GREMLIN Database
YPHG - Uncharacterized protein YphG
UniProt: P76585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13468
Length: 1093 (1072)
Sequences: 242 (199)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
863_Q866_K7.6421.00
66_D167_D6.8501.00
946_N991_L6.0801.00
354_S432_L5.7710.99
515_V519_T5.7680.99
994_E997_T5.6240.99
618_R621_N5.2030.99
80_V171_L4.8760.98
515_V548_Q4.6510.97
950_D953_E4.5500.97
781_W801_Y4.4540.97
989_L994_E4.4000.96
382_R396_D4.3940.96
82_R91_D4.2900.96
499_L540_I4.1850.95
816_L837_L4.1640.95
10_R57_S4.1480.95
462_E524_R4.1460.95
555_E579_A4.1150.95
146_W161_G4.0030.94
60_A73_L3.9610.94
579_A591_F3.9580.93
1053_A1065_R3.8700.93
989_L997_T3.7850.92
420_T435_Q3.6100.90
357_A432_L3.5890.89
990_R995_Q3.5560.89
718_I721_F3.4400.87
906_Q909_Q3.4350.87
938_W957_C3.4310.87
647_G652_A3.3680.86
744_W774_S3.3370.86
70_V171_L3.2920.85
21_Q46_T3.2860.85
397_D409_G3.2730.84
385_I411_L3.2580.84
794_D797_L3.2380.84
771_V780_G3.1460.82
611_L679_M3.1360.82
87_V90_R3.1310.81
747_R766_F3.1120.81
519_T545_Y3.0930.81
898_A914_L3.0410.79
592_C612_L3.0220.79
614_V642_L3.0160.79
614_V674_L2.9960.78
642_L674_L2.9620.78
17_E54_T2.9300.77
1067_E1070_A2.9230.77
733_E736_A2.9210.77
487_G497_C2.9180.76
385_I421_I2.9090.76
202_Q268_H2.9030.76
1006_K1051_A2.8720.75
90_R267_C2.8390.74
58_W877_H2.8290.74
87_V345_H2.7800.73
955_T959_R2.7700.72
1009_A1048_A2.7610.72
138_H142_A2.7230.71
537_A855_L2.7080.71
460_T497_C2.6860.70
561_A571_G2.6840.70
515_V550_Q2.6410.69
385_I419_L2.6150.68
671_A687_L2.5940.67
261_D354_S2.5850.67
12_E55_L2.5620.66
753_F756_N2.5600.66
550_Q553_Q2.5200.65
451_P466_I2.4990.64
383_L399_V2.4760.63
97_E308_N2.4740.63
555_E591_F2.4720.63
593_Q609_H2.4620.63
745_F774_S2.3990.61
785_A802_L2.3860.60
718_I722_P2.3690.60
1052_S1057_E2.3650.60
535_G564_S2.3640.59
88_K267_C2.3540.59
202_Q917_A2.3490.59
486_R490_L2.3450.59
151_E154_H2.3410.59
359_I432_L2.3340.58
552_Q582_N2.3330.58
709_E714_V2.3250.58
8_Q59_Q2.3080.58
1012_M1015_T2.2990.57
953_E956_R2.2930.57
155_G669_M2.2520.56
126_T151_E2.2390.55
17_E56_K2.2380.55
854_L858_W2.1850.53
499_L537_A2.1850.53
714_V721_F2.1760.53
268_H917_A2.1700.53
12_E57_S2.1500.52
138_H163_T2.1390.52
93_V115_I2.1280.51
515_V545_Y2.1010.50
493_L524_R2.0960.50
332_Y602_N2.0850.50
761_N792_Q2.0830.50
39_A151_E2.0800.49
383_L423_L2.0590.49
263_V316_T2.0490.48
180_G673_Q2.0270.48
90_R270_E2.0170.47
511_F735_A2.0060.47
453_A1018_E2.0020.47
464_W468_Q1.9940.46
868_A893_N1.9910.46
201_H501_L1.9890.46
347_L371_G1.9800.46
368_I385_I1.9780.46
501_L505_E1.9760.46
806_Y843_I1.9690.45
271_D346_S1.9620.45
17_E50_S1.9500.45
933_T979_V1.9440.45
897_R901_H1.9320.44
283_A318_I1.9310.44
599_C925_S1.9090.43
60_A71_M1.9020.43
764_I787_H1.8950.43
990_R999_Q1.8820.42
702_A740_I1.8780.42
1045_L1064_A1.8710.42
104_V289_W1.8690.42
71_M81_H1.8580.42
107_L129_M1.8500.41
933_T965_D1.8490.41
8_Q133_F1.8300.41
210_T1056_G1.8220.40
88_K345_H1.8180.40
946_N958_L1.8100.40
144_T161_G1.8030.40
537_A702_A1.8010.40
745_F770_C1.7910.39
727_F737_L1.7850.39
372_L480_P1.7770.39
11_V550_Q1.7740.39
1008_W1047_V1.7720.39
986_G1002_F1.7630.38
785_A1014_K1.7540.38
67_Y539_L1.7450.38
878_P1026_Q1.7420.38
201_H487_G1.7380.37
562_V572_Y1.7380.37
601_T632_D1.7330.37
90_R636_N1.7270.37
702_A714_V1.7190.37
545_Y550_Q1.7140.37
641_W871_L1.7140.37
88_K269_D1.7110.37
868_A872_A1.7010.36
359_I435_Q1.7010.36
423_L431_V1.6970.36
946_N951_E1.6960.36
58_W128_F1.6930.36
267_C636_N1.6930.36
263_V977_Q1.6850.36
896_L899_W1.6820.36
578_L582_N1.6770.35
72_I147_V1.6700.35
684_A701_Q1.6690.35
282_I864_A1.6650.35
160_T674_L1.6630.35
177_V1047_V1.6620.35
546_E577_R1.6590.35
943_I991_L1.6540.35
991_L1042_E1.6490.35
804_N902_L1.6340.34
519_T548_Q1.6240.34
393_A396_D1.6180.34
1049_M1064_A1.6150.33
87_V267_C1.6110.33
485_L489_A1.6100.33
610_N626_R1.6050.33
63_L131_V1.6040.33
268_H1032_L1.5930.33
72_I583_G1.5880.33
934_D979_V1.5720.32
514_A517_Y1.5640.32
384_A424_S1.5630.32
58_W882_G1.5540.32
878_P882_G1.5530.31
21_Q1047_V1.5430.31
589_L609_H1.5300.31
734_V753_F1.5260.31
22_D629_L1.5190.30
443_P1014_K1.5150.30
685_E810_P1.5140.30
685_E831_E1.5130.30
669_M672_G1.5120.30
1016_S1037_Q1.5080.30
637_A851_T1.5040.30
177_V543_S1.5010.30
47_D891_I1.5000.30
1049_M1068_L1.4950.30
514_A901_H1.4930.30
653_L702_A1.4890.30
627_E643_N1.4870.29
382_R702_A1.4850.29
151_E497_C1.4820.29
345_H487_G1.4800.29
1003_S1014_K1.4780.29
210_T444_L1.4750.29
569_A598_A1.4730.29
131_V756_N1.4710.29
1068_L1071_I1.4680.29
6_V145_V1.4650.29
62_W69_K1.4630.29
204_V263_V1.4610.29
794_D1074_A1.4500.28
90_R345_H1.4500.28
50_S1065_R1.4420.28
911_C945_A1.4410.28
312_I673_Q1.4350.28
357_A381_Y1.4310.28
177_V337_F1.4290.28
1049_M1053_A1.4280.28
261_D319_F1.4240.28
580_A612_L1.4220.28
558_F852_A1.4200.28
58_W320_A1.4160.27
154_H978_P1.4160.27
606_L628_K1.4140.27
24_H815_L1.4130.27
211_A445_P1.4110.27
1026_Q1030_L1.4110.27
1017_I1036_L1.4090.27
383_L1070_A1.4070.27
967_T1004_E1.4060.27
148_G349_M1.4010.27
209_V321_D1.3990.27
211_A975_N1.3990.27
1034_G1039_Q1.3930.27
155_G978_P1.3930.27
573_Y577_R1.3880.27
520_Q523_K1.3860.27
675_I704_L1.3760.26
307_N946_N1.3760.26
372_L511_F1.3750.26
156_L978_P1.3730.26
151_E817_F1.3700.26
631_R960_L1.3670.26
11_V71_M1.3640.26
21_Q1008_W1.3640.26
467_G500_A1.3620.26
272_G756_N1.3620.26
497_C501_L1.3590.26
726_R749_L1.3580.26
564_S778_A1.3550.26
464_W467_G1.3490.26
972_S1008_W1.3430.25
10_R59_Q1.3380.25
882_G1026_Q1.3360.25
482_D913_L1.3350.25
978_P981_Y1.3330.25
510_D513_Q1.3320.25
222_A514_A1.3300.25
7_W104_V1.3300.25
959_R997_T1.3290.25
1041_K1057_E1.3290.25
959_R994_E1.3260.25
51_E877_H1.3250.25
52_Q650_E1.3230.25
534_C786_I1.3230.25
578_L749_L1.3190.25
877_H882_G1.3190.25
383_L952_T1.3190.25
477_S812_D1.3180.25
462_E528_L1.3160.25
592_C667_A1.3120.25
347_L432_L1.3070.24
196_K1001_L1.3060.24
456_D832_K1.3050.24
571_G605_V1.3040.24
701_Q777_F1.2940.24
754_Y766_F1.2940.24
90_R151_E1.2900.24
1057_E1060_Q1.2890.24
512_P765_A1.2870.24
917_A937_I1.2860.24
316_T434_Y1.2830.24
62_W71_M1.2800.24
126_T129_M1.2800.24
69_K91_D1.2690.23
743_C944_C1.2670.23
562_V571_G1.2670.23
730_T740_I1.2650.23
272_G753_F1.2620.23
828_A832_K1.2620.23
210_T447_V1.2620.23
347_L354_S1.2600.23
1010_Q1035_D1.2590.23
451_P635_L1.2570.23
233_V983_F1.2560.23
261_D459_S1.2550.23
1048_A1052_S1.2550.23
1013_A1048_A1.2500.23
702_A718_I1.2500.23
770_C780_G1.2480.23
467_G578_L1.2470.23
227_T236_S1.2460.23
597_R601_T1.2420.23
513_Q681_T1.2400.23
642_L645_F1.2350.23
510_D762_K1.2340.23
88_K201_H1.2330.23
911_C941_Q1.2250.22
912_E1063_S1.2230.22
519_T541_R1.2220.22
511_F779_D1.2190.22
109_P244_Y1.2170.22
354_S1037_Q1.2170.22
383_L844_A1.2170.22
714_V720_V1.2160.22
87_V497_C1.2120.22
878_P928_R1.2070.22
58_W757_K1.2060.22
193_P232_K1.2050.22
936_D981_Y1.2040.22
193_P341_F1.2020.22
771_V781_W1.2020.22
222_A272_G1.1990.22
126_T295_E1.1990.22
39_A756_N1.1980.22
824_K853_E1.1970.22
486_R489_A1.1920.22
407_I411_L1.1880.21
345_H373_Y1.1840.21
505_E510_D1.1830.21
684_A832_K1.1830.21
1019_A1036_L1.1810.21
661_Q665_V1.1800.21
201_H497_C1.1780.21
275_L344_Y1.1750.21
945_A953_E1.1750.21
647_G653_L1.1740.21
464_W609_H1.1720.21
378_L432_L1.1670.21
345_H970_I1.1650.21
112_S305_T1.1620.21
70_V422_E1.1610.21
794_D842_E1.1570.21
778_A786_I1.1560.21
519_T544_A1.1540.21
106_L121_Q1.1530.21
738_E762_K1.1510.21
216_G232_K1.1490.21
232_K341_F1.1490.21
329_L561_A1.1440.20
223_F531_N1.1430.20
773_M1068_L1.1410.20
445_P882_G1.1370.20
429_N761_N1.1350.20
777_F1033_Y1.1330.20
263_V887_T1.1320.20
69_K759_S1.1310.20
590_D616_S1.1300.20
411_L1041_K1.1300.20
909_Q912_E1.1300.20
225_I238_G1.1280.20
656_W838_E1.1270.20
877_H975_N1.1250.20
702_A1065_R1.1240.20
411_L717_A1.1220.20
462_E979_V1.1220.20
270_E852_A1.1210.20
13_I53_K1.1140.20
1014_K1041_K1.1130.20
151_E501_L1.1110.20
459_S999_Q1.1100.20
673_Q821_L1.1100.20
91_D267_C1.1090.20
350_V464_W1.1070.20
1042_E1068_L1.1060.20
365_K842_E1.1040.19
716_K1041_K1.1040.19
233_V785_A1.1020.19
578_L606_L1.1000.19
162_F171_L1.0970.19
669_M759_S1.0970.19
962_A997_T1.0960.19
174_A730_T1.0960.19
272_G541_R1.0960.19
610_N846_K1.0960.19
155_G462_E1.0940.19
267_C981_Y1.0940.19
937_I1019_A1.0930.19
22_D47_D1.0930.19
482_D632_D1.0920.19
964_G976_D1.0920.19
90_R269_D1.0900.19
80_V354_S1.0880.19
658_G684_A1.0870.19
148_G635_L1.0850.19
282_I319_F1.0840.19
979_V1047_V1.0820.19
354_S606_L1.0820.19
568_K598_A1.0780.19
61_V133_F1.0770.19
756_N1032_L1.0760.19
396_D794_D1.0750.19
467_G539_L1.0730.19
775_P781_W1.0700.19
438_Q703_S1.0680.19
832_K905_R1.0670.19
615_L682_L1.0650.19
126_T669_M1.0650.19
161_G201_H1.0630.19
436_E724_F1.0620.19
361_L770_C1.0600.19
776_E1065_R1.0590.18
1045_L1067_E1.0590.18
728_P740_I1.0580.18
401_L911_C1.0550.18
341_F964_G1.0550.18
99_I714_V1.0550.18
320_A882_G1.0530.18
816_L871_L1.0530.18
374_A813_A1.0520.18
703_S736_A1.0490.18
539_L578_L1.0480.18
541_R890_F1.0440.18
481_F504_L1.0430.18
199_E1053_A1.0430.18
171_L279_N1.0420.18
82_R201_H1.0400.18
178_Y553_Q1.0400.18
497_C756_N1.0390.18
774_S1065_R1.0380.18
612_L1060_Q1.0380.18
727_F733_E1.0370.18
22_D642_L1.0370.18
142_A804_N1.0360.18
911_C944_C1.0360.18
20_P809_A1.0350.18
456_D1045_L1.0330.18
17_E21_Q1.0330.18
433_S558_F1.0330.18
770_C1074_A1.0320.18
380_G421_I1.0310.18
511_F547_R1.0310.18
388_I391_C1.0300.18
52_Q511_F1.0280.18
93_V373_Y1.0280.18
97_E524_R1.0280.18
722_P743_C1.0270.18
595_S957_C1.0260.18
819_R823_D1.0250.18
930_P1007_Q1.0240.18
658_G900_Q1.0230.18
642_L928_R1.0210.18
949_G1013_A1.0200.18
452_L456_D1.0190.18
500_A824_K1.0180.18
320_A849_D1.0180.18
90_R970_I1.0160.18
151_E1029_L1.0130.18
426_A656_W1.0110.17
855_L1018_E1.0110.17
454_A541_R1.0110.17
902_L907_P1.0100.17
159_M338_E1.0050.17
710_R780_G1.0040.17
341_F929_L1.0040.17
653_L657_R1.0040.17
357_A378_L1.0040.17
692_C946_N1.0030.17
63_L80_V1.0000.17
275_L341_F0.9980.17
441_A972_S0.9970.17
478_R1031_S0.9930.17
336_R556_E0.9920.17
165_R172_E0.9870.17
401_L590_D0.9860.17
24_H779_D0.9860.17
132_D759_S0.9830.17
441_A1003_S0.9830.17
896_L984_W0.9830.17
407_I785_A0.9830.17
418_R959_R0.9820.17
6_V495_Y0.9820.17
457_I466_I0.9820.17
80_V636_N0.9800.17
115_I232_K0.9790.17
612_L905_R0.9790.17
103_L848_D0.9750.17
211_A882_G0.9750.17
423_L571_G0.9720.17
733_E948_Q0.9710.17
402_M578_L0.9710.17
143_Q991_L0.9700.17
686_M919_H0.9700.17
170_A340_Y0.9700.17
1014_K1076_P0.9680.17
775_P810_P0.9670.17
631_R864_A0.9670.17
999_Q1010_Q0.9660.17
1048_A1064_A0.9660.17
39_A91_D0.9650.17
1037_Q1041_K0.9650.17
754_Y762_K0.9640.17
497_C970_I0.9640.17
237_A996_Q0.9640.17
651_S1049_M0.9630.17
216_G929_L0.9620.16
629_L639_L0.9610.16
852_A887_T0.9610.16
422_E835_A0.9600.16
341_F976_D0.9590.16
942_A958_L0.9590.16
535_G585_F0.9580.16
21_Q543_S0.9580.16
271_D523_K0.9570.16
175_S579_A0.9560.16
18_T46_T0.9540.16
513_Q1048_A0.9540.16
727_F740_I0.9530.16
138_H144_T0.9520.16
211_A877_H0.9510.16
535_G1007_Q0.9510.16
990_R997_T0.9490.16
631_R738_E0.9490.16
564_S585_F0.9460.16
106_L926_E0.9450.16
9_E71_M0.9450.16
859_H889_Q0.9450.16
995_Q1003_S0.9450.16
144_T163_T0.9440.16
267_C1032_L0.9440.16
400_A411_L0.9420.16
90_R272_G0.9420.16
515_V541_R0.9410.16
177_V547_R0.9390.16
72_I1049_M0.9350.16
702_A721_F0.9350.16
151_E981_Y0.9340.16
962_A965_D0.9340.16
1016_S1065_R0.9330.16
456_D617_G0.9320.16
543_S1047_V0.9320.16
1010_Q1048_A0.9310.16
587_A591_F0.9300.16
318_I1052_S0.9300.16
21_Q177_V0.9290.16
482_D862_G0.9280.16
201_H978_P0.9270.16
380_G391_C0.9270.16
404_A611_L0.9260.16
282_I571_G0.9250.16
93_V592_C0.9240.16
376_S1033_Y0.9230.16
171_L213_F0.9220.16
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654_A1070_A0.5120.09
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284_P289_W0.5110.09
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38_G326_F0.5110.09
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315_M472_Q0.5100.09
627_E949_G0.5100.09
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171_L663_R0.5080.09
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81_H540_I0.5070.09
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595_S959_R0.5070.09
154_H201_H0.5070.09
203_S223_F0.5060.09
101_P325_D0.5060.09
43_Y1032_L0.5060.09
231_Y448_A0.5060.09
785_A1017_I0.5060.09
46_T786_I0.5050.09
279_N293_H0.5050.09
438_Q1033_Y0.5050.09
512_P1072_N0.5050.09
124_R324_P0.5050.09
627_E953_E0.5050.09
241_I976_D0.5040.09
602_N633_Y0.5040.09
189_W194_A0.5040.09
1018_E1021_F0.5040.09
204_V968_I0.5040.09
151_E505_E0.5040.09
121_Q189_W0.5030.09
670_T978_P0.5030.09
644_W689_A0.5030.09
62_W544_A0.5030.09
69_K642_L0.5030.09
994_E1016_S0.5030.09
327_T564_S0.5030.09
218_R254_M0.5020.09
18_T1031_S0.5020.09
120_P848_D0.5020.09
388_I715_A0.5020.09
761_N908_Q0.5010.09
811_Q952_T0.5010.09
53_K58_W0.5010.09
1028_D1043_K0.5010.09
189_W473_Y0.5000.09
43_Y151_E0.5000.09
48_T877_H0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5cd6A 2 0.4968 100 0.87 Contact Map
4ui9J 2 0.4483 100 0.915 Contact Map
4hnyA 1 0.5096 100 0.915 Contact Map
4uzyA 1 0.4831 100 0.916 Contact Map
4kvmA 3 0.5242 100 0.916 Contact Map
1w3bA 2 0.3541 100 0.917 Contact Map
4bujB 1 0.7575 100 0.918 Contact Map
4rg9A 2 0.4053 100 0.92 Contact Map
4ui9C 2 0.4602 100 0.922 Contact Map
2xpiA 2 0.4538 100 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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