GUAD - ECOLI - GREMLIN Contacts

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GUAD - Guanine deaminase

UniProt:	P76641	Sequences: MMSGEHTLKAVRGSFIDVTRTIDNPEEIASALRFIEDGLLLIKQGKVEWFGEWENGKHQIPDTIRVRDYRGKLIVPGFVDTHIHYPQSEMVGAYGEQLLEWLNKHTFPTERRYEDLEYAREMSAFFIKQLLRNGTTTALVFGTVHPQSVDALFEAASHINMRMIAGKVMMDRNAPDYLLDTAESSYHQSKELIERWHKNGRLLYAITPRFAPTSSPEQMAMAQRLKEEYPDTWVHTHLCENKDEIAWVKSLYPDHDGYLDVYHQYGLTGKNCVFAHCVHLEEKEWDRLSETKSSIAFCPTSNLYLGSGLFNLKKAWQKKVKVGMGTDIGAGTTFNMLQTLNEAYKVLQLQGYRLSAYEAFYLATLGGAKSLGLDDLIGNFLPGKEADFVVMEPTATPLQQLRYDNSVSLVDKLFVMMTLGDDRSIYRTYVDGRLVYERN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13066
Length:	439 (354)
Sequences:	27262 (21269)
Seq/√Len:	1130.4

ECOLI - GUAD SSNA YAHJ CODA PHNM IADA PHYDA ALLB
BACSU - HUTI YTCJ NAGA ALLB PYRC
HALSA - MTAD Q9HQE0 HUTI Q9HNZ2 Q9HHS1 PYRC
SULSO - Q7LXN1 Q97VT3 Q97V65 Q97WS6 Q97XD4 Q980B7 Q97W09

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
429_Y	434_L	4.794	1.00
379_N	384_K	4.214	1.00
72_K	426_Y	4.033	1.00
43_K	48_E	3.942	1.00
427_R	434_L	3.812	1.00
20_R	69_Y	3.332	1.00
355_S	358_E	3.083	1.00
69_Y	390_V	2.972	1.00
21_T	66_V	2.940	1.00
77_G	136_T	2.910	1.00
381_L	384_K	2.908	1.00
75_V	391_M	2.802	1.00
385_E	431_D	2.778	1.00
23_D	69_Y	2.771	1.00
49_W	382_P	2.673	1.00
313_K	317_Q	2.649	1.00
361_Y	365_L	2.492	1.00
373_L	377_I	2.366	1.00
286_D	318_K	2.308	1.00
321_K	369_K	2.306	1.00
45_G	385_E	2.295	1.00
75_V	389_V	2.278	1.00
377_I	385_E	2.229	1.00
225_L	228_E	2.214	1.00
131_L	435_V	2.172	1.00
46_K	385_E	2.117	1.00
358_E	361_Y	2.115	1.00
286_D	290_E	2.044	1.00
39_L	54_E	1.971	1.00
361_Y	366_G	1.924	1.00
366_G	369_K	1.897	1.00
74_I	390_V	1.888	1.00
263_H	291_T	1.882	1.00
51_G	54_E	1.874	1.00
72_K	392_E	1.812	1.00
311_N	314_K	1.811	1.00
40_L	74_I	1.809	1.00
42_I	388_F	1.804	1.00
18_V	429_Y	1.789	1.00
392_E	426_Y	1.779	1.00
132_R	436_Y	1.778	1.00
19_T	41_L	1.778	1.00
388_F	429_Y	1.777	1.00
323_G	370_S	1.775	1.00
41_L	49_W	1.756	1.00
45_G	431_D	1.750	1.00
41_L	64_I	1.734	1.00
365_L	379_N	1.718	1.00
380_F	388_F	1.696	1.00
25_P	38_G	1.663	1.00
74_I	388_F	1.660	1.00
428_T	436_Y	1.657	1.00
316_W	358_E	1.655	1.00
72_K	390_V	1.643	1.00
188_Q	191_E	1.633	1.00
260_D	264_Q	1.621	1.00
50_F	382_P	1.621	1.00
75_V	78_F	1.587	1.00
40_L	380_F	1.559	1.00
35_I	38_G	1.559	1.00
282_E	314_K	1.542	1.00
190_K	194_E	1.539	1.00
369_K	374_D	1.534	1.00
216_P	220_A	1.533	1.00
365_L	369_K	1.531	1.00
338_Q	341_N	1.526	1.00
375_D	384_K	1.498	1.00
40_L	388_F	1.498	1.00
29_A	381_L	1.495	1.00
220_A	224_R	1.476	1.00
22_I	68_D	1.472	1.00
21_T	39_L	1.467	1.00
29_A	33_R	1.462	1.00
287_R	291_T	1.451	1.00
201_R	204_Y	1.442	1.00
282_E	286_D	1.429	1.00
294_S	321_K	1.427	1.00
183_E	187_H	1.422	1.00
191_E	195_R	1.419	1.00
23_D	74_I	1.416	1.00
130_L	138_A	1.394	1.00
120_R	154_E	1.389	1.00
81_T	323_G	1.387	1.00
254_D	264_Q	1.386	1.00
283_K	286_D	1.382	1.00
294_S	370_S	1.381	1.00
39_L	53_W	1.376	1.00
38_G	52_E	1.375	1.00
306_G	310_F	1.366	1.00
304_Y	309_L	1.352	1.00
75_V	360_F	1.343	1.00
430_V	435_V	1.342	1.00
315_A	320_V	1.337	1.00
225_L	229_Y	1.332	1.00
224_R	228_E	1.326	1.00
285_W	318_K	1.325	1.00
314_K	318_K	1.312	1.00
150_D	154_E	1.304	1.00
151_A	154_E	1.303	1.00
47_V	380_F	1.302	1.00
337_L	341_N	1.300	1.00
221_M	224_R	1.294	1.00
73_L	393_P	1.275	1.00
215_S	218_Q	1.272	1.00
41_L	48_E	1.270	1.00
246_A	250_S	1.267	1.00
247_W	250_S	1.251	1.00
344_Y	359_A	1.244	1.00
137_T	377_I	1.237	1.00
389_V	425_I	1.236	1.00
336_M	339_T	1.234	1.00
79_V	367_G	1.231	1.00
390_V	427_R	1.223	1.00
81_T	367_G	1.212	1.00
286_D	289_S	1.208	1.00
314_K	317_Q	1.204	1.00
288_L	291_T	1.202	1.00
20_R	42_I	1.196	1.00
42_I	429_Y	1.195	1.00
341_N	345_K	1.192	1.00
335_N	338_Q	1.191	1.00
369_K	379_N	1.189	1.00
184_S	188_Q	1.181	1.00
336_M	341_N	1.181	1.00
190_K	225_L	1.176	1.00
235_H	275_A	1.172	1.00
297_F	301_S	1.169	1.00
139_L	371_L	1.169	1.00
339_T	344_Y	1.166	1.00
390_V	429_Y	1.164	1.00
191_E	194_E	1.163	1.00
277_C	295_I	1.162	1.00
19_T	39_L	1.159	1.00
339_T	342_E	1.150	1.00
187_H	190_K	1.150	1.00
287_R	290_E	1.149	1.00
201_R	205_A	1.146	1.00
25_P	40_L	1.146	1.00
323_G	367_G	1.142	1.00
306_G	309_L	1.142	1.00
190_K	228_E	1.140	1.00
51_G	55_N	1.131	1.00
233_W	372_G	1.124	1.00
154_E	158_H	1.120	1.00
81_T	371_L	1.119	1.00
149_V	153_F	1.114	1.00
298_C	301_S	1.112	1.00
18_V	42_I	1.109	1.00
120_R	158_H	1.108	1.00
339_T	343_A	1.105	1.00
124_A	128_K	1.105	1.00
81_T	296_A	1.101	1.00
189_S	192_L	1.094	1.00
166_G	169_M	1.078	1.00
189_S	196_W	1.076	1.00
24_N	35_I	1.074	1.00
323_G	366_G	1.070	1.00
69_Y	74_I	1.066	1.00
39_L	55_N	1.066	1.00
374_D	384_K	1.063	1.00
288_L	295_I	1.060	1.00
79_V	137_T	1.058	1.00
164_I	168_V	1.057	1.00
220_A	264_Q	1.056	1.00
38_G	51_G	1.055	1.00
341_N	344_Y	1.048	1.00
360_F	364_T	1.045	1.00
18_V	65_R	1.044	1.00
20_R	388_F	1.041	1.00
151_A	155_A	1.034	1.00
292_K	296_A	1.032	1.00
284_E	287_R	1.029	1.00
168_V	171_D	1.028	1.00
277_C	280_L	1.027	1.00
67_R	429_Y	1.026	1.00
342_E	345_K	1.021	1.00
39_L	51_G	1.021	1.00
391_M	425_I	1.018	1.00
181_T	184_S	1.018	1.00
61_P	64_I	1.018	1.00
185_S	188_Q	1.014	1.00
49_W	55_N	1.008	1.00
217_E	220_A	1.008	1.00
41_L	63_T	1.007	1.00
305_L	308_G	1.007	1.00
336_M	343_A	1.006	1.00
79_V	377_I	1.006	1.00
336_M	340_L	1.002	1.00
166_G	170_M	0.999	1.00
38_G	50_F	0.997	1.00
194_E	229_Y	0.986	1.00
337_L	340_L	0.985	1.00
362_L	366_G	0.985	1.00
170_M	173_N	0.982	1.00
131_L	430_V	0.978	1.00
289_S	320_V	0.978	1.00
153_F	159_I	0.975	1.00
22_I	37_D	0.974	1.00
155_A	158_H	0.973	1.00
155_A	159_I	0.972	1.00
226_K	234_V	0.970	1.00
226_K	232_T	0.962	1.00
20_R	429_Y	0.962	1.00
67_R	427_R	0.958	1.00
261_V	265_Y	0.951	1.00
354_L	362_L	0.945	1.00
128_K	132_R	0.945	1.00
334_F	337_L	0.944	1.00
167_K	170_M	0.944	1.00
314_K	352_Y	0.944	1.00
282_E	288_L	0.943	1.00
127_I	131_L	0.936	1.00
167_K	173_N	0.933	1.00
24_N	37_D	0.931	1.00
336_M	345_K	0.927	1.00
304_Y	307_S	0.926	1.00
156_A	159_I	0.925	1.00
336_M	342_E	0.921	1.00
283_K	287_R	0.921	1.00
334_F	339_T	0.917	1.00
184_S	187_H	0.915	1.00
48_E	382_P	0.915	1.00
321_K	366_G	0.911	1.00
282_E	311_N	0.909	1.00
275_A	278_V	0.906	1.00
22_I	70_R	0.905	1.00
334_F	341_N	0.904	1.00
84_H	276_H	0.904	1.00
274_F	277_C	0.903	1.00
29_A	32_L	0.903	1.00
149_V	156_A	0.900	1.00
24_N	73_L	0.899	1.00
335_N	341_N	0.894	1.00
65_R	434_L	0.892	1.00
19_T	60_I	0.890	1.00
63_T	66_V	0.890	1.00
152_L	155_A	0.888	1.00
152_L	159_I	0.887	1.00
187_H	191_E	0.877	1.00
153_F	156_A	0.876	1.00
153_F	157_S	0.874	1.00
305_L	309_L	0.873	1.00
154_E	157_S	0.867	1.00
338_Q	342_E	0.858	1.00
259_L	263_H	0.857	1.00
166_G	171_D	0.856	1.00
167_K	171_D	0.855	1.00
280_L	315_A	0.853	1.00
282_E	289_S	0.852	1.00
247_W	251_L	0.851	1.00
203_L	206_I	0.850	1.00
157_S	160_N	0.849	1.00
248_V	252_Y	0.846	1.00
85_Y	138_A	0.843	1.00
85_Y	126_F	0.842	1.00
21_T	68_D	0.842	1.00
200_G	204_Y	0.842	1.00
338_Q	344_Y	0.839	1.00
79_V	368_A	0.837	1.00
336_M	344_Y	0.836	1.00
357_Y	361_Y	0.835	1.00
397_P	424_S	0.830	1.00
79_V	371_L	0.830	1.00
168_V	173_N	0.829	1.00
47_V	388_F	0.827	1.00
22_I	71_G	0.825	1.00
298_C	325_G	0.820	1.00
149_V	155_A	0.815	1.00
20_R	67_R	0.815	1.00
193_I	232_T	0.815	1.00
27_E	30_S	0.813	1.00
363_A	367_G	0.811	1.00
249_K	252_Y	0.811	1.00
296_A	323_G	0.809	1.00
260_D	263_H	0.808	1.00
337_L	344_Y	0.807	1.00
168_V	172_R	0.806	1.00
219_M	236_T	0.802	1.00
129_Q	132_R	0.797	1.00
289_S	318_K	0.797	1.00
339_T	345_K	0.793	1.00
156_A	160_N	0.789	1.00
20_R	74_I	0.789	1.00
324_M	362_L	0.788	1.00
52_E	55_N	0.788	1.00
261_V	264_Q	0.786	1.00
24_N	36_E	0.781	1.00
199_N	203_L	0.779	1.00
162_R	166_G	0.779	1.00
389_V	428_T	0.777	1.00
304_Y	308_G	0.777	1.00
41_L	51_G	0.770	1.00
141_F	235_H	0.763	1.00
229_Y	232_T	0.762	1.00
149_V	152_L	0.761	1.00
425_I	428_T	0.759	1.00
182_A	185_S	0.758	1.00
392_E	395_A	0.758	1.00
238_L	274_F	0.756	1.00
131_L	428_T	0.755	1.00
166_G	173_N	0.753	1.00
262_Y	266_G	0.751	1.00
69_Y	72_K	0.748	1.00
281_E	284_E	0.746	1.00
392_E	424_S	0.745	1.00
193_I	196_W	0.745	1.00
365_L	384_K	0.744	1.00
125_F	129_Q	0.743	1.00
153_F	160_N	0.743	1.00
193_I	197_H	0.740	1.00
396_T	419_L	0.740	1.00
220_A	254_D	0.739	1.00
200_G	203_L	0.738	1.00
72_K	427_R	0.736	1.00
340_L	363_A	0.734	1.00
39_L	49_W	0.734	1.00
313_K	316_W	0.733	1.00
135_T	336_M	0.730	1.00
26_E	73_L	0.730	1.00
276_H	327_D	0.730	1.00
227_E	268_T	0.729	1.00
303_L	306_G	0.728	1.00
307_S	310_F	0.728	1.00
259_L	262_Y	0.727	1.00
169_M	172_R	0.725	1.00
38_G	53_W	0.723	1.00
37_D	70_R	0.723	1.00
152_L	156_A	0.722	1.00
78_F	135_T	0.722	1.00
199_N	204_Y	0.721	1.00
334_F	338_Q	0.718	1.00
152_L	160_N	0.717	1.00
260_D	283_K	0.715	1.00
84_H	237_H	0.714	1.00
137_T	387_D	0.714	1.00
223_Q	227_E	0.712	1.00
156_A	163_M	0.704	1.00
350_Q	419_L	0.703	1.00
231_D	271_N	0.702	1.00
293_S	296_A	0.700	1.00
218_Q	221_M	0.697	1.00
162_R	165_A	0.696	1.00
78_F	363_A	0.696	1.00
273_V	370_S	0.695	1.00
21_T	53_W	0.695	1.00
358_E	362_L	0.695	1.00
335_N	339_T	0.693	1.00
274_F	288_L	0.692	1.00
273_V	294_S	0.692	1.00
275_A	279_H	0.691	1.00
395_A	426_Y	0.689	1.00
150_D	153_F	0.688	1.00
263_H	287_R	0.687	1.00
262_Y	267_L	0.685	1.00
237_H	327_D	0.682	1.00
23_D	390_V	0.681	1.00
37_D	53_W	0.679	1.00
295_I	320_V	0.679	1.00
276_H	281_E	0.678	1.00
41_L	60_I	0.678	1.00
169_M	173_N	0.676	1.00
305_L	310_F	0.676	1.00
340_L	345_K	0.675	1.00
80_D	83_I	0.674	1.00
217_E	221_M	0.674	1.00
304_Y	310_F	0.673	1.00
124_A	158_H	0.673	1.00
201_R	206_I	0.672	1.00
181_T	185_S	0.668	1.00
84_H	327_D	0.667	1.00
303_L	307_S	0.664	1.00
284_E	288_L	0.664	1.00
262_Y	265_Y	0.664	1.00
337_L	343_A	0.661	1.00
282_E	318_K	0.661	1.00
150_D	155_A	0.660	1.00
223_Q	234_V	0.656	1.00
138_A	163_M	0.655	1.00
202_L	205_A	0.655	1.00
188_Q	192_L	0.653	1.00
42_I	48_E	0.653	1.00
80_D	326_T	0.651	1.00
277_C	288_L	0.648	1.00
86_P	143_T	0.646	1.00
125_F	128_K	0.646	1.00
161_M	165_A	0.646	1.00
139_L	273_V	0.646	1.00
38_G	380_F	0.645	1.00
23_D	388_F	0.645	1.00
145_H	148_S	0.643	1.00
151_A	156_A	0.642	1.00
82_H	327_D	0.641	1.00
340_L	359_A	0.641	1.00
243_D	247_W	0.640	1.00
131_L	436_Y	0.640	1.00
379_N	382_P	0.637	1.00
120_R	124_A	0.637	1.00
136_T	428_T	0.637	1.00
150_D	195_R	0.633	1.00
189_S	193_I	0.632	1.00
150_D	159_I	0.631	1.00
368_A	378_G	0.631	1.00
186_Y	190_K	0.630	1.00
268_T	271_N	0.628	1.00
144_V	148_S	0.627	1.00
40_L	50_F	0.626	1.00
276_H	280_L	0.625	1.00
275_A	296_A	0.625	1.00
276_H	279_H	0.625	1.00
32_L	361_Y	0.624	1.00
190_K	229_Y	0.624	1.00
50_F	380_F	0.623	1.00
345_K	349_L	0.622	1.00
285_W	315_A	0.622	1.00
190_K	193_I	0.619	1.00
285_W	289_S	0.618	1.00
336_M	363_A	0.612	1.00
297_F	312_L	0.612	1.00
300_T	342_E	0.611	1.00
85_Y	127_I	0.611	1.00
194_E	198_K	0.611	1.00
260_D	287_R	0.610	1.00
167_K	172_R	0.607	1.00
24_N	394_T	0.606	1.00
82_H	237_H	0.606	1.00
338_Q	343_A	0.605	1.00
129_Q	133_N	0.604	1.00
186_Y	189_S	0.603	1.00
220_A	265_Y	0.601	1.00
248_V	251_L	0.601	1.00
303_L	309_L	0.601	1.00
83_I	130_L	0.600	1.00
246_A	249_K	0.598	1.00
337_L	345_K	0.597	1.00
137_T	373_L	0.596	1.00
60_I	64_I	0.596	1.00
190_K	195_R	0.595	1.00
284_E	289_S	0.594	1.00
216_P	264_Q	0.592	1.00
199_N	202_L	0.591	1.00
22_I	69_Y	0.590	1.00
19_T	63_T	0.587	1.00
200_G	205_A	0.587	1.00
280_L	311_N	0.587	1.00
18_V	67_R	0.587	1.00
235_H	273_V	0.585	1.00
237_H	276_H	0.582	1.00
295_I	315_A	0.580	1.00
294_S	323_G	0.579	1.00
204_Y	207_T	0.578	1.00
34_F	357_Y	0.575	1.00
83_I	138_A	0.575	1.00
394_T	397_P	0.573	1.00
189_S	194_E	0.573	1.00
137_T	371_L	0.572	1.00
155_A	160_N	0.572	1.00
273_V	296_A	0.571	1.00
335_N	342_E	0.571	1.00
202_L	206_I	0.570	1.00
393_P	419_L	0.567	1.00
292_K	298_C	0.566	1.00
141_F	275_A	0.566	1.00
205_A	208_P	0.564	1.00
49_W	54_E	0.564	1.00
26_E	360_F	0.561	1.00
161_M	170_M	0.561	1.00
161_M	164_I	0.558	1.00
161_M	166_G	0.557	1.00
295_I	298_C	0.557	1.00
335_N	340_L	0.556	1.00
322_V	362_L	0.555	1.00
195_R	198_K	0.554	1.00
183_E	189_S	0.551	1.00
283_K	289_S	0.551	1.00
199_N	205_A	0.550	1.00
296_A	300_T	0.549	1.00
395_A	424_S	0.548	1.00
419_L	422_D	0.547	1.00
192_L	196_W	0.547	1.00
31_A	34_F	0.546	1.00
194_E	197_H	0.546	1.00
23_D	71_G	0.545	1.00
377_I	384_K	0.545	1.00
427_R	436_Y	0.542	1.00
128_K	159_I	0.541	1.00
82_H	276_H	0.541	1.00
37_D	52_E	0.540	1.00
136_T	387_D	0.539	1.00
158_H	161_M	0.539	1.00
32_L	35_I	0.538	1.00
164_I	170_M	0.538	1.00
239_C	278_V	0.535	1.00
298_C	302_N	0.534	1.00
263_H	266_G	0.533	1.00
227_E	271_N	0.533	1.00
356_A	396_T	0.533	1.00
209_R	212_P	0.531	1.00
285_W	314_K	0.530	1.00
163_M	170_M	0.530	1.00
163_M	167_K	0.530	1.00
210_F	213_T	0.528	1.00
274_F	293_S	0.526	1.00
30_S	33_R	0.525	1.00
182_A	189_S	0.524	1.00
221_M	225_L	0.524	1.00
152_L	157_S	0.524	1.00
181_T	189_S	0.524	1.00
338_Q	345_K	0.523	1.00
185_S	193_I	0.521	1.00
192_L	195_R	0.520	1.00
242_K	246_A	0.520	1.00
377_I	387_D	0.520	1.00
335_N	344_Y	0.520	1.00
40_L	47_V	0.516	1.00
354_L	358_E	0.514	1.00
188_Q	195_R	0.511	1.00
180_D	184_S	0.510	1.00
26_E	357_Y	0.509	1.00
127_I	161_M	0.509	1.00
224_R	227_E	0.507	1.00
186_Y	221_M	0.506	1.00
288_L	320_V	0.506	1.00
324_M	343_A	0.506	1.00
85_Y	140_V	0.505	1.00
161_M	167_K	0.504	1.00
313_K	358_E	0.504	1.00
41_L	54_E	0.503	1.00
199_N	207_T	0.502	1.00
130_L	135_T	0.501	1.00
274_F	279_H	0.500	1.00
67_R	434_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2oodA	2	0.959	100	0.272	Contact Map
4dzhA	2	0.9339	100	0.296	Contact Map
3lnpA	2	0.9226	100	0.298	Contact Map
2i9uA	2	0.9294	100	0.298	Contact Map
3ls9A	2	0.9226	100	0.301	Contact Map
2pajA	2	0.8428	100	0.302	Contact Map
4aqlA	2	0.9613	100	0.31	Contact Map
3hpaA	2	0.8884	100	0.317	Contact Map
4gbdA	2	0.9271	100	0.318	Contact Map
4f0rA	2	0.9248	100	0.323	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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