PKA - ECOLI - GREMLIN Contacts

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PKA - Protein lysine acetyltransferase Pka

UniProt:	P76594	Sequences: MSQRGLEALLRPKSIAVIGASMKPNRAGYLMMRNLLAGGFNGPVLPVTPAWKAVLGVLAWPDIASLPFTPDLAVLCTNASRNLALLEELGEKGCKTCIILSAPASQHEDLRACALRHNMRLLGPNSLGLLAPWQGLNASFSPVPIKRGKLAFISQSAAVSNTILDWAQQRKMGFSYFIALGDSLDIDVDELLDYLARDSKTSAILLYLEQLSDARRFVSAARSASRNKPILVIKSGRSPAAQRLLNTTAGMDPAWDAAIQRAGLLRVQDTHELFSAVETLSHMRPLRGDRLMIISNGAAPAALALDALWSRNGKLATLSEETCQKLRDALPEHVAISNPLDLRDDASSEHYIKTLDILLHSQDFDALMVIHSPSAAAPATESAQVLIEAVKHHPRSKYVSLLTNWCGEHSSQEARRLFSEAGLPTYRTPEGTITAFMHMVEYRRNQKQLRETPALPSNLTSNTAEAHLLLQQAIAEGATSLDTHEVQPILQAYGMNTLPTWIASDSTEAVHIAEQIGYPVALKLRSPDIPHKSEVQGVMLYLRTANEVQQAANAIFDRVKMAWPQARVHGLLVQSMANRAGAQELRVVVEHDPVFGPLIMLGEGGVEWRPEDQAVVALPPLNMNLARYLVIQGIKSKKIRARSALRPLDVAGLSQLLVQVSNLIVDCPEIQRLDIHPLLASGSEFTALDVTLDISPFEGDNESRLAVRPYPHQLEEWVELKNGERCLFRPILPEDEPQLQQFISRVTKEDLYYRYFSEINEFTHEDLANMTQIDYDREMAFVAVRRIDQTEEILGVTRAISDPDNIDAEFAVLVRSDLKGLGLGRRLMEKLITYTRDHGLQRLNGITMPNNRGMVALARKLGFNVDIQLEEGIVGLTLNLAQREES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14224
Length:	886 (686)
Sequences:	1921 (1423)
Seq/√Len:	54.3

ECOLI - PKA
SULSO - Q97XD9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
542_L	548_V	5.005	1.00
290_R	365_D	4.708	1.00
501_W	515_Q	4.662	1.00
62_D	65_S	4.662	1.00
587_V	660_V	4.232	1.00
61_P	65_S	4.164	1.00
675_I	678_L	4.063	1.00
493_Y	666_D	4.025	1.00
252_D	266_R	4.017	1.00
90_G	117_H	3.667	1.00
66_L	70_P	3.565	1.00
589_V	664_I	3.535	1.00
489_I	692_L	3.526	1.00
120_R	185_D	3.373	1.00
522_L	573_V	3.205	1.00
87_E	109_D	3.095	1.00
77_T	85_L	3.048	1.00
149_K	202_S	3.010	1.00
539_M	554_A	2.958	1.00
506_S	553_N	2.943	1.00
288_G	365_D	2.906	1.00
656_L	678_L	2.869	1.00
64_A	88_E	2.859	1.00
47_V	66_L	2.823	1.00
505_D	552_A	2.766	1.00
601_L	633_G	2.739	1.00
520_V	573_V	2.705	1.00
617_A	629_L	2.680	1.00
495_M	687_A	2.675	1.00
514_E	545_A	2.655	1.00
510_V	548_V	2.638	1.00
542_L	551_A	2.627	1.00
77_T	81_R	2.602	1.00
499_P	575_S	2.581	1.00
679_L	688_L	2.559	1.00
507_T	549_Q	2.522	1.00
256_D	266_R	2.506	1.00
528_D	567_R	2.501	1.00
87_E	116_R	2.467	1.00
89_L	94_C	2.432	1.00
75_L	85_L	2.399	1.00
535_V	559_V	2.398	1.00
521_A	540_L	2.390	1.00
87_E	91_E	2.371	1.00
322_T	361_S	2.352	1.00
255_W	259_I	2.349	1.00
505_D	508_E	2.298	1.00
478_A	485_E	2.286	1.00
319_S	363_D	2.283	1.00
617_A	632_Q	2.272	1.00
8_A	95_K	2.252	1.00
585_L	653_L	2.247	1.00
552_A	571_L	2.246	1.00
73_A	89_L	2.210	1.00
325_K	360_H	2.180	1.00
555_I	559_V	2.178	1.00
503_A	512_I	2.108	1.00
254_A	598_L	2.106	1.00
621_L	657_L	2.099	1.00
86_L	113_C	2.094	1.00
15_I	136_L	2.091	1.00
73_A	94_C	2.076	1.00
675_I	687_A	2.073	1.00
64_A	91_E	2.068	1.00
18_I	73_A	2.064	1.00
86_L	97_C	2.056	1.00
610_P	642_R	2.033	1.00
600_M	616_V	2.022	1.00
655_Q	659_Q	2.017	1.00
99_I	110_L	2.003	1.00
31_M	100_L	2.002	1.00
108_E	112_A	2.002	1.00
51_W	59_A	1.996	1.00
261_R	617_A	1.981	1.00
631_I	650_V	1.973	1.00
601_L	630_V	1.973	1.00
501_W	512_I	1.963	1.00
483_T	487_Q	1.946	1.00
623_M	655_Q	1.943	1.00
387_I	417_L	1.943	1.00
198_D	201_T	1.942	1.00
316_A	364_F	1.937	1.00
45_L	60_W	1.921	1.00
528_D	566_A	1.917	1.00
506_S	510_V	1.916	1.00
603_E	635_K	1.908	1.00
151_A	175_S	1.906	1.00
22_M	51_W	1.901	1.00
221_A	264_L	1.883	0.99
295_S	301_A	1.881	0.99
510_V	549_Q	1.881	0.99
79_A	101_S	1.875	0.99
518_Y	548_V	1.873	0.99
355_L	367_L	1.871	0.99
275_S	431_G	1.851	0.99
63_I	89_L	1.848	0.99
122_L	129_L	1.843	0.99
23_K	26_R	1.842	0.99
630_V	654_S	1.840	0.99
509_A	548_V	1.831	0.99
53_A	56_G	1.829	0.99
60_W	67_P	1.827	0.99
221_A	230_I	1.823	0.99
289_D	444_R	1.813	0.99
87_E	113_C	1.803	0.99
545_A	549_Q	1.795	0.99
289_D	314_K	1.785	0.99
509_A	513_A	1.784	0.99
518_Y	544_T	1.781	0.99
384_Q	388_E	1.779	0.99
504_S	508_E	1.779	0.99
84_A	88_E	1.775	0.99
175_S	201_T	1.758	0.99
43_P	68_F	1.752	0.99
555_I	558_R	1.751	0.99
524_L	529_I	1.739	0.99
521_A	576_M	1.735	0.99
178_I	195_L	1.724	0.99
69_T	92_K	1.721	0.99
292_M	364_F	1.717	0.99
114_A	121_L	1.700	0.99
539_M	551_A	1.690	0.99
660_V	673_L	1.684	0.99
330_L	334_V	1.667	0.99
552_A	556_F	1.659	0.99
615_V	629_L	1.654	0.99
502_I	525_R	1.652	0.99
487_Q	500_T	1.632	0.98
482_D	485_E	1.628	0.98
18_I	63_I	1.622	0.98
186_I	191_L	1.614	0.98
66_L	69_T	1.613	0.98
86_L	119_M	1.607	0.98
526_S	529_I	1.605	0.98
544_T	547_E	1.604	0.98
319_S	361_S	1.590	0.98
356_D	392_H	1.587	0.98
259_I	264_L	1.583	0.98
599_I	619_P	1.578	0.98
678_L	687_A	1.577	0.98
543_R	547_E	1.575	0.98
267_V	276_A	1.572	0.98
327_R	336_I	1.571	0.98
513_A	517_G	1.564	0.98
585_L	680_A	1.562	0.98
663_L	667_C	1.553	0.98
535_V	562_A	1.548	0.98
205_L	277_V	1.548	0.98
654_S	658_V	1.518	0.98
416_R	420_E	1.513	0.97
245_L	302_A	1.510	0.97
36_L	57_V	1.499	0.97
539_M	558_R	1.497	0.97
62_D	88_E	1.492	0.97
333_H	343_R	1.486	0.97
630_V	653_L	1.484	0.97
231_L	280_L	1.480	0.97
631_I	636_S	1.474	0.97
586_R	600_M	1.473	0.97
291_L	436_F	1.468	0.97
272_E	434_T	1.460	0.97
90_G	113_C	1.459	0.97
213_D	216_R	1.459	0.97
378_P	381_E	1.448	0.97
516_I	575_S	1.446	0.97
667_C	670_I	1.444	0.97
109_D	112_A	1.436	0.97
248_T	608_W	1.428	0.96
514_E	518_Y	1.427	0.96
626_A	657_L	1.421	0.96
17_V	32_M	1.420	0.96
627_R	654_S	1.407	0.96
46_P	57_V	1.403	0.96
652_G	684_E	1.400	0.96
656_L	685_F	1.396	0.96
672_R	693_D	1.375	0.96
204_I	224_A	1.369	0.95
72_L	138_A	1.358	0.95
151_A	201_T	1.354	0.95
619_P	661_S	1.350	0.95
22_M	54_V	1.349	0.95
206_L	232_V	1.341	0.95
627_R	651_A	1.340	0.95
448_Q	628_Y	1.339	0.95
510_V	545_A	1.337	0.95
539_M	555_I	1.333	0.95
530_P	691_T	1.331	0.95
356_D	360_H	1.330	0.95
294_I	358_L	1.329	0.95
352_I	388_E	1.328	0.95
513_A	520_V	1.324	0.95
151_A	195_L	1.323	0.95
553_N	557_D	1.322	0.94
160_S	177_F	1.319	0.94
83_L	109_D	1.313	0.94
649_D	684_E	1.306	0.94
33_R	37_A	1.303	0.94
656_L	675_I	1.300	0.94
524_L	537_G	1.294	0.94
190_E	216_R	1.293	0.94
648_L	680_A	1.291	0.94
509_A	517_G	1.286	0.94
279_T	435_A	1.286	0.94
325_K	357_I	1.283	0.94
522_L	552_A	1.277	0.93
84_A	87_E	1.271	0.93
551_A	555_I	1.270	0.93
218_V	258_A	1.264	0.93
542_L	547_E	1.254	0.93
545_A	548_V	1.253	0.93
97_C	114_A	1.253	0.93
522_L	571_L	1.246	0.93
112_A	116_R	1.245	0.93
35_L	44_V	1.244	0.92
107_H	184_L	1.242	0.92
152_F	174_F	1.238	0.92
66_L	92_K	1.235	0.92
22_M	53_A	1.232	0.92
403_T	425_T	1.231	0.92
63_I	92_K	1.230	0.92
359_L	367_L	1.229	0.92
663_L	670_I	1.225	0.92
518_Y	545_A	1.224	0.92
247_T	298_A	1.223	0.92
196_A	224_A	1.222	0.92
9_L	96_T	1.221	0.92
345_D	350_H	1.220	0.92
261_R	625_L	1.218	0.92
54_V	59_A	1.214	0.92
630_V	633_G	1.212	0.91
441_E	444_R	1.205	0.91
234_K	266_R	1.204	0.91
588_V	674_D	1.204	0.91
189_D	220_A	1.203	0.91
466_A	489_I	1.202	0.91
63_I	73_A	1.195	0.91
308_L	313_G	1.191	0.91
75_L	82_N	1.190	0.91
513_A	518_Y	1.188	0.91
555_I	571_L	1.187	0.91
52_K	61_P	1.186	0.91
289_D	440_V	1.179	0.90
260_Q	632_Q	1.178	0.90
506_S	552_A	1.177	0.90
96_T	122_L	1.177	0.90
237_R	310_S	1.176	0.90
67_P	92_K	1.174	0.90
467_H	669_E	1.172	0.90
292_M	358_L	1.171	0.90
318_L	364_F	1.170	0.90
633_G	637_K	1.170	0.90
462_N	465_E	1.169	0.90
649_D	652_G	1.169	0.90
320_E	324_Q	1.167	0.90
636_S	650_V	1.167	0.90
522_L	548_V	1.163	0.90
623_M	658_V	1.157	0.89
589_V	660_V	1.156	0.89
27_A	140_F	1.155	0.89
325_K	328_D	1.155	0.89
324_Q	328_D	1.154	0.89
83_L	90_G	1.152	0.89
626_A	658_V	1.152	0.89
252_D	256_D	1.151	0.89
16_A	46_P	1.146	0.89
381_E	384_Q	1.144	0.89
122_L	186_I	1.142	0.89
322_T	362_Q	1.142	0.89
586_R	608_W	1.137	0.89
510_V	518_Y	1.136	0.89
506_S	549_Q	1.135	0.89
534_E	643_S	1.134	0.88
554_A	558_R	1.131	0.88
319_S	322_T	1.130	0.88
196_A	230_I	1.129	0.88
327_R	334_V	1.129	0.88
524_L	568_V	1.127	0.88
246_N	672_R	1.127	0.88
150_L	203_A	1.124	0.88
623_M	654_S	1.119	0.88
46_P	59_A	1.119	0.88
9_L	122_L	1.118	0.88
29_Y	33_R	1.114	0.88
442_Y	446_Q	1.110	0.87
506_S	548_V	1.109	0.87
366_A	436_F	1.100	0.87
208_L	232_V	1.095	0.87
585_L	633_G	1.093	0.87
556_F	571_L	1.090	0.86
524_L	559_V	1.089	0.86
559_V	571_L	1.082	0.86
384_Q	417_L	1.079	0.86
329_A	357_I	1.079	0.86
67_P	70_P	1.074	0.86
607_E	642_R	1.074	0.86
489_I	492_A	1.074	0.86
374_S	377_A	1.067	0.85
20_A	28_G	1.064	0.85
7_E	11_R	1.064	0.85
261_R	618_L	1.064	0.85
470_L	474_I	1.059	0.85
193_D	223_S	1.056	0.85
230_I	264_L	1.051	0.84
324_Q	327_R	1.050	0.84
490_L	690_V	1.049	0.84
269_D	430_E	1.047	0.84
237_R	252_D	1.041	0.84
629_L	632_Q	1.041	0.84
279_T	439_M	1.035	0.83
550_Q	554_A	1.032	0.83
68_F	92_K	1.032	0.83
486_V	692_L	1.026	0.83
17_V	46_P	1.024	0.83
526_S	568_V	1.022	0.83
368_M	432_T	1.022	0.83
334_V	343_R	1.022	0.83
70_P	94_C	1.020	0.83
483_T	486_V	1.020	0.83
304_A	368_M	1.019	0.82
500_T	574_Q	1.016	0.82
613_Q	634_I	1.016	0.82
268_Q	310_S	1.014	0.82
159_V	270_T	1.011	0.82
261_R	632_Q	1.011	0.82
317_T	320_E	1.011	0.82
465_E	488_P	1.011	0.82
622_N	625_L	1.008	0.82
583_Q	645_L	1.007	0.82
320_E	323_C	1.003	0.81
234_K	252_D	1.000	0.81
493_Y	667_C	0.996	0.81
318_L	358_L	0.995	0.81
552_A	555_I	0.993	0.81
242_Q	245_L	0.993	0.81
349_E	353_K	0.991	0.81
532_K	689_D	0.990	0.81
670_I	673_L	0.988	0.80
231_L	267_V	0.987	0.80
32_M	46_P	0.986	0.80
291_L	308_L	0.983	0.80
353_K	356_D	0.982	0.80
294_I	354_T	0.982	0.80
300_P	406_C	0.981	0.80
535_V	558_R	0.975	0.80
232_V	264_L	0.975	0.80
630_V	636_S	0.973	0.79
311_R	437_M	0.972	0.79
107_H	182_D	0.968	0.79
176_Y	195_L	0.967	0.79
81_R	85_L	0.963	0.79
585_L	678_L	0.960	0.78
531_H	676_H	0.960	0.78
104_A	182_D	0.960	0.78
361_S	399_V	0.959	0.78
664_I	670_I	0.957	0.78
102_A	343_R	0.957	0.78
18_I	89_L	0.956	0.78
22_M	55_L	0.955	0.78
466_A	470_L	0.952	0.78
192_L	204_I	0.951	0.78
583_Q	641_A	0.950	0.78
521_A	577_A	0.949	0.78
52_K	59_A	0.948	0.78
244_L	298_A	0.947	0.78
10_L	194_Y	0.947	0.78
6_L	10_L	0.944	0.77
40_F	43_P	0.944	0.77
626_A	661_S	0.944	0.77
510_V	520_V	0.942	0.77
26_R	29_Y	0.942	0.77
601_L	680_A	0.940	0.77
49_P	59_A	0.938	0.77
519_P	548_V	0.937	0.77
451_E	622_N	0.936	0.77
241_A	298_A	0.932	0.76
621_L	626_A	0.931	0.76
106_Q	182_D	0.930	0.76
90_G	119_M	0.929	0.76
680_A	683_S	0.929	0.76
196_A	220_A	0.929	0.76
520_V	548_V	0.926	0.76
20_A	46_P	0.926	0.76
20_A	54_V	0.924	0.76
386_L	401_L	0.920	0.75
63_I	66_L	0.920	0.75
148_G	173_G	0.918	0.75
355_L	389_A	0.916	0.75
326_L	354_T	0.915	0.75
517_G	520_V	0.914	0.75
9_L	129_L	0.913	0.75
380_T	417_L	0.912	0.75
509_A	520_V	0.911	0.75
11_R	194_Y	0.910	0.75
582_A	688_L	0.909	0.75
636_S	640_R	0.909	0.75
577_A	686_T	0.908	0.74
481_L	692_L	0.906	0.74
519_P	544_T	0.905	0.74
258_A	618_L	0.904	0.74
232_V	259_I	0.903	0.74
122_L	191_L	0.899	0.74
531_H	604_G	0.898	0.74
495_M	656_L	0.896	0.74
66_L	89_L	0.895	0.73
358_L	361_S	0.892	0.73
522_L	551_A	0.892	0.73
149_K	281_S	0.890	0.73
245_L	298_A	0.890	0.73
29_Y	55_L	0.889	0.73
480_S	693_D	0.887	0.73
201_T	228_K	0.884	0.72
183_S	212_S	0.884	0.72
32_M	57_V	0.881	0.72
585_L	630_V	0.880	0.72
126_S	179_A	0.879	0.72
531_H	643_S	0.877	0.72
670_I	692_L	0.877	0.72
437_M	441_E	0.877	0.72
79_A	104_A	0.873	0.72
290_R	314_K	0.872	0.71
39_G	42_G	0.872	0.71
472_Q	476_E	0.872	0.71
37_A	85_L	0.871	0.71
188_V	208_L	0.871	0.71
609_R	643_S	0.870	0.71
461_S	494_G	0.869	0.71
615_V	632_Q	0.869	0.71
524_L	555_I	0.869	0.71
319_S	362_Q	0.869	0.71
87_E	117_H	0.869	0.71
45_L	68_F	0.868	0.71
285_P	443_R	0.867	0.71
559_V	563_W	0.865	0.71
513_A	548_V	0.865	0.71
45_L	67_P	0.864	0.71
48_T	78_N	0.864	0.71
48_T	51_W	0.864	0.71
613_Q	633_G	0.863	0.71
152_F	163_I	0.862	0.71
167_A	174_F	0.860	0.70
355_L	386_L	0.858	0.70
599_I	621_L	0.858	0.70
579_R	582_A	0.858	0.70
247_T	609_R	0.857	0.70
583_Q	648_L	0.857	0.70
164_L	177_F	0.857	0.70
83_L	113_C	0.854	0.70
99_I	114_A	0.854	0.70
85_L	88_E	0.854	0.70
153_I	195_L	0.853	0.70
146_K	168_Q	0.851	0.70
82_N	86_L	0.850	0.70
102_A	158_A	0.849	0.69
346_A	351_Y	0.845	0.69
597_P	619_P	0.841	0.69
238_S	241_A	0.840	0.69
318_L	322_T	0.840	0.69
165_D	407_G	0.840	0.69
462_N	492_A	0.838	0.68
103_P	106_Q	0.838	0.68
469_L	473_A	0.837	0.68
13_K	68_F	0.837	0.68
652_G	685_F	0.836	0.68
55_L	59_A	0.834	0.68
196_A	223_S	0.833	0.68
556_F	568_V	0.833	0.68
35_L	71_D	0.833	0.68
529_I	566_A	0.832	0.68
359_L	399_V	0.832	0.68
604_G	676_H	0.832	0.68
294_I	355_L	0.831	0.68
250_G	298_A	0.829	0.68
651_A	654_S	0.828	0.67
271_H	431_G	0.828	0.67
621_L	629_L	0.826	0.67
359_L	393_H	0.826	0.67
78_N	81_R	0.825	0.67
31_M	34_N	0.824	0.67
490_L	663_L	0.822	0.67
14_S	43_P	0.821	0.67
479_T	485_E	0.821	0.67
211_L	255_W	0.819	0.67
45_L	66_L	0.818	0.67
588_V	676_H	0.818	0.67
498_L	577_A	0.818	0.67
133_W	200_K	0.817	0.66
566_A	570_G	0.814	0.66
617_A	625_L	0.814	0.66
470_L	667_C	0.813	0.66
291_L	433_I	0.813	0.66
548_V	552_A	0.809	0.66
64_A	92_K	0.807	0.65
329_A	353_K	0.807	0.65
46_P	60_W	0.806	0.65
522_L	555_I	0.806	0.65
587_V	657_L	0.805	0.65
524_L	564_P	0.802	0.65
76_C	100_L	0.801	0.65
524_L	528_D	0.801	0.65
207_Y	244_L	0.799	0.65
322_T	326_L	0.798	0.65
23_K	29_Y	0.797	0.65
526_S	566_A	0.797	0.65
626_A	629_L	0.795	0.64
540_L	576_M	0.795	0.64
533_S	584_E	0.794	0.64
323_C	336_I	0.794	0.64
21_S	28_G	0.790	0.64
125_N	140_F	0.790	0.64
247_T	584_E	0.789	0.64
671_Q	695_S	0.788	0.64
678_L	685_F	0.787	0.64
544_T	548_V	0.786	0.63
154_S	207_Y	0.786	0.63
208_L	212_S	0.786	0.63
125_N	247_T	0.786	0.63
109_D	113_C	0.786	0.63
238_S	310_S	0.781	0.63
63_I	85_L	0.781	0.63
587_V	656_L	0.781	0.63
487_Q	690_V	0.780	0.63
579_R	681_S	0.780	0.63
193_D	220_A	0.779	0.63
98_I	129_L	0.778	0.63
192_L	220_A	0.778	0.63
197_R	223_S	0.778	0.63
359_L	401_L	0.775	0.62
27_A	344_D	0.773	0.62
526_S	570_G	0.773	0.62
558_R	562_A	0.771	0.62
44_V	57_V	0.770	0.62
527_P	569_H	0.770	0.62
236_G	250_G	0.768	0.62
532_K	676_H	0.766	0.61
290_R	316_A	0.765	0.61
217_F	221_A	0.765	0.61
91_E	116_R	0.764	0.61
248_T	609_R	0.763	0.61
183_S	188_V	0.762	0.61
53_A	58_L	0.762	0.61
111_R	115_L	0.761	0.61
520_V	542_L	0.760	0.61
531_H	609_R	0.759	0.61
413_E	416_R	0.758	0.61
473_A	492_A	0.756	0.60
244_L	302_A	0.756	0.60
178_I	191_L	0.750	0.60
96_T	186_I	0.750	0.60
241_A	244_L	0.749	0.60
53_A	57_V	0.748	0.60
17_V	31_M	0.748	0.60
608_W	676_H	0.747	0.59
387_I	421_A	0.746	0.59
533_S	606_V	0.745	0.59
495_M	659_Q	0.743	0.59
612_D	637_K	0.742	0.59
609_R	674_D	0.740	0.59
298_A	341_D	0.740	0.59
599_I	664_I	0.738	0.59
342_L	354_T	0.738	0.59
15_I	70_P	0.738	0.59
130_L	139_S	0.737	0.58
512_I	573_V	0.736	0.58
20_A	48_T	0.735	0.58
125_N	157_A	0.733	0.58
582_A	679_L	0.732	0.58
247_T	250_G	0.730	0.58
377_A	411_S	0.727	0.57
36_L	55_L	0.727	0.57
601_L	629_L	0.725	0.57
511_H	514_E	0.724	0.57
507_T	510_V	0.724	0.57
524_L	566_A	0.722	0.57
531_H	608_W	0.721	0.57
557_D	561_M	0.721	0.57
559_V	568_V	0.717	0.56
524_L	535_V	0.715	0.56
170_R	278_E	0.714	0.56
402_L	436_F	0.712	0.56
8_A	71_D	0.712	0.56
249_A	616_V	0.712	0.56
173_G	185_D	0.712	0.56
463_T	467_H	0.711	0.56
380_T	384_Q	0.710	0.56
174_F	177_F	0.710	0.56
193_D	222_R	0.709	0.56
532_K	584_E	0.708	0.55
559_V	564_P	0.708	0.55
510_V	514_E	0.705	0.55
366_A	400_S	0.704	0.55
620_P	626_A	0.704	0.55
154_S	160_S	0.704	0.55
621_L	625_L	0.704	0.55
298_A	302_A	0.703	0.55
175_S	228_K	0.703	0.55
627_R	631_I	0.703	0.55
408_E	427_R	0.700	0.55
111_R	184_L	0.697	0.54
335_A	340_L	0.696	0.54
45_L	89_L	0.695	0.54
584_E	604_G	0.695	0.54
424_P	508_E	0.694	0.54
16_A	19_G	0.694	0.54
69_T	94_C	0.694	0.54
160_S	344_D	0.693	0.54
217_F	264_L	0.693	0.54
278_E	282_H	0.693	0.54
499_P	515_Q	0.692	0.54
511_H	545_A	0.692	0.54
126_S	244_L	0.692	0.54
78_N	101_S	0.691	0.54
495_M	663_L	0.690	0.53
70_P	92_K	0.690	0.53
244_L	295_S	0.689	0.53
137_N	296_N	0.689	0.53
110_L	115_L	0.687	0.53
15_I	40_F	0.687	0.53
51_W	61_P	0.686	0.53
507_T	545_A	0.686	0.53
82_N	99_I	0.686	0.53
9_L	522_L	0.685	0.53
86_L	114_A	0.685	0.53
28_G	76_C	0.684	0.53
187_D	190_E	0.684	0.53
631_I	640_R	0.683	0.53
244_L	247_T	0.683	0.53
242_Q	687_A	0.682	0.53
259_I	618_L	0.682	0.53
158_A	344_D	0.680	0.52
585_L	601_L	0.679	0.52
577_A	681_S	0.678	0.52
248_T	588_V	0.676	0.52
152_F	177_F	0.676	0.52
589_V	673_L	0.675	0.52
660_V	675_I	0.675	0.52
104_A	107_H	0.674	0.52
241_A	247_T	0.673	0.52
140_F	331_P	0.671	0.51
15_I	35_L	0.671	0.51
63_I	88_E	0.670	0.51
152_F	167_A	0.669	0.51
640_R	650_V	0.668	0.51
629_L	657_L	0.667	0.51
486_V	690_V	0.667	0.51
35_L	136_L	0.666	0.51
293_I	315_L	0.666	0.51
529_I	559_V	0.665	0.51
523_K	584_E	0.665	0.51
103_P	124_P	0.663	0.51
189_D	196_A	0.662	0.51
45_L	58_L	0.662	0.51
187_D	213_D	0.661	0.50
380_T	413_E	0.660	0.50
163_I	291_L	0.660	0.50
512_I	515_Q	0.659	0.50
8_A	96_T	0.658	0.50
196_A	204_I	0.658	0.50
598_L	618_L	0.658	0.50
487_Q	497_T	0.657	0.50
535_V	555_I	0.656	0.50
272_E	438_H	0.656	0.50
527_P	566_A	0.656	0.50
236_G	241_A	0.656	0.50
590_E	674_D	0.655	0.50
663_L	673_L	0.654	0.50
31_M	76_C	0.654	0.50
267_V	273_L	0.654	0.50
176_Y	201_T	0.653	0.50
465_E	468_L	0.653	0.50
321_E	391_K	0.651	0.49
491_Q	497_T	0.650	0.49
680_A	684_E	0.649	0.49
21_S	234_K	0.649	0.49
45_L	70_P	0.648	0.49
246_N	588_V	0.648	0.49
582_A	682_G	0.647	0.49
588_V	604_G	0.647	0.49
501_W	516_I	0.646	0.49
79_A	312_N	0.645	0.49
500_T	572_L	0.645	0.49
601_L	657_L	0.645	0.49
241_A	245_L	0.645	0.49
296_N	407_G	0.644	0.49
589_V	670_I	0.643	0.48
331_P	350_H	0.642	0.48
463_T	667_C	0.641	0.48
647_P	674_D	0.640	0.48
535_V	563_W	0.639	0.48
193_D	216_R	0.639	0.48
239_P	309_W	0.639	0.48
196_A	226_R	0.639	0.48
582_A	681_S	0.635	0.48
321_E	362_Q	0.634	0.48
559_V	562_A	0.634	0.48
403_T	418_F	0.634	0.48
260_Q	441_E	0.633	0.47
189_D	216_R	0.632	0.47
31_M	74_V	0.632	0.47
292_M	318_L	0.632	0.47
70_P	85_L	0.632	0.47
140_F	302_A	0.632	0.47
603_E	611_E	0.632	0.47
174_F	201_T	0.632	0.47
43_P	58_L	0.631	0.47
489_I	663_L	0.630	0.47
609_R	691_T	0.629	0.47
537_G	576_M	0.629	0.47
526_S	569_H	0.629	0.47
79_A	83_L	0.627	0.47
481_L	485_E	0.627	0.47
291_L	368_M	0.627	0.47
673_L	678_L	0.625	0.47
145_I	259_I	0.625	0.47
526_S	535_V	0.625	0.47
466_A	667_C	0.625	0.47
246_N	606_V	0.625	0.47
211_L	217_F	0.624	0.46
193_D	219_S	0.624	0.46
648_L	685_F	0.623	0.46
176_Y	194_Y	0.622	0.46
224_A	297_G	0.621	0.46
516_I	520_V	0.621	0.46
662_N	665_V	0.621	0.46
659_Q	662_N	0.620	0.46
158_A	296_N	0.620	0.46
48_T	59_A	0.620	0.46
150_L	277_V	0.619	0.46
298_A	676_H	0.619	0.46
196_A	228_K	0.618	0.46
556_F	559_V	0.617	0.46
63_I	94_C	0.617	0.46
524_L	556_F	0.616	0.46
75_L	86_L	0.616	0.46
247_T	533_S	0.616	0.46
331_P	343_R	0.616	0.46
24_P	646_R	0.615	0.46
298_A	643_S	0.614	0.45
18_I	85_L	0.614	0.45
326_L	330_L	0.613	0.45
321_E	550_Q	0.613	0.45
44_V	60_W	0.613	0.45
313_G	437_M	0.612	0.45
527_P	568_V	0.611	0.45
198_D	228_K	0.611	0.45
70_P	93_G	0.611	0.45
344_D	350_H	0.611	0.45
508_E	512_I	0.610	0.45
390_V	401_L	0.610	0.45
240_A	305_L	0.610	0.45
247_T	676_H	0.610	0.45
511_H	515_Q	0.610	0.45
681_S	684_E	0.610	0.45
482_D	569_H	0.610	0.45
131_A	194_Y	0.609	0.45
157_A	588_V	0.609	0.45
292_M	367_L	0.608	0.45
533_S	643_S	0.608	0.45
489_I	670_I	0.606	0.45
494_G	659_Q	0.606	0.45
483_T	690_V	0.606	0.45
296_N	373_P	0.605	0.44
114_A	117_H	0.605	0.44
193_D	196_A	0.605	0.44
534_E	537_G	0.605	0.44
18_I	92_K	0.605	0.44
177_F	574_Q	0.605	0.44
284_R	400_S	0.604	0.44
322_T	358_L	0.604	0.44
463_T	493_Y	0.603	0.44
488_P	491_Q	0.603	0.44
99_I	184_L	0.603	0.44
254_A	595_F	0.602	0.44
352_I	356_D	0.602	0.44
482_D	525_R	0.601	0.44
417_L	421_A	0.601	0.44
467_H	470_L	0.599	0.44
115_L	185_D	0.599	0.44
265_L	442_Y	0.598	0.44
599_I	629_L	0.597	0.44
157_A	341_D	0.597	0.44
528_D	556_F	0.597	0.44
292_M	316_A	0.596	0.43
125_N	298_A	0.595	0.43
125_N	244_L	0.594	0.43
386_L	389_A	0.594	0.43
90_G	93_G	0.594	0.43
316_A	354_T	0.594	0.43
110_L	119_M	0.593	0.43
334_V	340_L	0.593	0.43
47_V	186_I	0.593	0.43
241_A	302_A	0.593	0.43
250_G	295_S	0.593	0.43
190_E	273_L	0.591	0.43
125_N	250_G	0.590	0.43
676_H	689_D	0.589	0.43
203_A	280_L	0.588	0.43
205_L	274_F	0.587	0.43
71_D	80_S	0.587	0.43
642_R	645_L	0.585	0.42
102_A	125_N	0.585	0.42
219_S	625_L	0.585	0.42
246_N	531_H	0.583	0.42
247_T	588_V	0.582	0.42
167_A	274_F	0.582	0.42
81_R	84_A	0.582	0.42
192_L	432_T	0.581	0.42
276_A	438_H	0.580	0.42
638_K	641_A	0.577	0.42
603_E	633_G	0.577	0.42
563_W	566_A	0.577	0.42
467_H	471_Q	0.576	0.41
63_I	67_P	0.576	0.41
45_L	57_V	0.575	0.41
473_A	485_E	0.575	0.41
451_E	658_V	0.574	0.41
637_K	642_R	0.574	0.41
498_L	574_Q	0.574	0.41
642_R	646_R	0.574	0.41
110_L	121_L	0.574	0.41
507_T	544_T	0.573	0.41
503_A	508_E	0.573	0.41
587_V	678_L	0.572	0.41
274_F	296_N	0.572	0.41
243_R	337_S	0.572	0.41
577_A	678_L	0.572	0.41
86_L	110_L	0.571	0.41
215_R	219_S	0.571	0.41
528_D	570_G	0.571	0.41
26_R	31_M	0.570	0.41
16_A	47_V	0.570	0.41
207_Y	383_A	0.570	0.41
621_L	661_S	0.570	0.41
279_T	402_L	0.570	0.41
588_V	608_W	0.570	0.41
564_P	567_R	0.569	0.41
249_A	600_M	0.569	0.41
246_N	302_A	0.567	0.40
399_V	692_L	0.567	0.40
47_V	53_A	0.567	0.40
653_L	680_A	0.567	0.40
88_E	91_E	0.567	0.40
159_V	303_L	0.566	0.40
131_A	176_Y	0.566	0.40
11_R	134_Q	0.565	0.40
46_P	58_L	0.565	0.40
142_P	634_I	0.565	0.40
497_T	687_A	0.565	0.40
244_L	301_A	0.565	0.40
577_A	688_L	0.564	0.40
586_R	641_A	0.564	0.40
273_L	663_L	0.564	0.40
477_G	682_G	0.564	0.40
10_L	178_I	0.564	0.40
64_A	67_P	0.562	0.40
321_E	324_Q	0.562	0.40
74_V	138_A	0.561	0.40
246_N	249_A	0.560	0.40
623_M	651_A	0.560	0.40
103_P	247_T	0.559	0.40
35_L	73_A	0.559	0.40
241_A	250_G	0.557	0.39
195_L	201_T	0.557	0.39
599_I	665_V	0.557	0.39
87_E	90_G	0.556	0.39
533_S	689_D	0.556	0.39
527_P	567_R	0.555	0.39
531_H	689_D	0.553	0.39
247_T	531_H	0.553	0.39
484_H	488_P	0.553	0.39
241_A	309_W	0.553	0.39
528_D	568_V	0.551	0.39
487_Q	574_Q	0.551	0.39
236_G	306_D	0.551	0.39
454_A	655_Q	0.550	0.39
41_N	135_G	0.550	0.39
27_A	127_L	0.549	0.39
109_D	560_K	0.549	0.39
161_N	372_S	0.549	0.39
322_T	363_D	0.549	0.39
480_S	530_P	0.548	0.39
241_A	521_A	0.548	0.39
247_T	674_D	0.547	0.38
157_A	247_T	0.547	0.38
240_A	247_T	0.547	0.38
466_A	493_Y	0.547	0.38
362_Q	399_V	0.546	0.38
247_T	341_D	0.546	0.38
259_I	366_A	0.546	0.38
503_A	509_A	0.545	0.38
153_I	675_I	0.545	0.38
125_N	531_H	0.544	0.38
465_E	492_A	0.542	0.38
225_S	668_P	0.542	0.38
584_E	676_H	0.541	0.38
258_A	595_F	0.541	0.38
607_E	610_P	0.541	0.38
83_L	87_E	0.541	0.38
89_L	185_D	0.540	0.38
248_T	586_R	0.540	0.38
18_I	75_L	0.540	0.38
551_A	626_A	0.538	0.38
601_L	635_K	0.538	0.38
216_R	219_S	0.538	0.38
323_C	334_V	0.537	0.37
526_S	559_V	0.537	0.37
523_K	643_S	0.536	0.37
45_L	48_T	0.536	0.37
564_P	568_V	0.536	0.37
640_R	647_P	0.536	0.37
674_D	692_L	0.536	0.37
560_K	566_A	0.535	0.37
269_D	272_E	0.535	0.37
19_G	28_G	0.535	0.37
221_A	308_L	0.535	0.37
556_F	564_P	0.535	0.37
75_L	89_L	0.534	0.37
247_T	643_S	0.534	0.37
291_L	432_T	0.534	0.37
83_L	86_L	0.534	0.37
17_V	207_Y	0.533	0.37
151_A	636_S	0.533	0.37
507_T	546_N	0.533	0.37
544_T	550_Q	0.533	0.37
494_G	545_A	0.533	0.37
110_L	545_A	0.532	0.37
17_V	521_A	0.532	0.37
14_S	470_L	0.532	0.37
637_K	640_R	0.532	0.37
154_S	158_A	0.531	0.37
248_T	600_M	0.531	0.37
318_L	440_V	0.531	0.37
269_D	377_A	0.530	0.37
14_S	45_L	0.530	0.37
96_T	129_L	0.529	0.37
187_D	195_L	0.529	0.37
523_K	532_K	0.529	0.37
445_N	448_Q	0.529	0.37
93_G	290_R	0.528	0.37
210_Q	255_W	0.528	0.37
656_L	687_A	0.528	0.37
86_L	121_L	0.527	0.36
591_H	671_Q	0.527	0.36
28_G	48_T	0.527	0.36
582_A	684_E	0.527	0.36
341_D	531_H	0.527	0.36
95_K	111_R	0.526	0.36
403_T	423_L	0.525	0.36
619_P	665_V	0.525	0.36
371_H	574_Q	0.524	0.36
111_R	568_V	0.524	0.36
661_S	664_I	0.524	0.36
82_N	102_A	0.524	0.36
313_G	436_F	0.523	0.36
298_A	584_E	0.523	0.36
560_K	565_Q	0.523	0.36
427_R	431_G	0.522	0.36
470_L	473_A	0.522	0.36
575_S	686_T	0.522	0.36
585_L	648_L	0.522	0.36
384_Q	656_L	0.522	0.36
20_A	26_R	0.521	0.36
254_A	258_A	0.521	0.36
236_G	247_T	0.521	0.36
30_L	34_N	0.521	0.36
125_N	341_D	0.521	0.36
454_A	662_N	0.520	0.36
28_G	34_N	0.520	0.36
298_A	532_K	0.518	0.36
18_I	77_T	0.518	0.36
178_I	243_R	0.518	0.36
47_V	63_I	0.515	0.35
140_F	158_A	0.515	0.35
67_P	593_P	0.515	0.35
260_Q	367_L	0.515	0.35
510_V	659_Q	0.515	0.35
311_R	434_T	0.514	0.35
216_R	230_I	0.513	0.35
328_D	353_K	0.512	0.35
111_R	118_N	0.512	0.35
9_L	555_I	0.512	0.35
346_A	350_H	0.512	0.35
368_M	436_F	0.512	0.35
103_P	244_L	0.511	0.35
547_E	551_A	0.511	0.35
116_R	420_E	0.511	0.35
326_L	358_L	0.511	0.35
463_T	666_D	0.511	0.35
82_N	125_N	0.510	0.35
383_A	405_W	0.510	0.35
79_A	94_C	0.510	0.35
129_L	178_I	0.510	0.35
600_M	674_D	0.510	0.35
518_Y	542_L	0.509	0.35
514_E	544_T	0.509	0.35
153_I	568_V	0.509	0.35
113_C	119_M	0.509	0.35
106_Q	125_N	0.509	0.35
297_G	376_A	0.509	0.35
619_P	674_D	0.508	0.35
482_D	692_L	0.508	0.35
83_L	110_L	0.507	0.34
28_G	296_N	0.507	0.34
151_A	176_Y	0.507	0.34
313_G	365_D	0.507	0.34
493_Y	663_L	0.506	0.34
47_V	60_W	0.505	0.34
127_L	167_A	0.505	0.34
506_S	509_A	0.505	0.34
523_K	531_H	0.505	0.34
599_I	661_S	0.504	0.34
402_L	576_M	0.504	0.34
304_A	432_T	0.504	0.34
180_L	191_L	0.504	0.34
526_S	537_G	0.504	0.34
58_L	66_L	0.503	0.34
556_F	560_K	0.503	0.34
261_R	313_G	0.503	0.34
27_A	162_T	0.502	0.34
358_L	367_L	0.502	0.34
247_T	299_A	0.502	0.34
45_L	94_C	0.501	0.34
484_H	525_R	0.501	0.34
323_C	337_S	0.501	0.34
203_A	436_F	0.501	0.34
507_T	511_H	0.501	0.34
604_G	689_D	0.500	0.34
388_E	392_H	0.500	0.34
532_K	604_G	0.500	0.34
96_T	180_L	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2csuA	2	0.4786	100	0.628	Contact Map
3dmyA	2	0.4616	100	0.693	Contact Map
3pffA	2	0.3059	100	0.777	Contact Map
3mwdB	1	0.316	100	0.785	Contact Map
2yv1A	1	0.2912	100	0.804	Contact Map
2fp4A	1	0.3183	100	0.807	Contact Map
2nu8A	1	0.3002	100	0.809	Contact Map
2yv2A	1	0.2912	100	0.811	Contact Map
1oi7A	1	0.2912	100	0.813	Contact Map
1wr2A	1	0.2619	100	0.861	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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