GREMLIN Database
YFGM - UPF0070 protein YfgM
UniProt: P76576 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14209
Length: 206 (162)
Sequences: 6873 (6408)
Seq/√Len: 503.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_Q143_A4.2271.00
173_D176_G4.1901.00
103_E106_K3.6631.00
91_S110_Q2.8861.00
165_G181_W2.8321.00
161_A180_A2.7461.00
128_N147_T2.6211.00
149_D164_R2.5551.00
95_A111_L2.4861.00
164_R180_A2.4771.00
131_L147_T2.4771.00
112_Q131_L2.3971.00
132_A148_L2.2731.00
111_L130_R2.2411.00
148_L163_L2.1591.00
168_L176_G2.1531.00
94_L110_Q2.0631.00
168_L180_A1.8771.00
75_A93_E1.8031.00
98_F106_K1.7751.00
76_E94_L1.7711.00
145_L149_D1.7211.00
108_A112_Q1.7121.00
135_Q143_A1.7051.00
98_F110_Q1.6681.00
142_D171_K1.6521.00
178_R182_E1.6141.00
60_A75_A1.5891.00
135_Q147_T1.5831.00
108_A134_V1.5511.00
131_L135_Q1.5271.00
113_Q116_A1.4981.00
115_L127_I1.4601.00
161_A183_A1.4261.00
84_N87_G1.4251.00
164_R168_L1.4221.00
168_L173_D1.4191.00
145_L171_K1.4151.00
183_A186_K1.4081.00
145_L167_A1.3731.00
108_A131_L1.3591.00
69_P101_K1.3481.00
135_Q140_Q1.3431.00
39_W42_W1.3221.00
129_L163_L1.3211.00
124_K127_I1.3091.00
151_I160_V1.2731.00
108_A138_L1.2651.00
169_L181_W1.2651.00
125_A151_I1.2491.00
98_F103_E1.2481.00
188_D191_P1.2471.00
63_A74_A1.2471.00
114_G127_I1.2431.00
88_A114_G1.2401.00
143_A146_K1.2311.00
94_L98_F1.2301.00
118_T124_K1.2261.00
145_L164_R1.2261.00
158_A184_G1.2101.00
56_A74_A1.1881.00
105_E138_L1.1881.00
133_R163_L1.1871.00
176_G179_S1.1821.00
92_L130_R1.1681.00
154_E157_A1.1551.00
145_L168_L1.1501.00
134_V138_L1.1181.00
167_A171_K1.1111.00
128_N150_T1.0861.00
95_A114_G1.0721.00
165_G184_G1.0631.00
72_I76_E1.0501.00
72_I97_Q1.0381.00
79_A90_A1.0371.00
97_Q101_K1.0291.00
136_V148_L1.0081.00
162_D184_G1.0021.00
59_N63_A0.9951.00
99_V111_L0.9951.00
136_V163_L0.9811.00
115_L128_N0.9791.00
183_A187_S0.9761.00
63_A70_D0.9731.00
57_Y61_V0.9591.00
162_D166_E0.9531.00
182_E186_K0.9371.00
158_A188_D0.9371.00
92_L96_Q0.9361.00
104_L134_V0.9321.00
136_V167_A0.9211.00
96_Q111_L0.9141.00
72_I98_F0.9031.00
77_K81_E0.9021.00
36_L39_W0.8991.00
88_A118_T0.8981.00
110_Q114_G0.8961.00
72_I101_K0.8931.00
92_L127_I0.8911.00
129_L157_A0.8851.00
73_P77_K0.8831.00
108_A135_Q0.8821.00
129_L160_V0.8811.00
77_K80_A0.8811.00
60_A78_F0.8751.00
79_A91_S0.8711.00
87_G90_A0.8671.00
114_G117_D0.8611.00
128_N151_I0.8581.00
157_A160_V0.8561.00
179_S182_E0.8501.00
78_F90_A0.8451.00
144_A148_L0.8391.00
99_V134_V0.8271.00
70_D73_P0.8221.00
166_E181_W0.8191.00
96_Q130_R0.8191.00
145_L173_D0.8161.00
129_L151_I0.8111.00
129_L133_R0.8081.00
54_S58_Q0.8061.00
180_A183_A0.7971.00
40_R43_N0.7911.00
177_A181_W0.7901.00
132_A151_I0.7851.00
142_D145_L0.7791.00
78_F81_E0.7731.00
161_A184_G0.7701.00
107_A111_L0.7691.00
63_A68_K0.7691.00
106_K109_A0.7671.00
169_L174_K0.7591.00
91_S113_Q0.7551.00
64_V75_A0.7511.00
40_R44_S0.7471.00
76_E110_Q0.7461.00
96_Q100_D0.7441.00
99_V104_L0.7441.00
147_T150_T0.7421.00
113_Q117_D0.7401.00
166_E169_L0.7371.00
112_Q116_A0.7371.00
91_S114_G0.7341.00
112_Q147_T0.7331.00
111_L134_V0.7321.00
72_I94_L0.7301.00
136_V141_A0.7281.00
124_K128_N0.7281.00
180_A184_G0.7251.00
59_N74_A0.7241.00
74_A77_K0.7091.00
71_S75_A0.7081.00
61_V75_A0.7001.00
142_D146_K0.6971.00
88_A124_K0.6931.00
146_K150_T0.6891.00
141_A167_A0.6811.00
61_V93_E0.6811.00
92_L124_K0.6801.00
136_V170_S0.6781.00
76_E106_K0.6741.00
56_A81_E0.6731.00
184_G187_S0.6731.00
174_K178_R0.6711.00
175_Q179_S0.6711.00
99_V137_Q0.6691.00
143_A147_T0.6621.00
149_D180_A0.6591.00
162_D191_P0.6571.00
149_D168_L0.6551.00
79_A94_L0.6541.00
56_A59_N0.6481.00
161_A187_S0.6431.00
112_Q135_Q0.6391.00
90_A93_E0.6301.00
108_A140_Q0.6291.00
52_S56_A0.6281.00
73_P76_E0.6261.00
104_L138_L0.6261.00
128_N153_G0.6221.00
144_A167_A0.6181.00
110_Q113_Q0.6151.00
146_K149_D0.6121.00
71_S97_Q0.6070.99
125_A154_E0.6060.99
37_I40_R0.6040.99
181_W185_V0.5980.99
60_A71_S0.5960.99
76_E80_A0.5950.99
69_P72_I0.5930.99
166_E170_S0.5880.99
42_W45_H0.5880.99
158_A162_D0.5860.99
104_L137_Q0.5820.99
71_S78_F0.5770.99
64_V93_E0.5760.99
163_L166_E0.5740.99
179_S183_A0.5740.99
72_I75_A0.5740.99
132_A144_A0.5730.99
165_G177_A0.5720.99
132_A147_T0.5710.99
129_L159_I0.5700.99
105_E108_A0.5690.99
92_L114_G0.5690.99
158_A191_P0.5690.99
148_L164_R0.5670.99
99_V130_R0.5640.99
109_A112_Q0.5630.99
112_Q143_A0.5630.99
182_E185_V0.5610.99
69_P73_P0.5590.99
141_A171_K0.5560.99
39_W43_N0.5520.99
53_A56_A0.5500.99
138_L141_A0.5410.99
133_R148_L0.5400.99
153_G157_A0.5400.99
147_T151_I0.5380.99
93_E96_Q0.5340.99
164_R171_K0.5320.99
118_T127_I0.5300.99
114_G118_T0.5290.99
176_G180_A0.5270.99
67_G71_S0.5260.99
102_N139_K0.5240.99
74_A78_F0.5200.98
115_L131_L0.5190.98
109_A113_Q0.5190.98
130_R163_L0.5180.98
56_A60_A0.5160.98
132_A160_V0.5160.98
124_K157_A0.5150.98
76_E79_A0.5140.98
99_V107_A0.5110.98
105_E109_A0.5110.98
61_V65_S0.5090.98
171_K174_K0.5080.98
41_Y44_S0.5060.98
53_A78_F0.5050.98
104_L108_A0.5040.98
52_S55_L0.5020.98
150_T153_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dssA 1 0.9417 99.6 0.455 Contact Map
2pziA 1 0.9175 99.6 0.455 Contact Map
2vsyA 1 0.5728 99.6 0.46 Contact Map
1dceA 1 0.9757 99.6 0.461 Contact Map
2e2eA 2 0.7427 99.6 0.461 Contact Map
4gywA 2 0.7379 99.6 0.462 Contact Map
3qkyA 1 0.7573 99.6 0.466 Contact Map
3q7aA 1 0.9126 99.6 0.47 Contact Map
5aioA 1 0.7087 99.6 0.472 Contact Map
4l9pA 1 0.966 99.6 0.474 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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