GREMLIN Database
YGAZ - Inner membrane protein YgaZ
UniProt: P76630 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13528
Length: 245 (217)
Sequences: 3098 (2265)
Seq/√Len: 153.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_D140_W4.8781.00
46_S49_E4.6091.00
51_V157_V4.3201.00
116_G145_A3.6641.00
40_A50_S3.4871.00
55_C153_V3.3851.00
15_F143_G3.2311.00
18_G143_G3.1151.00
96_S122_F2.9591.00
47_P160_A2.7711.00
53_F66_I2.7101.00
52_F56_I2.6341.00
54_S156_T2.6211.00
16_M20_K2.6181.00
69_M74_S2.5961.00
168_Q173_V2.5261.00
33_A155_G2.4351.00
29_Y118_T2.3861.00
65_V86_M2.3731.00
15_F146_F2.2391.00
59_A87_D2.0701.00
51_V153_V2.0431.00
53_F57_I1.9051.00
149_W153_V1.8571.00
109_K138_E1.8361.00
22_S144_I1.8171.00
58_Y118_T1.8111.00
17_E128_K1.8031.00
107_K111_A1.8011.00
21_D128_K1.7831.00
29_Y148_S1.7481.00
25_I148_S1.7411.00
59_A90_H1.7371.00
215_F223_A1.7221.00
224_G228_G1.7181.00
30_I158_I1.6851.00
59_A62_S1.6831.00
36_F156_T1.6631.00
200_C204_A1.6311.00
43_L67_T1.6221.00
41_T160_A1.6121.00
36_F63_Q1.5901.00
109_K142_I1.5871.00
65_V82_T1.5791.00
15_F147_S1.5701.00
30_I34_F1.5621.00
66_I83_V1.5201.00
121_V148_S1.5071.00
119_D152_W1.5011.00
50_S160_A1.4981.00
112_L149_W1.4931.00
58_Y149_W1.4661.00
17_E21_D1.4631.00
90_H117_L1.4281.00
97_L117_L1.4191.00
36_F67_T1.4181.00
59_A83_V1.3801.00
115_F149_W1.3691.00
26_V147_S1.3671.00
55_C149_W1.3611.00
228_G232_A1.3461.00
151_S155_G1.3271.00
22_S151_S1.3221.00
121_V144_I1.3001.00
34_F158_I1.2961.00
157_V161_F1.2661.00
90_H93_Y1.2621.00
106_Q109_K1.2521.00
187_S191_A1.2361.00
26_V151_S1.2271.00
63_Q156_T1.2081.00
13_A16_M1.2031.00
14_T137_S1.2001.00
17_E20_K1.1911.00
207_G211_G1.1911.00
36_F40_A1.1901.00
54_S63_Q1.1801.00
211_G223_A1.1651.00
15_F18_G1.1631.00
90_H120_E1.1551.00
205_L209_L1.1511.00
108_S111_A1.1441.00
29_Y184_L1.1371.00
69_M82_T1.1361.00
117_L141_M1.1241.00
62_S83_V1.1231.00
118_T148_S1.1231.00
76_L80_A1.1191.00
120_E183_A1.1070.99
204_A208_A1.0810.99
204_A209_L1.0660.99
36_F64_F1.0620.99
16_M19_C1.0520.99
175_A178_G1.0500.99
22_S147_S1.0370.99
29_Y32_V1.0370.99
121_V145_A1.0310.99
14_T139_N1.0300.99
32_V148_S1.0270.99
68_A72_A1.0230.99
204_A227_C1.0190.99
139_N143_G1.0180.99
43_L71_A1.0170.99
67_T71_A1.0060.99
125_A141_M1.0050.99
47_P50_S0.9830.99
79_A83_V0.9740.99
94_G97_L0.9630.99
122_F126_T0.9620.99
19_C147_S0.9590.98
93_Y229_C0.9550.98
168_Q174_E0.9530.98
162_S165_G0.9470.98
88_V91_V0.9470.98
39_N67_T0.9300.98
57_I62_S0.9250.98
47_P51_V0.9230.98
200_C235_Q0.9190.98
58_Y153_V0.9100.98
59_A86_M0.9020.98
210_A213_T0.8980.98
22_S25_I0.8960.98
23_L27_I0.8920.98
196_K199_L0.8830.97
158_I162_S0.8810.97
141_M145_A0.8790.97
168_Q175_A0.8780.97
125_A144_I0.8780.97
31_P35_A0.8770.97
64_F181_L0.8760.97
231_T235_Q0.8730.97
14_T17_E0.8700.97
45_F49_E0.8700.97
15_F19_C0.8690.97
93_Y122_F0.8580.97
66_I70_L0.8500.97
201_V224_G0.8450.97
225_I228_G0.8420.97
203_A207_G0.8410.97
60_G119_D0.8400.97
112_L116_G0.8340.96
47_P157_V0.8340.96
33_A152_W0.8330.96
193_F199_L0.8280.96
108_S112_L0.8280.96
203_A231_T0.8270.96
220_A224_G0.8250.96
39_N181_L0.8240.96
68_A71_A0.8240.96
62_S69_M0.8190.96
61_A65_V0.8160.96
19_C23_L0.8150.96
45_F53_F0.8130.96
77_W81_L0.8110.96
58_Y148_S0.8070.96
116_G149_W0.8050.96
215_F219_V0.8040.96
31_P101_I0.8030.95
31_P117_L0.7920.95
29_Y58_Y0.7920.95
93_Y185_F0.7900.95
41_T46_S0.7790.95
18_G140_W0.7780.95
35_A184_L0.7780.95
120_E184_L0.7720.94
147_S151_S0.7720.94
33_A119_D0.7690.94
230_L234_I0.7680.94
113_W142_I0.7670.94
25_I29_Y0.7590.94
96_S99_S0.7470.93
30_I155_G0.7360.93
92_L225_I0.7360.93
37_G159_G0.7330.93
31_P90_H0.7260.92
100_R129_L0.7210.92
208_A212_V0.7190.92
100_R137_S0.7160.92
206_V223_A0.7160.92
32_V184_L0.7150.92
63_Q118_T0.7140.92
22_S26_V0.7130.92
28_S35_A0.7060.91
197_Q235_Q0.7060.91
51_V55_C0.6950.91
28_S120_E0.6950.91
63_Q153_V0.6940.91
211_G224_G0.6920.90
234_I237_F0.6910.90
205_L224_G0.6890.90
35_A39_N0.6870.90
60_G152_W0.6870.90
181_L184_L0.6850.90
22_S29_Y0.6820.90
204_A223_A0.6760.89
75_S78_I0.6740.89
32_V181_L0.6740.89
36_F54_S0.6690.89
105_L113_W0.6690.89
34_F74_S0.6680.89
13_A17_E0.6550.88
200_C231_T0.6540.88
203_A206_V0.6520.88
92_L120_E0.6510.88
122_F184_L0.6510.88
168_Q176_A0.6480.87
191_A194_Q0.6460.87
59_A66_I0.6460.87
145_A148_S0.6440.87
173_V176_A0.6410.87
44_G226_V0.6390.87
57_I83_V0.6380.87
112_L142_I0.6380.87
155_G158_I0.6260.86
61_A119_D0.6230.85
209_L213_T0.6220.85
93_Y179_F0.6200.85
14_T128_K0.6170.85
212_V215_F0.6170.85
40_A45_F0.6160.85
57_I90_H0.6090.84
210_A214_L0.6080.84
204_A207_G0.6060.84
228_G231_T0.6060.84
20_K23_L0.6060.84
40_A53_F0.6030.83
129_L186_M0.6030.83
33_A60_G0.5970.83
31_P177_L0.5960.83
105_L109_K0.5950.83
124_A144_I0.5950.83
29_Y181_L0.5950.83
143_G147_S0.5930.82
166_L237_F0.5910.82
26_V29_Y0.5910.82
18_G139_N0.5900.82
112_L146_F0.5890.82
38_L195_R0.5870.82
32_V92_L0.5870.82
69_M79_A0.5860.82
200_C203_A0.5830.81
114_A193_F0.5830.81
120_E188_F0.5830.81
208_A227_C0.5830.81
32_V180_M0.5800.81
153_V158_I0.5780.81
69_M117_L0.5780.81
176_A183_A0.5770.81
200_C206_V0.5770.81
35_A141_M0.5730.80
180_M183_A0.5720.80
55_C59_A0.5720.80
112_L138_E0.5710.80
60_G120_E0.5710.80
45_F66_I0.5660.79
112_L157_V0.5650.79
41_T51_V0.5640.79
146_F150_S0.5640.79
158_I214_L0.5630.79
48_L52_F0.5620.79
185_F225_I0.5600.79
155_G184_L0.5590.79
52_F206_V0.5550.78
63_Q124_A0.5550.78
30_I33_A0.5530.78
135_R139_N0.5520.78
23_L196_K0.5520.78
204_A229_C0.5510.78
88_V219_V0.5500.77
18_G167_L0.5470.77
116_G148_S0.5470.77
22_S155_G0.5460.77
28_S180_M0.5460.77
95_P99_S0.5460.77
121_V149_W0.5450.77
233_L237_F0.5430.77
58_Y90_H0.5430.77
179_F182_P0.5420.76
109_K139_N0.5410.76
201_V205_L0.5400.76
36_F50_S0.5380.76
13_A111_A0.5370.76
204_A210_A0.5370.76
90_H181_L0.5360.76
209_L214_L0.5360.76
39_N63_Q0.5350.75
34_F154_F0.5340.75
204_A232_A0.5340.75
176_A181_L0.5340.75
120_E180_M0.5300.75
125_A129_L0.5280.75
162_S166_L0.5270.74
41_T226_V0.5260.74
32_V35_A0.5250.74
18_G49_E0.5250.74
29_Y144_I0.5240.74
189_L201_V0.5240.74
79_A137_S0.5230.74
85_A120_E0.5230.74
61_A180_M0.5220.74
204_A212_V0.5220.74
180_M225_I0.5210.74
197_Q206_V0.5200.73
100_R166_L0.5190.73
120_E181_L0.5180.73
92_L96_S0.5180.73
148_S181_L0.5180.73
40_A49_E0.5170.73
145_A149_W0.5160.73
94_G117_L0.5150.73
142_I189_L0.5150.73
36_F141_M0.5140.73
186_M203_A0.5140.73
203_A227_C0.5110.72
23_L144_I0.5100.72
28_S148_S0.5090.72
53_F67_T0.5090.72
72_A75_S0.5080.72
200_C232_A0.5080.72
25_I116_G0.5070.72
206_V226_V0.5050.71
62_S85_A0.5030.71
108_S231_T0.5030.71
200_C214_L0.5030.71
22_S186_M0.5020.71
202_T206_V0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nr9A 2 0.649 25.8 0.95 Contact Map
4cbcA 3 0.3714 22.6 0.951 Contact Map
2kluA 1 0.1714 19.9 0.952 Contact Map
2l2tA 2 0.1796 11.8 0.957 Contact Map
4qncA 2 0.2653 11.3 0.957 Contact Map
2m20A 2 0.151 11 0.957 Contact Map
4x5mA 2 0.3061 10.9 0.957 Contact Map
4ltoA 3 0.4204 9.6 0.959 Contact Map
4j05A 3 0.8408 8 0.96 Contact Map
2ls4A 1 0.098 7.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.