PBPC - ECOLI - GREMLIN Contacts

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PBPC - Penicillin-binding protein 1C

UniProt:	P76577	Sequences: MPRLLTKRGCWITLAAAPFLLFLAAWGADKLWPLPLHEVNPARVVVAQDGTPLWRFADADGIWRYPVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKESREEPIWLAPRQMPQLAPLFSRMMLGKSKSDKITTTLDAGLQRRLEELAQNWKGRLPPRSSLAMIVVDHTDMRVRGWVGSVDLNDDSRFGHVDMVNSIRSPGSVLKPFVYGLALDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPLYLPNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKAGKLRLQPDDPLLERPLMSSGAAWIIRRIMADEAQPLPDSALPRVAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNNILLSRSANLPEDPRPNSVTRGVICWPGGQSLPEGDGNCRRRLATWLLDGSQPPTLLLPEQEGINGIRFPIWLDENGKRVAADCPQARQEMINVWPLPLEPWLPASERRAVRLPPASTSCPPYGHDAQLPLQLTGVRDGAIIKRLPGAAEATLPLQSSGGAGERWWFLNGEPLTERGRNVTLHLTDKGDYQLLVMDDVGQIATVKFVMQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14210
Length:	770 (607)
Sequences:	5045 (3645)
Seq/√Len:	147.9

ECOLI - PBPC PBPA PBPB
BACSU - PBPA PBPF PBPG PBPD YQGF PBPH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
183_K	192_E	5.071	1.00
174_G	184_S	4.682	1.00
234_R	238_K	4.482	1.00
449_A	533_G	4.042	1.00
233_S	236_Q	3.936	1.00
524_I	533_G	3.703	1.00
227_A	237_V	3.683	1.00
305_V	532_I	3.488	1.00
74_P	78_E	3.366	1.00
387_I	397_L	3.344	1.00
305_V	560_V	3.216	1.00
259_F	275_T	3.157	1.00
76_Y	173_I	3.134	1.00
216_E	220_N	3.011	1.00
460_K	476_P	2.871	1.00
288_A	301_L	2.808	1.00
487_R	526_V	2.774	1.00
174_G	185_P	2.737	1.00
227_A	234_R	2.734	1.00
98_S	101_R	2.671	1.00
308_H	531_V	2.663	1.00
89_W	154_R	2.621	1.00
29_D	32_W	2.588	1.00
47_A	51_T	2.582	1.00
87_W	95_N	2.561	1.00
48_Q	277_D	2.555	1.00
152_S	155_E	2.515	1.00
78_E	231_V	2.476	1.00
46_V	271_K	2.408	1.00
237_V	241_R	2.404	1.00
74_P	77_L	2.375	1.00
191_S	243_E	2.349	1.00
69_I	77_L	2.346	1.00
307_D	310_D	2.321	1.00
355_E	412_R	2.315	1.00
69_I	154_R	2.276	1.00
75_R	78_E	2.230	1.00
303_M	560_V	2.219	1.00
313_V	466_L	2.214	1.00
360_P	485_I	2.198	1.00
68_T	71_D	2.187	1.00
224_E	241_R	2.185	1.00
190_Y	232_W	2.132	1.00
312_R	465_R	2.125	1.00
83_Y	221_K	2.122	1.00
488_R	491_A	2.101	1.00
450_A	464_L	2.093	1.00
73_S	185_P	2.071	1.00
44_V	52_P	2.060	1.00
314_R	530_Y	2.029	1.00
307_D	314_R	2.027	1.00
450_A	461_A	2.021	1.00
304_I	445_L	2.018	1.00
69_I	158_T	1.994	1.00
76_Y	193_A	1.974	1.00
86_R	225_R	1.967	1.00
75_R	193_A	1.942	1.00
481_G	579_S	1.942	1.00
445_L	533_G	1.940	1.00
80_L	166_F	1.937	1.00
340_P	443_A	1.937	1.00
77_L	154_R	1.927	1.00
391_E	395_R	1.921	1.00
360_P	489_I	1.915	1.00
202_A	205_R	1.896	1.00
28_A	31_L	1.888	1.00
390_S	488_R	1.873	1.00
105_Q	114_S	1.869	1.00
328_F	331_V	1.866	1.00
170_L	179_A	1.856	1.00
46_V	273_T	1.855	1.00
284_L	303_M	1.853	1.00
225_R	228_V	1.835	1.00
390_S	492_D	1.809	1.00
290_N	559_Q	1.808	1.00
71_D	186_A	1.804	1.00
91_H	148_E	1.803	1.00
44_V	271_K	1.795	1.00
344_L	417_L	1.779	1.00
565_L	568_S	1.774	1.00
195_M	215_A	1.763	1.00
280_L	564_L	1.763	1.00
48_Q	314_R	1.761	1.00
80_L	197_A	1.718	1.00
81_I	89_W	1.716	1.00
405_L	413_F	1.714	1.00
347_F	451_A	1.706	1.00
82_N	231_V	1.702	1.00
455_F	486_I	1.700	1.00
307_D	312_R	1.700	1.00
484_W	607_W	1.692	1.00
304_I	446_E	1.686	1.00
280_L	314_R	1.673	1.00
101_R	114_S	1.650	1.00
508_L	527_N	1.647	1.00
448_M	524_I	1.646	1.00
224_E	237_V	1.637	1.00
415_A	419_N	1.627	1.00
510_W	523_A	1.622	1.00
164_A	200_P	1.620	1.00
262_M	466_L	1.619	1.00
509_A	526_V	1.614	1.00
332_D	539_P	1.610	1.00
351_L	416_K	1.607	1.00
389_M	404_V	1.593	1.00
77_L	89_W	1.592	1.00
190_Y	240_S	1.589	1.00
380_D	384_H	1.587	1.00
86_R	229_Q	1.586	1.00
82_N	229_Q	1.584	1.00
263_M	274_T	1.578	1.00
303_M	532_I	1.576	1.00
189_S	243_E	1.575	1.00
484_W	577_P	1.570	1.00
67_V	72_V	1.564	1.00
69_I	89_W	1.554	1.00
69_I	72_V	1.543	1.00
124_A	147_L	1.538	1.00
165_P	169_T	1.535	1.00
178_W	182_G	1.530	1.00
363_L	386_P	1.529	1.00
350_G	455_F	1.527	1.00
76_Y	80_L	1.525	1.00
558_N	562_N	1.521	1.00
394_V	492_D	1.517	1.00
353_L	489_I	1.506	1.00
350_G	478_M	1.502	1.00
283_R	563_I	1.500	1.00
282_R	286_E	1.497	1.00
507_P	570_N	1.493	1.00
329_G	333_M	1.491	1.00
348_V	437_I	1.487	1.00
225_R	229_Q	1.479	1.00
618_L	621_E	1.477	1.00
184_S	187_N	1.473	1.00
557_L	561_N	1.470	1.00
384_H	397_L	1.469	1.00
379_F	548_F	1.469	1.00
109_S	113_I	1.466	1.00
309_T	529_R	1.462	1.00
22_F	26_W	1.458	1.00
445_L	449_A	1.455	1.00
223_L	237_V	1.455	1.00
259_F	276_L	1.449	1.00
67_V	185_P	1.449	1.00
227_A	232_W	1.445	1.00
532_I	560_V	1.442	1.00
306_V	449_A	1.433	1.00
155_E	158_T	1.431	1.00
476_P	480_S	1.428	1.00
343_V	448_M	1.424	1.00
405_L	410_P	1.419	1.00
406_E	434_L	1.418	1.00
28_A	32_W	1.413	1.00
499_D	502_L	1.406	1.00
83_Y	225_R	1.371	1.00
286_E	290_N	1.370	1.00
261_R	264_L	1.367	1.00
529_R	572_P	1.366	1.00
350_G	482_A	1.365	1.00
347_F	417_L	1.361	1.00
478_M	483_A	1.354	1.00
283_R	287_L	1.349	1.00
48_Q	312_R	1.341	1.00
392_A	400_P	1.340	1.00
353_L	485_I	1.340	1.00
520_D	535_W	1.339	1.00
563_I	566_S	1.339	1.00
235_E	239_E	1.338	1.00
188_L	193_A	1.337	1.00
507_P	573_E	1.335	1.00
346_P	455_F	1.333	1.00
51_T	278_A	1.328	1.00
350_G	486_I	1.326	1.00
330_H	333_M	1.325	1.00
286_E	563_I	1.322	1.00
354_D	419_N	1.322	1.00
338_R	520_D	1.320	1.00
377_G	381_S	1.317	1.00
151_L	159_L	1.312	1.00
45_V	56_F	1.308	1.00
213_E	217_A	1.300	1.00
72_V	76_Y	1.296	1.00
354_D	482_A	1.288	1.00
457_R	462_G	1.283	1.00
389_M	489_I	1.283	1.00
234_R	237_V	1.274	1.00
134_F	138_I	1.274	1.00
79_A	226_M	1.272	1.00
458_H	484_W	1.270	1.00
453_T	531_V	1.268	1.00
424_L	447_D	1.266	1.00
481_G	580_V	1.263	1.00
364_L	407_A	1.260	1.00
306_V	531_V	1.260	1.00
420_V	478_M	1.259	1.00
354_D	416_K	1.259	1.00
166_F	173_I	1.254	1.00
412_R	415_A	1.250	1.00
397_L	400_P	1.247	1.00
262_M	266_K	1.245	1.00
236_Q	239_E	1.241	1.00
536_T	556_L	1.238	1.00
288_A	303_M	1.235	1.00
95_N	98_S	1.233	1.00
391_E	394_V	1.230	1.00
75_R	236_Q	1.214	1.00
94_V	141_L	1.206	1.00
492_D	496_P	1.204	1.00
112_V	132_K	1.201	1.00
352_A	404_V	1.200	1.00
227_A	241_R	1.200	1.00
354_D	479_S	1.199	1.00
303_M	534_I	1.196	1.00
123_V	159_L	1.195	1.00
52_P	55_R	1.194	1.00
487_R	509_A	1.193	1.00
284_L	560_V	1.191	1.00
455_F	526_V	1.190	1.00
399_L	403_Q	1.188	1.00
87_W	90_K	1.186	1.00
220_N	241_R	1.185	1.00
350_G	416_K	1.184	1.00
420_V	454_A	1.183	1.00
458_H	480_S	1.180	1.00
135_G	139_R	1.180	1.00
525_G	557_L	1.179	1.00
285_E	289_Q	1.176	1.00
494_A	508_L	1.173	1.00
285_E	317_V	1.172	1.00
69_I	157_L	1.167	1.00
387_I	400_P	1.167	1.00
80_L	200_P	1.166	1.00
211_W	214_R	1.165	1.00
79_A	197_A	1.164	1.00
116_G	125_R	1.162	1.00
532_I	561_N	1.162	1.00
148_E	156_I	1.153	1.00
608_L	614_P	1.152	1.00
100_A	103_A	1.151	1.00
191_S	240_S	1.150	1.00
471_P	474_E	1.145	1.00
238_K	242_E	1.144	1.00
280_L	315_G	1.143	1.00
287_L	559_Q	1.139	1.00
291_W	556_L	1.138	1.00
224_E	228_V	1.137	1.00
190_Y	223_L	1.136	0.99
508_L	557_L	1.136	0.99
374_Y	402_V	1.132	0.99
161_L	173_I	1.127	0.99
191_S	219_R	1.127	0.99
329_G	332_D	1.126	0.99
85_D	91_H	1.125	0.99
87_W	91_H	1.124	0.99
68_T	158_T	1.123	0.99
43_R	272_I	1.122	0.99
75_R	190_Y	1.118	0.99
405_L	436_L	1.118	0.99
146_Q	149_W	1.116	0.99
495_Q	503_P	1.102	0.99
416_K	420_V	1.096	0.99
387_I	392_A	1.096	0.99
586_C	618_L	1.089	0.99
284_L	317_V	1.088	0.99
506_A	529_R	1.087	0.99
401_A	404_V	1.086	0.99
308_H	530_Y	1.082	0.99
419_N	475_R	1.082	0.99
99_V	116_G	1.081	0.99
165_P	171_Q	1.080	0.99
109_S	112_V	1.079	0.99
23_L	27_G	1.074	0.99
456_A	526_V	1.071	0.99
461_A	475_R	1.067	0.99
411_K	415_A	1.067	0.99
47_A	278_A	1.064	0.99
270_D	472_L	1.063	0.99
99_V	121_M	1.061	0.99
348_V	413_F	1.061	0.99
399_L	402_V	1.060	0.99
364_L	400_P	1.059	0.99
168_G	207_R	1.058	0.99
120_T	148_E	1.058	0.99
280_L	560_V	1.057	0.99
288_A	317_V	1.055	0.99
484_W	576_R	1.054	0.99
380_D	397_L	1.054	0.99
45_V	53_L	1.052	0.99
106_D	134_F	1.051	0.99
370_R	375_R	1.050	0.99
224_E	227_A	1.049	0.99
383_F	399_L	1.048	0.99
77_L	157_L	1.046	0.99
370_R	373_D	1.044	0.99
411_K	432_P	1.040	0.99
106_D	116_G	1.038	0.99
361_A	608_L	1.033	0.99
72_V	77_L	1.032	0.99
66_P	158_T	1.028	0.99
262_M	265_G	1.028	0.99
239_E	243_E	1.028	0.99
212_P	216_E	1.025	0.99
119_L	164_A	1.025	0.99
350_G	483_A	1.025	0.99
284_L	315_G	1.025	0.99
146_Q	150_H	1.024	0.99
100_A	104_W	1.023	0.99
216_E	219_R	1.022	0.99
609_L	612_S	1.021	0.99
227_A	238_K	1.020	0.99
125_R	130_H	1.019	0.99
435_S	440_G	1.018	0.99
304_I	449_A	1.017	0.99
301_L	556_L	1.017	0.99
491_A	573_E	1.017	0.99
103_A	106_D	1.016	0.99
528_A	574_D	1.014	0.99
590_G	593_L	1.014	0.99
106_D	112_V	1.012	0.99
367_V	403_Q	1.010	0.99
308_H	456_A	1.007	0.99
104_W	108_T	1.005	0.99
76_Y	161_L	1.004	0.99
365_Q	386_P	1.003	0.99
347_F	420_V	1.003	0.99
582_R	607_W	0.997	0.99
326_S	329_G	0.993	0.99
183_K	187_N	0.991	0.99
483_A	487_R	0.988	0.99
202_A	206_L	0.988	0.99
106_D	109_S	0.988	0.99
340_P	440_G	0.987	0.99
173_I	196_L	0.986	0.99
306_V	464_L	0.985	0.99
402_V	438_L	0.980	0.99
214_R	217_A	0.980	0.99
491_A	507_P	0.979	0.98
353_L	486_I	0.979	0.98
444_K	447_D	0.978	0.98
530_Y	564_L	0.978	0.98
449_A	524_I	0.972	0.98
366_D	385_G	0.972	0.98
506_A	570_N	0.968	0.98
238_K	241_R	0.968	0.98
134_F	141_L	0.966	0.98
576_R	582_R	0.964	0.98
364_L	404_V	0.963	0.98
585_I	606_T	0.963	0.98
112_V	134_F	0.963	0.98
349_Y	401_A	0.957	0.98
422_L	443_A	0.955	0.98
198_V	215_A	0.948	0.98
394_V	496_P	0.948	0.98
405_L	437_I	0.948	0.98
262_M	316_W	0.946	0.98
8_R	12_I	0.946	0.98
608_L	611_G	0.944	0.98
87_W	97_F	0.940	0.98
96_P	99_V	0.939	0.98
343_V	524_I	0.937	0.98
340_P	344_L	0.936	0.98
121_M	140_Q	0.934	0.98
536_T	553_A	0.934	0.98
487_R	490_M	0.930	0.98
344_L	348_V	0.928	0.98
519_R	541_G	0.923	0.98
124_A	127_L	0.920	0.98
416_K	478_M	0.920	0.98
584_V	603_R	0.920	0.98
83_Y	201_Q	0.919	0.98
340_P	442_G	0.918	0.98
275_T	312_R	0.918	0.98
27_G	32_W	0.916	0.98
416_K	419_N	0.913	0.98
278_A	282_R	0.910	0.98
500_S	503_P	0.908	0.98
96_P	100_A	0.905	0.97
308_H	453_T	0.903	0.97
277_D	280_L	0.903	0.97
81_I	231_V	0.899	0.97
586_C	600_C	0.898	0.97
591_Q	616_T	0.898	0.97
494_A	523_A	0.898	0.97
480_S	579_S	0.895	0.97
305_V	530_Y	0.895	0.97
445_L	524_I	0.890	0.97
316_W	466_L	0.890	0.97
185_P	188_L	0.886	0.97
506_A	565_L	0.883	0.97
80_L	161_L	0.883	0.97
499_D	523_A	0.882	0.97
384_H	387_I	0.882	0.97
49_D	278_A	0.878	0.97
609_L	613_Q	0.877	0.97
304_I	316_W	0.877	0.97
493_E	499_D	0.876	0.97
393_L	401_A	0.876	0.97
81_I	157_L	0.873	0.97
339_S	515_S	0.871	0.97
599_N	603_R	0.864	0.97
586_C	590_G	0.862	0.97
504_R	507_P	0.862	0.97
310_D	465_R	0.861	0.97
195_M	219_R	0.860	0.97
261_R	322_L	0.859	0.97
521_A	549_G	0.858	0.97
350_G	420_V	0.855	0.96
550_F	554_V	0.855	0.96
168_G	179_A	0.855	0.96
364_L	389_M	0.854	0.96
483_A	486_I	0.851	0.96
205_R	214_R	0.851	0.96
328_F	332_D	0.849	0.96
384_H	395_R	0.849	0.96
92_P	96_P	0.848	0.96
449_A	531_V	0.846	0.96
219_R	244_P	0.845	0.96
340_P	441_A	0.845	0.96
80_L	164_A	0.844	0.96
586_C	589_G	0.842	0.96
65_Y	174_G	0.842	0.96
46_V	52_P	0.841	0.96
408_Y	413_F	0.837	0.96
521_A	547_Q	0.836	0.96
80_L	173_I	0.832	0.96
259_F	466_L	0.831	0.96
44_V	55_R	0.831	0.96
174_G	178_W	0.829	0.96
490_M	526_V	0.826	0.96
606_T	609_L	0.826	0.96
106_D	141_L	0.824	0.96
598_G	601_R	0.823	0.96
89_W	157_L	0.822	0.96
157_L	161_L	0.822	0.96
520_D	537_G	0.822	0.96
408_Y	412_R	0.821	0.96
326_S	331_V	0.821	0.96
588_P	602_R	0.821	0.96
99_V	141_L	0.820	0.96
485_I	580_V	0.820	0.96
78_E	89_W	0.818	0.95
94_V	145_L	0.817	0.95
422_L	451_A	0.816	0.95
213_E	216_E	0.815	0.95
148_E	153_K	0.814	0.95
182_G	248_A	0.812	0.95
390_S	606_T	0.812	0.95
479_S	482_A	0.811	0.95
185_P	193_A	0.810	0.95
72_V	173_I	0.810	0.95
73_S	193_A	0.808	0.95
195_M	198_V	0.808	0.95
521_A	553_A	0.806	0.95
71_D	174_G	0.806	0.95
105_Q	113_I	0.806	0.95
561_N	565_L	0.805	0.95
83_Y	218_A	0.804	0.95
182_G	250_R	0.803	0.95
112_V	116_G	0.801	0.95
455_F	478_M	0.801	0.95
41_P	66_P	0.801	0.95
454_A	461_A	0.801	0.95
138_I	142_W	0.799	0.95
305_V	564_L	0.796	0.95
393_L	489_I	0.796	0.95
353_L	482_A	0.795	0.95
235_E	238_K	0.793	0.95
585_I	593_L	0.792	0.95
377_G	383_F	0.792	0.95
258_L	319_S	0.791	0.95
409_G	412_R	0.789	0.94
526_V	561_N	0.788	0.94
366_D	383_F	0.788	0.94
366_D	384_H	0.785	0.94
491_A	495_Q	0.784	0.94
80_L	119_L	0.784	0.94
76_Y	190_Y	0.781	0.94
177_S	181_L	0.780	0.94
502_L	554_V	0.779	0.94
414_A	418_R	0.777	0.94
232_W	237_V	0.777	0.94
65_Y	178_W	0.772	0.94
106_D	114_S	0.772	0.94
105_Q	109_S	0.769	0.94
56_F	264_L	0.768	0.94
113_I	132_K	0.767	0.94
589_G	592_S	0.766	0.94
83_Y	229_Q	0.766	0.94
585_I	590_G	0.765	0.94
417_L	422_L	0.765	0.94
165_P	170_L	0.763	0.93
357_L	407_A	0.762	0.93
280_L	305_V	0.760	0.93
330_H	336_S	0.760	0.93
25_A	28_A	0.760	0.93
608_L	612_S	0.759	0.93
584_V	605_A	0.757	0.93
340_P	448_M	0.754	0.93
583_G	592_S	0.754	0.93
582_R	605_A	0.753	0.93
201_Q	205_R	0.753	0.93
600_C	618_L	0.752	0.93
51_T	279_G	0.750	0.93
482_A	486_I	0.750	0.93
73_S	76_Y	0.748	0.93
69_I	73_S	0.748	0.93
167_G	180_Y	0.748	0.93
602_R	606_T	0.748	0.93
604_L	608_L	0.746	0.93
487_R	574_D	0.746	0.93
443_A	448_M	0.744	0.93
113_I	116_G	0.743	0.93
493_E	523_A	0.743	0.93
405_L	434_L	0.742	0.92
559_Q	563_I	0.742	0.92
579_S	610_D	0.742	0.92
313_V	446_E	0.741	0.92
534_I	556_L	0.741	0.92
509_A	574_D	0.739	0.92
67_V	174_G	0.738	0.92
388_S	391_E	0.738	0.92
455_F	487_R	0.738	0.92
581_T	613_Q	0.737	0.92
600_C	604_L	0.737	0.92
357_L	404_V	0.737	0.92
30_K	33_P	0.735	0.92
523_A	557_L	0.735	0.92
431_A	441_A	0.734	0.92
479_S	483_A	0.733	0.92
128_D	131_P	0.733	0.92
529_R	568_S	0.732	0.92
422_L	448_M	0.732	0.92
76_Y	185_P	0.732	0.92
128_D	136_G	0.729	0.92
67_V	73_S	0.729	0.92
9_G	16_A	0.726	0.92
534_I	553_A	0.725	0.92
94_V	99_V	0.725	0.92
494_A	510_W	0.724	0.92
577_P	580_V	0.724	0.92
484_W	580_V	0.723	0.91
450_A	453_T	0.722	0.91
478_M	482_A	0.721	0.91
304_I	531_V	0.721	0.91
12_I	16_A	0.718	0.91
351_L	408_Y	0.718	0.91
606_T	611_G	0.716	0.91
120_T	144_A	0.716	0.91
492_D	495_Q	0.715	0.91
77_L	81_I	0.713	0.91
347_F	448_M	0.712	0.91
583_G	613_Q	0.711	0.91
363_L	388_S	0.711	0.91
589_G	618_L	0.710	0.91
601_R	605_A	0.710	0.91
521_A	550_F	0.710	0.91
348_V	405_L	0.708	0.91
174_G	177_S	0.707	0.91
233_S	237_V	0.706	0.91
415_A	418_R	0.706	0.91
98_S	114_S	0.703	0.90
201_Q	206_L	0.703	0.90
302_A	445_L	0.702	0.90
121_M	128_D	0.701	0.90
198_V	222_V	0.700	0.90
23_L	26_W	0.699	0.90
368_P	383_F	0.699	0.90
275_T	465_R	0.696	0.90
369_R	406_E	0.696	0.90
232_W	240_S	0.695	0.90
201_Q	221_K	0.695	0.90
201_Q	222_V	0.695	0.90
178_W	184_S	0.695	0.90
359_H	362_S	0.693	0.90
615_P	619_L	0.692	0.90
576_R	580_V	0.689	0.89
262_M	313_V	0.689	0.89
418_R	423_P	0.688	0.89
189_S	193_A	0.687	0.89
362_S	404_V	0.685	0.89
10_C	14_L	0.684	0.89
21_L	26_W	0.684	0.89
326_S	330_H	0.684	0.89
621_E	624_G	0.683	0.89
72_V	75_R	0.683	0.89
331_V	334_V	0.682	0.89
18_P	26_W	0.682	0.89
327_R	330_H	0.682	0.89
366_D	397_L	0.681	0.89
445_L	522_W	0.681	0.89
106_D	110_G	0.680	0.89
351_L	413_F	0.679	0.89
319_S	332_D	0.679	0.89
506_A	569_A	0.678	0.89
493_E	510_W	0.676	0.89
608_L	613_Q	0.676	0.89
243_E	247_L	0.676	0.89
613_Q	617_L	0.675	0.88
337_I	447_D	0.674	0.88
280_L	283_R	0.673	0.88
349_Y	393_L	0.673	0.88
364_L	403_Q	0.672	0.88
59_A	64_R	0.672	0.88
619_L	624_G	0.672	0.88
195_M	209_D	0.671	0.88
494_A	499_D	0.671	0.88
482_A	609_L	0.670	0.88
560_V	564_L	0.669	0.88
125_R	132_K	0.669	0.88
621_E	625_I	0.668	0.88
340_P	343_V	0.667	0.88
328_F	333_M	0.667	0.88
28_A	33_P	0.666	0.88
420_V	451_A	0.666	0.88
243_E	246_W	0.666	0.88
606_T	614_P	0.665	0.88
282_R	285_E	0.664	0.88
244_P	247_L	0.664	0.88
423_P	447_D	0.661	0.87
21_L	25_A	0.660	0.87
496_P	500_S	0.660	0.87
611_G	617_L	0.659	0.87
190_Y	193_A	0.658	0.87
266_K	465_R	0.657	0.87
600_C	603_R	0.657	0.87
102_A	106_D	0.656	0.87
96_P	145_L	0.656	0.87
450_A	463_K	0.655	0.87
11_W	14_L	0.654	0.87
8_R	15_A	0.654	0.87
221_K	224_E	0.653	0.87
57_A	60_D	0.652	0.87
591_Q	619_L	0.652	0.87
221_K	225_R	0.651	0.87
458_H	575_P	0.651	0.87
414_A	436_L	0.650	0.87
240_S	243_E	0.648	0.86
486_I	489_I	0.648	0.86
168_G	209_D	0.646	0.86
490_M	493_E	0.646	0.86
488_R	492_D	0.646	0.86
26_W	29_D	0.645	0.86
581_T	610_D	0.644	0.86
193_A	200_P	0.644	0.86
232_W	236_Q	0.643	0.86
414_A	432_P	0.642	0.86
227_A	230_G	0.640	0.86
279_G	283_R	0.639	0.86
387_I	391_E	0.639	0.86
114_S	132_K	0.638	0.86
101_R	105_Q	0.638	0.86
50_G	273_T	0.638	0.86
528_A	572_P	0.637	0.85
456_A	509_A	0.637	0.85
330_H	539_P	0.637	0.85
279_G	567_R	0.637	0.85
412_R	416_K	0.635	0.85
454_A	477_L	0.635	0.85
364_L	387_I	0.635	0.85
425_Y	447_D	0.635	0.85
327_R	331_V	0.635	0.85
521_A	552_S	0.634	0.85
593_L	603_R	0.633	0.85
501_A	554_V	0.633	0.85
454_A	478_M	0.633	0.85
590_G	608_L	0.633	0.85
309_T	572_P	0.632	0.85
195_M	245_I	0.631	0.85
166_F	200_P	0.631	0.85
286_E	289_Q	0.631	0.85
181_L	245_I	0.629	0.85
236_Q	240_S	0.629	0.85
461_A	464_L	0.629	0.85
518_Y	521_A	0.629	0.85
257_P	260_S	0.628	0.85
313_V	316_W	0.628	0.85
177_S	188_L	0.627	0.85
315_G	560_V	0.627	0.85
433_N	440_G	0.625	0.84
125_R	136_G	0.624	0.84
319_S	539_P	0.623	0.84
197_A	200_P	0.621	0.84
619_L	623_E	0.620	0.84
521_A	536_T	0.620	0.84
20_L	24_A	0.619	0.84
29_D	33_P	0.619	0.84
196_L	200_P	0.618	0.84
258_L	300_S	0.617	0.84
404_V	408_Y	0.617	0.84
594_P	618_L	0.616	0.83
53_L	276_L	0.615	0.83
618_L	624_G	0.614	0.83
99_V	106_D	0.612	0.83
54_W	260_S	0.612	0.83
590_G	614_P	0.611	0.83
378_N	383_F	0.610	0.83
316_W	332_D	0.608	0.83
549_G	553_A	0.608	0.83
393_L	486_I	0.607	0.83
610_D	613_Q	0.606	0.82
306_V	453_T	0.605	0.82
106_D	132_K	0.605	0.82
532_I	557_L	0.605	0.82
151_L	155_E	0.604	0.82
195_M	212_P	0.604	0.82
199_L	202_A	0.604	0.82
374_Y	434_L	0.603	0.82
353_L	360_P	0.601	0.82
603_R	608_L	0.601	0.82
525_G	561_N	0.600	0.82
69_I	81_I	0.599	0.82
589_G	608_L	0.598	0.82
81_I	86_R	0.598	0.82
21_L	24_A	0.598	0.82
53_L	278_A	0.597	0.82
618_L	622_Q	0.597	0.82
369_R	403_Q	0.596	0.81
530_Y	565_L	0.595	0.81
207_R	210_R	0.595	0.81
337_I	442_G	0.594	0.81
92_P	145_L	0.594	0.81
105_Q	112_V	0.594	0.81
586_C	621_E	0.594	0.81
73_S	77_L	0.589	0.81
344_L	347_F	0.589	0.81
131_P	136_G	0.588	0.81
598_G	602_R	0.588	0.81
506_A	528_A	0.587	0.80
105_Q	108_T	0.586	0.80
73_S	186_A	0.586	0.80
446_E	466_L	0.585	0.80
590_G	594_P	0.584	0.80
174_G	186_A	0.584	0.80
359_H	612_S	0.584	0.80
617_L	621_E	0.583	0.80
16_A	19_F	0.582	0.80
519_R	540_D	0.580	0.80
128_D	143_R	0.580	0.80
49_D	277_D	0.579	0.80
76_Y	188_L	0.579	0.80
17_A	23_L	0.578	0.79
585_I	589_G	0.578	0.79
116_G	132_K	0.578	0.79
592_S	614_P	0.577	0.79
106_D	111_R	0.575	0.79
527_N	574_D	0.574	0.79
338_R	535_W	0.574	0.79
410_P	432_P	0.574	0.79
46_V	50_G	0.573	0.79
67_V	71_D	0.571	0.79
607_W	611_G	0.569	0.78
21_L	27_G	0.569	0.78
216_E	245_I	0.569	0.78
365_Q	403_Q	0.567	0.78
593_L	598_G	0.566	0.78
566_S	569_A	0.565	0.78
615_P	623_E	0.565	0.78
527_N	565_L	0.565	0.78
494_A	502_L	0.564	0.78
262_M	334_V	0.562	0.78
287_L	563_I	0.560	0.77
20_L	23_L	0.560	0.77
401_A	489_I	0.560	0.77
564_L	567_R	0.560	0.77
83_Y	222_V	0.559	0.77
328_F	335_N	0.558	0.77
585_I	608_L	0.557	0.77
16_A	20_L	0.557	0.77
92_P	148_E	0.557	0.77
346_P	393_L	0.557	0.77
612_S	618_L	0.557	0.77
612_S	615_P	0.556	0.77
446_E	449_A	0.556	0.77
24_A	28_A	0.555	0.77
611_G	615_P	0.555	0.77
265_G	335_N	0.555	0.77
170_L	204_S	0.554	0.77
440_G	515_S	0.554	0.77
121_M	136_G	0.553	0.76
339_S	516_Y	0.553	0.76
591_Q	594_P	0.550	0.76
42_A	55_R	0.550	0.76
554_V	558_N	0.549	0.76
177_S	193_A	0.549	0.76
448_M	522_W	0.548	0.76
261_R	265_G	0.548	0.76
256_A	282_R	0.548	0.76
13_T	16_A	0.548	0.76
103_A	108_T	0.547	0.76
266_K	466_L	0.547	0.76
300_S	539_P	0.547	0.76
309_T	457_R	0.546	0.76
101_R	225_R	0.545	0.75
515_S	520_D	0.545	0.75
256_A	259_F	0.545	0.75
195_M	208_P	0.543	0.75
15_A	19_F	0.542	0.75
124_A	143_R	0.542	0.75
502_L	558_N	0.542	0.75
594_P	599_N	0.542	0.75
19_F	22_F	0.541	0.75
619_L	622_Q	0.541	0.75
394_V	493_E	0.541	0.75
281_Q	316_W	0.541	0.75
476_P	479_S	0.540	0.75
611_G	614_P	0.540	0.75
192_E	243_E	0.540	0.75
457_R	460_K	0.539	0.75
198_V	221_K	0.539	0.75
65_Y	175_A	0.539	0.75
587_W	604_L	0.537	0.74
536_T	550_F	0.536	0.74
302_A	535_W	0.536	0.74
371_T	434_L	0.536	0.74
515_S	541_G	0.535	0.74
259_F	263_M	0.535	0.74
589_G	593_L	0.535	0.74
284_L	305_V	0.535	0.74
593_L	599_N	0.534	0.74
27_G	138_I	0.534	0.74
121_M	125_R	0.534	0.74
300_S	332_D	0.534	0.74
173_I	185_P	0.534	0.74
41_P	467_Q	0.534	0.74
87_W	148_E	0.534	0.74
423_P	426_L	0.533	0.74
588_P	591_Q	0.533	0.74
548_F	551_A	0.533	0.74
211_W	215_A	0.533	0.74
212_P	247_L	0.533	0.74
78_E	154_R	0.532	0.74
509_A	561_N	0.531	0.73
219_R	247_L	0.530	0.73
493_E	498_P	0.529	0.73
300_S	320_V	0.529	0.73
491_A	494_A	0.529	0.73
245_I	248_A	0.529	0.73
72_V	158_T	0.528	0.73
622_Q	625_I	0.527	0.73
360_P	606_T	0.526	0.73
308_H	528_A	0.526	0.73
121_M	141_L	0.526	0.73
605_A	609_L	0.525	0.73
435_S	442_G	0.525	0.73
165_P	168_G	0.525	0.73
484_W	579_S	0.524	0.73
353_L	389_M	0.524	0.73
550_F	553_A	0.523	0.72
179_A	199_L	0.523	0.72
307_D	529_R	0.523	0.72
177_S	196_L	0.522	0.72
260_S	264_L	0.522	0.72
400_P	403_Q	0.522	0.72
436_L	441_A	0.521	0.72
291_W	559_Q	0.521	0.72
277_D	314_R	0.520	0.72
48_Q	278_A	0.520	0.72
401_A	437_I	0.519	0.72
216_E	244_P	0.518	0.72
24_A	27_G	0.518	0.72
204_S	211_W	0.518	0.72
18_P	22_F	0.517	0.72
371_T	376_P	0.516	0.71
103_A	107_L	0.516	0.71
529_R	565_L	0.516	0.71
302_A	332_D	0.516	0.71
366_D	400_P	0.516	0.71
277_D	568_S	0.515	0.71
67_V	173_I	0.515	0.71
422_L	426_L	0.515	0.71
47_A	50_G	0.515	0.71
433_N	442_G	0.514	0.71
561_N	564_L	0.514	0.71
371_T	392_A	0.514	0.71
601_R	606_T	0.513	0.71
493_E	497_L	0.513	0.71
593_L	600_C	0.513	0.71
534_I	557_L	0.512	0.71
13_T	17_A	0.512	0.71
287_L	556_L	0.511	0.71
219_R	245_I	0.511	0.71
226_M	232_W	0.511	0.71
452_Y	524_I	0.510	0.71
526_V	531_V	0.510	0.71
177_S	185_P	0.510	0.71
389_M	400_P	0.509	0.70
26_W	32_W	0.509	0.70
316_W	334_V	0.508	0.70
614_P	621_E	0.508	0.70
586_C	592_S	0.508	0.70
64_R	269_S	0.507	0.70
456_A	487_R	0.507	0.70
461_A	477_L	0.507	0.70
202_A	214_R	0.507	0.70
218_A	226_M	0.506	0.70
547_Q	552_S	0.506	0.70
339_S	440_G	0.503	0.69
47_A	53_L	0.503	0.69
283_R	286_E	0.503	0.69
283_R	564_L	0.503	0.69
422_L	447_D	0.502	0.69
515_S	519_R	0.502	0.69
376_P	402_V	0.502	0.69
546_G	550_F	0.502	0.69
587_W	602_R	0.502	0.69
288_A	556_L	0.501	0.69
344_L	441_A	0.500	0.69
233_S	240_S	0.500	0.69
344_L	413_F	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4oonA	1	0.4649	100	0.229	Contact Map
2jchA	1	0.513	100	0.265	Contact Map
3vmaA	1	0.7584	100	0.269	Contact Map
3udfA	2	0.6	100	0.284	Contact Map
2olvA	1	0.713	100	0.326	Contact Map
3zg9B	1	0.5325	100	0.474	Contact Map
2y2mA	2	0.5649	100	0.602	Contact Map
3un7A	1	0.4351	100	0.67	Contact Map
2v2fF	1	0.4221	100	0.674	Contact Map
2oqoA	2	0.2338	100	0.674	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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