
418_Q422_A1.0780.62
43_V54_A1.0740.62
351_I467_I1.0740.62
251_T292_G1.0730.62
54_A71_G1.0710.62
34_P154_K1.0600.61
269_V286_F1.0560.61
119_L390_V1.0550.61
440_I447_W1.0540.61
128_V133_L1.0480.60
68_R144_I1.0460.60
73_T93_C1.0440.60
130_P133_L1.0370.59
344_M425_L1.0280.59
71_G102_P1.0270.59
28_P44_N1.0260.58
141_L147_L1.0230.58
445_E448_A1.0210.58
402_A405_A1.0160.58
393_L397_M1.0150.58
154_K179_K1.0080.57
34_P40_V1.0030.57
34_P258_D0.9910.56
12_G68_R0.9910.56
429_L440_I0.9800.55
260_T300_T0.9790.55
16_V163_M0.9780.55
216_G455_V0.9760.55
92_K97_S0.9750.55
200_E206_C0.9740.54
119_L367_G0.9730.54
329_K423_G0.9730.54
107_L121_F0.9700.54
416_T434_D0.9690.54
23_R105_T0.9670.54
357_V402_A0.9660.54
188_G224_E0.9640.54
199_F215_R0.9640.54
374_V393_L0.9610.53
414_E419_R0.9580.53
166_L170_A0.9570.53
256_V259_V0.9510.53
49_R343_V0.9500.53
373_A420_L0.9500.53
417_P434_D0.9440.52
26_Y45_T0.9430.52
371_I423_G0.9380.52
332_V336_R0.9330.51
186_Y288_N0.9320.51
115_Q256_V0.9310.51
105_T121_F0.9270.51
122_E154_K0.9240.51
59_N265_T0.9240.51
293_V300_T0.9230.50
143_S146_A0.9200.50
217_M240_L0.9170.50
321_G325_E0.9150.50
279_S282_E0.9150.50
34_P56_V0.9100.49
393_L402_A0.9090.49
399_V402_A0.9060.49
395_Q408_W0.9050.49
26_Y110_L0.9050.49
216_G246_P0.9040.49
276_A279_S0.9040.49
425_L441_A0.9030.49
387_S405_A0.9020.49
15_V109_V0.9000.49
55_N265_T0.8980.49
19_V69_L0.8970.48
279_S459_E0.8970.48
240_L465_T0.8970.48
19_V71_G0.8930.48
403_L410_V0.8920.48
179_K259_V0.8910.48
190_T274_L0.8840.47
375_N417_P0.8820.47
90_N425_L0.8790.47
193_T267_I0.8780.47
43_V121_F0.8750.47
73_T97_S0.8670.46
32_I174_V0.8650.46
354_A399_V0.8620.46
186_Y256_V0.8580.45
24_Y119_L0.8570.45
142_S170_A0.8550.45
153_A192_L0.8530.45
112_R200_E0.8470.45
20_M34_P0.8470.45
372_V406_V0.8470.45
328_L467_I0.8450.44
393_L413_E0.8440.44
81_A84_K0.8420.44
66_N342_V0.8390.44
137_I147_L0.8360.44
381_K387_S0.8360.44
57_A91_V0.8330.44
243_G364_R0.8320.43
339_G433_G0.8300.43
203_V223_Y0.8260.43
178_P182_D0.8240.43
186_Y258_D0.8220.43
112_R260_T0.8180.42
200_E260_T0.8150.42
75_I100_T0.8130.42
115_Q122_E0.8120.42
252_Q292_G0.8110.42
343_V433_G0.8110.42
196_L455_V0.8100.42
56_V154_K0.8070.42
91_V94_D0.8050.41
34_P179_K0.8040.41
130_P158_A0.8030.41
266_V442_G0.7990.41
153_A270_L0.7980.41
20_M154_K0.7970.41
154_K186_Y0.7950.41
225_L228_L0.7950.41
230_V348_V0.7940.41
119_L343_V0.7930.40
68_R92_K0.7880.40
273_T338_R0.7840.40
438_E448_A0.7840.40
268_G365_K0.7830.40
154_K259_V0.7800.39
421_I449_N0.7790.39
31_R34_P0.7750.39
115_Q442_G0.7740.39
101_H455_V0.7740.39
425_L447_W0.7720.39
449_N461_G0.7700.39
286_F293_V0.7690.39
366_L405_A0.7690.39
410_V420_L0.7630.38
115_Q186_Y0.7630.38
180_G223_Y0.7620.38
192_L223_Y0.7590.38
137_I163_M0.7580.38
38_V41_V0.7570.38
416_T442_G0.7570.38
67_A272_A0.7540.38
193_T266_V0.7520.37
457_N460_D0.7520.37
229_L301_S0.7500.37
122_E186_Y0.7480.37
111_S284_C0.7480.37
94_D136_R0.7480.37
344_M440_I0.7460.37
25_W216_G0.7450.37
437_P455_V0.7440.37
84_K88_D0.7380.36
66_N162_Q0.7370.36
391_N467_I0.7360.36
428_L452_E0.7340.36
300_T438_E0.7320.36
55_N63_L0.7320.36
165_Q333_A0.7310.36
326_E329_K0.7310.36
153_A193_T0.7290.36
336_R405_A0.7290.36
157_L183_F0.7270.36
101_H344_M0.7270.36
46_I121_F0.7240.35
122_E441_A0.7230.35
15_V119_L0.7220.35
293_V303_V0.7190.35
422_A425_L0.7190.35
359_Y391_N0.7180.35
71_G219_L0.7160.35
85_S89_V0.7160.35
12_G70_V0.7150.35
249_M284_C0.7120.35
344_M445_E0.7120.35
207_K211_E0.7110.34
346_N429_L0.7110.34
56_V297_K0.7070.34
354_A358_S0.7060.34
271_A289_A0.7050.34
180_G183_F0.7030.34
74_G265_T0.7030.34
77_D390_V0.7010.34
54_A105_T0.6990.34
34_P259_V0.6970.33
204_G229_L0.6970.33
61_A71_G0.6960.33
107_L203_V0.6950.33
352_L403_L0.6930.33
391_N411_S0.6930.33
224_E242_P0.6930.33
122_E442_G0.6920.33
294_V303_V0.6920.33
30_S197_S0.6920.33
55_N176_I0.6910.33
96_V228_L0.6900.33
441_A445_E0.6890.33
25_W359_Y0.6880.33
186_Y442_G0.6870.33
174_V289_A0.6860.33
326_E423_G0.6860.33
181_T399_V0.6850.33
81_A85_S0.6850.33
418_Q459_E0.6850.33
83_S93_C0.6840.33
353_H388_R0.6820.32
351_I359_Y0.6810.32
15_V26_Y0.6810.32
325_E342_V0.6810.32
65_A272_A0.6800.32
192_L228_L0.6800.32
161_Q164_I0.6800.32
328_L408_W0.6790.32
35_E453_V0.6790.32
212_I215_R0.6780.32
88_D427_D0.6770.32
447_W455_V0.6770.32
281_E424_I0.6770.32
59_N179_K0.6770.32
58_M373_A0.6750.32
186_Y266_V0.6750.32
34_P233_S0.6740.32
230_V244_K0.6740.32
12_G144_I0.6710.32
154_K178_P0.6710.32
398_I408_W0.6700.32
186_Y429_L0.6700.32
192_L306_I0.6690.32
427_D451_G0.6660.31
138_N169_K0.6640.31
113_N257_Y0.6640.31
183_F302_T0.6640.31
20_M259_V0.6630.31
91_V95_F0.6620.31
154_K256_V0.6620.31
273_T286_F0.6600.31
200_E230_V0.6590.31
397_M401_G0.6590.31
343_V430_V0.6590.31
183_F297_K0.6590.31
154_K288_N0.6580.31
83_S138_N0.6580.31
256_V307_E0.6580.31
55_N346_N0.6580.31
258_D429_L0.6570.31
34_P178_P0.6570.31
218_K313_R0.6560.31
250_P296_G0.6550.31
47_E453_V0.6550.31
358_S402_A0.6540.31
75_I139_Q0.6540.31
342_V369_R0.6530.31
373_A400_L0.6530.31
199_F212_I0.6510.30
143_S171_G0.6490.30
199_F206_C0.6460.30
266_V288_N0.6460.30
117_I465_T0.6430.30
321_G328_L0.6430.30
70_V169_K0.6410.30
138_N162_Q0.6410.30
227_A237_M0.6400.30
55_N294_V0.6400.30
259_V297_K0.6400.30
156_A275_A0.6400.30
62_S192_L0.6390.30
89_V428_L0.6390.30
24_Y54_A0.6370.29
199_F207_K0.6370.29
288_N429_L0.6370.29
56_V256_V0.6360.29
270_L284_C0.6350.29
435_Y441_A0.6350.29
223_Y467_I0.6320.29
274_L364_R0.6320.29
267_I294_V0.6320.29
118_R122_E0.6300.29
10_R73_T0.6280.29
176_I254_Q0.6280.29
20_M179_K0.6280.29
75_I79_A0.6270.29
61_A82_L0.6270.29
154_K297_K0.6260.29
256_V266_V0.6260.29
382_R464_T0.6260.29
41_V404_E0.6250.29
465_T469_K0.6250.29
375_N434_D0.6240.29
239_L251_T0.6240.29
344_M449_N0.6240.29
70_V133_L0.6240.29
154_K258_D0.6240.29
41_V367_G0.6230.29
270_L280_L0.6230.29
242_P279_S0.6230.29
116_L243_G0.6220.28
429_L441_A0.6210.28
364_R369_R0.6200.28
225_L288_N0.6200.28
54_A119_L0.6190.28
416_T441_A0.6180.28
363_A370_L0.6180.28
217_M243_G0.6170.28
267_I364_R0.6150.28
210_E214_E0.6140.28
376_S424_I0.6100.28
249_M313_R0.6100.28
16_V161_Q0.6100.28
150_S186_Y0.6080.28
310_N337_K0.6060.27
179_K297_K0.6050.27
186_Y259_V0.6050.27
251_T291_A0.6050.27
376_S404_E0.6050.27
353_H384_K0.6040.27
55_N300_T0.6030.27
332_V424_I0.6030.27
74_G307_E0.6030.27
96_V136_R0.6030.27
56_V229_L0.6020.27
257_Y283_A0.6000.27
159_S327_E0.6000.27
33_S258_D0.6000.27
391_N468_I0.6000.27
216_G391_N0.5980.27
307_E311_A0.5980.27
298_L376_S0.5980.27
327_E330_L0.5960.27
322_V401_G0.5950.27
440_I445_E0.5950.27
172_V301_S0.5940.27
460_D465_T0.5940.27
191_L227_A0.5940.27
25_W107_L0.5920.27
366_L468_I0.5920.27
115_Q259_V0.5910.27
32_I38_V0.5900.26
454_L457_N0.5900.26
67_A424_I0.5900.26
104_I411_S0.5890.26
357_V390_V0.5880.26
214_E327_E0.5880.26
221_A242_P0.5880.26
122_E237_M0.5880.26
86_L433_G0.5870.26
324_T332_V0.5870.26
386_D464_T0.5850.26
35_E63_L0.5850.26
190_T421_I0.5840.26
288_N292_G0.5830.26
184_E222_D0.5820.26
189_A256_V0.5820.26
173_P226_S0.5800.26
123_E233_S0.5760.26
79_A149_L0.5750.26
357_V405_A0.5740.26
79_A220_I0.5740.26
102_P251_T0.5740.26
328_L424_I0.5730.25
131_Q135_E0.5730.25
251_T361_A0.5730.25
304_S327_E0.5720.25
24_Y179_K0.5720.25
188_G258_D0.5720.25
20_M288_N0.5720.25
178_P186_Y0.5710.25
216_G220_I0.5700.25
73_T286_F0.5700.25
174_V409_V0.5700.25
61_A339_G0.5700.25
122_E266_V0.5690.25
367_G433_G0.5690.25
390_V398_I0.5690.25
148_V257_Y0.5690.25
115_Q154_K0.5690.25
444_K448_A0.5680.25
33_S444_K0.5680.25
171_G214_E0.5680.25
141_L381_K0.5670.25
156_A345_T0.5670.25
15_V67_A0.5660.25
164_I174_V0.5650.25
308_L311_A0.5640.25
265_T290_A0.5640.25
129_D132_P0.5640.25
214_E413_E0.5640.25
354_A459_E0.5630.25
111_S292_G0.5620.25
119_L381_K0.5610.25
15_V60_I0.5600.25
84_K128_V0.5600.25
217_M324_T0.5600.25
111_S199_F0.5590.25
260_T408_W0.5590.25
277_G339_G0.5580.25
115_Q260_T0.5580.25
346_N373_A0.5570.25
211_E220_I0.5570.25
193_T202_V0.5570.25
420_L470_K0.5560.24
40_V54_A0.5560.24
363_A417_P0.5550.24
160_V164_I0.5550.24
111_S116_L0.5550.24
329_K332_V0.5550.24
16_V214_E0.5540.24
23_R39_P0.5540.24
254_Q296_G0.5530.24
459_E462_C0.5530.24
13_V60_I0.5530.24
267_I408_W0.5510.24
57_A153_A0.5510.24
160_V166_L0.5510.24
66_N181_T0.5500.24
193_T291_A0.5500.24
371_I457_N0.5490.24
145_G173_P0.5490.24
392_P465_T0.5480.24
168_R382_R0.5480.24
243_G306_I0.5480.24
182_D186_Y0.5470.24
146_A172_V0.5470.24
344_M421_I0.5460.24
109_V378_A0.5450.24
147_L457_N0.5450.24
149_L174_V0.5450.24
141_L306_I0.5450.24
255_E415_D0.5450.24
300_T308_L0.5450.24
53_A57_A0.5390.24
179_K233_S0.5380.23
418_Q421_I0.5380.23
68_R145_G0.5370.23
71_G82_L0.5360.23
154_K442_G0.5360.23
34_P253_A0.5350.23
29_T335_A0.5350.23
38_V82_L0.5350.23
54_A91_V0.5350.23
202_V397_M0.5330.23
275_A445_E0.5320.23
72_L100_T0.5320.23
24_Y340_E0.5320.23
104_I470_K0.5300.23
327_E469_K0.5290.23
332_V386_D0.5290.23
56_V60_I0.5290.23
241_Q247_L0.5290.23
62_S303_V0.5280.23
203_V408_W0.5280.23
401_G420_L0.5280.23
325_E329_K0.5270.23
398_I402_A0.5270.23
250_P285_F0.5270.23
33_S154_K0.5250.23
179_K288_N0.5250.23
59_N294_V0.5250.23
358_S456_L0.5240.23
186_Y257_Y0.5240.23
259_V265_T0.5230.23
66_N394_E0.5220.23
266_V440_I0.5220.23
395_Q402_A0.5210.23
164_I168_R0.5200.22
252_Q341_K0.5190.22
34_P429_L0.5180.22
104_I123_E0.5170.22
180_G294_V0.5160.22
56_V148_V0.5150.22
78_A387_S0.5140.22
233_S302_T0.5130.22
363_A375_N0.5120.22
283_A331_A0.5120.22
87_A341_K0.5120.22
56_V59_N0.5110.22
59_N259_V0.5100.22
364_R368_D0.5100.22
150_S234_E0.5100.22
154_K266_V0.5100.22
149_L222_D0.5090.22
417_P464_T0.5090.22
143_S241_Q0.5080.22
348_V353_H0.5070.22
328_L359_Y0.5070.22
230_V380_T0.5070.22
191_L270_L0.5070.22
268_G295_V0.5060.22
168_R224_E0.5050.22
336_R404_E0.5050.22
199_F228_L0.5050.22
217_M306_I0.5040.22
68_R140_A0.5030.22
113_N130_P0.5030.22
90_N310_N0.5030.22
207_K279_S0.5020.22
90_N390_V0.5020.22
163_M187_R0.5020.22
50_P58_M0.5020.22
154_K429_L0.5010.21
354_A392_P0.5010.21
268_G402_A0.5000.21
203_V216_G0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e84A 2 0.6478 100 0.73 Contact Map
3vasA 1 0.631 100 0.772 Contact Map
4k8kA 2 0.6247 100 0.776 Contact Map
3looA 1 0.6268 100 0.777 Contact Map
2rbcA 2 0.6164 100 0.779 Contact Map
1bx4A 1 0.6268 100 0.779 Contact Map
2qcvA 3 0.6352 100 0.779 Contact Map
2jg1A 2 0.6457 100 0.78 Contact Map
2fv7A 2 0.6143 100 0.781 Contact Map
2ajrA 2 0.6373 100 0.783 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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