GREMLIN Database
GUAD - Guanine deaminase
UniProt: P76641 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13066
Length: 439 (354)
Sequences: 27262 (21269)
Seq/√Len: 1130.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
429_Y434_L4.7941.00
379_N384_K4.2141.00
72_K426_Y4.0331.00
43_K48_E3.9421.00
427_R434_L3.8121.00
20_R69_Y3.3321.00
355_S358_E3.0831.00
69_Y390_V2.9721.00
21_T66_V2.9401.00
77_G136_T2.9101.00
381_L384_K2.9081.00
75_V391_M2.8021.00
385_E431_D2.7781.00
23_D69_Y2.7711.00
49_W382_P2.6731.00
313_K317_Q2.6491.00
361_Y365_L2.4921.00
373_L377_I2.3661.00
286_D318_K2.3081.00
321_K369_K2.3061.00
45_G385_E2.2951.00
75_V389_V2.2781.00
377_I385_E2.2291.00
225_L228_E2.2141.00
131_L435_V2.1721.00
46_K385_E2.1171.00
358_E361_Y2.1151.00
286_D290_E2.0441.00
39_L54_E1.9711.00
361_Y366_G1.9241.00
366_G369_K1.8971.00
74_I390_V1.8881.00
263_H291_T1.8821.00
51_G54_E1.8741.00
72_K392_E1.8121.00
311_N314_K1.8111.00
40_L74_I1.8091.00
42_I388_F1.8041.00
18_V429_Y1.7891.00
392_E426_Y1.7791.00
132_R436_Y1.7781.00
19_T41_L1.7781.00
388_F429_Y1.7771.00
323_G370_S1.7751.00
41_L49_W1.7561.00
45_G431_D1.7501.00
41_L64_I1.7341.00
365_L379_N1.7181.00
380_F388_F1.6961.00
25_P38_G1.6631.00
74_I388_F1.6601.00
428_T436_Y1.6571.00
316_W358_E1.6551.00
72_K390_V1.6431.00
188_Q191_E1.6331.00
260_D264_Q1.6211.00
50_F382_P1.6211.00
75_V78_F1.5871.00
40_L380_F1.5591.00
35_I38_G1.5591.00
282_E314_K1.5421.00
190_K194_E1.5391.00
369_K374_D1.5341.00
216_P220_A1.5331.00
365_L369_K1.5311.00
338_Q341_N1.5261.00
375_D384_K1.4981.00
40_L388_F1.4981.00
29_A381_L1.4951.00
220_A224_R1.4761.00
22_I68_D1.4721.00
21_T39_L1.4671.00
29_A33_R1.4621.00
287_R291_T1.4511.00
201_R204_Y1.4421.00
282_E286_D1.4291.00
294_S321_K1.4271.00
183_E187_H1.4221.00
191_E195_R1.4191.00
23_D74_I1.4161.00
130_L138_A1.3941.00
120_R154_E1.3891.00
81_T323_G1.3871.00
254_D264_Q1.3861.00
283_K286_D1.3821.00
294_S370_S1.3811.00
39_L53_W1.3761.00
38_G52_E1.3751.00
306_G310_F1.3661.00
304_Y309_L1.3521.00
75_V360_F1.3431.00
430_V435_V1.3421.00
315_A320_V1.3371.00
225_L229_Y1.3321.00
224_R228_E1.3261.00
285_W318_K1.3251.00
314_K318_K1.3121.00
150_D154_E1.3041.00
151_A154_E1.3031.00
47_V380_F1.3021.00
337_L341_N1.3001.00
221_M224_R1.2941.00
73_L393_P1.2751.00
215_S218_Q1.2721.00
41_L48_E1.2701.00
246_A250_S1.2671.00
247_W250_S1.2511.00
344_Y359_A1.2441.00
137_T377_I1.2371.00
389_V425_I1.2361.00
336_M339_T1.2341.00
79_V367_G1.2311.00
390_V427_R1.2231.00
81_T367_G1.2121.00
286_D289_S1.2081.00
314_K317_Q1.2041.00
288_L291_T1.2021.00
20_R42_I1.1961.00
42_I429_Y1.1951.00
341_N345_K1.1921.00
335_N338_Q1.1911.00
369_K379_N1.1891.00
184_S188_Q1.1811.00
336_M341_N1.1811.00
190_K225_L1.1761.00
235_H275_A1.1721.00
297_F301_S1.1691.00
139_L371_L1.1691.00
339_T344_Y1.1661.00
390_V429_Y1.1641.00
191_E194_E1.1631.00
277_C295_I1.1621.00
19_T39_L1.1591.00
339_T342_E1.1501.00
187_H190_K1.1501.00
287_R290_E1.1491.00
201_R205_A1.1461.00
25_P40_L1.1461.00
323_G367_G1.1421.00
306_G309_L1.1421.00
190_K228_E1.1401.00
51_G55_N1.1311.00
233_W372_G1.1241.00
154_E158_H1.1201.00
81_T371_L1.1191.00
149_V153_F1.1141.00
298_C301_S1.1121.00
18_V42_I1.1091.00
120_R158_H1.1081.00
339_T343_A1.1051.00
124_A128_K1.1051.00
81_T296_A1.1011.00
189_S192_L1.0941.00
166_G169_M1.0781.00
189_S196_W1.0761.00
24_N35_I1.0741.00
323_G366_G1.0701.00
69_Y74_I1.0661.00
39_L55_N1.0661.00
374_D384_K1.0631.00
288_L295_I1.0601.00
79_V137_T1.0581.00
164_I168_V1.0571.00
220_A264_Q1.0561.00
38_G51_G1.0551.00
341_N344_Y1.0481.00
360_F364_T1.0451.00
18_V65_R1.0441.00
20_R388_F1.0411.00
151_A155_A1.0341.00
292_K296_A1.0321.00
284_E287_R1.0291.00
168_V171_D1.0281.00
277_C280_L1.0271.00
67_R429_Y1.0261.00
342_E345_K1.0211.00
39_L51_G1.0211.00
391_M425_I1.0181.00
181_T184_S1.0181.00
61_P64_I1.0181.00
185_S188_Q1.0141.00
49_W55_N1.0081.00
217_E220_A1.0081.00
41_L63_T1.0071.00
305_L308_G1.0071.00
336_M343_A1.0061.00
79_V377_I1.0061.00
336_M340_L1.0021.00
166_G170_M0.9991.00
38_G50_F0.9971.00
194_E229_Y0.9861.00
337_L340_L0.9851.00
362_L366_G0.9851.00
170_M173_N0.9821.00
131_L430_V0.9781.00
289_S320_V0.9781.00
153_F159_I0.9751.00
22_I37_D0.9741.00
155_A158_H0.9731.00
155_A159_I0.9721.00
226_K234_V0.9701.00
226_K232_T0.9621.00
20_R429_Y0.9621.00
67_R427_R0.9581.00
261_V265_Y0.9511.00
354_L362_L0.9451.00
128_K132_R0.9451.00
334_F337_L0.9441.00
167_K170_M0.9441.00
314_K352_Y0.9441.00
282_E288_L0.9431.00
127_I131_L0.9361.00
167_K173_N0.9331.00
24_N37_D0.9311.00
336_M345_K0.9271.00
304_Y307_S0.9261.00
156_A159_I0.9251.00
336_M342_E0.9211.00
283_K287_R0.9211.00
334_F339_T0.9171.00
184_S187_H0.9151.00
48_E382_P0.9151.00
321_K366_G0.9111.00
282_E311_N0.9091.00
275_A278_V0.9061.00
22_I70_R0.9051.00
334_F341_N0.9041.00
84_H276_H0.9041.00
274_F277_C0.9031.00
29_A32_L0.9031.00
149_V156_A0.9001.00
24_N73_L0.8991.00
335_N341_N0.8941.00
65_R434_L0.8921.00
19_T60_I0.8901.00
63_T66_V0.8901.00
152_L155_A0.8881.00
152_L159_I0.8871.00
187_H191_E0.8771.00
153_F156_A0.8761.00
153_F157_S0.8741.00
305_L309_L0.8731.00
154_E157_S0.8671.00
338_Q342_E0.8581.00
259_L263_H0.8571.00
166_G171_D0.8561.00
167_K171_D0.8551.00
280_L315_A0.8531.00
282_E289_S0.8521.00
247_W251_L0.8511.00
203_L206_I0.8501.00
157_S160_N0.8491.00
248_V252_Y0.8461.00
85_Y138_A0.8431.00
85_Y126_F0.8421.00
21_T68_D0.8421.00
200_G204_Y0.8421.00
338_Q344_Y0.8391.00
79_V368_A0.8371.00
336_M344_Y0.8361.00
357_Y361_Y0.8351.00
397_P424_S0.8301.00
79_V371_L0.8301.00
168_V173_N0.8291.00
47_V388_F0.8271.00
22_I71_G0.8251.00
298_C325_G0.8201.00
149_V155_A0.8151.00
20_R67_R0.8151.00
193_I232_T0.8151.00
27_E30_S0.8131.00
363_A367_G0.8111.00
249_K252_Y0.8111.00
296_A323_G0.8091.00
260_D263_H0.8081.00
337_L344_Y0.8071.00
168_V172_R0.8061.00
219_M236_T0.8021.00
129_Q132_R0.7971.00
289_S318_K0.7971.00
339_T345_K0.7931.00
156_A160_N0.7891.00
20_R74_I0.7891.00
324_M362_L0.7881.00
52_E55_N0.7881.00
261_V264_Q0.7861.00
24_N36_E0.7811.00
199_N203_L0.7791.00
162_R166_G0.7791.00
389_V428_T0.7771.00
304_Y308_G0.7771.00
41_L51_G0.7701.00
141_F235_H0.7631.00
229_Y232_T0.7621.00
149_V152_L0.7611.00
425_I428_T0.7591.00
182_A185_S0.7581.00
392_E395_A0.7581.00
238_L274_F0.7561.00
131_L428_T0.7551.00
166_G173_N0.7531.00
262_Y266_G0.7511.00
69_Y72_K0.7481.00
281_E284_E0.7461.00
392_E424_S0.7451.00
193_I196_W0.7451.00
365_L384_K0.7441.00
125_F129_Q0.7431.00
153_F160_N0.7431.00
193_I197_H0.7401.00
396_T419_L0.7401.00
220_A254_D0.7391.00
200_G203_L0.7381.00
72_K427_R0.7361.00
340_L363_A0.7341.00
39_L49_W0.7341.00
313_K316_W0.7331.00
135_T336_M0.7301.00
26_E73_L0.7301.00
276_H327_D0.7301.00
227_E268_T0.7291.00
303_L306_G0.7281.00
307_S310_F0.7281.00
259_L262_Y0.7271.00
169_M172_R0.7251.00
38_G53_W0.7231.00
37_D70_R0.7231.00
152_L156_A0.7221.00
78_F135_T0.7221.00
199_N204_Y0.7211.00
334_F338_Q0.7181.00
152_L160_N0.7171.00
260_D283_K0.7151.00
84_H237_H0.7141.00
137_T387_D0.7141.00
223_Q227_E0.7121.00
156_A163_M0.7041.00
350_Q419_L0.7031.00
231_D271_N0.7021.00
293_S296_A0.7001.00
218_Q221_M0.6971.00
162_R165_A0.6961.00
78_F363_A0.6961.00
273_V370_S0.6951.00
21_T53_W0.6951.00
358_E362_L0.6951.00
335_N339_T0.6931.00
274_F288_L0.6921.00
273_V294_S0.6921.00
275_A279_H0.6911.00
395_A426_Y0.6891.00
150_D153_F0.6881.00
263_H287_R0.6871.00
262_Y267_L0.6851.00
237_H327_D0.6821.00
23_D390_V0.6811.00
37_D53_W0.6791.00
295_I320_V0.6791.00
276_H281_E0.6781.00
41_L60_I0.6781.00
169_M173_N0.6761.00
305_L310_F0.6761.00
340_L345_K0.6751.00
80_D83_I0.6741.00
217_E221_M0.6741.00
304_Y310_F0.6731.00
124_A158_H0.6731.00
201_R206_I0.6721.00
181_T185_S0.6681.00
84_H327_D0.6671.00
303_L307_S0.6641.00
284_E288_L0.6641.00
262_Y265_Y0.6641.00
337_L343_A0.6611.00
282_E318_K0.6611.00
150_D155_A0.6601.00
223_Q234_V0.6561.00
138_A163_M0.6551.00
202_L205_A0.6551.00
188_Q192_L0.6531.00
42_I48_E0.6531.00
80_D326_T0.6511.00
277_C288_L0.6481.00
86_P143_T0.6461.00
125_F128_K0.6461.00
161_M165_A0.6461.00
139_L273_V0.6461.00
38_G380_F0.6451.00
23_D388_F0.6451.00
145_H148_S0.6431.00
151_A156_A0.6421.00
82_H327_D0.6411.00
340_L359_A0.6411.00
243_D247_W0.6401.00
131_L436_Y0.6401.00
379_N382_P0.6371.00
120_R124_A0.6371.00
136_T428_T0.6371.00
150_D195_R0.6331.00
189_S193_I0.6321.00
150_D159_I0.6311.00
368_A378_G0.6311.00
186_Y190_K0.6301.00
268_T271_N0.6281.00
144_V148_S0.6271.00
40_L50_F0.6261.00
276_H280_L0.6251.00
275_A296_A0.6251.00
276_H279_H0.6251.00
32_L361_Y0.6241.00
190_K229_Y0.6241.00
50_F380_F0.6231.00
345_K349_L0.6221.00
285_W315_A0.6221.00
190_K193_I0.6191.00
285_W289_S0.6181.00
336_M363_A0.6121.00
297_F312_L0.6121.00
300_T342_E0.6111.00
85_Y127_I0.6111.00
194_E198_K0.6111.00
260_D287_R0.6101.00
167_K172_R0.6071.00
24_N394_T0.6061.00
82_H237_H0.6061.00
338_Q343_A0.6051.00
129_Q133_N0.6041.00
186_Y189_S0.6031.00
220_A265_Y0.6011.00
248_V251_L0.6011.00
303_L309_L0.6011.00
83_I130_L0.6001.00
246_A249_K0.5981.00
337_L345_K0.5971.00
137_T373_L0.5961.00
60_I64_I0.5961.00
190_K195_R0.5951.00
284_E289_S0.5941.00
216_P264_Q0.5921.00
199_N202_L0.5911.00
22_I69_Y0.5901.00
19_T63_T0.5871.00
200_G205_A0.5871.00
280_L311_N0.5871.00
18_V67_R0.5871.00
235_H273_V0.5851.00
237_H276_H0.5821.00
295_I315_A0.5801.00
294_S323_G0.5791.00
204_Y207_T0.5781.00
34_F357_Y0.5751.00
83_I138_A0.5751.00
394_T397_P0.5731.00
189_S194_E0.5731.00
137_T371_L0.5721.00
155_A160_N0.5721.00
273_V296_A0.5711.00
335_N342_E0.5711.00
202_L206_I0.5701.00
393_P419_L0.5671.00
292_K298_C0.5661.00
141_F275_A0.5661.00
205_A208_P0.5641.00
49_W54_E0.5641.00
26_E360_F0.5611.00
161_M170_M0.5611.00
161_M164_I0.5581.00
161_M166_G0.5571.00
295_I298_C0.5571.00
335_N340_L0.5561.00
322_V362_L0.5551.00
195_R198_K0.5541.00
183_E189_S0.5511.00
283_K289_S0.5511.00
199_N205_A0.5501.00
296_A300_T0.5491.00
395_A424_S0.5481.00
419_L422_D0.5471.00
192_L196_W0.5471.00
31_A34_F0.5461.00
194_E197_H0.5461.00
23_D71_G0.5451.00
377_I384_K0.5451.00
427_R436_Y0.5421.00
128_K159_I0.5411.00
82_H276_H0.5411.00
37_D52_E0.5401.00
136_T387_D0.5391.00
158_H161_M0.5391.00
32_L35_I0.5381.00
164_I170_M0.5381.00
239_C278_V0.5351.00
298_C302_N0.5341.00
263_H266_G0.5331.00
227_E271_N0.5331.00
356_A396_T0.5331.00
209_R212_P0.5311.00
285_W314_K0.5301.00
163_M170_M0.5301.00
163_M167_K0.5301.00
210_F213_T0.5281.00
274_F293_S0.5261.00
30_S33_R0.5251.00
182_A189_S0.5241.00
221_M225_L0.5241.00
152_L157_S0.5241.00
181_T189_S0.5241.00
338_Q345_K0.5231.00
185_S193_I0.5211.00
192_L195_R0.5201.00
242_K246_A0.5201.00
377_I387_D0.5201.00
335_N344_Y0.5201.00
40_L47_V0.5161.00
354_L358_E0.5141.00
188_Q195_R0.5111.00
180_D184_S0.5101.00
26_E357_Y0.5091.00
127_I161_M0.5091.00
224_R227_E0.5071.00
186_Y221_M0.5061.00
288_L320_V0.5061.00
324_M343_A0.5061.00
85_Y140_V0.5051.00
161_M167_K0.5041.00
313_K358_E0.5041.00
41_L54_E0.5031.00
199_N207_T0.5021.00
130_L135_T0.5011.00
274_F279_H0.5001.00
67_R434_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oodA 2 0.959 100 0.272 Contact Map
4dzhA 2 0.9339 100 0.296 Contact Map
3lnpA 2 0.9226 100 0.298 Contact Map
2i9uA 2 0.9294 100 0.298 Contact Map
3ls9A 2 0.9226 100 0.301 Contact Map
2pajA 2 0.8428 100 0.302 Contact Map
4aqlA 2 0.9613 100 0.31 Contact Map
3hpaA 2 0.8884 100 0.317 Contact Map
4gbdA 2 0.9271 100 0.318 Contact Map
4f0rA 2 0.9248 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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