GREMLIN Database
YFHM - Uncharacterized lipoprotein YfhM
UniProt: P76578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13394
Length: 1653 (1495)
Sequences: 1414 (1160)
Seq/√Len: 30.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
292_I316_Q7.9991.00
316_Q319_I7.8971.00
292_I307_T7.8121.00
307_T316_Q5.9321.00
774_K811_T5.6451.00
407_G446_Y5.6441.00
510_G592_L5.5031.00
564_D568_R5.4891.00
334_A342_V5.3661.00
654_D658_V5.2871.00
319_I355_A5.2401.00
1549_D1614_Y5.1521.00
978_N982_E5.1451.00
1187_C1190_Q5.1091.00
874_P986_T5.0641.00
913_D916_Q5.0361.00
764_K771_D4.9941.00
880_K982_E4.9201.00
1036_T1088_R4.9001.00
876_T986_T4.8791.00
737_F740_G4.8601.00
763_D767_Y4.8581.00
1378_W1381_D4.8561.00
1185_Y1601_A4.8431.00
1258_M1279_G4.8221.00
1188_L1233_M4.7631.00
1623_T1647_D4.4191.00
975_V983_G4.3731.00
404_I449_T4.2871.00
1513_G1517_K4.2761.00
1237_N1249_E4.2401.00
1183_Y1187_C4.2211.00
103_V137_V4.1901.00
403_V477_F4.0971.00
737_F741_Y4.0531.00
878_K982_E4.0521.00
815_D818_W3.9981.00
1195_L1226_G3.8591.00
1187_C1634_M3.8231.00
1187_C1425_T3.7361.00
878_K984_S3.5211.00
1530_V1616_A3.5201.00
307_T319_I3.5011.00
321_V342_V3.4671.00
1136_T1486_L3.4591.00
874_P988_P3.4271.00
294_V307_T3.3871.00
1554_G1618_A3.3701.00
1183_Y1190_Q3.3511.00
307_T321_V3.3231.00
1183_Y1425_T3.3071.00
1183_Y1189_E3.2501.00
1190_Q1425_T3.2471.00
489_L592_L3.2431.00
1190_Q1634_M3.2001.00
772_T811_T3.1991.00
1532_V1614_Y3.1851.00
405_L463_I3.1831.00
1029_R1595_D3.1821.00
859_L881_A3.1781.00
1163_L1488_M3.1251.00
896_V998_V3.0811.00
1189_E1425_T3.0651.00
1183_Y1634_M3.0471.00
784_K802_D3.0451.00
1099_Q1118_Q3.0441.00
1623_T1649_L3.0411.00
291_D309_S3.0131.00
1387_R1426_Q2.9931.00
667_V700_Q2.9381.00
1053_L1073_V2.9121.00
1425_T1634_M2.9101.00
876_T984_S2.8701.00
669_L723_L2.7841.00
901_S997_R2.7691.00
199_F270_A2.7381.00
405_L448_F2.7261.00
947_F950_D2.7241.00
320_E333_Q2.7211.00
350_A355_A2.7121.00
1191_T1233_M2.6751.00
741_Y745_D2.6711.00
665_L725_V2.6681.00
398_R1595_D2.6621.00
1023_A1100_A2.6611.00
1314_L1318_R2.6591.00
1029_R1556_E2.6571.00
865_T998_V2.6291.00
773_I813_P2.6261.00
1629_P1643_G2.6251.00
995_E1014_K2.6131.00
513_L905_N2.6001.00
1036_T1086_P2.5861.00
1185_Y1189_E2.5851.00
1532_V1549_D2.5841.00
425_D433_V2.5650.99
1187_C1635_Y2.5620.99
1188_L1253_L2.5360.99
336_S342_V2.5350.99
1188_L1230_L2.5300.99
1189_E1634_M2.5180.99
901_S1014_K2.5140.99
1377_I1381_D2.4860.99
1256_Y1429_N2.4850.99
1555_L1648_L2.4840.99
1524_L1618_A2.4760.99
1184_P1189_E2.4650.99
320_E335_T2.4520.99
1227_I1261_L2.4400.99
1191_T1229_R2.4310.99
1508_E1535_Q2.4160.99
427_I464_R2.4110.99
764_K767_Y2.4050.99
1184_P1425_T2.4040.99
733_S737_F2.4030.99
294_V355_A2.3990.99
773_I850_L2.3750.99
1185_Y1190_Q2.3730.99
891_Q976_T2.3720.99
388_F409_L2.3700.99
785_G827_T2.3680.99
665_L702_L2.3650.99
296_A364_L2.3620.99
1097_E1118_Q2.3610.99
509_V568_R2.3450.99
946_R950_D2.3310.99
1547_V1602_V2.3200.99
297_H790_E2.3110.99
1555_L1616_A2.3090.99
510_G563_L2.2980.99
347_D350_A2.2970.99
294_V319_I2.2710.99
1259_D1311_Y2.2550.99
544_F616_G2.2540.99
1284_L1321_K2.2500.99
1047_T1077_P2.2420.99
527_L588_F2.2310.99
1317_A1352_T2.2130.98
1239_G1249_E2.2040.98
1184_P1187_C2.2040.98
530_R587_I2.1870.98
1533_W1613_V2.1850.98
732_V737_F2.1850.98
1279_G1283_L2.1680.98
896_V987_L2.1590.98
1240_F1279_G2.1560.98
187_V195_V2.1550.98
1030_F1553_A2.1430.98
349_N354_L2.1380.98
1235_R1249_E2.1270.98
403_V452_L2.1250.98
1043_I1073_V2.1220.98
773_I814_V2.1110.98
542_F649_D2.1100.98
734_S740_G2.0990.98
1184_P1190_Q2.0990.98
1535_Q1611_T2.0970.98
1276_I1279_G2.0960.98
1524_L1555_L2.0910.98
1589_K1603_A2.0900.98
996_L1017_V2.0880.98
1556_E1595_D2.0820.98
894_V1000_A2.0800.98
349_N355_A2.0610.98
441_P893_N2.0550.98
433_V436_S2.0520.97
526_Q591_S2.0520.97
875_L1015_V2.0500.97
883_T887_E2.0380.97
1532_V1616_A2.0380.97
1073_V1083_L2.0320.97
1551_L1616_A2.0320.97
136_I158_T2.0300.97
864_E878_K2.0190.97
393_P969_V2.0170.97
1507_I1547_V2.0110.97
426_V452_L2.0110.97
1189_E1193_S2.0080.97
1524_L1530_V1.9990.97
734_S737_F1.9970.97
666_Q701_T1.9960.97
1185_Y1425_T1.9910.97
1311_Y1314_L1.9860.97
862_A880_K1.9850.97
267_V290_S1.9850.97
1076_A1079_V1.9840.97
391_F895_L1.9800.97
1188_L1257_V1.9740.97
1605_D1608_Q1.9700.97
309_S312_N1.9640.97
1241_A1247_G1.9600.97
1052_K1074_E1.9570.97
774_K809_D1.9550.97
428_K432_Q1.9490.97
524_Q591_S1.9460.97
427_I462_H1.9440.96
350_A353_L1.9290.96
1048_D1077_P1.9240.96
406_N893_N1.9220.96
1191_T1226_G1.9150.96
860_D882_S1.9140.96
732_V740_G1.9120.96
1047_T1078_G1.9050.96
668_R724_E1.9030.96
1530_V1555_L1.8940.96
141_K154_D1.8910.96
665_L704_L1.8890.96
270_A287_F1.8880.96
507_S570_E1.8830.96
1254_T1279_G1.8800.96
879_I894_V1.8760.96
741_Y744_Q1.8750.96
1466_L1471_L1.8730.96
733_S740_G1.8670.96
787_A801_I1.8620.96
1231_L1275_A1.8570.95
1525_R1528_D1.8560.95
1534_L1549_D1.8430.95
869_M989_I1.8410.95
355_A789_V1.8390.95
489_L510_G1.8330.95
666_Q699_E1.8290.95
864_E880_K1.8270.95
1057_L1100_A1.8220.95
1384_S1387_R1.8180.95
1314_L1317_A1.8160.95
1241_A1245_K1.8060.95
350_A354_L1.8000.95
814_V852_L1.7940.94
520_G565_D1.7900.94
426_V477_F1.7890.94
297_H928_I1.7870.94
763_D774_K1.7840.94
318_G335_T1.7840.94
395_D909_Y1.7820.94
480_E1559_N1.7660.94
789_V825_L1.7640.94
1547_V1631_V1.7600.94
198_N273_N1.7580.94
134_D158_T1.7550.94
767_Y771_D1.7460.94
877_V896_V1.7430.94
740_G744_Q1.7420.94
565_D568_R1.7400.94
664_G701_T1.7360.93
1509_R1549_D1.7360.93
863_L1011_N1.7290.93
1054_N1072_A1.7240.93
1534_L1614_Y1.7200.93
390_M407_G1.7190.93
1519_K1530_V1.7140.93
736_R740_G1.7120.93
813_P816_K1.7110.93
1064_E1090_L1.7070.93
119_D122_K1.6910.93
664_G703_D1.6890.92
897_S999_M1.6890.92
615_P652_Y1.6890.92
1258_M1276_I1.6890.92
1510_H1535_Q1.6830.92
185_L270_A1.6720.92
670_I724_E1.6700.92
1265_G1276_I1.6680.92
767_Y773_I1.6610.92
869_M875_L1.6590.92
786_Y800_E1.6370.91
103_V139_I1.6350.91
291_D311_E1.6280.91
862_A882_S1.6280.91
320_E356_R1.6200.91
1339_S1342_P1.6110.91
678_W686_W1.6080.90
1556_E1594_R1.6060.90
198_N271_V1.6040.90
452_L479_V1.5930.90
968_V996_L1.5900.90
1065_L1068_D1.5890.90
772_T813_P1.5860.90
304_D341_H1.5810.90
1523_S1651_V1.5790.90
812_I850_L1.5770.90
774_K812_I1.5760.90
896_V1000_A1.5730.89
736_R739_A1.5710.89
1530_V1650_I1.5700.89
1190_Q1635_Y1.5700.89
1531_L1615_L1.5690.89
1529_L1617_R1.5610.89
1326_A1330_I1.5610.89
1124_R1596_D1.5600.89
870_R873_Q1.5550.89
1004_T1007_D1.5470.89
868_K1018_A1.5400.88
1054_N1070_P1.5390.88
85_L137_V1.5370.88
513_L902_G1.5370.88
356_R359_G1.5340.88
899_V904_L1.5310.88
1534_L1629_P1.5190.88
1505_L1631_V1.5130.88
1163_L1449_T1.5130.88
1041_L1055_V1.5100.87
865_T1013_S1.5090.87
1537_K1609_P1.5080.87
1186_G1197_P1.5030.87
1043_I1055_V1.5020.87
1311_Y1316_L1.5000.87
1282_R1286_Y1.4970.87
1180_L1197_P1.4970.87
700_Q712_V1.4890.87
1510_H1533_W1.4770.86
704_L710_G1.4760.86
678_W683_D1.4730.86
1618_A1650_I1.4670.86
1422_W1428_S1.4660.86
1058_T1099_Q1.4650.86
668_R726_K1.4640.86
1193_S1256_Y1.4620.86
1185_Y1634_M1.4600.86
520_G562_T1.4570.85
505_K572_S1.4560.85
294_V364_L1.4550.85
861_L879_I1.4550.85
1230_L1275_A1.4550.85
402_T449_T1.4510.85
1165_L1449_T1.4510.85
1545_A1631_V1.4450.85
1280_N1321_K1.4440.85
322_S356_R1.4440.85
452_L1449_T1.4410.85
197_V254_L1.4400.85
790_E926_A1.4370.85
645_N713_S1.4360.85
105_D135_L1.4340.85
995_E1016_I1.4320.84
670_I696_I1.4300.84
1050_P1076_A1.4300.84
962_V965_V1.4290.84
187_V1650_I1.4280.84
647_A711_K1.4260.84
102_H140_G1.4230.84
169_G188_M1.4230.84
460_M478_H1.4170.84
487_M521_N1.4120.84
1139_Q1142_E1.4100.83
733_S736_R1.4060.83
323_L344_L1.4010.83
1506_Q1537_K1.4010.83
737_F744_Q1.4000.83
144_K148_N1.3960.83
1064_E1088_R1.3900.83
1189_E1635_Y1.3880.82
1184_P1634_M1.3870.82
1138_L1486_L1.3840.82
1311_Y1315_V1.3750.82
883_T886_G1.3740.82
1179_E1183_Y1.3730.82
1254_T1282_R1.3710.82
1507_I1629_P1.3670.82
797_W815_D1.3660.81
652_Y704_L1.3610.81
1195_L1260_F1.3610.81
1327_L1350_L1.3560.81
898_A998_V1.3560.81
801_I1534_L1.3550.81
484_P902_G1.3510.81
1027_M1057_L1.3500.81
901_S995_E1.3460.80
1032_A1124_R1.3450.80
458_T1592_E1.3440.80
1415_Q1418_F1.3390.80
1313_A1316_L1.3390.80
189_A242_L1.3370.80
679_N689_Q1.3350.80
1531_L1613_V1.3330.80
424_L465_A1.3270.80
189_A252_L1.3250.79
1057_L1085_I1.3230.79
488_A511_Y1.3230.79
1031_M1037_S1.3190.79
768_R855_E1.3170.79
997_R1014_K1.3150.79
735_V739_A1.3120.79
594_E1624_Y1.3110.79
322_S333_Q1.3110.79
759_T778_A1.3070.78
777_I803_V1.3050.78
1533_W1611_T1.3050.78
1183_Y1632_E1.3010.78
126_L129_L1.2990.78
664_G728_P1.2960.78
484_P967_I1.2890.77
1447_A1484_L1.2880.77
391_F909_Y1.2860.77
673_R695_L1.2830.77
732_V739_A1.2810.77
1393_L1401_L1.2800.77
863_L896_V1.2800.77
773_I812_I1.2790.77
775_L825_L1.2770.77
1027_M1098_I1.2750.77
490_N509_V1.2730.77
965_V1595_D1.2700.76
1100_A1138_L1.2650.76
1425_T1635_Y1.2630.76
1052_K1072_A1.2580.76
1183_Y1635_Y1.2580.76
483_M598_R1.2560.76
1036_T1623_T1.2550.76
539_L653_S1.2510.75
866_P869_M1.2510.75
485_E902_G1.2500.75
883_T889_P1.2470.75
505_K570_E1.2460.75
1512_L1533_W1.2460.75
1192_A1260_F1.2450.75
1187_C1193_S1.2440.75
652_Y727_A1.2440.75
463_I998_V1.2430.75
371_L376_F1.2430.75
139_I142_E1.2430.75
903_V967_I1.2410.75
427_I433_V1.2380.75
406_N445_L1.2370.74
732_V736_R1.2340.74
1249_E1254_T1.2310.74
733_S738_W1.2310.74
657_G1254_T1.2300.74
529_L1017_V1.2290.74
1179_E1187_C1.2280.74
391_F791_S1.2280.74
1383_G1387_R1.2210.73
1193_S1425_T1.2210.73
1478_N1482_Q1.2210.73
729_N732_V1.2180.73
91_L124_L1.2160.73
1250_E1382_Y1.2140.73
1055_V1102_I1.2140.73
1239_G1282_R1.2110.73
787_A827_T1.2100.73
486_R1024_E1.2090.73
402_T451_P1.2090.73
898_A1000_A1.2080.73
1435_A1547_V1.2070.73
386_K417_L1.2060.73
1223_V1269_Y1.2060.73
191_N247_N1.2030.72
1194_G1198_S1.2020.72
425_D466_N1.1980.72
564_D702_L1.1980.72
129_L161_T1.1970.72
965_V992_F1.1970.72
1188_L1241_A1.1970.72
617_I725_V1.1910.72
507_S568_R1.1900.72
989_I996_L1.1890.71
503_E574_E1.1850.71
1055_V1454_E1.1850.71
1187_C1191_T1.1840.71
683_D686_W1.1830.71
1355_D1358_R1.1820.71
489_L602_R1.1820.71
134_D160_T1.1810.71
1359_G1363_I1.1810.71
609_W614_L1.1810.71
814_V1554_G1.1790.71
1131_T1491_S1.1750.71
739_A742_S1.1750.71
1186_G1229_R1.1740.70
877_V996_L1.1720.70
1600_A1612_L1.1720.70
790_E826_S1.1700.70
192_V195_V1.1700.70
653_S659_K1.1690.70
762_L850_L1.1690.70
441_P445_L1.1680.70
1060_S1097_E1.1660.70
390_M465_A1.1650.70
445_L1003_W1.1640.70
863_L998_V1.1590.69
1184_P1191_T1.1580.69
1253_L1257_V1.1570.69
1047_T1313_A1.1550.69
132_K163_D1.1540.69
404_I968_V1.1540.69
685_G688_S1.1540.69
185_L542_F1.1510.69
1534_L1616_A1.1510.69
1389_N1393_L1.1500.69
425_D464_R1.1480.69
347_D355_A1.1460.69
945_L948_G1.1460.69
290_S362_T1.1460.69
901_S1257_V1.1450.69
893_N976_T1.1430.68
585_Q605_E1.1400.68
341_H798_W1.1390.68
613_A652_Y1.1370.68
1041_L1100_A1.1360.68
1043_I1081_T1.1360.68
488_A995_E1.1360.68
1241_A1244_D1.1340.68
1140_P1478_N1.1330.68
1310_S1316_L1.1320.68
1187_C1243_W1.1300.67
563_L1191_T1.1300.67
92_D144_K1.1280.67
733_S739_A1.1260.67
314_A784_K1.1250.67
1179_E1190_Q1.1250.67
879_I1452_S1.1250.67
734_S739_A1.1180.67
138_T156_E1.1180.67
1038_R1624_Y1.1160.67
760_L810_L1.1140.66
1390_A1413_L1.1130.66
89_I147_N1.1110.66
1631_V1641_A1.1100.66
200_F234_L1.1090.66
1039_L1057_L1.1090.66
1263_R1266_E1.1090.66
129_L135_L1.1090.66
892_V1004_T1.1060.66
1220_R1224_D1.1060.66
1262_V1319_Q1.1050.66
1527_G1536_V1.1040.66
859_L1002_A1.1040.66
785_G801_I1.1020.66
1180_L1185_Y1.1000.65
641_D644_S1.1000.65
786_Y790_E1.0990.65
781_T831_R1.0980.65
1075_L1081_T1.0980.65
776_H809_D1.0960.65
537_S540_P1.0950.65
705_K708_E1.0920.65
317_Q338_A1.0920.65
139_I155_Y1.0920.65
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162_R166_P0.5090.22
146_L321_V0.5090.22
235_V1547_V0.5090.22
1413_L1526_S0.5090.22
100_V117_L0.5090.22
814_V998_V0.5090.22
555_T558_E0.5080.22
168_V1605_D0.5080.22
439_S1393_L0.5080.22
139_I153_K0.5080.22
137_V404_I0.5080.22
969_V1642_T0.5080.22
1063_L1072_A0.5080.22
783_G1617_R0.5070.22
1180_L1243_W0.5070.22
1460_K1465_N0.5070.22
1193_S1635_Y0.5070.22
339_Q1055_V0.5070.22
236_Y287_F0.5060.22
1445_W1449_T0.5060.22
409_L440_Q0.5060.22
1061_G1073_V0.5060.22
87_F90_P0.5060.22
405_L666_Q0.5060.22
1033_S1597_R0.5060.22
1044_T1555_L0.5060.22
1526_S1621_P0.5060.22
563_L1314_L0.5060.22
114_A126_L0.5060.22
455_N564_D0.5060.22
1083_L1623_T0.5060.22
1095_D1466_L0.5060.22
239_R789_V0.5050.22
469_D905_N0.5050.22
1243_W1425_T0.5050.22
199_F424_L0.5050.22
396_L991_D0.5050.22
895_L899_V0.5050.22
783_G1124_R0.5050.22
1436_R1439_Q0.5050.22
591_S599_P0.5040.22
1261_L1551_L0.5040.22
488_A1050_P0.5040.22
783_G902_G0.5040.22
103_V142_E0.5040.22
652_Y825_L0.5040.22
356_R361_T0.5040.22
270_A807_G0.5030.22
895_L898_A0.5030.22
643_G979_E0.5030.22
497_P1477_S0.5030.22
1361_E1368_K0.5030.22
594_E1550_L0.5030.22
825_L909_Y0.5030.22
324_L342_V0.5020.22
1075_L1078_G0.5020.22
1144_W1374_D0.5020.22
991_D996_L0.5020.22
340_G567_G0.5020.22
163_D247_N0.5020.22
194_N923_R0.5010.22
514_Y1018_A0.5010.22
387_Q1317_A0.5010.22
932_Y938_G0.5010.22
1176_Y1422_W0.5010.22
512_Y1042_D0.5010.22
866_P1169_P0.5010.22
1530_V1553_A0.5010.22
757_R1424_S0.5000.22
1622_G1634_M0.5000.22
97_F118_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3prxB 1 0.5723 100 0.566 Contact Map
2hr0B 1 0.4077 100 0.733 Contact Map
4fxkB 1 0.363 100 0.78 Contact Map
4fxkA 1 0.363 100 0.818 Contact Map
2hr0A 1 0.3612 100 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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