GREMLIN Database
CSID - Protein CsiD
UniProt: P76621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13523
Length: 325 (299)
Sequences: 102 (57)
Seq/√Len: 3.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_M248_V4.9980.90
115_A308_M4.0740.77
198_H265_A3.1640.57
47_E198_H2.9360.51
286_N289_F2.7610.46
157_M189_L2.7060.45
32_L258_W2.7060.45
131_S248_V2.6290.43
97_I197_E2.6000.42
197_E269_S2.5760.41
208_A258_W2.5530.41
127_F218_P2.5350.40
107_Q277_V2.4510.38
153_P255_E2.4190.37
142_N300_H2.4020.37
133_Q165_Y2.1560.31
172_Y286_N2.1560.31
184_Q230_V2.1520.31
83_L118_V2.1200.30
154_H189_L2.1110.30
242_R288_L2.1010.30
29_S273_L2.0690.29
60_K63_L2.0580.29
125_S133_Q1.9570.27
202_Y265_A1.9440.27
97_I269_S1.8810.25
225_D249_Q1.8760.25
74_L77_N1.8620.25
283_L295_D1.8520.25
69_K73_D1.8480.25
210_R255_E1.8470.25
214_F228_H1.8420.25
142_N154_H1.8230.24
39_E113_K1.7710.23
139_V304_R1.7500.23
94_A165_Y1.7460.23
119_A226_V1.7400.23
242_R252_D1.7260.22
119_A125_S1.7120.22
218_P277_V1.6400.21
91_A238_R1.6400.21
75_C127_F1.6360.21
70_I76_A1.6300.21
118_V284_L1.6270.21
232_D242_R1.6230.21
187_N277_V1.6130.20
112_V216_A1.6090.20
94_A176_M1.6060.20
57_L222_V1.6030.20
172_Y289_F1.6020.20
169_I242_R1.5780.20
92_E159_L1.5730.20
43_K91_A1.5680.20
154_H161_N1.5650.20
35_L275_V1.5530.19
158_E295_D1.5460.19
50_A53_P1.5440.19
20_G198_H1.5390.19
29_S100_V1.5270.19
249_Q308_M1.5220.19
49_V94_A1.5100.19
76_A198_H1.5090.19
82_L97_I1.4900.18
214_F256_G1.4870.18
228_H256_G1.4860.18
113_K278_P1.4820.18
203_F252_D1.4820.18
114_L165_Y1.4720.18
168_E236_Q1.4710.18
165_Y216_A1.4570.18
21_F85_K1.4470.18
178_I272_I1.4410.18
35_L69_K1.4400.18
77_N85_K1.4300.17
262_L286_N1.4120.17
156_V187_N1.4010.17
260_S263_S1.3890.17
179_D269_S1.3870.17
127_F176_M1.3750.17
169_I288_L1.3730.17
211_P233_V1.3700.17
157_M256_G1.3280.16
89_N262_L1.3260.16
139_V248_V1.3190.16
161_N187_N1.2990.16
60_K214_F1.2990.16
152_Q155_R1.2930.15
118_V275_V1.2890.15
176_M218_P1.2820.15
242_R248_V1.2740.15
23_L253_F1.2740.15
82_L86_T1.2740.15
110_E224_K1.2570.15
34_E97_I1.2440.15
42_T67_V1.2380.15
68_A71_L1.2370.15
41_T74_L1.2360.15
204_R258_W1.2300.15
16_Q51_E1.2100.14
60_K256_G1.2100.14
88_L242_R1.2080.14
109_D176_M1.2070.14
134_Y221_N1.2050.14
60_K228_H1.2030.14
93_G286_N1.1970.14
30_P91_A1.1960.14
157_M214_F1.1920.14
173_V241_M1.1920.14
33_L97_I1.1910.14
157_M275_V1.1910.14
75_C79_L1.1910.14
157_M228_H1.1840.14
155_R275_V1.1830.14
93_G289_F1.1760.14
81_P85_K1.1750.14
202_Y225_D1.1640.14
161_N173_V1.1560.14
119_A133_Q1.1530.14
158_E189_L1.1510.14
87_L93_G1.1450.14
87_L95_L1.1400.14
74_L257_V1.1370.13
158_E214_F1.1330.13
216_A310_Q1.1210.13
238_R296_R1.1210.13
218_P308_M1.1170.13
286_N313_Y1.1120.13
167_E230_V1.1090.13
178_I238_R1.1060.13
112_V255_E1.1040.13
95_L284_L1.0970.13
167_E224_K1.0930.13
254_E289_F1.0810.13
131_S262_L1.0800.13
29_S304_R1.0750.13
22_T76_A1.0740.13
142_N161_N1.0740.13
133_Q308_M1.0710.13
158_E161_N1.0700.13
169_I284_L1.0700.13
154_H157_M1.0680.13
97_I254_E1.0630.13
26_S111_M1.0630.13
119_A243_Y1.0630.13
39_E91_A1.0630.13
205_H208_A1.0580.13
47_E51_E1.0520.12
119_A236_Q1.0510.12
158_E228_H1.0510.12
113_K269_S1.0500.12
112_V226_V1.0490.12
110_E255_E1.0480.12
59_Y188_S1.0480.12
119_A190_L1.0460.12
81_P200_D1.0440.12
65_F182_N1.0400.12
61_S172_Y1.0380.12
76_A278_P1.0330.12
134_Y141_K1.0310.12
52_W301_P1.0300.12
22_T30_P1.0300.12
138_F206_P1.0280.12
176_M299_P1.0210.12
145_N179_D1.0150.12
134_Y165_Y1.0120.12
58_E71_L1.0050.12
46_L92_E1.0050.12
161_N277_V1.0030.12
43_K255_E1.0020.12
42_T227_F1.0010.12
169_I240_V0.9970.12
171_D191_L0.9960.12
131_S286_N0.9800.12
198_H268_T0.9750.12
38_T43_K0.9740.12
87_L91_A0.9720.12
75_C249_Q0.9700.12
108_A139_V0.9630.11
20_G120_H0.9630.11
45_F55_Q0.9630.11
47_E261_E0.9580.11
190_L283_L0.9500.11
112_V126_N0.9470.11
58_E217_P0.9470.11
86_T270_K0.9410.11
107_Q283_L0.9380.11
45_F152_Q0.9340.11
125_S253_F0.9330.11
242_R262_L0.9300.11
183_M277_V0.9290.11
98_N114_L0.9250.11
248_V263_S0.9230.11
154_H158_E0.9190.11
110_E211_P0.9190.11
154_H173_V0.9180.11
17_D30_P0.9180.11
107_Q181_Q0.9150.11
159_L290_W0.9140.11
87_L127_F0.9140.11
32_L208_A0.9140.11
125_S255_E0.9090.11
125_S308_M0.9070.11
127_F268_T0.9030.11
100_V223_S0.9020.11
42_T198_H0.9000.11
211_P271_G0.9000.11
133_Q257_V0.8980.11
125_S178_I0.8960.11
142_N299_P0.8960.11
75_C218_P0.8940.11
215_A256_G0.8850.11
67_V82_L0.8840.11
77_N143_V0.8810.11
20_G74_L0.8780.11
100_V199_L0.8760.11
117_A132_G0.8650.10
237_G275_V0.8640.10
49_V248_V0.8630.10
156_V165_Y0.8630.10
22_T27_A0.8620.10
173_V295_D0.8610.10
38_T81_P0.8560.10
33_L125_S0.8540.10
44_Q48_Q0.8460.10
97_I200_D0.8380.10
98_N173_V0.8380.10
41_T302_D0.8330.10
24_T223_S0.8330.10
161_N295_D0.8300.10
125_S258_W0.8240.10
198_H264_D0.8240.10
214_F266_I0.8230.10
158_E283_L0.8220.10
62_F229_P0.8120.10
158_E173_V0.8090.10
133_Q243_Y0.8080.10
108_A269_S0.8070.10
61_S153_P0.8060.10
138_F180_E0.8010.10
182_N255_E0.8010.10
18_Y24_T0.7980.10
115_A176_M0.7970.10
109_D178_I0.7950.10
70_I198_H0.7930.10
249_Q255_E0.7920.10
71_L75_C0.7910.10
57_L289_F0.7900.10
60_K157_M0.7850.10
165_Y271_G0.7780.10
32_L310_Q0.7760.10
23_L139_V0.7740.10
25_P113_K0.7730.10
111_M284_L0.7730.10
167_E276_P0.7710.10
47_E176_M0.7700.10
269_S284_L0.7660.10
19_S40_Q0.7620.09
62_F237_G0.7610.09
187_N274_S0.7550.09
209_R233_V0.7550.09
62_F249_Q0.7540.09
112_V137_R0.7530.09
63_L266_I0.7530.09
48_Q51_E0.7520.09
96_L256_G0.7490.09
129_A302_D0.7490.09
102_V110_E0.7480.09
56_A234_D0.7480.09
72_D79_L0.7460.09
239_P290_W0.7460.09
115_A233_V0.7440.09
197_E264_D0.7390.09
95_L178_I0.7380.09
85_K200_D0.7380.09
288_L315_A0.7370.09
42_T74_L0.7360.09
251_K264_D0.7330.09
159_L291_L0.7330.09
57_L101_G0.7250.09
158_E256_G0.7230.09
169_I232_D0.7200.09
89_N129_A0.7200.09
189_L256_G0.7190.09
34_E66_R0.7150.09
95_L129_A0.7130.09
38_T91_A0.7100.09
56_A63_L0.7090.09
129_A168_E0.7090.09
181_Q252_D0.7090.09
94_A283_L0.7050.09
154_H299_P0.7030.09
17_D97_I0.6970.09
154_H183_M0.6970.09
40_Q81_P0.6900.09
87_L122_I0.6900.09
53_P167_E0.6890.09
52_W63_L0.6890.09
122_I235_Q0.6840.09
142_N158_E0.6800.09
92_E236_Q0.6790.09
189_L295_D0.6780.09
159_L239_P0.6770.09
118_V200_D0.6740.09
61_S125_S0.6740.09
78_Q82_L0.6740.09
258_W296_R0.6740.09
29_S37_F0.6730.09
101_G112_V0.6720.09
111_M225_D0.6700.09
120_H310_Q0.6700.09
59_Y265_A0.6690.09
43_K200_D0.6690.09
44_Q54_V0.6670.09
115_A159_L0.6670.09
92_E290_W0.6640.09
172_Y272_I0.6640.09
142_N173_V0.6630.09
88_L103_D0.6550.09
216_A222_V0.6530.09
157_M299_P0.6520.09
27_A30_P0.6520.09
110_E271_G0.6520.09
101_G300_H0.6510.09
96_L158_E0.6470.09
37_F262_L0.6470.09
36_T255_E0.6460.08
98_N176_M0.6440.08
200_D222_V0.6380.08
229_P249_Q0.6340.08
89_N92_E0.6330.08
92_E203_F0.6320.08
276_P296_R0.6310.08
37_F109_D0.6300.08
179_D268_T0.6290.08
54_V265_A0.6280.08
282_F285_I0.6280.08
154_H295_D0.6280.08
17_D38_T0.6260.08
187_N296_R0.6260.08
56_A60_K0.6240.08
44_Q209_R0.6210.08
155_R189_L0.6210.08
240_V289_F0.6200.08
30_P200_D0.6190.08
226_V242_R0.6180.08
67_V190_L0.6150.08
42_T187_N0.6140.08
277_V302_D0.6110.08
29_S79_L0.6110.08
189_L275_V0.6100.08
248_V261_E0.6100.08
261_E264_D0.6100.08
101_G200_D0.6100.08
54_V100_V0.6100.08
47_E207_L0.6100.08
129_A207_L0.6090.08
190_L239_P0.6060.08
113_K185_G0.6050.08
139_V308_M0.6050.08
184_Q256_G0.6040.08
81_P129_A0.6040.08
157_M183_M0.6020.08
51_E89_N0.6000.08
229_P288_L0.5980.08
30_P178_I0.5960.08
98_N282_F0.5920.08
229_P237_G0.5920.08
52_W154_H0.5890.08
96_L173_V0.5890.08
230_V249_Q0.5880.08
67_V78_Q0.5880.08
222_V300_H0.5880.08
169_I282_F0.5870.08
42_T111_M0.5870.08
158_E183_M0.5860.08
229_P242_R0.5840.08
44_Q50_A0.5840.08
190_L310_Q0.5830.08
218_P225_D0.5820.08
53_P227_F0.5800.08
228_H266_I0.5800.08
35_L167_E0.5760.08
93_G185_G0.5690.08
262_L282_F0.5690.08
75_C176_M0.5670.08
161_N189_L0.5660.08
89_N134_Y0.5660.08
113_K268_T0.5650.08
193_L289_F0.5630.08
75_C284_L0.5620.08
70_I74_L0.5620.08
86_T103_D0.5620.08
21_F209_R0.5600.08
189_L214_F0.5600.08
103_D106_K0.5590.08
26_S168_E0.5590.08
80_Q269_S0.5580.08
65_F229_P0.5580.08
94_A288_L0.5570.08
214_F295_D0.5560.08
272_I286_N0.5560.08
29_S243_Y0.5560.08
47_E184_Q0.5530.08
40_Q212_M0.5490.08
82_L85_K0.5490.08
86_T211_P0.5480.08
156_V189_L0.5480.08
181_Q308_M0.5480.08
124_R273_L0.5470.08
139_V218_P0.5470.08
159_L308_M0.5460.08
88_L127_F0.5440.08
78_Q121_L0.5440.08
106_K241_M0.5420.08
55_Q132_G0.5420.08
215_A228_H0.5410.08
183_M256_G0.5400.08
189_L299_P0.5400.08
95_L174_L0.5390.08
213_R227_F0.5350.08
189_L228_H0.5340.08
173_V283_L0.5320.08
97_I119_A0.5320.08
38_T300_H0.5310.08
41_T92_E0.5290.08
106_K121_L0.5280.08
183_M189_L0.5270.08
35_L85_K0.5270.08
197_E223_S0.5240.08
114_L282_F0.5240.08
143_V157_M0.5240.08
263_S289_F0.5240.08
44_Q181_Q0.5230.08
55_Q152_Q0.5220.08
232_D262_L0.5210.08
173_V212_M0.5200.08
22_T38_T0.5200.08
117_A155_R0.5170.07
202_Y272_I0.5170.07
21_F41_T0.5150.07
52_W189_L0.5140.07
156_V254_E0.5140.07
79_L266_I0.5110.07
154_H172_Y0.5050.07
110_E249_Q0.5020.07
213_R251_K0.5010.07
117_A265_A0.5010.07
226_V257_V0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jr7A 5 0.9415 100 0.677 Contact Map
4oj8A 4 0.7508 99.6 0.903 Contact Map
3pvjA 3 0.7692 99.6 0.904 Contact Map
4ylmX 5 0.7754 99.6 0.905 Contact Map
4m23A 2 0.8585 99.6 0.905 Contact Map
2og5A 1 0.8431 99.5 0.906 Contact Map
4c5wA 2 0.9108 99.5 0.908 Contact Map
2wbqA 1 0.8646 99.5 0.908 Contact Map
1otjA 2 0.7815 99.5 0.91 Contact Map
4j5iA 3 0.7538 99.4 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.