GREMLIN Database
YGEH - Uncharacterized protein YgeH
UniProt: P76639 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13038
Length: 458 (396)
Sequences: 1974 (1716)
Seq/√Len: 86.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
353_Q356_V6.4821.00
422_P425_N6.4041.00
387_K390_E6.0571.00
379_A395_I4.7701.00
319_A322_K4.1271.00
42_V56_I3.9641.00
345_G361_F3.8321.00
159_A162_N3.5841.00
262_G281_F3.5501.00
158_M161_T3.3491.00
46_S49_H3.2671.00
413_E430_Y3.2341.00
273_S276_R3.1901.00
341_L360_L2.9851.00
402_E406_R2.6971.00
158_M162_N2.5021.00
47_A51_V2.4421.00
44_L101_F2.4291.00
403_P406_R2.3631.00
302_A327_L2.2361.00
200_L210_A2.2191.00
256_S260_L2.1851.00
39_V60_V2.1851.00
402_E405_R2.1831.00
159_A164_C2.1711.00
197_Y200_L2.1691.00
181_Y186_R2.1641.00
46_S55_M2.1481.00
417_M422_P2.1171.00
278_M282_D2.0961.00
36_E74_C2.0931.00
69_E72_T2.0881.00
281_F300_L2.0721.00
381_V385_N2.0321.00
22_I29_Q2.0171.00
207_F210_A2.0091.00
21_G38_G2.0081.00
392_R420_P1.9471.00
70_S73_R1.9211.00
291_Q294_K1.8841.00
158_M163_F1.8751.00
358_H362_E1.8671.00
358_H381_V1.8611.00
200_L204_K1.8581.00
258_E280_I1.8501.00
74_C77_S1.8411.00
328_D344_M1.8301.00
362_E378_R1.8211.00
382_H387_K1.8161.00
218_E222_T1.8141.00
161_T164_C1.8051.00
70_S74_C1.7931.00
278_M304_C1.7811.00
42_V46_S1.7621.00
25_Q28_E1.7591.00
33_P74_C1.7361.00
375_Y394_C1.7201.00
278_M301_L1.7141.00
358_H385_N1.7141.00
158_M164_C1.7131.00
298_Y326_L1.7081.00
182_F186_R1.7021.00
204_K207_F1.6871.00
73_R77_S1.6821.00
382_H394_C1.6821.00
417_M425_N1.6771.00
177_F181_Y1.6731.00
348_T356_V1.6631.00
215_P218_E1.6571.00
348_T353_Q1.6451.00
282_D301_L1.6371.00
396_D412_K1.6311.00
201_I205_N1.6151.00
375_Y397_K1.5951.00
42_V60_V1.5801.00
237_P245_K1.5601.00
229_N233_T1.5501.00
355_K385_N1.5461.00
242_R245_K1.5421.00
117_D125_F1.5311.00
56_I71_L1.5261.00
181_Y185_G1.5101.00
36_E77_S1.5061.00
181_Y187_I1.5051.00
392_R412_K1.4950.99
92_E100_R1.4800.99
278_M308_L1.4740.99
62_K70_S1.4690.99
37_L41_I1.4650.99
178_K181_Y1.4630.99
33_P73_R1.4630.99
413_E433_E1.4550.99
204_K210_A1.4450.99
191_N200_L1.4380.99
53_K68_D1.4230.99
45_E59_S1.4140.99
361_F377_Y1.4070.99
283_R286_N1.4010.99
290_I293_L1.3870.99
120_I125_F1.3590.99
358_H378_R1.3540.99
44_L47_A1.3490.99
358_H382_H1.3440.99
219_L222_T1.3430.99
229_N234_V1.3170.99
418_Y423_L1.3050.99
205_N208_L1.3000.99
280_I284_L1.2980.99
193_V200_L1.2950.99
200_L203_A1.2920.99
342_A377_Y1.2870.98
159_A163_F1.2830.98
347_I351_S1.2770.98
76_Y80_C1.2660.98
146_S155_T1.2650.98
412_K417_M1.2640.98
78_L91_I1.2640.98
193_V197_Y1.2550.98
196_L200_L1.2470.98
42_V59_S1.2440.98
69_E73_R1.2410.98
417_M429_L1.2400.98
418_Y427_I1.2400.98
261_A264_K1.2360.98
37_L66_V1.2350.98
60_V70_S1.2310.98
44_L103_G1.2250.98
174_L177_F1.2200.98
378_R382_H1.2190.98
324_L328_D1.2090.98
354_A381_V1.2090.98
21_G37_L1.2090.98
393_I397_K1.2060.98
37_L60_V1.1940.97
123_F126_T1.1940.97
298_Y329_Y1.1890.97
57_I68_D1.1880.97
382_H385_N1.1850.97
118_Y121_A1.1830.97
220_H223_S1.1720.97
362_E390_E1.1700.97
138_N142_V1.1660.97
257_D264_K1.1580.97
329_Y333_I1.1470.97
415_V420_P1.1370.97
158_M165_N1.1370.97
209_I213_H1.1300.96
40_L78_L1.1280.96
232_Q236_K1.1260.96
120_I123_F1.1220.96
254_Y258_E1.1180.96
348_T360_L1.1180.96
84_K88_D1.1170.96
423_L427_I1.1170.96
218_E223_S1.1120.96
201_I204_K1.1090.96
52_L55_M1.0980.96
90_C103_G1.0940.96
116_S125_F1.0920.96
101_F105_V1.0910.96
43_L51_V1.0910.96
33_P77_S1.0840.96
301_L305_H1.0840.96
41_I45_E1.0820.96
358_H387_K1.0700.95
72_T76_Y1.0640.95
77_S97_K1.0620.95
53_K72_T1.0610.95
259_M294_K1.0600.95
33_P60_V1.0590.95
262_G266_L1.0580.95
363_Q366_I1.0580.95
205_N210_A1.0570.95
390_E393_I1.0550.95
50_V98_G1.0500.95
344_M360_L1.0490.95
392_R415_V1.0440.95
72_T75_I1.0380.94
197_Y204_K1.0350.94
231_L235_H1.0340.94
216_V219_L1.0280.94
395_I411_I1.0260.94
223_S233_T1.0220.94
35_K60_V1.0200.94
34_Q70_S1.0200.94
225_F229_N1.0180.94
118_Y125_F1.0180.94
58_E63_N1.0150.94
121_A124_P1.0140.94
176_R181_Y1.0070.93
395_I415_V1.0060.93
67_S74_C1.0030.93
218_E224_Q0.9990.93
70_S77_S0.9990.93
203_A210_A0.9980.93
33_P36_E0.9970.93
304_C307_S0.9930.93
39_V51_V0.9920.93
46_S59_S0.9820.93
365_K374_L0.9820.93
257_D261_A0.9800.92
379_A411_I0.9780.92
417_M420_P0.9770.92
202_D205_N0.9770.92
92_E102_S0.9770.92
50_V97_K0.9750.92
35_K71_L0.9750.92
75_I99_Y0.9750.92
285_Q298_Y0.9680.92
231_L234_V0.9650.92
389_E420_P0.9650.92
134_P138_N0.9630.92
329_Y332_D0.9610.92
207_F211_S0.9590.92
324_L351_S0.9590.92
392_R396_D0.9560.92
414_C419_V0.9530.91
78_L82_F0.9530.91
282_D322_K0.9460.91
383_F395_I0.9430.91
72_T101_F0.9400.91
412_K415_V0.9380.91
177_F186_R0.9370.91
220_H224_Q0.9330.91
327_L347_I0.9320.90
53_K62_K0.9290.90
382_H390_E0.9230.90
219_L223_S0.9160.90
361_F378_R0.9150.90
129_L132_L0.9070.89
354_A358_H0.8990.89
210_A214_L0.8950.89
21_G74_C0.8940.89
330_V333_I0.8910.88
255_L262_G0.8900.88
218_E226_I0.8900.88
294_K297_C0.8880.88
345_G377_Y0.8860.88
153_L157_P0.8840.88
57_I65_I0.8790.88
346_L350_L0.8780.88
104_Q107_K0.8780.88
21_G33_P0.8770.88
172_S176_R0.8760.88
53_K93_T0.8760.88
163_F176_R0.8680.87
338_G364_A0.8680.87
262_G267_Y0.8680.87
141_L148_K0.8670.87
305_H326_L0.8650.87
66_V97_K0.8640.87
260_L264_K0.8630.87
84_K90_C0.8620.87
222_T226_I0.8580.86
216_V220_H0.8580.86
375_Y401_L0.8540.86
364_A374_L0.8530.86
178_K182_F0.8520.86
223_S229_N0.8510.86
344_M348_T0.8490.86
406_R413_E0.8480.86
200_L211_S0.8470.86
304_C308_L0.8450.86
120_I124_P0.8440.86
296_E300_L0.8440.86
24_T78_L0.8420.85
205_N212_N0.8410.85
36_E39_V0.8360.85
57_I62_K0.8350.85
217_D220_H0.8260.84
118_Y123_F0.8260.84
219_L224_Q0.8240.84
152_G156_Y0.8200.84
409_V417_M0.8100.83
57_I70_S0.8090.83
32_I81_I0.8060.83
35_K74_C0.8030.83
241_V245_K0.8000.82
41_I60_V0.7980.82
257_D262_G0.7950.82
341_L345_G0.7930.82
79_R99_Y0.7910.82
24_T29_Q0.7910.82
322_K326_L0.7900.82
220_H234_V0.7900.82
52_L97_K0.7870.81
193_V196_L0.7860.81
392_R417_M0.7850.81
224_Q229_N0.7850.81
395_I408_A0.7820.81
328_D356_V0.7810.81
305_H322_K0.7780.81
35_K73_R0.7770.80
196_L202_D0.7770.80
357_S381_V0.7750.80
389_E422_P0.7740.80
164_C168_I0.7740.80
84_K89_R0.7730.80
220_H227_I0.7710.80
224_Q233_T0.7710.80
33_P67_S0.7710.80
327_L343_I0.7700.80
69_E74_C0.7690.80
383_F415_V0.7680.80
140_E153_L0.7670.80
222_T234_V0.7670.80
356_V359_I0.7590.79
418_Y422_P0.7580.79
161_T165_N0.7570.79
250_Y253_H0.7560.79
297_C304_C0.7540.78
210_A213_H0.7540.78
323_A347_I0.7530.78
205_N211_S0.7530.78
35_K38_G0.7500.78
32_I36_E0.7480.78
388_I392_R0.7470.78
338_G345_G0.7450.78
345_G360_L0.7440.78
410_V430_Y0.7440.78
375_Y382_H0.7440.78
237_P241_V0.7410.77
178_K186_R0.7400.77
254_Y283_R0.7390.77
97_K100_R0.7370.77
226_I235_H0.7320.76
116_S122_I0.7310.76
95_Y99_Y0.7300.76
37_L96_R0.7290.76
249_G253_H0.7270.76
60_V73_R0.7270.76
346_L376_Y0.7260.76
238_E242_R0.7230.75
50_V102_S0.7220.75
19_E24_T0.7220.75
33_P38_G0.7220.75
414_C418_Y0.7200.75
205_N209_I0.7180.75
73_R76_Y0.7180.75
72_T100_R0.7160.75
174_L178_K0.7140.75
90_C101_F0.7120.74
321_Q351_S0.7120.74
320_A347_I0.7090.74
140_E156_Y0.7070.74
341_L344_M0.7070.74
146_S158_M0.7070.74
223_S231_L0.7070.74
197_Y201_I0.7070.74
64_I70_S0.7060.74
257_D260_L0.7040.74
73_R100_R0.7040.74
117_D120_I0.7020.73
22_I70_S0.7010.73
230_I234_V0.6990.73
78_L86_G0.6990.73
21_G96_R0.6970.73
262_G277_A0.6960.73
383_F388_I0.6960.73
35_K70_S0.6950.73
290_I294_K0.6950.73
88_D102_S0.6940.72
219_L234_V0.6920.72
86_G90_C0.6920.72
362_E366_I0.6900.72
230_I233_T0.6890.72
93_T96_R0.6890.72
159_A177_F0.6890.72
266_L281_F0.6870.72
396_D425_N0.6850.71
35_K69_E0.6840.71
77_S80_C0.6820.71
331_S341_L0.6820.71
33_P69_E0.6810.71
48_G99_Y0.6800.71
246_Q250_Y0.6800.71
183_V186_R0.6790.71
69_E75_I0.6780.71
19_E41_I0.6760.70
125_F185_G0.6740.70
177_F187_I0.6740.70
118_Y124_P0.6730.70
232_Q235_H0.6730.70
259_M264_K0.6720.70
366_I370_D0.6670.69
144_I155_T0.6660.69
25_Q84_K0.6650.69
195_T220_H0.6630.69
21_G72_T0.6630.69
117_D122_I0.6630.69
365_K371_I0.6630.69
281_F301_L0.6630.69
222_T233_T0.6630.69
204_K208_L0.6620.69
419_V423_L0.6620.69
144_I157_P0.6610.69
324_L327_L0.6600.69
72_T93_T0.6570.68
239_R242_R0.6560.68
127_T130_N0.6530.68
218_E230_I0.6520.68
20_D109_K0.6490.67
78_L95_Y0.6490.67
403_P407_K0.6480.67
223_S226_I0.6430.67
324_L348_T0.6420.67
73_R78_L0.6390.66
36_E70_S0.6370.66
67_S70_S0.6360.66
246_Q249_G0.6340.66
327_L333_I0.6330.65
77_S96_R0.6320.65
349_G382_H0.6310.65
200_L214_L0.6300.65
215_P220_H0.6290.65
19_E22_I0.6260.65
55_M59_S0.6240.64
144_I156_Y0.6220.64
388_I415_V0.6210.64
78_L99_Y0.6190.64
117_D123_F0.6190.64
397_K400_Q0.6190.64
305_H319_A0.6180.64
195_T206_L0.6170.63
35_K77_S0.6170.63
409_V429_L0.6170.63
209_I212_N0.6160.63
282_D286_N0.6150.63
215_P222_T0.6130.63
122_I125_F0.6120.63
176_R179_P0.6110.63
346_L349_G0.6110.63
56_I70_S0.6090.62
46_S101_F0.6080.62
218_E234_V0.6080.62
207_F212_N0.6070.62
300_L304_C0.6070.62
33_P37_L0.6050.62
57_I66_V0.6050.62
181_Y184_T0.6050.62
189_Q205_N0.6040.62
193_V204_K0.6030.62
44_L78_L0.6030.62
53_K66_V0.6020.62
117_D121_A0.6010.61
318_L352_G0.6010.61
57_I60_V0.6010.61
219_L226_I0.6010.61
36_E73_R0.6010.61
327_L340_I0.6000.61
193_V201_I0.6000.61
71_L75_I0.5960.61
39_V73_R0.5950.61
67_S72_T0.5940.61
91_I94_I0.5920.60
53_K101_F0.5920.60
396_D428_K0.5920.60
33_P72_T0.5920.60
38_G55_M0.5910.60
277_A281_F0.5910.60
93_T98_G0.5910.60
231_L236_K0.5910.60
378_R394_C0.5880.60
409_V415_V0.5870.60
25_Q89_R0.5870.60
103_G106_F0.5860.60
223_S234_V0.5840.59
200_L212_N0.5830.59
302_A326_L0.5810.59
141_L146_S0.5810.59
402_E407_K0.5800.59
255_L284_L0.5790.59
341_L367_H0.5770.58
36_E76_Y0.5770.58
175_S178_K0.5760.58
50_V53_K0.5750.58
205_N214_L0.5740.58
128_S133_D0.5740.58
62_K65_I0.5720.58
346_L361_F0.5720.58
36_E97_K0.5710.58
178_K187_I0.5710.58
227_I230_I0.5700.57
224_Q234_V0.5700.57
262_G280_I0.5690.57
225_F231_L0.5690.57
419_V427_I0.5680.57
398_S431_Y0.5680.57
255_L260_L0.5650.57
118_Y122_I0.5630.57
419_V430_Y0.5630.57
320_A350_L0.5630.57
412_K429_L0.5620.56
360_L386_E0.5620.56
216_V223_S0.5610.56
399_L412_K0.5600.56
191_N197_Y0.5590.56
53_K57_I0.5590.56
117_D124_P0.5590.56
237_P240_S0.5580.56
140_E146_S0.5570.56
80_C83_E0.5560.56
127_T136_I0.5560.56
274_I304_C0.5550.55
59_S68_D0.5540.55
50_V60_V0.5530.55
23_L97_K0.5520.55
352_G421_N0.5520.55
169_S172_S0.5510.55
121_A126_T0.5510.55
38_G41_I0.5500.55
331_S344_M0.5500.55
220_H226_I0.5500.55
411_I433_E0.5490.55
37_L67_S0.5480.55
62_K66_V0.5480.55
345_G371_I0.5480.55
41_I46_S0.5480.55
380_L383_F0.5480.55
422_P428_K0.5470.54
284_L297_C0.5470.54
53_K71_L0.5470.54
53_K99_Y0.5470.54
141_L151_D0.5460.54
201_I210_A0.5460.54
354_A384_H0.5450.54
256_S264_K0.5440.54
229_N232_Q0.5430.54
21_G66_V0.5430.54
37_L95_Y0.5420.54
334_T337_D0.5420.54
33_P70_S0.5420.54
180_D184_T0.5410.54
140_E159_A0.5400.53
270_T273_S0.5400.53
425_N428_K0.5390.53
181_Y188_N0.5390.53
119_S125_F0.5380.53
405_R408_A0.5380.53
401_L405_R0.5370.53
59_S62_K0.5350.53
171_N175_S0.5350.53
253_H260_L0.5350.53
70_S92_E0.5350.53
167_H173_F0.5340.53
275_Y308_L0.5340.53
179_P186_R0.5330.53
136_I257_D0.5330.53
134_P142_V0.5320.52
410_V414_C0.5320.52
216_V224_Q0.5320.52
291_Q336_V0.5300.52
405_R409_V0.5300.52
402_E408_A0.5290.52
34_Q38_G0.5290.52
21_G41_I0.5280.52
223_S228_D0.5280.52
341_L363_Q0.5270.52
200_L208_L0.5250.51
342_A381_V0.5250.51
74_C80_C0.5250.51
33_P80_C0.5230.51
60_V72_T0.5230.51
208_L212_N0.5220.51
325_E329_Y0.5200.51
122_I140_E0.5200.51
220_H230_I0.5190.51
428_K432_K0.5180.50
182_F187_I0.5180.50
141_L144_I0.5180.50
32_I221_N0.5180.50
376_Y395_I0.5170.50
138_N153_L0.5170.50
77_S101_F0.5160.50
208_L213_H0.5160.50
67_S73_R0.5160.50
184_T187_I0.5150.50
170_Q177_F0.5140.50
265_E276_R0.5140.50
144_I160_A0.5100.49
70_S100_R0.5090.49
227_I234_V0.5090.49
321_Q325_E0.5080.49
197_Y202_D0.5080.49
85_I91_I0.5080.49
425_N429_L0.5060.49
72_T95_Y0.5050.49
138_N141_L0.5050.49
47_A50_V0.5040.49
238_E387_K0.5030.48
200_L209_I0.5020.48
207_F214_L0.5010.48
180_D186_R0.5000.48
64_I97_K0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ly7A 2 0.6769 100 0.609 Contact Map
4gywA 2 0.417 99.9 0.726 Contact Map
1dceA 1 0.5437 99.9 0.726 Contact Map
4l9pA 1 0.4913 99.9 0.726 Contact Map
3dssA 1 0.4454 99.9 0.732 Contact Map
1w3bA 2 0.4782 99.9 0.736 Contact Map
3q7aA 1 0.4825 99.9 0.737 Contact Map
2vsyA 1 0.3406 99.9 0.737 Contact Map
5aioA 1 0.4039 99.9 0.743 Contact Map
3urzA 1 0.4105 99.9 0.744 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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