GREMLIN Database
YPHH - Uncharacterized protein YphH
UniProt: P76586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13469
Length: 397 (361)
Sequences: 8378 (6031)
Seq/√Len: 317.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_N103_S3.8771.00
107_E379_A3.4691.00
171_E174_Y3.4191.00
187_D229_R3.3781.00
142_N389_Y2.9271.00
210_V335_Y2.9191.00
152_D155_T2.8711.00
98_A386_G2.7651.00
58_V77_A2.7481.00
209_C323_F2.7101.00
96_Q382_V2.6041.00
173_K177_E2.5741.00
143_L180_L2.5531.00
232_L328_N2.5481.00
252_C257_C2.4931.00
250_C257_C2.4901.00
258_L319_S2.4831.00
270_Q311_R2.4461.00
84_L129_W2.4181.00
331_Q372_G2.3851.00
241_T322_N2.3471.00
314_N352_Q2.3101.00
123_S179_K2.2901.00
22_L28_A2.2541.00
126_E179_K2.2281.00
320_L332_I2.1971.00
58_V75_L2.1821.00
203_S208_F2.1451.00
95_C128_C2.1231.00
108_F131_R2.1081.00
313_A317_G2.1011.00
223_I228_Y2.0861.00
249_V255_Y2.0471.00
194_A220_S2.0321.00
310_D348_T2.0311.00
350_I354_G2.0071.00
231_S330_N1.9601.00
211_I320_L1.9581.00
174_Y178_E1.9571.00
187_D192_M1.9441.00
207_D330_N1.9421.00
145_L176_L1.9421.00
85_C382_V1.9191.00
317_G352_Q1.9051.00
130_H179_K1.8911.00
187_D191_V1.8771.00
175_L178_E1.8371.00
313_A349_I1.8121.00
22_L57_V1.8111.00
193_L210_V1.8031.00
194_A222_V1.7851.00
353_T371_I1.7651.00
200_Q387_Y1.7451.00
206_R330_N1.7431.00
343_E347_N1.7271.00
18_I33_L1.7061.00
52_E59_N1.7041.00
346_L350_I1.6841.00
296_A300_S1.6801.00
240_H250_C1.6671.00
318_L322_N1.6581.00
146_A192_M1.6561.00
143_L182_I1.6331.00
242_I322_N1.6081.00
170_V175_L1.6061.00
250_C253_G1.6031.00
206_R224_N1.5981.00
240_H252_C1.5861.00
290_T293_Q1.5831.00
60_I75_L1.5651.00
248_V269_K1.5541.00
82_W105_K1.5501.00
331_Q370_Q1.5321.00
208_F222_V1.5241.00
48_L57_V1.5221.00
351_R355_F1.5091.00
59_N72_G1.4961.00
217_I262_A1.4931.00
313_A348_T1.4891.00
84_L140_T1.4841.00
352_Q356_N1.4831.00
292_A296_A1.4721.00
270_Q273_V1.4671.00
240_H257_C1.4591.00
297_A302_E1.4551.00
188_N237_Q1.4531.00
299_Q344_N1.4471.00
352_Q355_F1.4461.00
83_T390_V1.4451.00
126_E180_L1.4391.00
267_L312_S1.4331.00
108_F132_H1.4311.00
86_L95_C1.4211.00
92_S109_E1.4091.00
86_L125_I1.4091.00
342_G346_L1.4011.00
346_L373_F1.3981.00
25_Q36_L1.3921.00
140_T182_I1.3891.00
196_A376_L1.3721.00
271_A308_W1.3651.00
146_A381_Q1.3471.00
33_L44_V1.3391.00
324_L353_T1.3261.00
323_F326_I1.3221.00
248_V261_V1.3121.00
192_M385_I1.3091.00
32_T35_R1.3031.00
96_Q104_P1.3001.00
136_W139_H1.2931.00
130_H180_L1.2831.00
194_A208_F1.2721.00
108_F128_C1.2721.00
48_L74_W1.2711.00
81_D141_I1.2691.00
274_W307_S1.2651.00
171_E175_L1.2571.00
52_E74_W1.2531.00
348_T351_R1.2511.00
298_W309_V1.2401.00
208_F333_W1.2341.00
245_P318_L1.2221.00
324_L332_I1.2211.00
199_W391_E1.2191.00
176_L184_V1.2181.00
197_E201_N1.2071.00
21_L28_A1.2051.00
248_V260_T1.2051.00
348_T352_Q1.2041.00
253_G257_C1.1981.00
85_C385_I1.1971.00
198_K208_F1.1931.00
221_F228_Y1.1891.00
119_Q175_L1.1871.00
270_Q274_W1.1851.00
175_L179_K1.1811.00
248_V270_Q1.1791.00
21_L36_L1.1761.00
123_S127_K1.1621.00
79_E99_N1.1611.00
293_Q296_A1.1531.00
135_L139_H1.1341.00
86_L129_W1.1321.00
177_E184_V1.1291.00
191_V227_I1.1281.00
270_Q308_W1.1251.00
30_K74_W1.1181.00
117_T120_A1.1171.00
310_D351_R1.1161.00
94_E109_E1.1161.00
98_A104_P1.1051.00
110_Y127_K1.0951.00
150_Q161_M1.0951.00
271_A305_I1.0941.00
185_M389_Y1.0921.00
181_G184_V1.0881.00
110_Y128_C1.0791.00
128_C131_R1.0751.00
187_D388_L1.0741.00
190_C212_N1.0731.00
157_V169_P1.0701.00
213_V316_I1.0621.00
157_V171_E1.0611.00
209_C219_S1.0561.00
347_N351_R1.0441.00
20_E24_R1.0431.00
32_T36_L1.0401.00
298_W306_T1.0351.00
188_N216_G1.0321.00
59_N74_W1.0291.00
28_A36_L1.0271.00
83_T389_Y1.0241.00
248_V273_V1.0211.00
296_A299_Q1.0211.00
271_A275_L1.0171.00
177_E181_G1.0161.00
230_G235_S1.0091.00
224_N228_Y1.0091.00
85_C144_A1.0071.00
209_C221_F1.0051.00
275_L289_L1.0051.00
130_H137_P0.9991.00
293_Q297_A0.9961.00
228_Y327_L0.9921.00
19_L76_I0.9921.00
18_I44_V0.9921.00
122_L175_L0.9911.00
216_G237_Q0.9911.00
207_D231_S0.9871.00
198_K225_E0.9841.00
244_N261_V0.9801.00
274_W308_W0.9791.00
207_D224_N0.9761.00
199_W387_Y0.9731.00
198_K222_V0.9721.00
325_N358_F0.9661.00
207_D223_I0.9641.00
204_Q375_Q0.9621.00
30_K59_N0.9581.00
271_A276_K0.9581.00
61_D73_T0.9561.00
221_F327_L0.9511.00
347_N350_I0.9491.00
110_Y131_R0.9481.00
317_G353_T0.9461.00
27_R75_L0.9461.00
207_D228_Y0.9421.00
318_L356_N0.9381.00
267_L294_L0.9381.00
41_I45_S0.9341.00
132_H135_L0.9341.00
317_G321_Y0.9321.00
21_L37_A0.9291.00
313_A352_Q0.9281.00
310_D352_Q0.9271.00
324_L369_T0.9261.00
82_W139_H0.9251.00
343_E373_F0.9241.00
206_R225_E0.9231.00
144_A192_M0.9171.00
333_W372_G0.9161.00
257_C260_T0.9121.00
295_I309_V0.9101.00
334_L339_C0.9081.00
197_E376_L0.9061.00
306_T310_D0.9061.00
192_M388_L0.9041.00
98_A383_L0.9031.00
106_G132_H0.9011.00
298_W344_N0.8991.00
342_G373_F0.8991.00
193_L381_Q0.8971.00
209_C332_I0.8961.00
230_G236_G0.8951.00
316_I349_I0.8921.00
122_L172_V0.8881.00
240_H253_G0.8871.00
173_K186_V0.8851.00
298_W301_G0.8841.00
311_R315_A0.8831.00
270_Q312_S0.8821.00
274_W304_W0.8811.00
78_P101_C0.8781.00
250_C256_G0.8751.00
110_Y124_E0.8711.00
275_L304_W0.8671.00
82_W135_L0.8671.00
244_N248_V0.8661.00
377_S380_Q0.8641.00
126_E130_H0.8591.00
156_G173_K0.8591.00
104_P107_E0.8571.00
55_K77_A0.8531.00
118_P175_L0.8471.00
244_N247_G0.8461.00
83_T98_A0.8441.00
49_Q53_S0.8421.00
258_L312_S0.8421.00
144_A389_Y0.8411.00
299_Q343_E0.8411.00
185_M392_A0.8371.00
333_W374_G0.8351.00
267_L308_W0.8301.00
201_N204_Q0.8291.00
190_C220_S0.8261.00
242_I245_P0.8241.00
31_S71_S0.8221.00
86_L143_L0.8191.00
127_K131_R0.8181.00
242_I318_L0.8161.00
268_K294_L0.8141.00
317_G356_N0.8121.00
147_I158_S0.8121.00
120_A123_S0.8111.00
314_N318_L0.8101.00
22_L33_L0.8091.00
297_A305_I0.8081.00
242_I254_R0.8061.00
122_L170_V0.8061.00
208_F331_Q0.8041.00
342_G347_N0.8021.00
211_I238_I0.7991.00
119_Q123_S0.7991.00
124_E127_K0.7991.00
94_E107_E0.7971.00
194_A210_V0.7961.00
96_Q107_E0.7941.00
271_A294_L0.7921.00
52_E57_V0.7911.00
95_C110_Y0.7891.00
304_W307_S0.7881.00
161_M166_W0.7881.00
295_I299_Q0.7881.00
63_E71_S0.7851.00
254_R257_C0.7841.00
84_L97_V0.7841.00
254_R356_N0.7821.00
97_V133_R0.7821.00
241_T319_S0.7801.00
134_K137_P0.7791.00
88_V93_I0.7781.00
58_V78_P0.7771.00
39_I44_V0.7771.00
216_G259_E0.7771.00
231_S329_I0.7721.00
250_C260_T0.7700.99
177_E183_R0.7680.99
84_L143_L0.7650.99
298_W305_I0.7650.99
27_R73_T0.7640.99
161_M164_A0.7600.99
221_F236_G0.7580.99
99_N105_K0.7570.99
314_N348_T0.7530.99
56_R80_G0.7530.99
247_G261_V0.7510.99
124_E128_C0.7490.99
92_S264_L0.7470.99
219_S238_I0.7470.99
376_L380_Q0.7420.99
152_D159_Q0.7420.99
191_V237_Q0.7380.99
23_Y76_I0.7340.99
268_K272_R0.7330.99
22_L74_W0.7320.99
309_V313_A0.7310.99
174_Y177_E0.7310.99
189_D218_G0.7300.99
230_G328_N0.7300.99
41_I46_N0.7240.99
345_W348_T0.7230.99
235_S328_N0.7220.99
272_R287_E0.7210.99
261_V315_A0.7200.99
351_R354_G0.7190.99
269_K273_V0.7180.99
135_L138_D0.7150.99
156_G171_E0.7150.99
118_P170_V0.7150.99
252_C256_G0.7140.99
245_P314_N0.7140.99
289_L293_Q0.7130.99
83_T141_I0.7110.99
193_L335_Y0.7110.99
113_I116_P0.7090.99
176_L180_L0.7080.99
340_A378_R0.7070.99
303_P307_S0.7040.99
31_S35_R0.7040.99
320_L353_T0.7040.99
213_V338_S0.7020.99
200_Q383_L0.7010.99
244_N318_L0.6980.99
354_G368_A0.6960.99
346_L349_I0.6950.99
231_S328_N0.6950.99
307_S311_R0.6940.99
328_N369_T0.6930.99
238_I258_L0.6930.99
321_Y356_N0.6930.99
297_A300_S0.6920.99
191_V220_S0.6910.99
94_E382_V0.6910.99
188_N218_G0.6890.99
75_L101_C0.6870.99
163_Q251_D0.6860.99
98_A102_L0.6820.99
308_W312_S0.6820.99
25_Q28_A0.6810.99
188_N191_V0.6800.99
218_G237_Q0.6780.99
374_G380_Q0.6730.99
216_G239_G0.6720.99
372_G375_Q0.6710.99
148_H163_Q0.6690.99
63_E66_T0.6680.99
214_D337_R0.6660.99
201_N205_E0.6620.98
97_V140_T0.6620.98
210_V333_W0.6610.98
147_I151_V0.6600.98
209_C329_I0.6590.98
343_E350_I0.6580.98
320_L349_I0.6580.98
126_E176_L0.6580.98
310_D313_A0.6570.98
127_K130_H0.6550.98
77_A80_G0.6550.98
195_L198_K0.6500.98
149_G259_E0.6500.98
88_V147_I0.6470.98
252_C260_T0.6440.98
250_C254_R0.6400.98
106_G133_R0.6380.98
268_K291_T0.6380.98
295_I341_F0.6360.98
240_H256_G0.6350.98
202_N375_Q0.6330.98
21_L33_L0.6310.98
142_N185_M0.6300.98
246_D314_N0.6300.98
156_G177_E0.6280.98
82_W97_V0.6270.98
335_Y374_G0.6270.98
89_T215_Y0.6260.98
307_S310_D0.6230.98
302_E305_I0.6230.98
197_E374_G0.6230.98
342_G348_T0.6220.98
295_I298_W0.6220.98
178_E181_G0.6190.98
87_N381_Q0.6190.98
314_N355_F0.6180.98
321_Y325_N0.6170.98
243_V315_A0.6150.98
18_I47_I0.6140.98
369_T373_F0.6130.98
60_I73_T0.6120.97
320_L334_L0.6100.97
40_S43_A0.6090.97
243_V319_S0.6080.97
90_P215_Y0.6080.97
330_N370_Q0.6070.97
89_T337_R0.6040.97
29_N71_S0.6030.97
152_D156_G0.6000.97
334_L371_I0.6000.97
244_N315_A0.5970.97
243_V258_L0.5960.97
104_P383_L0.5960.97
189_D212_N0.5960.97
202_N205_E0.5930.97
198_K207_D0.5930.97
350_I370_Q0.5920.97
197_E375_Q0.5900.97
242_I356_N0.5890.97
342_G345_W0.5890.97
303_P306_T0.5890.97
195_L388_L0.5860.97
48_L52_E0.5850.97
78_P103_S0.5840.97
116_P124_E0.5830.97
85_C386_G0.5830.97
193_L212_N0.5820.97
203_S333_W0.5810.97
274_W311_R0.5800.97
211_I219_S0.5800.97
134_K138_D0.5790.97
142_N183_R0.5780.96
88_V125_I0.5770.96
129_W180_L0.5770.96
315_A319_S0.5760.96
254_R260_T0.5710.96
134_K139_H0.5710.96
253_G256_G0.5710.96
113_I124_E0.5700.96
150_Q234_G0.5700.96
20_E23_Y0.5690.96
83_T142_N0.5690.96
185_M388_L0.5650.96
260_T269_K0.5630.96
291_T294_L0.5630.96
93_I110_Y0.5620.96
97_V135_L0.5620.96
161_M167_T0.5610.96
37_A44_V0.5600.96
264_L268_K0.5600.96
344_N348_T0.5590.96
97_V106_G0.5580.96
349_I353_T0.5570.96
267_L291_T0.5550.96
301_G306_T0.5540.96
21_L25_Q0.5510.95
30_K41_I0.5500.95
354_G366_V0.5500.95
334_L373_F0.5480.95
242_I247_G0.5470.95
241_T323_F0.5460.95
202_N372_G0.5450.95
247_G255_Y0.5450.95
145_L172_V0.5450.95
343_E346_L0.5440.95
321_Y352_Q0.5440.95
376_L383_L0.5430.95
267_L338_S0.5420.95
272_R276_K0.5410.95
133_R138_D0.5400.95
95_C108_F0.5390.95
126_E175_L0.5380.95
198_K206_R0.5370.95
120_A124_E0.5370.95
50_E53_S0.5370.95
271_A297_A0.5360.95
160_T167_T0.5350.95
238_I326_I0.5320.94
268_K271_A0.5320.94
272_R277_S0.5310.94
264_L338_S0.5310.94
313_A345_W0.5310.94
78_P99_N0.5310.94
262_A315_A0.5290.94
193_L380_Q0.5290.94
93_I124_E0.5280.94
292_A340_A0.5280.94
93_I112_Q0.5270.94
202_N333_W0.5270.94
153_P229_R0.5270.94
243_V261_V0.5260.94
173_K184_V0.5260.94
137_P182_I0.5250.94
162_P251_D0.5230.94
85_C96_Q0.5220.94
234_G328_N0.5220.94
191_V195_L0.5210.94
226_Q391_E0.5210.94
223_I329_I0.5200.94
89_T92_S0.5200.94
129_W143_L0.5200.94
44_V48_L0.5180.94
247_G257_C0.5170.94
147_I172_V0.5160.94
191_V236_G0.5160.94
159_Q169_P0.5160.94
46_N49_Q0.5160.94
46_N50_E0.5150.93
47_I50_E0.5140.93
213_V264_L0.5120.93
349_I352_Q0.5110.93
87_N188_N0.5110.93
79_E105_K0.5110.93
21_L24_R0.5100.93
83_T100_A0.5080.93
88_V145_L0.5080.93
94_E378_R0.5080.93
272_R275_L0.5070.93
244_N255_Y0.5060.93
294_L298_W0.5050.93
256_G260_T0.5040.93
54_E58_V0.5030.93
195_L199_W0.5020.93
208_F330_N0.5010.93
383_L386_G0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z05A 2 0.9647 100 0.164 Contact Map
1z6rA 3 0.932 100 0.175 Contact Map
2hoeA 2 0.8766 100 0.223 Contact Map
4ijaA 2 0.9068 100 0.257 Contact Map
3o8mA 1 0.9169 100 0.367 Contact Map
2ap1A 2 0.7406 100 0.378 Contact Map
4db3A 2 0.7557 100 0.38 Contact Map
2yhwA 2 0.7531 100 0.395 Contact Map
1bdgA 1 0.8892 100 0.399 Contact Map
3f9mA 1 0.8942 100 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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